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7 results for “optogenetic response”
Optogenetic response of mouse and macaque retinal ganglion cells
<p>Data presented in "Towards optogenetic vision restoration with high resolution"<br> BioRxiv https://www.biorxiv.org/content/10.1101/470773v1, to appear in PLOS Computational Biology.<br> Please cite this paper if the data have been useful for you.</p> <p>Data contains multi-electrode array recordings of optogenetic response of retinal ganglion cells subject to checkerboard visual stimulation.<br> Mouse: blind rd1 mice (4-5 weeks old) with an AAV2 encoding ReaChR-mCitrine under a pan-neuronal hSyn promoter via intravitreal injections. <br> Macaque: retinal ganglion cells have been targeted with an AAV2 encoding a human codon optimized CatCh under a strong, RGC-specific promoter. Retinas were harvested three months after injection of the virus in the adult macaque retina.</p>
Mouse substantia nigra responses to optogenetic stimulation of projections from striatum and globus pallidus
<p>As a rodent basal ganglia (BG) output nucleus, the substantia nigra pars reticulata (SNr) is well positioned to impact behavior. SNr neurons receive GABAergic inputs from the striatum (direct pathway) and globus pallidus (GPe, indirect pathway). Dominant theories of action selection rely on these pathways' inhibitory actions. Yet, experimental results on SNr responses to these inputs are limited and include excitatory effects. Our study combines experimental and computational work to characterize, explain, and make predictions about these pathways. We observe diverse SNr responses to stimulation of SNr-projecting striatal and GPe neurons, including biphasic and excitatory effects, which our modeling shows can be explained by intracellular chloride processing. Our work predicts that ongoing GPe activity could tune the SNr operating mode, including its responses in decision-making scenarios, and GPe output may modulate synchrony and low-frequency oscillations of SNr neurons, which we confirm using optogenetic stimulation of GPe terminals within the SNr.</p>
Dataset 2 for paper - Distinct prelimbic cortex neuronal responses drive emotion recognition in male mice during Social Interactions-Behavior - Behavior, Piezo, FP and optogenetics datasets
<p>The uploaded folders contain data for:</p> <p>1) Analyzed video clips for behavioral testing of C57BL/6J ESP data for both males and females in ESPr, ESPs, ESPi, and ESPi with female subject and male stimuli, and the Three Discrimination Task. Relevant for Figure.1 and Supp.1.</p> <p>2) Piezo data for ESPs with males, ESPi with males, and ESPi with females. Relevant for Fig.2 Each task folder contains 3 subfolders:</p> <p> 1- Timestamps</p> <p> 2- Piezo-sensors signal</p> <p> 3- Analyzed videos</p> <p>2) Fiber Photometry data for the SP, ESPs, ESPi, and Food vs. Object tasks. Relevant for Fig.3-4 and Supp.2-8. The data for each task is divided into 3 folders:</p> <p> 1- Timestamps</p> <p> 2- Fiber photometry signal</p> <p> 3- Analyzed videos</p> <p>3) Optogenetics data for SP, ESPs (excitation and inhibition), and stimulation with Empty Chambers. Relevant for Fig.8 and Supp.16. The SP and ESPs tasks in this experiment have 4 conditions, and the stimulation with empty chambers test has only the first 3 conditions of the following:</p> <p> 1- No stimulation</p> <p> 2- Stimulation with stimulus 1</p> <p> 3- Stimulation with stimulus 2</p> <p> 4- Free stimulation</p> <p>Data folders for conditions 2 and 3 contain two sub-folders:</p> <p> 1- Timestamps for the delivered optic stimulations</p> <p> 2- Analyzed videos</p>
Mouse substantia nigra responses to optogenetic stimulation of projections from striatum and globus pallidus
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Data from: Optogenetic recruitment of dorsal raphe serotonergic neurons acutely decreases mechanosensory responsivity in behaving mice
The inhibition of sensory responsivity is considered a core serotonin function, yet this hypothesis lacks direct support due to methodological obstacles. We adapted an optogenetic approach to induce acute, robust and specific firing of dorsal raphe serotonergic neurons. In vitro, the responsiveness of individual dorsal raphe serotonergic neurons to trains of light pulses varied with frequency and intensity as well as between cells, and the photostimulation protocol was therefore adjusted to maximize their overall output rate. In vivo, the photoactivation of dorsal raphe serotonergic neurons gave rise to a prominent light-evoked field response that displayed some sensitivity to a 5-HT1A agonist, consistent with autoreceptor inhibition of raphe neurons. In behaving mice, the photostimulation of dorsal raphe serotonergic neurons produced a rapid and reversible decrease in the animals' responses to plantar stimulation, providing a new level of evidence that serotonin gates sensory-driven responses.
Data from: Optogenetic recruitment of dorsal raphe serotonergic neurons acutely decreases mechanosensory responsivity in behaving mice
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Optogenetic control of the integrated stress response reveals proportional encoding and the stress memory landscape
GEO Series GSE210019. Homo sapiens. 7 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.