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NIH funding notice PA-16-161

NIH Exploratory/Developmental Research Grant Program (Parent R21)

Closed on January 23, 2018.

Posted
March 31, 2016
Close date
January 23, 2018
Activity codes
R21
Institutes taking part
NEI, NHGRI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDCD, NIDCR, NIDA, NIEHS, NIMH, NINDS, NINR, NIMHD, NLM, NCCIH

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

  1. Reissues: PA-13-303 NIH Exploratory/Developmental Research Grant Program (Parent R21)
  2. 2 steps back: PA-11-261 NIH Exploratory/Developmental Research Grant Program (Parent R21)
  3. 3 steps back: PA-10-069 NIH Exploratory Developmental Research Grant Program (Parent R21)
  4. 4 steps back: PA-09-164 NIH Exploratory/Developmental Research Grant Program (Parent R21)
  5. 5 steps back: PA-06-181 NIH Exploratory/Developmental Research Grant Program (Parent R21)
  6. 6 steps back: PA-03-107

Replaced by PA-18-489.

Who won it before

6,100 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $1,363,197,969 in first-year total cost, median $228,750.

Most frequent study sections

  1. Special Emphasis Panel[ZRG1 IDM-B (80)]235
  2. Pathogenic Eukaryotes Study Section[PTHE]102
  3. Special Emphasis Panel[ZRG1 IDM-B (81)]91
  4. Virology - B Study Section[VIRB]88
  5. Cellular and Molecular Immunology - B Study Section[CMIB]87

Most frequent institutions

  1. JOHNS HOPKINS UNIVERSITY146
  2. UNIVERSITY OF PITTSBURGH AT PITTSBURGH141
  3. UNIVERSITY OF PENNSYLVANIA112
  4. UNIVERSITY OF WASHINGTON112
  5. UNIVERSITY OF CALIFORNIA LOS ANGELES111
Competing awards under PA-16-161 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2019Gating-Free Ultra-Fast Fetal Cardiac MRI with Sub-Nyquist Sampling for Live in Utero Imaging and Cardiovascular Phenotyping of Fetal Mice1R21EB023507-01A1WU, YIJEN LINUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$252,859BMIT
2019Testing a Novel Approach to Solve the On-target, Off-site Effects of Alzheimer's Drugs1R21AG056007-01A1LAHIRI, DEBOMOY KINDIANA UNIVERSITY INDIANAPOLIS, IN$237,531CDIN
2019Influence of reward on memory consolidation in adults and adolescence1R21DA043568-01A1MURTY, VISHNU PRADEEPTEMPLE UNIV OF THE COMMONWEALTH, PA$230,072CP
2019Acute Effects of Alcohol Use on Chronic Orofacial Pain1R21AA026805-01BOISSONEAULT, JEFFREY BUNIVERSITY OF FLORIDA, FL$219,219AA
2019Binge alcohol intoxication and pathobiology of ulcerative colitis1R21AA025806-01A1CHOUDHRY, MASHKOOR ALOYOLA UNIVERSITY CHICAGO, IL$214,007AA
2018Role of chromosomal context in IgVk locus novel enhancer effects on individual Vk gene utilization, germline transcription, and long-range interactions within the Igk locus1R21AI137867-01FEENEY, ANN JSCRIPPS RESEARCH INSTITUTE, THE, CA$387,000CMIA
2018Exploring Reactions to Health Warnings on Waterpipe Tobacco Ads1R21DA044249-01A1LIPKUS, ISAAC MDUKE UNIVERSITY, NC$340,600ARM
2018Distinguishing Chronic Fatigue Syndrome from Fibromyalgia by Unbiased Proteomics1R21AI135879-01A1SCHUTZER, STEVEN ERBHS-NEW JERSEY MEDICAL SCHOOL, NJ$337,987ZRG1
2018Health Disparities: Inflammatory Response, Immune Function, and Environmental (In)Congruence1R21HD095448-01GAYDOSH, LAUREN MHARGROVE, TAYLORUNIV OF NORTH CAROLINA CHAPEL HILL, NC$334,969SSPB
2018Directed Evolution of Zika EDE Glycoantigens1R21AI140030-01KRAUSS, ISAAC JONATHANBRANDEIS UNIVERSITY, MA$328,330SBCA
2018Maternal Exposure to Vicarious Structural Racism and Newborn Health Disparities in Michigan: The Flint Water Crisis1R21MD012683-01ABDOU, CLEOPATRA MIRIAMNEEDHAM, BELINDA L.UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$326,502HDEP
2018Socioeconomic Disadvantage, Adverse Birth Outcomes and Fetal Programming of Inflammation1R21MD012345-01A1SIMANEK, AMANDA MAEUNIVERSITY OF WISCONSIN MILWAUKEE, WI$324,871SSPB
2018Viral causes of idiopathic chronic kidney disease1R21AI135434-01BRUGGEMAN, LESLIE ACLEVELAND CLINIC LERNER COM-CWRU, OH$320,000PBKD
