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361 results for “nrf2”
Broccoli Sprout Extracts Trial to See if NRF2 is Enhanced by Sulforaphane Treatment in Patients With COPD
ClinicalTrials.gov study NCT01335971. IPD Sharing: YES. Countries: 1. Publications: 2.
Exogenous foods that activate the NRF2 protein: Systematic review
<p><strong>Background: </strong>The activation of the NRF2 signaling pathway, whether through natural compounds, diet, or supplements, plays a crucial role in protecting against oxidative stress and promoting health in various aspects. The objective of this research was to identify studies on exogenous foods that activate the NRF2 protein in the scientific literature.</p> <p><strong>Method: </strong>A comprehensive literature review was conducted with the aim of identifying manuscripts related to the activation of NRF2 with exogenous foods and their benefits within the human body. This search was carried out through a systematic review of articles in three languages: English and Spanish, using the MEDLINE, MUBMEB, SCIELO, and SCOPUS repositories. Inclusion criteria focused on foods that activate NRF2 and potential benefits, while exclusion criteria encompassed articles that did not discuss activation, unrelated topics, research in languages other than those specified, and those that did not specifically address the study's objective. The search and article filters were implemented during the period from January to February 2023. To minimize biases, filters were applied in multiple stages, beginning with title search and selection, followed by abstract review, and finally, reading the remaining articles to analyze the information relevant to the research.</p> <p><strong>Results: </strong>A total of 26 articles were analyzed, which discussed the adaptive mechanism of NRF2 and its role in hormone dose response, the effects of certain foods, health benefits associated with NRF2 activation, antioxidant, and anti-inflammatory effects, altered NRF2 association with aging, and neurodegenerative diseases.</p> <p><strong>Conclusion: </strong>The studies support the notion that NRF2 activation plays a fundamental role in promoting health in various spheres, underscoring the relevance of factors such as diet, natural components, and antioxidant supplementation in defending against oxidative stress and its implications for overall well-being. For future research on this topic, it is important to analyze how the population stands regarding the consumption of exogenous foods that activate NRF2, to understand both the consumption, quantity, and frequency of certain foods and whether they are doing so correctly.</p>
Effect of Sulforaphane in Broccoli Sprouts on Nrf2 Activation
ClinicalTrials.gov study NCT01315665. IPD Sharing: Not stated. Countries: 1. Publications: 19.
The Spike Protein of SARS-CoV-2 Impairs Lipid Metabolism and Increases Susceptibility to Lipotoxicity: Implication for a Role of Nrf2
<p>Original figures for the following publication: </p> <p>The Spike Protein of SARS-CoV-2 Impairs Lipid Metabolism and Increases Susceptibility to Lipotoxicity: Implication for a Role of Nrf2</p> <table align="left"> <tbody> <tr> <td> <p><em>Cells </em><strong>2022</strong>, <em>11</em>, x. https://doi.org/10.3390/xxxxx</p> </td> </tr> </tbody> </table>
Data from: Molecular evolution of the nuclear factor (erythroid-derived 2)-like 2 gene Nrf2 in Old World fruit bats (Chiroptera: Pteropodidae)
Mammals developed antioxidant systems to defend against oxidative damage in their daily life. Enzymatic antioxidants and low molecular weight antioxidants (LMWAs) constitute major parts of the antioxidant systems. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2, encoded by the Nrf2 gene) is a central transcriptional regulator, regulating transcription, of many antioxidant enzymes. Frugivorous bats eat large amounts of fruits that contain high levels of LMWAs such as vitamin C, thus, a reliance on LMWAs might greatly reduce the need for antioxidant enzymes in comparison to insectivorous bats. Therefore, it is possible that frugivorous bats have a reduced need for Nrf2 function due to their substantial intake of diet-antioxidants. To test whether the Nrf2 gene has undergone relaxed evolution in fruit-eating bats, we obtained Nrf2 sequences from 16 species of bats, including four Old World fruit bats (Pteropodidae) and one New World fruit bat (Phyllostomidae). Our molecular evolutionary analyses revealed changes in the selection pressure acting on Nrf2 gene and identified seven specific amino acid substitutions that occurred on the ancestral lineage leading to Old World fruit bats. Biochemical experiments were conducted to examine Nrf2 in Old World fruit bats and showed that the amount of catalase, which is regulated by Nrf2, was significantly lower in the brain, heart and liver of Old World fruit bats despite higher levels of Nrf2 protein in Old World fruit bats. Computational predictions suggest that three of these seven amino acid replacements might be deleterious to Nrf2 function. Therefore, the results suggest that Nrf2 gene might have experienced relaxed constraint in Old World fruit bats, however, we cannot rule out the possibility of positive selection. Our study provides the first data on the molecular adaptation of Nrf2 gene in frugivorous bats in compensation to the increased levels of LWMAs from their fruit-diet.
