Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
258
datasets available to search
ShareScore release 0.9.0
Dataset results
258 results for “rejuvenation”
How to start a LINE: 5' switching rejuvenates LINE retrotransposons in tobacco and related Nicotiana species
<p>Here we provide supplementary data for our study of Retrotransosable Elements (RTE) in tobacco and other Nightshades.</p> <p> </p> <p>In contrast to their conserved mammalian counterparts, plant long interspersed nuclear elements (LINEs) are highly variable, splitting into many low-copy families. Curiously, LINE families from the RTE clade retain a stronger sequence conservation and hence reach higher copy numbers. The cause of this RTE-typical property is not yet understood, but would help clarifying why some transposable elements are removed quickly whereas others persist in plant genomes. Here, we bring forward the first detailed study of RTE LINE structure, diversity and evolution in plants. For this, we argue that the Nightshade family is the ideal taxon to follow the evolutionary trajectories of RTE LINEs, given their high abundance, recent activity and partnership to non-autonomous elements.</p> <p>Using bioinformatic, cytogenetic and molecular approaches, we detect 4029 full-length RTE LINEs across the <em>Solanaceae</em>. We finely characterize and manually curate a core group of 458 full-length LINEs in allotetraploid tobacco, show amplification after polyploidization, and trace hybridization events by RTE LINE composition of parental genomes. Finally, we reveal the role of the untranslated regions (UTRs) as causes for the unique RTE LINE amplification and evolution pattern in plants: On one hand, we detect a highly conserved motif at the 3’ UTR, suggesting strong selective constraints acting on the RTE terminus. On the other hand, we observed successive rounds of 5’ UTR cycling, constantly rejuvenating the promoter sequences. This interplay between exchangeable promoters and conserved LINE bodies and 3’ UTR likely allows RTE LINEs to persist and thrive in plant genomes.</p> <p> </p> <p>This dataset contains the nHMMs and their underlying alignments that were used for RTE detection (S1 - S4). In addition, we provide the final multiple nucleotide alignment of 458 full length SolRTE LINEs (S5) and an alignment and an annotated list of 19 representative SolRTE LINEs of tobacco (S6 - S7). Sequence names include information on the analysed genome assembly of <em>Nicotiana tabacum </em><em>Cultivar ‘TN90’</em> (GCA_000715135.1; Sierro <em>et al</em>. 2014): scaffold position (scaffold identifier; start and stop position), and sequence orientation (forward = plus; reverse = minus). Sequences of the probes used for Fluorescent <em>in situ</em> hybridisation (FISH) were provided as S8.</p>
Rapamycin rejuvenates oral health in aging mice
<p>Periodontal disease is an age-associated disorder clinically defined by periodontal bone loss, inflammation of the specialized tissues that surround and support the tooth, and microbiome dysbiosis. Currently, there is no therapy for reversing periodontal disease, and treatment is generally restricted to preventive measures or tooth extraction. The FDA-approved drug rapamycin slows aging and extends lifespan in multiple organisms, including mice. Here we demonstrate that short-term treatment with rapamycin rejuvenates the aged oral cavity of elderly mice, including regeneration of periodontal bone, attenuation of gingival and periodontal bone inflammation, and revertive shift of the oral microbiome toward a more youthful composition. This provides a geroscience strategy to potentially rejuvenate oral health and reverse periodontal disease in the elderly.</p>
Development of a Self-Healing and Rejuvenating Mechanisms for Asphalt Mixtures Containing Recycled Asphalt Shingle
<p>Corresponding data set for Tran-SET Project No. 17BLSU06. Abstract of the final report is stated below for reference:</p> <p>"The objective of this study was to test the hypothesis that hollow-fibers encapsulating a rejuvenator product could improve both self-healing, rejuvenation, and mechanical properties of asphalt mixtures. Hollow-fibers containing a rejuvenating product were synthesized via a wet spinning procedure with sodium-alginate polymer as the encapsulating material. An optimization of the production parameters for the synthesis of fibers was performed to develop fibers suitable for high-temperature and shear stress environment typical of asphalt mixture production. A self-healing experiment was conducted to evaluate the healing/rejuvenation capabilities of sodium-alginate fibers in asphalt mixtures with