2018Examining the effects of genes and metabolism on inflammation in asthma by leveraging an isolated founder population.1R21AI138043-01DAYA, MICHELLEUNIVERSITY OF COLORADO DENVER, CO$311,000ZRG1
2018Structure-Function of PLA2g61R21NS108724-01BOLOTINA, VICTORIA MSERYSHEVA, IRINA IBOSTON MEDICAL CENTER, MA$310,000BPNS
2018Targeting scramblase TMEM16F to break T cell exhaustion1R21AI137921-01A1WINAU, FLORIANBOSTON CHILDREN'S HOSPITAL, MA$309,750CMIA
2018Repurposing S1P receptor drugs as therapeutics for pertussis in the baboon model1R21AI137778-01CARBONETTI, NICHOLAS HUNIVERSITY OF MARYLAND BALTIMORE, MD$309,000ZRG1
2018Chaperone-mediated autophagy in corneal cystinosis1R21EY028642-01CATZ, SERGIO DANIELCHERQUI, STEPHANIESCRIPPS RESEARCH INSTITUTE, THE, CA$306,443ZRG1
2018Ontogeny of Brainstem Arousal Networks in Human Consciousness1R21HD095338-01ZOLLEI, LILLAMASSACHUSETTS GENERAL HOSPITAL, MA$305,773BMIT
2018Feasibility of in-home semen testing in a North American preconception cohort study1R21HD094322-01EISENBERG, MICHAEL LWISE, LAUREN ABOSTON UNIVERSITY MEDICAL CAMPUS, MA$302,331SSPA
2018Assessing Mother and Infant Antiretroviral Exposure Using Hair Measures1R21AI138618-01GANDHI, MONICAPINTYE, JILLIANUNIVERSITY OF WASHINGTON, WA$301,430ACE
2018Identification of exosome signature in serum from ALS patients1R21NS104609-01A1BERRY, JAMES DALEBUTOVSKY, OLEGIKEZU, TSUNEYABRIGHAM AND WOMEN'S HOSPITAL, MA$300,740CNN
2018Bayesian multivariate image analysis for studying oral microbiome biogeography1R21DE026872-01A1LEE, KYU HASTARR, JACQUELINE RADA FORSYTH INSTITUTE, INC., MA$298,500ZRG1
2018Saliva-mediated Mechanisms of Post-Eruptive Enamel Mineralization1R21DE026874-01A1BIDLACK, FELICITAS BADA FORSYTH INSTITUTE, INC., MA$298,500SBDD
2018SPOT-CHECK: capture of site-specific complexes in vivo1R21NS105158-01A1MCMURRAY, CYNTHIA THERESEUNIVERSITY OF CALIF-LAWRENC BERKELEY LAB, CA$297,975MNG
2018Heterogeneous Effects of Retirement on Health and Cognition: The Role of Job Demands1R21AG058114-01A1LOPEZ GARCIA, ITALORAND CORPORATION, CA$297,283SSPA
2018A Four Core Genotype (FCG) Approach to Investigating Sex Differences in Health and Longevity1R21AG058811-01AUSTAD, STEVEN N.UNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$297,000CMAD
2018Cationic Amphiphilc Drugs for the Treatment of Meibomian Gland Dysfunction1R21EY028653-01SULLIVAN, DAVID A.SCHEPENS EYE RESEARCH INSTITUTE, MA$295,500ZRG1
2018Molecular Mechanisms of Synaptic Aging1R21AG055049-01A1PUTHANVEETTIL, SATHYASCRIPPS FLORIDA, FL$294,755MNG
2018Phage Display Detection of Alzheimer's Disease Markers1R21AG058013-01RUOSLAHTI, ERKKISANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, CA$292,500ZRG1
2018A role for TREM2/Abeta interactions in microglia-regulated AD pathogenesis1R21AG059217-01HUANG, TIMOTHY YIKAISANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, CA$292,500CDIN
2018CD44 Promotes Chronic Virus Infection1R21AI133280-01A1BRADLEY, LINDA MAC PHERSONSANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, CA$292,500ZRG1
2018Promoting survival of dopamine neurons in models of Parkinsons disease using a novel transcriptional regulator1R21NS105436-01BRUNDIN, PATRIKTAYLOR, MERRITT KEARNYVAN ANDEL RESEARCH INSTITUTE, MI$292,250CDIN
2018The influence of the milk microbiome on inflammation of the preterm infant1R21NR017256-01A1GREGORY, KATHERINE ELIZABETHBRIGHAM AND WOMEN'S HOSPITAL, MA$291,592NRCS
2018Do Xenobiotics Exacerbate Idiopathic Autoimmunity?1R21ES029263-01POLLARD, KENNETH MICHAELSCRIPPS RESEARCH INSTITUTE, THE, CA$290,250ZRG1
2018Pre-fusion Arenavirus GP trimers: Structural template for functional analysis1R21AI137809-01HASTIE, KATHRYN MARIESCRIPPS RESEARCH INSTITUTE, THE, CA$290,250ZRG1
2018Identification of sialic acid-degrading microbiome proteins during colitis1R21AI139744-01WOLAN, DENNIS WILLIAMSCRIPPS RESEARCH INSTITUTE, THE, CA$290,250GMPB
