Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
171
datasets available to search
ShareScore release 0.9.0
Dataset results
171 results for “herbal medicine”
Large scale virtual screening for finding inhibitor against the main protease from herbal medicine for SARS-Cov2 therapy
<p>The pandemic COVID-19 caused by SARS-CoV-2 has raised global health concerns. However, there is still no targeted medicine available for treatment of this disease. It is reported that 3CLpro plays an important role for the life cycle of virus and this protein has also been proved as an effective drug target in the case of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). Medicinal plantsare important resource for drug discovery. Therefore, we executed large scale virtual screening on the herbal medicine library and hoped to find a potential drug againstthe main protease. As a result, we obtained three available compounds derived from Chinese herbal medicines through the docking and binding free energy calculation.Then 100 ns molecular dynamic (MD) were employed to uncover the potential mechanisms which is helpful for further drug optimization.</p>
Three-tiered authentication of herbal Traditional Chinese Medicine ingredients used in women's health provides progressive qualitative and quantitative insight - part 2/4
<p>Traditional Chinese Medicine herbal products are increasingly used in Europe but prevalent authentication methods have significant gaps in detection. In this study, three authentication methods were tested in a tiered approach to improve accuracy on a collection of 51 TCM plant ingredients obtained on the European market. We show the relative performance of conventional barcoding, metabarcoding and standardized chromatographic profiling for TCM ingredients used in one of the most diagnosed disease patterns in women, endometriosis. DNA barcoding using marker ITS2 and chromatographic profiling are methods of choice reported by regulatory authorities and relevant national pharmacopeias. HPTLC was shown to be a valuable authentication tool, combined with metabarcoding, which gives an increased resolution on species diversity, despite dealing with highly processed herbal ingredients. Conventional DNA barcoding as a recommended method was shown to be an insufficient tool for authentication of these samples, while DNA metabarcoding yields an insight into biological contaminants. We conclude that a tiered identification strategy can provide progressive qualitative and quantitative insight in an integrative approach for quality control of processed herbal ingredients. </p>
Three-tiered authentication of herbal Traditional Chinese Medicine ingredients used in women's health provides progressive qualitative and quantitative insight - part 1/4
<p>Traditional Chinese Medicine herbal products are increasingly used in Europe but prevalent authentication methods have significant gaps in detection. In this study, three authentication methods were tested in a tiered approach to improve accuracy on a collection of 51 TCM plant ingredients obtained on the European market. We show the relative performance of conventional barcoding, metabarcoding and standardized chromatographic profiling for TCM ingredients used in one of the most diagnosed disease patterns in women, endometriosis. DNA barcoding using marker ITS2 and chromatographic profiling are methods of choice reported by regulatory authorities and relevant national pharmacopeias. HPTLC was shown to be a valuable authentication tool, combined with metabarcoding, which gives an increased resolution on species diversity, despite dealing with highly processed herbal ingredients. Conventional DNA barcoding as a recommended method was shown to be an insufficient tool for authentication of these samples, while DNA metabarcoding yields an insight into biological contaminants. We conclude that a tiered identification strategy can provide progressive qualitative and quantitative insight in an integrative approach for quality control of processed herbal ingredients. </p>
Three-tiered authentication of herbal Traditional Chinese Medicine ingredients used in women's health provides progressive qualitative and quantitative insight - part 3/4
<p>Traditional Chinese Medicine herbal products are increasingly used in Europe but prevalent authentication methods have significant gaps in detection. In this study, three authentication methods were tested in a tiered approach to improve accuracy on a collection of 51 TCM plant ingredients obtained on the European market. We show the relative performance of conventional barcoding, metabarcoding and standardized chromatographic profiling for TCM ingredients used in one of the most diagnosed disease patterns in women, endometriosis. DNA barcoding using marker ITS2 and chromatographic profiling are methods of choice reported by regulatory authorities and relevant national pharmacopeias. HPTLC was shown to be a valuable authentication tool, combined with metabarcoding, which gives an increased resolution on species diversity, despite dealing with highly processed herbal ingredients. Conventional DNA barcoding as a recommended method was shown to be an insufficient tool for authentication of these samples, while DNA metabarcoding yields an insight into biological contaminants. We conclude that a tiered identification strategy can provide progressive qualitative and quantitative insight in an integrative approach for quality control of processed herbal ingredients.</p>
Three-tiered authentication of herbal Traditional Chinese Medicine ingredients used in women's health provides progressive qualitative and quantitative insight - part 4/4
<p>Traditional Chinese Medicine herbal products are increasingly used in Europe but prevalent authentication methods have significant gaps in detection. In this study, three authentication methods were tested in a tiered approach to improve accuracy on a collection of 51 TCM plant ingredients obtained on the European market. We show the relative performance of conventional barcoding, metabarcoding and standardized chromatographic profiling for TCM ingredients used in one of the most diagnosed disease patterns in women, endometriosis. DNA barcoding using marker ITS2 and chromatographic profiling are methods of choice reported by regulatory authorities and relevant national pharmacopeias. HPTLC was shown to be a valuable authentication tool, combined with metabarcoding, which gives an increased resolution on species diversity, despite dealing with highly processed herbal ingredients. Conventional DNA barcoding as a recommended method was shown to be an insufficient tool for authentication of these samples, while DNA metabarcoding yields an insight into biological contaminants. We conclude that a tiered identification strategy can provide progressive qualitative and quantitative insight in an integrative approach for quality control of processed herbal ingredients.</p>
A Dose Determination Study of Chinese Herbal Medicine for Functional Constipation
ClinicalTrials.gov study NCT00299975. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Chinese Herbal Medicine in Acute INtracerebral Haemorrhage (CHAIN) Trial
ClinicalTrials.gov study NCT05066620. IPD Sharing: YES. Countries: 1. Publications: 1.
