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21 results for “kdr”
Fig. 1 in First report of kdr mutations in the voltage-gated sodium channel gene in the arbovirus vector, Aedes aegypti, from Nouakchott, Mauritania
Fig. 1 The combinations of kdr point mutations S989P, V1016G, and F1534C in adult female Aedes aegypti mosquitoes in Nouakchott, Mauritania
Figure 1 in Genetic diversity and Kdr mutations of natural Aedes (Stegomyia) aegypti (Diptera: Culicidae) populations of Brazil
Figure 1 Distribution of the kdr alleles in Aedes aegypti populations for each Paraná locality. The state is detached, showing its multiple cities of collection.
Fig. 3 in Contrasting patterns of insecticide resistance and knockdown resistance (kdr) in Aedes aegypti populations from Jacarezinho (Brazil) after a Dengue Outbreak
Fig. 3. Allelic frequencies of 1016Val and 1016Ile in the Nav of A.aegypti populations from Jacarezinho in 2011 and 2012. Besides, the allelic frequencies of the Val1016Ile mutation by regions (Region I–IV) for 2012 are presented.
Fig. 2 in Contrasting patterns of insecticide resistance and knockdown resistance (kdr) in Aedes aegypti populations from Jacarezinho (Brazil) after a Dengue Outbreak
Fig. 2. Jacarezinho map shows the collection sites by regions in the urban area used for the analysis of the Val1016Ile mutation in 2012. Additionally, the main roads that cross Jacarezinho are presented.
Figure 3 in Genetic diversity and Kdr mutations of natural Aedes (Stegomyia) aegypti (Diptera: Culicidae) populations of Brazil
Figure 3 Dendrogram of the 40 haplotypes of Aedes aegypti divided into four groups. Neighbor-joining (NJ) tree of A. aegypti haplotypes using the Tamura-Nei parameter genetic distance model. Bootstrap values are marked under the respective nodes. S. albopictus was considered as external group. AS - Alvorada do Sul; MR - Marilena; MG -Maringá, NL - Nova Londrina; PV - Paranavaí; SC - São Carlos do Ivaí.
Figure 2 in Genetic diversity and Kdr mutations of natural Aedes (Stegomyia) aegypti (Diptera: Culicidae) populations of Brazil
Figure 2 Haplotype network of ND4 gene of Aedes aegypti populations of the six minicipalities of Paraná and others from America (Gonçalves da Silva et al., 2012). The mosquitoes referring to this analysis were renamed with PR next to the haplotype number (ex: H1PR), to differentiate from the haplotypes (H) found by Gonçalves da Silva et al. (2012). The rectangle represents the ancestral haplotype. The smaller circles connecting the identified haplotypes correspond to the non-sampled haplotypes (missing haplotypes) and classified as intermediaries.
Knockdown resistance (kdr) genotypes and collection information for Aedes aegytpi from Iquitos, Peru (2000 - 2017)
<p>This study describes the evolution of <i>knockdown resistance (kdr)</i> haplotypes in <i>Aedes aegypti</i> in response to pyrethroid insecticide use over the course of 18 years in Iquitos, Peru. Based on the duration and intensiveness<span> of sampling (~10,000 samples), this is the most thorough study of kdr population genetics in <i>Ae. aegypti</i> to date within a city.</span> We provide evidence for the direct connection between programmatic citywide pyrethroid spraying and the increase in frequency of specific <i>kdr</i> haplotypes by identifying two evolutionary events in the population. The relatively high selection coefficients, even under infrequent insecticide pressure, emphasize how quickly <i>Ae. aegypti </i>populations can evolve. In our examination of the literature on mosquitoes and other insect pests, we could find no cases where a pest evolved so quickly to so few exposures to low or non-residual insecticide applications. <span>The observed rapid increase in frequency of resistance alleles might have been aided by the incomplete dominance of resistance-conferring alleles over corresponding susceptibility alleles.</span> In addition to dramatic temporal shifts, spatial suppression experiments reveal that genetic heterogeneity existed not only at the citywide scale, but also on a very fine scale within the city.</p>
Figure 5 Nav kdr 1016 and 1534 in Genetic study in Aedes (Stegomyia) aegypti (Linnaeus, 1762) from Londrina (Paraná State, Brazil): an approach to population structure and pyrethroid resistance
Figure 5 Nav kdr 1016 and 1534 site allele frequencies in UEL. Collection site locations were distributed in the three regions of the campus.
