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156 results for “immune memory”
Long Term Immune Memory Responses to HPV Vaccination Following 2 vs 3 Doses of Quad-HPV Vaccine
ClinicalTrials.gov study NCT02968420. IPD Sharing: NO. Countries: 1. Publications: 2.
Simulation data from: Dynamics of immune memory and learning in bacterial communities
Open the record for dataset details and reuse information.
Preexisting memory CD4 T cells in naïve individuals confer robust immunity upon vaccination
<p>Data set accompanying the publication "Preexisting memory CD4 T cells in naïve individuals confer robust immunity upon vaccination".</p> <p>In this study, we utilize high-throughput sequencing to profile the memory CD4 TCRβ repertoire and track vaccine-specific and epitope-specific TCRβ clonotypes following the de novo administration of hepatitis B (HepB) vaccine in healthy HepB-naïve individuals.</p> <p>The data set is comprised out of the following parts:</p> <ul> <li>repTCRb: Folder containing CD4+ TCR repertoire data from volunteers. Some of these samples are also available in ImmuneAccess (https://clients.adaptivebiotech.com/pub/deneuter-2018-cmvserostatus).</li> <li>peptideTCRab: Folder containing peptide-specific or peptide-pool-specific TCR data</li> <li>df_all: Meta and FC data for samples and volunteers</li> <li>freqCD154: CD154-based group definitions</li> <li>groups.csv: Group definitions used for classes</li> </ul>
Data from: Experimental evolution of insect immune memory versus pathogen resistance
Under strong pathogen pressure, insects often evolve resistance to infection. Many insects are also protected via immune memory ('immune priming'), whereby sub-lethal exposure to a pathogen enhances survival after secondary infection. Theory predicts that immune memory should evolve when the pathogen is highly virulent, or when pathogen exposure is relatively rare. However, there are no empirical tests of these hypotheses, and the adaptive benefits of immune memory relative to direct resistance against a pathogen are poorly understood. To determine the selective pressures and ecological conditions that shape immune evolution, we imposed strong pathogen selection on flour beetle (Tribolium castaneum) populations, infecting them with Bacillus thuringiensis (Bt) for 11 generations. Populations injected first with heat-killed and then live Bt each generation evolved high basal resistance against multiple Bt strains. In contrast, populations injected only with a high dose of live Bt evolved a less effective but strain-specific priming response. Control populations injected with heat-killed Bt did not evolve priming; and in the ancestor, priming was effective only against a low Bt dose. Intriguingly, one replicate population first evolved priming and subsequently evolved basal resistance, suggesting the potential for dynamic evolution of different immune strategies. Our work is the first report showing that pathogens can select for rapid modulation of insect priming ability, allowing hosts to evolve divergent immune strategies (generalized resistance vs. specific immune memory) with potentially distinct mechanisms.
Evaluation of Antibody Persistence & Immune Memory in Subjects Vaccinated During Adolescence With Twinrix™
ClinicalTrials.gov study NCT00875485. IPD Sharing: YES. Countries: 2. Publications: 2.
Antibody Persistence & Immune Memory in Healthy Adults Previously Vaccinated With Twinrix Adult
ClinicalTrials.gov study NCT01000324. IPD Sharing: YES. Countries: 1. Publications: 1.
Evaluation of Antibody Persistence and Immune Memory Against the Hepatitis B Antigen in Previously Vaccinated Children
ClinicalTrials.gov study NCT01138098. IPD Sharing: YES. Countries: 1. Publications: 1.
Evaluation of Immune Memory to Twinrix or Comparator by Challenge Dose Administration 4 Years After Primary Vaccination
ClinicalTrials.gov study NCT00684671. IPD Sharing: YES. Countries: 2. Publications: 1.
Immune Memory of DTPw-HBV/Hib Vaccine Following Primary Vaccination, Immuno & Reacto of a Booster Dose Given in Infants
ClinicalTrials.gov study NCT00169442. IPD Sharing: YES. Countries: 1. Publications: 1.