2018Mechanisms of mRNA translation that modulate protein aggregation1R21NS107951-01PETRASCHECK, MICHAELSCRIPPS RESEARCH INSTITUTE, THE, CA$290,250CMND
2018Role of Lymphangiogenesis in the Initiation and Progression of Type 1 Diabetes1R21AI140281-01TEYTON, LUCSCRIPPS RESEARCH INSTITUTE, THE, CA$290,250HAI
2018Car T Cells Encoding alpha-chain-anchored and soluble bnAbs for HIV latency1R21AI140966-01LAWSON, BRIANSCRIPPS RESEARCH INSTITUTE, THE, CA$290,250AIP
2018Hypocretin/orexin replacement with brain penetrant small molecule agonists1R21NS106882-01KILDUFF, THOMAS SSRI INTERNATIONAL, CA$290,241ZRG1
2018Mitochondrial-Nuclear Genetic Interactions in Spontaneous HCV Clearance1R21AI139012-01HULGAN, TODD MKIM, ARTHUR YVANDERBILT UNIVERSITY MEDICAL CENTER, TN$288,869ZRG1
2018Impact of Occult Hepatitis C Virus Infection in Progression of Liver Diseases1R21AI139954-01SAITO, TAKESHIUNIVERSITY OF SOUTHERN CALIFORNIA, CA$288,750CRFS
2018A Novel Drug Candidate for the Treatment of Huntington's Disease1R21NS106305-01A1MAHER, PAMELA ANNESCHUBERT, DAVID RSALK INSTITUTE FOR BIOLOGICAL STUDIES, CA$288,600NOMD
2018Can a modest change in regulation of NOD1 expression have a major impact on inflammation and gastric cancer?1R21AI138258-01SUBRAMANIAN, NAEHAINSTITUTE FOR SYSTEMS BIOLOGY, WA$286,426CE
2018Non-tuberculous Mycobacteria & Heterologous Immunity1R21AI125777-01A1HAWN, THOMAS RSETTE, ALESSANDROUNIVERSITY OF WASHINGTON, WA$285,935IHD
2018Developing novel treatments for Parkinson's disease by targeting molecular pathways that have been shown to modulate aging1R21AG058241-01MOORE, DARREN JOHNVAN ANDEL RESEARCH INSTITUTE, MI$285,000NOMD
2018Culture-free next generation sequencing for rapid detection of drug-resistant tuberculosis1R21AI135756-01RODWELL, TIMOTHY CHARLESUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$283,785ZRG1
2018The Role of the lncRNA MORRBID in Controlling Dendritic Cell Lifespan and Adaptive Immunity1R21AI135221-01WILLIAMS, ADAMJACKSON LABORATORY, ME$283,500ZRG1
2018The Function of lncRNAs in Airway Epithelial Cells1R21AI133440-01A1WILLIAMS, ADAMJACKSON LABORATORY, ME$283,500LCMI
2018Impact of Over-the-Counter Availability of Emergency Contraception on Uptake, Pregnancy, and Births1R21MD012341-01A1BIRD, CHLOE E.RAND CORPORATION, CA$282,878ZRG1
2018Effector Function of Regulatory T Cells in EAE1R21AI136572-01OUKKA, MOHAMEDSEATTLE CHILDREN'S HOSPITAL, WA$282,450ZRG1
2018Cytoskeletal Dynamics of Brain Pericytes and Impact on Capillary Flow1R21NS106138-01SHIH, ANDY YSEATTLE CHILDREN'S HOSPITAL, WA$282,450HM
2018Structural Analysis and inhibitor optimization of Cryptosporidium n-myristoyltransferase for drug discovery1R21AI137815-01STAKER, BART LEESEATTLE BIOMEDICAL RESEARCH INSTITUTE, WA$282,210ZRG1
2018Targeting islet microenvironment via inducing immunity to MSC-derived exosomes1R21AI139564-01DAI, YANG D.BIOMEDICAL RESEARCH INSTIT/ SOUTHERN, CA, CA$282,000CADO
2018Metabolomic Pathways in Food Allergy1R21AI132843-01A1CHATILA, TALAL AMINEBOSTON CHILDREN'S HOSPITAL, MA$280,324ZRG1
2018Characterization of sleep behavior in a rodent model of headache1R21NS106345-01STRASSMAN, ANDREW MARKBETH ISRAEL DEACONESS MEDICAL CENTER, MA$278,927ZRG1
2018Improving Specialty Care Delivery in the Safety Net with Natural Language Processing1R21MD012693-01A1BARNETT, MICHAEL LAWRENCEMILLER, TIMOTHY ABOSTON CHILDREN'S HOSPITAL, MA$278,902HSOD
2018Sensitive detection of malignancy in primary acquired melanosis by advanced optical imaging1R21EY029412-01LEE, HYUNJOO JEANYI, JIBOSTON MEDICAL CENTER, MA$277,819NOIT
2018Assessing Cognitive and Psychosocial Mechanisms of Useful Field of View Cognitive Training using Ecological Momentary Assessment1R21AG060216-01ROSS, LESLEY APENNSYLVANIA STATE UNIVERSITY, THE, PA$277,550CP
2018Role of top-down factors in threat perception in anxiety1R21MH111999-01A1MOHANTY, APRAJITASTATE UNIVERSITY NEW YORK STONY BROOK, NY$277,015APDA
