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8 results for “iTRAQ”
Exploring the anti-glioma mechanism of the active components of Cortex Periplocae based on network pharmacology and iTRAQ proteomics in vitro
<p>Hierarchical clustering analysis of candidate proteins was illustrated in heat map, which showed obvious differences between CP-induced cells and controls (Fig. 6). Each column is a sample and each rowindicates a differentially expressed protein. Log values (log<sub>2</sub>expression) of significantly differentially expressed proteins in different samples are displayed in heat maps in different colors. GreenandRedrepresent up-regulation and down-regulation, respectively. The gray part represents no quantitative information of the proteins. T1, T2 and T3 means the CP-treated U251 cells group and C2, C2 and C3 means control group (n=3).</p>
iTRAQ proteomics dataset on ceramide-dependent exosomal cargoes from SW480 and SW620 cells
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Data from: iTRAQ-based quantitative proteomic analysis on S100 calcium binding protein A2 in metastasis of laryngeal cancer
Laryngeal cancer is the most frequent neoplasm in the head and neck region, with the vast majority of tumors originating from squamous cells. The survival rate of patients with laryngeal cancer has not improved substantially over the past 25 years. To acquire further knowledge regarding the molecules responsible for laryngeal cancer oncogenesis and, in turn, to improve target therapy,iTRAQ and mass spectrometry analysis were utilized to detect differences in protein expression from 15 paired laryngeal cancer and adjacent non-cancerous tissue samples. Using mass spectrometry analysis, the expression levels of 100 proteins in laryngeal cancer samples were distinct from the non-tumor, non-cancerous samples. Further validation of the differentially expressed proteins S100A2, KRT16, FGB and HSPB1 were carried out using quantitative real-time RT-PCR, immunoblot and immunohistochemistry. Functional analysis of one of the highly expressed proteins, S100 calcium binding protein A2 (S100A2), was performed using RNA interference. As a consequence, attenuated S100A2 expression enhanced the ability of HEp-2 cell lines to migrate and invade in vitro. Our investigation complements the current understanding of laryngeal cancer progression. Furthermore, this study supports the concept that enhanced expression of S100A2 may be a promising strategy in developing novel cancer therapeutic drugs.
Data from: iTRAQ-based quantitative proteomic analysis on S100 calcium binding protein A2 in metastasis of laryngeal cancer
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Correlation Analysis of Expression Profile and Quantitative iTRAQ-LC-MS/MS Proteomics Reveals Resistance Mechanism Against TuMV in Chinese Cabbage (Brassica rapa ssp. pekinensis)
GEO Series GSE151932. Brassica rapa subsp. pekinensis. 6 samples. Type: Expression profiling by high throughput sequencing.
Identification of transcription factors involved in the regulation of flowering in Adonis amurensis through combined RNA-seq transcriptomics and iTRAQ proteomics
GEO Series GSE126456. Adonis amurensis. 6 samples. Type: Expression profiling by high throughput sequencing.
Heart-muscle expression ratios in pig obtained by 454-sequencing, iTRAQ-based proteomics and cDNA microarrays
GEO Series GSE10122. Sus scrofa. 18 samples. Type: Expression profiling by array.
Investigating the Regulation of Hypopharyngeal Gland Activity in Honeybees Undergoing Harsh Winter Conditions through RNA-seq Transcriptomics Combined with iTRAQ-based Comparative Proteomics
GEO Series GSE56910. Apis mellifera. 3 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.