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30
datasets available to search
ShareScore release 0.9.0
Dataset results
30 results for “renal damage”
Ilofotase Alfa for Prevention of Renal Damage After Cardiac Surgery
ClinicalTrials.gov study NCT06168799. IPD Sharing: NO. Countries: 1. Publications: 1.
Renal Cell Arrest and Damage Biomarkers in Progression and Outcome of Septic AKI
ClinicalTrials.gov study NCT06064487. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
Clinical, Biological and Histological Pulmonary and Renal Damage Associated With the SARS-CoV-2 Syndrome in Patients Admitted in ICU
ClinicalTrials.gov study NCT04385004. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Antibiotic Prophylaxis and Renal Damage In Congenital Abnormalities of the Kidney and Urinary Tract
ClinicalTrials.gov study NCT02021006. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Dataset related to article "Manipulating Sirtuin 3 pathway ameliorates renal damage in experimental diabetes"
<p><em>The files contain raw data related to the article "Manipulating Sirtuin 3 pathway ameliorates renal damage in experimental diabetes", available from <a href="https://www.nature.com/articles/s41598-020-65423-0">https://www.nature.com/articles/s41598-020-65423-0</a>.</em></p> <p><strong>Abstract of the manuscript</strong>: More effective treatments for diabetic nephropathy remain a major unmet clinical need. Increased oxidative stress is one of the most important pathological mechanisms that lead to kidney damage and functional impairment induced by diabetes. Sirtuin 3 (SIRT3) is the main mitochondrial deacetylase and critically regulates cellular reactive oxygen species (ROS) production and detoxification. Honokiol is a natural biphenolic compound that, by activating mitochondrial SIRT3, can carry out anti-oxidant, anti-inflammatory and anti-fibrotic activities. Here, we sought to investigate the renoprotective effects of honokiol in BTBR <em>ob/ob</em> mice with type 2 diabetes. Diabetic mice were treated with vehicle or honokiol between the ages of 8 and 14 weeks. Wild-type mice served as controls. Renal <em>Sirt3</em> expression was significantly reduced in BTBR <em>ob/ob</em> mice, and this was associated with a reduction in its activity and increased ROS levels. Selective activation of SIRT3 through honokiol administration translated into the attenuation of albuminuria, amelioration of glomerular damage, and a reduction in podocyte injury. SIRT3 activation preserved mitochondrial wellness through the activation of SOD2 and the restoration of PGC-1α expression in glomerular cells. Additionally, the protective role of SIRT3 in glomerular changes was associated with enhanced tubular <em>Sirt3</em> expression and upregulated renal <em>Nampt</em> levels, indicating a possible tubule-glomerulus retrograde interplay, which resulted in improved glomerular SIRT3 activity. Our results demonstrate the hitherto unknown renoprotective effect of SIRT3 against diabetic glomerular disease and suggest that the pharmacological modulation of SIRT3 activity is a possible novel approach to treating diabetic nephropathy.</p>
Effect of Treatment With Finerenone on Cardio-Renal Target Organ Damage in Patients With Type 2 Diabetes.
ClinicalTrials.gov study NCT07026539. IPD Sharing: YES. Countries: 1. Publications: 0.
Trial Assessing Renal Damage During Ureteroscopy
ClinicalTrials.gov study NCT05350423. IPD Sharing: NO. Countries: 1. Publications: 0.
Propionate and butyrate counteract renal damage and progression to chronic kidney disease
GEO Series GSE221506. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Circulating miR-184 is a Potential Biomarker of Cardiac and Renal Damage in Anderson-Fabry Disease
GEO Series GSE162042. Homo sapiens. 12 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Bioinformatics-driven discovery of silica nanoparticles induces apoptosis and renal damage via the unfolded protein response in NRK-52E cells and rat kidney
GEO Series GSE240227. Rattus norvegicus. 10 samples. Type: Expression profiling by high throughput sequencing.
Identification of cathepsin L as a potential sex-specific biomarker for renal damage
GEO Series GSE19058. Rattus norvegicus. 31 samples. Type: Expression profiling by array.
Deep learning approach identified a gene signature predictive of the severity of renal damage caused by chronic cadmium accumulation
GEO Series GSE189530. Mus musculus. 36 samples. Type: Expression profiling by high throughput sequencing.
Glutamine attenuates renal ischemia-reperfusion injury and prevents acute kidney damage
GEO Series GSE188628. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Deficiency of CFB attenuates renal tubulointerstitial damage via inhibiting ceramide synthesis in diabetic kidney disease
GEO Series GSE217153. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
Identification of Transcripts Associated with Renal Damage Due to Ureteral Obstruction as Candidate Urinary Biomarkers
GEO Series GSE96571. Mus musculus. 231 samples. Type: Expression profiling by array.
Phosphodiesterase Type 5 Inhibition With Tadalafil Changes Outcomes in Heart Failure: Extent of Renal Damage
ClinicalTrials.gov study NCT01960153. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Preconditioning Against Renal Damage Under Contrast Examination
ClinicalTrials.gov study NCT02054858. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluation of Renal Damage After PCNL and ESWL Using Novel RNA Based Biomarkers
ClinicalTrials.gov study NCT05077007. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Damage and Renal Clearance of Glycocalyx in Cardiac Surgery
ClinicalTrials.gov study NCT04332952. IPD Sharing: NO. Countries: 1. Publications: 0.
Prediction of Renal Parenchymal Damage of CAKUT
ClinicalTrials.gov study NCT04537364. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.