2018Development of a Portable Synergy Resistant EMG-driven FES Device for Intuitive Control of Grasp and Release During Functional Arm Activities Following Stroke1R21HD094073-01YAO, JUNNORTHWESTERN UNIVERSITY AT CHICAGO, IL$276,500MFSR
2018Exploring Medicaid Analytic eXtract (MAX) to reduce infections in children with JIA1R21AI135743-01EL-HALLAK, MOUSSACHILDREN'S HOSPITAL MED CTR OF AKRON, OH$276,307ZRG1
2018Synaptic PLD1 Levels/Signaling is Elevated Through Epigenetic Regulation in the CNS of AD Patients as a Function of Disease Severity and Cognitive Decline1R21AG059223-01KRISHNAN, BALAJIUNIVERSITY OF TEXAS MED BR GALVESTON, TX$276,208ZRG1
2018Transthyretin as a generic inhibitor of amyloid and amyloid-associated biofilm infections1R21AI137535-01CHAPMAN, MATTHEW RICHARDUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$275,798PCMB
2018The effect of luminal bile acid biotransformations on host cognition1R21MH117780-01ZARRINPAR, AMIRUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$274,750NNRS
2018Genetically Engineered Hamsters as Small Animal Models for Testing RSV Therapeutics1R21AI138247-01PICKLES, RAYMOND JUNIV OF NORTH CAROLINA CHAPEL HILL, NC$273,925VIRB
2018Defining cell types of foveal and peripheral retina by high-throughput, single-celltranscriptional profiling1R21EY028633-01DO, MICHAEL TRI HOANGSANES, JOSHUA RHARVARD UNIVERSITY, MA$273,337BVS
2018An Experimental Treatment Approach for Inflammation-Induced Depression1R21MH113915-01A1CHO, JOSHUA HYONG-JINUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$272,563MESH
2018Mapping mu agonist-induced receptor-protein interactions for OPRM1 7TM variants1R21DA046714-01PAN, YING-XIANSLOAN-KETTERING INST CAN RESEARCH, NY$271,946MNG
2018Killing of P. vivax infected reticulocytes by cytotoxic T cells1R21AI131632-01A1GAZZINELLI, RICARDO TOSTESLIEBERMAN, JUDYUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$271,528IHD
2018Therapeutic Agonist of CX3CR1 for Alzheimer's Disease1R21AG055080-01A1NASH, KEVIN RONUNIVERSITY OF SOUTH FLORIDA, FL$271,005DDNS
2018Cortical activity and phasic REM sleep in human newborns1R21HD095153-01BLUMBERG, MARK SAMUELUNIVERSITY OF IOWA, IA$270,875NNRS
2018Development of a pipeline tool to predict immunogenicity of cancer neo-epitopes1R21AI134127-01PETERS, BJOERNSETTE, ALESSANDROLA JOLLA INSTITUTE FOR IMMUNOLOGY, CA$270,000TTT
2018Ubiquitination in Immune Tolerance1R21AI126487-01A1LIU, YUN-CAILA JOLLA INSTITUTE FOR IMMUNOLOGY, CA$270,000TTT
2018Vaginal Adaptive Immunity Against Zika Virus1R21AI140063-01SHRESTA, SUJANLA JOLLA INSTITUTE FOR IMMUNOLOGY, CA$270,000ZRG1
2018Cellular and molecular mechanisms underlying neuronal activity-controlled regeneration specificity1R21NS107924-01XIANG, YANGUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$269,700NDPR
2018Major contribution of non-classical antigen processing to Salmonella Typhimurium-specific CD4+ T cell responses1R21AI135567-01EISENLOHR, LAURENCE CRANECHILDREN'S HOSP OF PHILADELPHIA, PA$268,926IHD
2018Functional analysis of glia in alpha-synucleinopathy1R21NS105151-01FEANY, MEL BBRIGHAM AND WOMEN'S HOSPITAL, MA$268,500ZRG1
2018Functional analysis of glia in tauopathy1R21AG058275-01FEANY, MEL BBRIGHAM AND WOMEN'S HOSPITAL, MA$268,500CMBG
2018Exploring the Role of IgA in Human Immune Homeostasis1R21AI137940-01WESEMANN, DUANE R.BRIGHAM AND WOMEN'S HOSPITAL, MA$268,500GMPB
2018A new look at mechanism-based Alzheimer's Disease biomarkers in blood1R21AG056753-01A1SELKOE, DENNIS JBRIGHAM AND WOMEN'S HOSPITAL, MA$268,500CNN
2018Deciphering regulatory RNA networks underlying molecular pathology in Alzheimer's disease1R21AG060019-01KRICHEVSKY, ANNA M.BRIGHAM AND WOMEN'S HOSPITAL, MA$268,500CMND
2018Provider Networks and Quality of Physical Health Care for Adults with Serious Mental Illness1R21MH113882-01A1BRESLAU, JOSHUA ARAND CORPORATION, CA$268,448SERV
2018Stemness and the cellular response to virus infection1R21AI132913-01A1TENOEVER, BENJAMIN R.ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$268,425VIRB