Data from: Experimental evolution of insect immune memory versus pathogen resistance
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Blood memory CD8 T cell phenotypes in lung cancer patients predict immune checkpoint treatment responses
<p>Rscript for figure generation and data analysis:</p> <p>GenerateFigures.R</p> <p> </p> <p>Seurat objects containing processed data after quality control:</p> <p><a href="../api/records/10867209/draft/files/NCCS_For_Zenodo.RDS/content" target="_blank" rel="noopener noreferrer">NCCS_For_Zenodo.RDS</a> - NCCS discovery cohort.</p> <p><a href="../api/records/10867209/draft/files/Pavia_For_Zenodo.RDS/content" target="_blank" rel="noopener noreferrer">Pavia_For_Zenodo.RDS</a> - Pavia validation cohort.</p> <p> </p> <p>RDS files containing DEGs or differentially abundant surface markers:</p> <p>TestResults2Groups.rds - Cell type specific LTR vs Non Responder DEG </p> <p>TestResults2GroupsADT.rds - Cell type specific LTR vs Non Responder differential surface markers</p> <p>TestResults2GroupsLungOnly.rds - Cell type specific LTR vs Non Responder DEG on lung samples only</p> <p>TestResults2GroupsLungOnlyADT.rds - Cell type specific LTR vs Non Responder differential surface markers on lung samples only</p> <p>TestResults3Groups.rds - Cell type specific LTR vs R vs Non Responder differential DEG</p> <p>TestResults3GroupsGeneralADT.rds - Across cell type LTR vs R vs Non Responder differential surface markers</p> <p>TestResults2GroupsGeneralRNA.rds - Across cell type LTR vs Non Responder DEG </p> <p>TestResults2GroupsGeneralADT.rds - Across cell type LTR vs Non Responder differential surface markers</p> <p>TestResults2GroupsLungOnlyGeneralRNA.rds - Across cell type LTR vs Non Responder DEG on lung samples only</p> <p>TestResults2GroupsLungOnlyGeneralADT.rds - Across cell type LTR vs Non Responder differential surface markers on lung samples only</p> <p>TestResults3GroupsGeneralRNA.rds - Across cell type LTR vs R vs Non Responder differential DEG</p> <p>TestResults3GroupsGeneralADT.rds - Across cell type LTR vs R vs Non Responder differential surface markers</p> <p> </p> <p>Logistic regression models trained on the NCCS discovery cohort:</p> <p>PerCellPredictions <CellType> * - Celltype specific models predicting either LTR, R or control group trained on all NCCS samples</p> <p>PerCellPredictions_2Groups_LungOnly <CellType> * - Celltype specific models predicting either LTR or NonResponder group, trained on lung samples only.</p> <p>PerCellPredictions_2Groups_<CellType> * - Celltype specific models predicting either LTR or NonResponder trained on all NCCS samples</p>
Long-term memory T cells as preventive anticancer immunity elicited by TuA-derived heteroclitic peptides
<p>The host’s immune system may be primed against antigens during the lifetime (e.g. microorganisms antigens—MoAs), and swiftly<br> recalled upon growth of a tumor expressing antigens similar in sequence and structure. C57BL/6 mice were immunized in a preventive<br> setting with tumor antigens (TuAs) or corresponding heteroclitic peptides specific for TC-1 and B16 cell lines. AQ1 Immediately or 2-<br> months after the end of the vaccination protocol, animals were implanted with cell lines. The specific anti-vaccine immune response as<br> well as tumor growth were regularly evaluated for 2 months post-implantation. The preventive vaccination with TuA or their<br> heteroclitic peptides (hPep) was able to delay (B16) or completely suppress (TC-1) tumor growth when cancer cells were implanted<br> immediately after the end of the vaccination. More importantly, TC-1 tumor growth was significantly delayed, and suppressed in 6/8<br> animals, also when cells were implanted 2-months after the end of the vaccination. The vaccine-specific T cell response provided a<br> strong immune correlate to the pattern of tumor growth. A preventive immunization with heteroclitic peptides resembling a TuA is able<br> to strongly delay or even suppress tumor growth in a mouse model. More importantly, the same effect is observed also when tumor<br> cells are implanted 2 months after the end of vaccination, which corresponds to 8 – 10 years in human life. The observed potent tumor<br> control indicates that a memory T cell immunity elicited during the lifetime by a antigens similar to a TuA, i.e. viral antigens, may<br> ultimately represent a great advantage for cancer patients and may lead to a novel preventive anti-cancer vaccine strategy.</p>
Effector and Memory Immune Responses to HPV Vaccination in Vietnamese Women Post Virus Exposure
ClinicalTrials.gov study NCT06681636. IPD Sharing: NO. Countries: 2. Publications: 9.
Immune Memory Foll Pry Vaccination With DTPw-HBV/Hib Vaccine Formulation; Immuno & Reacto of Booster Dose at 15-18 Mths
ClinicalTrials.gov study NCT00158808. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Impacts of Different Training Modes (Intense Versus Ordinary) on the Immune System and Memory Functions in pwMS
ClinicalTrials.gov study NCT02571335. IPD Sharing: NO. Countries: 1. Publications: 1.
Immune Memory Evaluation in Children Following a Primary Vaccination With Pneumococcal Conjugate Vaccines.
ClinicalTrials.gov study NCT00333450. IPD Sharing: YES. Countries: 1. Publications: 1.
The Duration of Humoral Immunity and the Memory Cell Function After Vaccination With 7-valent Pneumococcal Conjugate Vaccine in CLL
ClinicalTrials.gov study NCT00919321. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Memory T-cell Infusion to Improve Immunity After TCR-alpha/Beta Depleted Hematopoietic Stem Cell Transplantation
ClinicalTrials.gov study NCT02337595. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Antibody Response and Immune Memory 15-18 Years After HBV Vaccination
ClinicalTrials.gov study NCT00172328. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Interplay between nutrient stress and lysosomal signaling imprints immune memory in tissues [microarray3]
GEO Series GSE231500. Mus musculus. 24 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
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