Fig. 8. Compound 14 activated Nrf2 in Diterpenoids with anti-inflammatory activity from Euphorbia wallichii
Fig. 8. Compound 14 activated Nrf2/HO-1 signaling pathway. (A–C) The expressions of Nrf2 and HO-1 were determined by Western blot analysis and the quantification of protein expression was performed by Image J. (D) The inhibitory effect of 14 (16 μM) on the nuclear translocation of Nrf2 induced by LPS via confocal laser scanning microscopy. RAW264.7 cells stained for Nrf2 (red) and nuclei (DAPI, blue) (scale bar: 10 μm). The values are presented as mean ± SD of three independent experiments, n 3. ###p <0.001, vs. the control group; **p <0.01, ***p <0.001, vs. LPS-treated group. (For interpretation of the references to color in = this figure legend, the reader is referred to the Web version of this article.)
Fig. 6. C3 activated the Nrf2 in Triterpenoids from Uncaria macrophylla as ferroptosis inhibitors
Fig. 6. C3 activated the Nrf2/SLC7A11/GPx4 axis. (A) C3 increased the protein levels of Nrf2, SLC7A11 and GPx4 in a dose-dependent manner. (B) ML385 treatment abolished the neuroprotective effect of C3 in PC12 cells. (C) ML385 blocked the activation of Nrf2, SLC7A11 and GPx4.
Fig. 6. Nrf2 in Guaiane-type sesquiterpenes from Curcuma wenyujin
Fig. 6. Nrf2-luciferase activity in HEK 293 cells treated with 15 and 16 (2.5–200 μM, n = 4). *p <0.05, **p <0.01 compared with the control group. Values are presented as the mean ± SD.
Fig. 8. Forrestline F suppressed LPSinduced inflammatory activity through Nrf2 in Diterpenoid alkaloids from Delphinium forrestii var. viride and their anti-inflammation activity
Fig. 8. Forrestline F suppressed LPSinduced inflammatory activity through Nrf2 pathways and promoted the LPSinduced nuclear translocation of Nrf2. (A–B) The cells were exposed to forrestline F (5, 10, 20 μM) for 3 h and cultured with LPS for 24 h, except for the control group. The protein expression of Keap-1/Nrf2 pathway was determined by western blotting and the quantifications of protein expression were performed by Image J. (C) The inhibitory effect of forrestline F (20 μM) on the nuclear translocation of Nrf2 induced by LPS via confocal laser scanning microscopy, in conjunction with nuclear DAPI stain (scale bar: 50 μM). The values are presented as mean ± SD of three independent experiments, n = 3. ###p <0.001, vs. the control group; ***p <0.001, vs. LPS-stimulated group.
Treatment Strategy to Enhance Nrf2 Signaling in Older Adults
ClinicalTrials.gov study NCT04848792. IPD Sharing: NO. Countries: 1. Publications: 1.
Effects of Physical Activities on the Expression of Nrf2 and Nf-kb Hemodialysis Patients
ClinicalTrials.gov study NCT02718638. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease
ClinicalTrials.gov study NCT06319339. IPD Sharing: NO. Countries: 1. Publications: 15.
The Mechanism of lncRNA NEAT1 in Alleviating Acute Respiratory Distress Syndrome Through miR-27b Regulated Nrf2 Pathway
ClinicalTrials.gov study NCT04937855. IPD Sharing: Not stated. Countries: 1. Publications: 19.