2018Inactivation of the internal globus pallidus in monkeys by chemogenetic modulation of ligand-gated ion channels1R21NS106346-01GALVAN, ADRIANAEMORY UNIVERSITY, GA$267,750CNN
2018Identification and characterization of individuals with elite anti-HIV-1 ADCC1R21AI137119-01A1SAGAR, MANISHBOSTON MEDICAL CENTER, MA$267,000ZRG1
2018Role of WASp in Golgi dispersal response to DNA damage in lymphocytes1R21AI138051-01VYAS, YATIN MUNIVERSITY OF IOWA, IA$266,875CSRS
2018A paperfluidic molecular diagnostic for Trichomonas vaginalis1R21AI137229-01CABODI, MARIOPOLLOCK, NIRABOSTON UNIVERSITY (CHARLES RIVER CAMPUS), MA$266,774ZRG1
2018Effect of HIV and ART therapy on developmental myelination1R21MH118121-01GRINSPAN, JUDITH BJORDAN-SCIUTTO, KELLY LCHILDREN'S HOSP OF PHILADELPHIA, PA$265,883NAED
2018Role of Candida albicans phosphate transport in cell wall maintenance and echinocandin tolerance1R21AI137716-01KOEHLER, JULIA RBOSTON CHILDREN'S HOSPITAL, MA$265,500PTHE
2018Base-resolution sequencing of 6mA in eukaryotic DNA1R21HG010066-01A1GREER, ERIC LIEBERMANBOSTON CHILDREN'S HOSPITAL, MA$265,500GCAT
2018Mesenchymal Stem Cell Regulation by Syndecan-1 in Lung Injury1R21AI134025-01A1KOUREMBANAS, STELLAPARK, PYONG WOOBOSTON CHILDREN'S HOSPITAL, MA$265,500ZRG1
2018Macrophage lineage SIV persistence and latency during suppressive ART in Macaques1R21AI140914-01ALDOVINI, ANNABOSTON CHILDREN'S HOSPITAL, MA$265,500AIP
2018Conformational ensembles associated with TRPV3 gating1R21AR072910-01A1LANDER, GABRIEL CSCRIPPS RESEARCH INSTITUTE, THE, CA$265,061BBM
2018Dynamic Contributions of Identified Neurons to High Frequency Oscillations1R21NS106434-01TAKANO, HAJIMECHILDREN'S HOSP OF PHILADELPHIA, PA$264,560CNNT
2018Functional diversity of zinc finger antiviral protein isoforms during viral infection1R21AI135437-01SAVAN, RAMUNIVERSITY OF WASHINGTON, WA$264,000IHD
2018Post-transcriptional regulatory modules: a novel host-pathogen interface that determines outcomes of viral infection1R21AI137956-01SAVAN, RAMUNIVERSITY OF WASHINGTON, WA$264,000III
2018Mice lack a novel innate immune response to intracellular DNA1R21AI130940-01A1STETSON, DANIEL BUNIVERSITY OF WASHINGTON, WA$264,000III
2018Modeling the generation and function of atypical memory B cells in Plasmodium infection1R21AI139740-01FONTANA, MARY FRANCESCAUNIVERSITY OF WASHINGTON, WA$264,000IHD
2018Diversity and modularity of innate immune responses to H. pylori1R21AI135381-01A1SALAMA, NINAFRED HUTCHINSON CANCER RESEARCH CENTER, WA$264,000ZRG1
2018SUMOylation and the type I interferon response1R21AI130655-01A1STETSON, DANIEL BUNIVERSITY OF WASHINGTON, WA$264,000CMIA
2018Microscopy-Based Antimicrobial Susceptibility Testing (MAST)1R21AI130434-01A1KIRBY, JAMES EBETH ISRAEL DEACONESS MEDICAL CENTER, MA$263,805CRFS
2018Development of simianized mice to study the biology of relapsing malaria parasites1R21AI135711-01MORENO, ALBERTOEMORY UNIVERSITY, GA$263,440PTHE
2018Neural Circuitry of Valence Flexibility across Development1R21MH112928-01A1BRITTON, JENNIFER CHRISTINAUNIVERSITY OF MIAMI CORAL GABLES, FL$263,375MESH
2018Age Compromises Novel Motility and Repair Functions in Stem Cell Niche of Intestinal Crypts1R21AG058173-01A1NISHIMURA, NOZOMICORNELL UNIVERSITY, NY$263,050CIMG
2018Genome-scale tracking of Mycobacterium tuberculosis VapC toxins1R21AI135461-01WOYCHIK, NANCY ANNRBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL, NJ$262,014ZRG1
2018Anti-drug Conjugates That Target Human Cytomegalovirus Infected Cells1R21AI136553-01TORTORELLA, DOMENICOICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$261,279ZRG1
2018Study Network of Acinetobacter as a Carbapenem-Resistant Pathogen (SNAP)1R21AI135522-01DOI, YOHEIUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$261,212CRFS
2018Developing Hybrids of Cardiac Tissue and Biodegradable Electronics Towards Heart Implants with On-line Monitoring and Stimulating Functions1R21EB026175-01YU, CUNJIANGUNIVERSITY OF HOUSTON, TX$261,125ISD