Study of the Effects of Chinese Herbal Medicine on Chronic Urticaria
ClinicalTrials.gov study NCT01715740. IPD Sharing: NO. Countries: 1. Publications: 4.
An Effectiveness and Safety Study of Chinese Herbal Medicine for Functional Constipation
ClinicalTrials.gov study NCT00741936. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Describing Chinese Herbal Medicine Telehealth Care for Symptoms Related to Infectious Diseases Such as COVID-19
ClinicalTrials.gov study NCT04380870. IPD Sharing: YES. Countries: 1. Publications: 30.
Efficacy and Safety of a Herbal Medicinal Product (Dry Extract BNO 1016) in Patients With Acute Rhinosinusitis
ClinicalTrials.gov study NCT01146860. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Large scale virtual screening for finding inhibitor against the main protease from herbal medicine for SARS-Cov2 therapy
Open the record for dataset details and reuse information.
Supplementary material 1 from: Kotov S, Gontova T, Kononenko N, Chernyavski E, Chikitkina V (2022) Phytochemical analysis and anti-allergic activity of a combined herbal medicine based on bur-marigold, calendula and hawthorn. Pharmacia 69(1): 237-247. https://doi.org/10.3897/pharmacia.69.e77624
HPLC results for dry extracts of the bur-marigold herb, calendula flowers, hawthorn leafand flowers and combined extract
Fig. 8 in Polyacetylenes in herbal medicine: A comprehensive review of its occurrence, pharmacology, toxicology, and pharmacokinetics (2014-2021)
Fig. 8. Schematic representation of the possible mechanism of anti-obesity and anti-hyperglycemia activities of polyacetylenes. (Akt, protein kinase B; AMPK, adenosine 5′-monophosphate-activated protein kinase; GLUT4, glucose transporter 4; HMGR, 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase; IRS, insulin receptor substrate; LKB1, liver kinase B1; MO25, mouse protein 25; PDK 1/2, pyruvate dehydrogenase kinase 1/2; PTP1B, protein tyrosine phosphatase 1B; PI3K, phosphatidylinositol 3-kinase; SREBP1c, sterol regulator elementing binding protein 1c; STRAD, STE-related adaptor protein).
Fig. 5 in Polyacetylenes in herbal medicine: A comprehensive review of its occurrence, pharmacology, toxicology, and pharmacokinetics (2014-2021)
Fig. 5. Schematic representation of the possible mechanism of antitumor activity of polyacetylenes. (AA, amino acid; Akt, protein kinase B; ASCT2, amino acid transporter alanine serine cysteine transporter 2; Bcl-2, B cell leukemia-2; CDK2, cyclin dependent kinase 2; Gln, glutamine; Glu, glutamate; HIF-1α, hypoxiainducible factor 1α; JAK, janus kinase; JNK, c-Jun N-terminal kinase; NF-κB, nuclear factor κB; PI3K, phosphatidylinositol 3-kinase; PTTG1, pituitary tumortransforming gene 1; STAT3, signal transducer and activator of transcription 3).
Fig. 7 in Polyacetylenes in herbal medicine: A comprehensive review of its occurrence, pharmacology, toxicology, and pharmacokinetics (2014-2021)
Fig. 7. Schematic representation of the possible mechanism of neuroprotective and anti-depression activities of polyacetylenes. (5-HIAA, 5-hydroxyindoleacetic acid; 5-HT, 5-hydroxytyrptamine; AC, adenylate cyclase; cAMP, cyclic adenosine monophosphate; CREB, cAMP-response element binding protein; COMT, catechol-Omethyltransferase; DA, dopamine; DAT, dopamine transporter; EAAT, excitatory amino acid transporter; EpAC1, the exchange protein directly activated by cAMP1; ERK, extracellular signal-regulated kinase; GS, stimulating adenylate cyclase g protein; HVA, homovanillic acid; MAO-A, monoamine oxidase-A; mGluR, metabotropic glutamate receptor; MEK, mitogen extracellular kinase; NMDAR, N-methyl-D-asparticacidreceptor; PSD95, postsynaptic density-95 kDa; Rap1, RASrelated protein 1; RSK, ribosomal S6 kinase; SERT, serotonin transporter).
Fig. 6 in Polyacetylenes in herbal medicine: A comprehensive review of its occurrence, pharmacology, toxicology, and pharmacokinetics (2014-2021)
Fig. 6. Schematic representation of the possible mechanism of immunoregulation activity of polyacetylenes. (COX-2, cyclo-oxygenase-2; GATA-3, GATA binding protein 3; GM-CSF, granulocyte macrophage-colony stimulating factor; IFN-γ, interferon-γ; IL-1/4/5/6/10, interleukin-1/4/5/6/10; NF-κB, nuclear factor κB; STAT3/6, signal transducer and activator of transcription 3/6; TGF-β, transforming growth factor-β; TNF-α, tumor necrosis factor-α; Th1/2/17 lymphocyte, helper T type 1/2/17; Treg cell, regulatory T cell).
dataset for paper entitled "Forty Six Years of Research about Extract of Plants as Herbal Medicine on Embryo of Zebrafish and Their Properties to Human "
<p>This is the dataset of list of papers related to use of plants on embryo of Zebrafish from 1977-2023 on Scopus website </p>
Oral Chinese Herbal Medicine for Psoriasis Vulgaris With Blood Stasis Syndrome
ClinicalTrials.gov study NCT03942198. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Effect of Prevalence of BMI on Efficacy of Herbal Medicines in Girls' Sexual Precocity
ClinicalTrials.gov study NCT04665713. IPD Sharing: UNDECIDED. Countries: 1. Publications: 7.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.