varying types of binders and recycled materials. Based on the self-healing experiment, a 5% fiber content was determined to be the optimum fiber content to enhance the self-healing ability of asphalt mixtures. In addition, the effect of different fiber contents on binder blends and asphalt mixtures was evaluated by performing the Multiple Stress Creep Recovery (MSCR) and Semi-Circular Bending (SCB) tests. Results of the self-healing experiment showed that the enhancement in the healing recovery depends on the breakage of the fibers. When the fibers break, the rejuvenator is released resulting in softening of the binder. In contrast, when the fibers do not break, they act as a reinforcement for the mix. Loaded Wheel Tester (LWT) test results showed a performance improvement against permanent deformation for asphalt mixtures containing recycled materials with sodium-alginate fibers compared to conventional asphalt mixtures. Furthermore, SCB test results showed that the addition of sodium-alginate fibers enhanced the fracture properties of asphalt mixtures with Recycled Asphalt Shingle (RAS) at intermediate temperatures. Moreover, the addition of fibers in mixtures with recycled materials resulted in an improved performance against low-temperature cracking as the mixtures resisted higher stresses before failure."</p>
Leaf angle as a leaf and canopy trait: Rejuvenating its role in ecology with new technology
<p>Life on Earth depends on the conversion of solar energy to chemical energy by plants through photosynthesis. A fundamental challenge in optimizing photosynthesis is to adjust leaf angles to efficiently use the intercepted sunlight under the constraints of heat stress, water loss, and competition. Despite the importance of leaf angle, until recently, we have lacked data and frameworks to describe and predict leaf angle dynamics and their impacts from leaves to the globe. We review the role of leaf angle in studies of ecophysiology, ecosystem ecology, and earth system science and highlight the essential yet understudied role of leaf angle as an ecological strategy to regulate plant carbon-water-energy nexus and to bridges leaf, canopy, and earth system processes. Using two models, we show that leaf angle variations have significant impacts on not only canopy-scale photosynthesis, energy balance, and water use efficiency but also light competition within forest canopy. New techniques to measure leaf angles are emerging, opening opportunities to understand the rarely-measured intraspecific, interspecific, seasonal, and interannual variations of leaf angles and their implications to plant biology and earth system science. We conclude by proposing three directions for future research.</p>
Appendix for the paper "Assessment of Aging and Rejuvenation for Resiliency in Heterogeneous Network Clusters"
<p><strong>Appendix for the paper "Alberto Avritzer, Andrea Janes, Andrea Marin, Andre van Hoorn, Matteo Camilli, Catia Trubiani, Daniel S. Menasché: Assessment of Aging and Rejuvenation for Resiliency in Heterogeneous Network Clusters"</strong></p> <p>This repository contains the complete set of charts for all core machines (in the paper, figures 3-8 contain only the results of one machine) and the collected data for each strategy.</p> <p><strong>Contents</strong></p> <p>The files contained in this appendix are:</p> <ul> <li>18 files of the format "experiment(strategy)(granularity).pdf, where "strategy" goes from -1 to 4 and granularity is one of i, dc, or dp (see table I in the paper).</li> <li>18 files of the format "output-(strategy)(granularity).csv, with the same format as the files above, containing the raw data.</li> </ul>
Comparative Study of a 1064-nm Fractional Picosecond Laser Versus IPL in Facial Rejuvenation
ClinicalTrials.gov study NCT07122310. IPD Sharing: NO. Countries: 1. Publications: 1.
Determine the PK and Safety and Tolerability of ATM-AVI for the Treatment of cIAIs in Hospitalized Adults (REJUVENATE)
ClinicalTrials.gov study NCT02655419. IPD Sharing: YES. Countries: 3. Publications: 3.
Clinical and Histological Evaluation of the Picosure 755nm Laser With Cap Array for Facial Rejuvenation
ClinicalTrials.gov study NCT02107157. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Radiofrequency and Hybrid Fractional Laser for Vaginal Rejuvenation
ClinicalTrials.gov study NCT03316950. IPD Sharing: NO. Countries: 1. Publications: 6.
Rapamycin rejuvenates oral health in aging mice
Open the record for dataset details and reuse information.
Leaf angle as a leaf and canopy trait: Rejuvenating its role in ecology with new technology
Open the record for dataset details and reuse information.