2018Neurometabolic profile of mild cognitive impairment using multiplexed edited MRS1R21AG060245-01EDDEN, RICHARD ANTHONY EDWARDJOHNS HOPKINS UNIVERSITY, MD$261,123CNN
2018Human Alveolar Macrophage Interactions with Francisella tularensis1R21AI130798-01A1SKERRETT, SHAWN J.UNIVERSITY OF WASHINGTON, WA$260,614LCMI
2018Imaging Functionally Distinct Eosinophil Subtypes Within Tissue Biopsies Using Gene Expression Profiling and an In Situ Hybridization Approach based on a Concurrent Multiple RNA Targeting Strategy1R21AI132840-01A1JACOBSEN, ELIZABETH AMAYO CLINIC ARIZONA, AZ$260,500ZRG1
2018Streptococcus pneumoniae capsule inhibitor1R21AI137799-01YOTHER, JANET LUNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$259,875ZRG1
2018Daily-Level Analysis of Ovarian Hormones, Smoking, and Anxiety1R21DA045182-01A1FARRIS, SAMANTHA GWENRUTGERS, THE STATE UNIV OF N.J., NJ$259,549APDA
2018FLOAT System to Study Salivary Gland Cancer Invasion1R21DE027713-01ANN, DAVID K.LIN, HER HELENBECKMAN RESEARCH INSTITUTE/CITY OF HOPE, CA$259,500ODCS
2018Osteopontin as a Blood Biomarker in severe Pediatric Traumatic Brain Injury1R21NS103507-01A1REISNER, ANDREWSAYEED, IQBALCHILDREN'S HEALTHCARE OF ATLANTA, INC., GA$259,390ZRG1
2018Discovery of small molecule co-factors of the neurotrophin BDNF1R21MH116275-01SAMES, DALIBORTEESALU, TAMBETCOLUMBIA UNIV NEW YORK MORNINGSIDE, NY$259,338ZRG1
2018Effect of placental oxygen transport on the fetal cortical growth and folding1R21HD094130-01IM, KIHOBOSTON CHILDREN'S HOSPITAL, MA$259,321ZRG1
2018Dueling PPxY Motifs of Filovirus VP40 and Host Angiomotin: Effects on Innate Immune Defenses and Tight Junction Integrity at Immune Privileged Sites1R21AI139392-01HARTY, RONALD NUNIVERSITY OF PENNSYLVANIA, PA$258,750VIRB
2018Role of permanently farnesylated prelamin in the cardiovascular disease of aging1R21AG058032-01MICHAELIS, SUSAN D.WORMAN, HOWARD JJOHNS HOPKINS UNIVERSITY, MD$258,709CMAD
2018Understanding Nrf2-Mediated Restriction of HIV Infection1R21AI140993-01DE NORONHA, CARLOS MALBANY MEDICAL COLLEGE, NY$258,184AMCB
2018Developing Homology-Independent Targeted Insertion (HITI) toolkits for molecular genetic manipulation of Drosophila melanogaster and Anopheles gambiae1R21AI140018-01GARRITY, PAULBRANDEIS UNIVERSITY, MA$258,175ZRG1
2018Persistent rubella in immune deficient patients1R21AI130967-01A1SULLIVAN, KATHLEEN ECHILDREN'S HOSP OF PHILADELPHIA, PA$258,000IHD
2018Modulation of myelination by IL-4 following intrauterine growth restriction1R21NS103075-01A1GRINSPAN, JUDITH BCHILDREN'S HOSP OF PHILADELPHIA, PA$258,000CMBG
2018Defining the MHC-II processing and presentation landscape of HIV-11R21AI141110-01EISENLOHR, LAURENCE CRANECHILDREN'S HOSP OF PHILADELPHIA, PA$258,000VACC
2018Identification and Pathology of a Macula-Related Structure in the Mouse Eye1R21EY027894-01A1KREBS, MARK PJACKSON LABORATORY, ME$257,893DPVS
2018Activating adrenergic receptors to suppress the anti-graft immune response and improve survival of composite tissue allografts1R21AI136367-01A1KIM, MINHYUNGREPASKY, ELIZABETH AROSWELL PARK CANCER INSTITUTE CORP, NY$257,700SAT
2018Using in vivo CRISPR-Cas9 to dissect the neural circuits mediating compulsive behaviors1R21MH115395-01DULAWA, STEPHANIE CNEUMAIER, JOHN FUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$257,501MNPS
2018Exploring a new mechanism for thrombocytopenia in experimental malaria1R21AI137877-01VAN DER HEYDE, HENRI CLA JOLLA INFECTIOUS DISEASE INSTITUTE, CA$257,500HT
2018ICR-Independent Establishment of Domain Imprinting1R21HD095374-01MANN, MELLISSA RAE WIGLEMAGEE-WOMEN'S RES INST AND FOUNDATION, PA$257,387CMIR
2018Establishing Sts-1 as a novel target for treatment of systemic candidiasis1R21AI130859-01A1CARPINO, NICHOLAS ASTATE UNIVERSITY NEW YORK STONY BROOK, NY$256,959ZRG1
2018Thrombolytic Stroke Therapy in Humanized Sickle Mice1R21NS106592-01SUN, YU-YOUNIVERSITY OF VIRGINIA, VA$256,500ANIE
2018Molecular and Genetic Pathways Controling Enamel Formation1R21DE028091-01BEI, MARIANNAMASSACHUSETTS GENERAL HOSPITAL, MA$256,500ODCS