Effect of Sulforaphane-rich Broccoli Sprout Homogenate on Ozone Induced Inflammation Through Modulation of NRF2
ClinicalTrials.gov study NCT01625130. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Endurance Exercise on nrf2 mRNA Expression Gene and VO2max
ClinicalTrials.gov study NCT04366479. IPD Sharing: NO. Countries: 1. Publications: 2.
Data from: Molecular evolution of the nuclear factor (erythroid-derived 2)-like 2 gene Nrf2 in Old World fruit bats (Chiroptera: Pteropodidae)
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Data from: Nrf2 ameliorates DDC-induced sclerosing cholangitis and biliary fibrosis and improves the regenerative capacity of the liver.
The Nrf2 pathway protects against oxidative stress and induces regeneration of various tissues. Here, we investigated whether Nrf2 protects from sclerosing cholangitis and biliary fibrosis and simultaneously induces liver regeneration. Diet containing 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) was fed to Nrf2-KO mice (Nrf2-/-), mice with liver-specific hyper-activated Nrf2 (HKeap1-/-) and wild type (WT) littermates to induce cholangitis, liver fibrosis, and oval cell expansion. HKeap1-/--mice were protected from almost all DDC-induced injury compared to WT and Nrf2-/-. Liver injury in Nrf2-/- and WT mice was mostly similar, albeit Nrf2-/- suffered more from DDC diet as seen for several parameters. Nrf2 activity was especially important for the expression of the hepatic efflux transporters Abcg2 and Abcc2-4, which are involved in hepatic toxin elimination. Surprisingly, cell proliferation was more enhanced in Nrf2-/-- but also HKeap1-/--mice compared to WT. Interestingly, Nrf2-/--mice failed to sufficiently activate oval cell expansion after DDC-treatment and showed almost no resident oval cell population under control conditions. The resident oval cell population of untreated HKeap1-/--mice was increased and DDC-treatment resulted in a stronger oval cell expansion compared to WT. We provide evidence that Nrf2 activation protects from DDC-induced sclerosing cholangitis and biliary fibrosis. Moreover, our data establish a possible role of Nrf2 in oval cell expansion.
The transcriptomic response of murine thyroid to iodide overload and the role of the Nrf2 antioxidant system
<p>Wild-type and Nrf2(Nfe2l2) knockout male C57BL6J mice 3-4 months old were administred 0.05% NaI in their drinking water for 7 days. Control mice were administered regular drinking water. After this treatment mice were euthanized and thyroids were excised for RNA preparation and then for mRNA and miRNA RNAseq. </p> <p>The file titled "metadata RNAseq mRNA thyroid" contains the experimental information as well as the allocation of sample numbers to the relevant groups. Briefly, </p> <p>806 Knockout Iodide</p> <p>829 Wild type Iodide</p> <p>815 Knockout Control</p> <p>811 Knockout Control</p> <p>801 Knockout Iodide</p> <p>836 Wild type Control</p> <p>838 Wild type Control</p> <p>807 Knockout Iodide</p> <p>834 Wild type Control</p> <p>827 Wild type Iodide</p> <p>831 Wild type Iodide</p> <p>804 Knockout Iodide</p> <p>825 Wild type Iodide</p> <p>841 Wild type Control</p> <p>812 Knockout Control</p> <p>803 Knockout Iodide</p> <p>810 Knockout Control</p> <p>The fastq data have been uploaded. The ones with "miRNA" in their file name refer to miRNA sequencing. All the others refer to mRNA sequencing.</p>
A Clinical Trial to Assess the Effectiveness of NRF2 Activator (Oral Sodium-copper- Chlophyllin ) in Locally Advanced Cervical Cancer to Reduce Late Radiotherapy Toxicity.
ClinicalTrials.gov study NCT07164534. IPD Sharing: UNDECIDED. Countries: 0. Publications: 36.
Data from: Nrf2 ameliorates DDC-induced sclerosing cholangitis and biliary fibrosis and improves the regenerative capacity of the liver.
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