Rejuvenation of Fuel Cells
<p>The deliverable presents the obtained measurement and analysis results of the accelerated stress test protocols consisting of voltage cycling, designed to target electrocatalyst degradation, with the intentional recovery periods (so-called soak time steps) every 2500 voltage cycles on an already conditioned 50 cm2 (single) fuel cell provided by ElringKlinger. Before and after every intentional stop, a series of diagnostic methods (polarization curves, electrochemical impedance spectroscopy, cyclic voltammetry, linear sweep voltammetry) were performed. During the conducted durability test, different shutdown procedures, as well as different duration of the soak time period were tested with their impact on performance recovery phenomenon. The results suggest that cause of the reversible degradation could be accumulated water within the cell and/or presence of oxygen within the catalyst layer. The prolonged soak time step reduces recovery effect, while rapid reduction of the cell temperature with ice proved to be counterproductive for performance recovery. Shutdown procedure without shortly-connected resistor has shown no effect on recovery. Shutdown procedure without nitrogen purge proved to be the most effective for performance recovery.</p>
Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte
<p>Aging-associated diseases, including cardiac dysfunction, are increasingly common in the population. However, the mechanisms of physiologic aging in general, and cardiac aging in particular, remain poorly understood. Age-related heart impairment is lacking a clinically effective treatment. Using the model of naturally aging mice and rats, we show direct evidence of increased proton leak in the aged heart mitochondria. Moreover, our data suggested ANT1 as the most likely site of mediating increased mitochondrial proton permeability in old cardiomyocytes. Most importantly, the tetra-peptide SS-31 prevents age-related excess proton entry, decreases the mitochondrial flash activity and mitochondrial permeability transition pore opening, rejuvenates mitochondrial function by direct association with ANT1 and the mitochondrial ATP synthasome, and leads to substantial reversal of diastolic dysfunction. Our results uncover the excessive proton leak as a novel mechanism of age-related cardiac dysfunction and elucidate how SS-31 is able to reverse this clinically important complication of cardiac aging.</p>
Processed MERFISH datasets for brain aging (coronal, sagittal) and rejuvenation (exercise, partial reprogramming)
<p>This repository contains several AnnData ".h5ad" objects containing the processed MERFISH data and metadata for the datasets generated in our study:</p> <blockquote> <p>"aging_coronal.h5ad" - the aging coronal section dataset</p> <p>"aging_sagittal.h5ad" - the aging sagittal section dataset</p> <p>"exercise.h5ad" - exercise dataset</p> <p>"reprogramming.h5ad" - partial reprogramming dataset</p> </blockquote> <p> </p> <p>Key metadata are saved as observation annotations in each object, and include:</p> <blockquote> <p>"mouse_id" - identifier for mouse from which the cell was derived</p> <p>"slide_id" - identifier for MERSCOPE slide</p> <p>"batch" - A and B denote different experimental batches for MERFISH</p> <p>"age" - mouse age in months</p> <p>"cohort" - experimental condition / group</p> <p>"celltype" - cell type annotation</p> <p>"region" - brain region annotation</p> <p>"subregion" - brain subregion annotation (will be more variabile/noisy than region)</p> </blockquote>
Processed Data for Cell type-specific aging clocks to quantify aging and rejuvenation in regenerative regions of the brain
<p>Seurat objects for data accompanying the publication "Cell type-specific aging clocks to quantify aging and rejuvenation in regenerative regions of the brain".</p> <p>Preprint available at <a href="https://doi.org/10.1101/2022.01.10.475747">https://doi.org/10.1101/2022.01.10.475747</a></p> <ul> <li>multi_intergrated_seurat_Dec2020.rds is the data from the SVZ of the cohort of 28 mice across different ages</li> <li>pb_combined.rds is the data from the SVZ of both heterochronic parabiosis mouse cohorts</li> <li>Dulken_svz_celltypes_2019-01-31.rda is the data associated with <a href="https://doi.org/10.1038/s41586-019-1362-5">https://doi.org/10.1038/s41586-019-1362-5</a></li> </ul> <p> </p>
Processed Single-cell RNA-seq Data for Exercise Rejuvenation Intervention on Mouse Subventricular Zone
<p>Exercise single-cell RNA-seq data of mouse subventricular zone (in processed Seurat object) used in the publication "Cell type-specific aging clocks to quantify aging and rejuvenation in regenerative regions of the brain" (preprint available at <a href="https://doi.org/10.1101/2022.01.10.475747">https://doi.org/10.1101/2022.01.10.475747</a>).</p>
Straberi Epistamp Needling Treatment For Skin Rejuvenation
ClinicalTrials.gov study NCT04742803. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Periocular Rejuvenation by Topical Hyaluronic Acid Nano Particles
ClinicalTrials.gov study NCT05742399. IPD Sharing: NO. Countries: 1. Publications: 0.
Effects of QUANTUM Probe for Skin Rejuvenation and Subdermal Retraction in Patients Undergoing High-Definition Liposculpture
ClinicalTrials.gov study NCT06958978. IPD Sharing: YES. Countries: 1. Publications: 3.
The Efficacy of Platelets Rich Plasma for Ovarian Rejuvenation
ClinicalTrials.gov study NCT03946813. IPD Sharing: NO. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.