2018The effects of a housing mobility program on home environmental and host airway microbiota and asthma morbidity among low-income minority children1R21AI133492-01A1DAVIS, MEGHAN F.JOHNS HOPKINS UNIVERSITY, MD$256,060ZRG1
2018Contact-dependent transcriptional networks in mycobacterial species1R21AI135173-01A1CHAMPION, MATTHEW MDERBYSHIRE, KEITH MGRAY, TODDWADSWORTH CENTER, NY$256,020ZRG1
2018Association of the evolving nasal microbiome and neonatal acquisition of Staphylococcus aureus colonization1R21AI135179-01A1MILSTONE, AARON MJOHNS HOPKINS UNIVERSITY, MD$255,959CRFS
2018Regulation of directed neuronal migration by Wnt signaling1R21NS108367-01CHANDRASEKHAR, ANANDUNIVERSITY OF MISSOURI-COLUMBIA, MO$255,873NCF
2018The Effects of MHCI Heterozygosity on T Cell Receptor Repertoires1R21AI135374-01A1MARRACK, PHILIPPA C.NATIONAL JEWISH HEALTH, CO$255,814CMIA
2018Norepinephrine: A Novel Regulator of Amyloid Beta-42 Peptides1R21AG058263-01A1THOMAS, STEVEN AVAN BOCKSTAELE, ELISABETH JDREXEL UNIVERSITY, PA$255,791CDIN
2018In vivo photoreceptor physiology in the human retina1R21EY027941-01A1SABESAN, RAMKUMARUNIVERSITY OF WASHINGTON, WA$255,748NOIT
2018Mechanistic Approaches to Inhibition of Emerging DNA Viruses1R21AI130927-01A1MCKENNA, CHARLES EPRICHARD, MARK NEALUNIVERSITY OF SOUTHERN CALIFORNIA, CA$255,500ZRG1
2018Nuclear sphingolipid metabolism in regulation of myogenesis1R21AR072916-01GERACE, LARRY R.SCRIPPS RESEARCH INSTITUTE, THE, CA$255,420MIST
2018Focused characterization of non-canonical T cells against SIV1R21AI138701-01MANESS, NICHOLAS JAMESTULANE UNIVERSITY OF LOUISIANA, LA$255,000AIP
2018Maternal Exposure to Inorganic Arsenic in Drinking Water and Adverse Birth Outcomes in Rural Colorado1R21ES028416-01A1JAMES, KATHERINE AUNIVERSITY OF COLORADO DENVER, CO$254,706ZRG1
2018Mechanisms underlying a novel, fast form of homeostatic plasticity at excitatory synapses1R21MH115404-01A1COBA, MARCELO PABLOO'DELL, THOMAS JUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$254,667LAM
2018Informal Resources of Persons Living with Alzheimer's Disease and Related Dementias: Impact on Hospitalizations, Potentially Avoidable Hopsitalizations and Nursing Home Admissions1R21AG059623-01JUTKOWITZ, ERICBROWN UNIVERSITY, RI$254,409ZRG1
2018Mechanisms of DNA repair in quiescent cells1R21ES028840-01HOLLOMAN, WILLIAM K.WEILL MEDICAL COLL OF CORNELL UNIV, NY$254,250RTB
2018A NOVEL ISCHEMIC STROKE MODEL TRIGGERED BY ENDOTHELIAL DYSFUNCTION1R21NS104512-01DI LORENZO, ANNARITAWEILL MEDICAL COLL OF CORNELL UNIV, NY$254,250BINP
2018Mapping Essential Elements and Toxic Metals in the Human Pancreas in Health and Disease1R21ES027916-01A1ARORA, MANISHHOMANN, DIRKICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$254,250SIEE
2018Identifying the thymus ligand that selects a natural regulatory T cell1R21AI133231-01A1LAFAILLE, JUANNEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$254,250CMIB
2018Determinants of lentiviral envelope tropism in macaques1R21AI134221-01A1HATZIIOANNOU, THEODORAROCKEFELLER UNIVERSITY, NY$254,250AMCB
2018Investigating the role and mechanism of RIPK1 in mediating cerebrovascular pathology of AD1R21AG059073-01YUAN, JUNYINGHARVARD MEDICAL SCHOOL, MA$254,250CDIN
2018Cell motility regulation by PCP signaling1R21HD095043-01MLODZIK, MAREKICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$254,250DEV2
2018The novel role of meningeal macrophages in amyloid plaque deposition1R21AG059220-01GAN, WENBIAOLAFAILLE, JUANNEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$254,250CDIN
2018Investigating the neural mechanism of maternal motivation1R21HD090563-01A1LIN, DAYUNEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$254,250NMB
2018Characterize the properties and differentiation of the multipotent cochlear stem/progenitor cell population1R21DC016351-01A1XU, PIN-XIANICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$254,250NCF