Knockdown resistance (kdr) genotypes and collection information for Aedes aegytpi from Iquitos, Peru (2000 - 2017)
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Data from: Genetic mapping identifies a major locus spanning P450 clusters associated with pyrethroid resistance in kdr-free Anopheles arabiensis from Chad
Prevention of malaria transmission throughout much of Africa is dependent on bednets that are impregnated with pyrethroid insecticides. Anopheles arabiensis is the major malaria vector in Chad and efforts to control this vector are threatened by the emergence of pyrethroid resistance. WHO bioassays revealed that An. arabiensis from Ndjamena is resistant to pyrethroids and dichlorodiphenyltrichloroethane (DDT) but fully susceptible to carbamates and organophosphates. No 1014F or 1014S kdr alleles were detected in this population. To determine the mechanisms that are responsible for resistance, genetic crosses were established between the Ndja strain and an insecticide susceptible population from Mozambique. Resistance was inherited as an autosomal trait and quantitative trait locus (QTL) mapping identified a single major locus on chromosome 2R, which explained 24.4% of the variance in resistance. This QTL is enriched in P450 genes including 25 cytochrome P450s in total. One of these, Cyp6p4 is 22-fold upregulated in the Ndja strain compared with the susceptible. Piperonyl butoxide (PBO) synergist and biochemical assays further support a role for P450s in conferring pyrethroid resistance in this population.
Understand the Association Between Peritoneal Dialysis Status and Gene Polymorphisms of VEGF and KDR
ClinicalTrials.gov study NCT04888065. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: Genetic mapping identifies a major locus spanning P450 clusters associated with pyrethroid resistance in kdr-free Anopheles arabiensis from Chad
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Fig. 1 in Contrasting patterns of insecticide resistance and knockdown resistance (kdr) in Aedes aegypti populations from Jacarezinho (Brazil) after a Dengue Outbreak
Fig. 1. Location of Jacarezinho town (PR = Paraná state) in Brazil (A). Jacarezinho map shows the collection sites in the urban area used for the analysis of the Val1016Ile mutation in 2011 and 2012. Additionally, the main roads that cross Jacarezinho are presented (B).
Epigenetic profiling of hematopoietic stem cells identifies KDR and PU.1 as regulators of aging transcriptome and caloric restriction response
GEO Series GSE284988. Mus musculus. 58 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Single nucleus RNA-seq of Kdr-FACS cells from late embryonic mouse kidney
GEO Series GSE288799. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
Study gene expression of KDR-expressing GL261 tumor associated hematopietic progenitor cells
GEO Series GSE94271. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
KDR2-2 Suspension Eyedrop in the Treatment of Neovascular Glaucoma (KDR-NVG) Trial
ClinicalTrials.gov study NCT04844619. IPD Sharing: NO. Countries: 1. Publications: 0.
Complete Remission with Conventional Chemoradiotherapy in Radiation-Induced Glioma Harboring Co-amplification of PDGFRA, KIT, and KDR: A Case Report and Literature Review
GEO Series GSE276059. Homo sapiens. 1 samples. Type: Methylation profiling by array.
Gene expression profile at single cell level of aortic cells from 2 adult R26-DreER;Ki67-CrexER;R26-GFP;Kdr rox/rox (Kdr-KO) mice after 8weeks of tamoxifen treatment.
GEO Series GSE234386. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profile among undifferentiated iPS cells (Und. iPSCs) , mesoderm cells (KDR+PDGFRα+ (KP)) at day 3(d3) to (d5) , and d5 KP derived-cardiomyocytes (CMs d5-19).
GEO Series GSE90000. Homo sapiens. 5 samples. Type: Expression profiling by array.
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International Brain Laboratory public data
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OpenNeuro
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