2018Cellular substrates of early life trauma1R21MH114170-01A1CLEM, ROGER LICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$254,250ZRG1
2018Single Domain Anti-Tau Antibodies as Potential Therapy for Alzheimer's Disease1R21AG058282-01A1SIGURDSSON, EINAR MNEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$254,250CMND
2018Mycobacterial Phosphopantetheine Hydrolase: Potential for Salvage of Coenzyme A1R21AI138939-01NATHAN, CARL FRANCISWEILL MEDICAL COLL OF CORNELL UNIV, NY$254,250ZRG1
2018Targeting astrocytic toxicity for ALS therapy1R21NS104520-01A1FUJITA, HIBIKIMANFREDI, GIOVANNIWEILL MEDICAL COLL OF CORNELL UNIV, NY$254,250NOMD
2018Nicotinamide Mononucleotide (NMN) as a Novel Therapeutic in the Treatment of Oral Mucositis1R21DE027490-01A1SINCLAIR, DAVID A.HARVARD MEDICAL SCHOOL, MA$254,250ODCS
2018Stimulant vs. non-stimulant treatments and reward processing in drug-naive youth at SUD risk1R21DA045218-01A1IVANOV, ILIYAN STOYANOVNEWCORN, JEFFREY HICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$254,250NPAS
2018An Infectious Etiology for Multiple Sclerosis1R21NS106581-01A1VARTANIAN, TIMOTHYWEILL MEDICAL COLL OF CORNELL UNIV, NY$254,250CNBT
2018Profiling axonal RNA in vivo using a viral TRAP approach.1R21NS105047-01A1SCHMIDT, ERIC FROCKEFELLER UNIVERSITY, NY$254,250MNG
2018Somatostatin interneuron subtypes control dendritic branch-specific calcium spike generation and synaptic plasticity1R21NS108447-01RUDY, BERNARDONEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$254,250SMI
2018Efficacy and Mechanism of Action of Heavy-Chain α-Synuclein Antibody Fragments Derived from Llama1R21AG059391-01A1SIGURDSSON, EINAR MNEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$254,250CMND
2018Analysis of Lumbar Spine Stenosis Speciments for Early Identification of TTR Cardiac Amyloidosis1R21AG058348-01MAURER, MATHEW SCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$254,230ZRG1
2018Viral genetic correlates of invasive neonatal HSV disease1R21AI140443-01A1SZPARA, MORIAHPENNSYLVANIA STATE UNIVERSITY, THE, PA$254,142VIRA
2018Composition and temporal changes of the oral microbiome in head and neck cancer patients at high risk for oral mucositis1R21DE026837-01A1REYES-GIBBY, CIELITO CSHETE, SANJAYUNIVERSITY OF TX MD ANDERSON CAN CTR, TX$254,042CHSA
2018Mapping representational format across the human brain1R21NS108380-01BADRE, DAVIDBROWN UNIVERSITY, RI$253,649ZRG1
2018The role of the cerebellum in visual learning1R21EY028749-01GOLDBERG, MICHAEL E.COLUMBIA UNIVERSITY HEALTH SCIENCES, NY$253,636SMI
2018Novel BEAM and R26-BEACON recombinase-based systems for mosaic analysis of gene function1R21NS104733-01MACKLIS, JEFFREY DHARVARD UNIVERSITY, MA$253,500NDPR
2018Bedside Optical Retinal Assessment of Hypoxic Ischemic Encephalopathy in Infants1R21EY029384-01TOTH, CYNTHIA ANNDUKE UNIVERSITY, NC$253,448DPVS
2018Mechanism-targeted treatment strategy in PTEN-associated autism and epilepsy1R21HD093033-01A1GROSS, CHRISTINACINCINNATI CHILDRENS HOSP MED CTR, OH$253,204DBD
2018Intranasal oxytocin as a means to enhance mother-infant bonding in the early postpartum period1R21HD090396-01A1DEKEL, SHARONMASSACHUSETTS GENERAL HOSPITAL, MA$252,750PDRP
2018Theranostic approach to transplant rejection using engineered cell biosensors1R21AI134116-01A1PAREKKADAN, BIJUUYGUN, KORKUTMASSACHUSETTS GENERAL HOSPITAL, MA$252,750BTSS
2018A high throughput assay to identify novel chromatin factors that regulate DNA repair1R21ES027931-01A1MOSTOSLAVSKY, RAULMASSACHUSETTS GENERAL HOSPITAL, MA$252,750RTB
2018Examining the dynamic and metabolic underpinnings of functional connectivity in preclinical Alzheimer's disease1R21AG060221-01SCHULTZ, AARON PMASSACHUSETTS GENERAL HOSPITAL, MA$252,750CNN
2018Circadian Rhythms Regulation in Pre-Manifest Synucleinopathies1R21NS108022-01VIDENOVIC, ALEKSANDARMASSACHUSETTS GENERAL HOSPITAL, MA$252,750CNN
2018Development of an adjuvant-free mucosal vaccine platform via sequential FcRn-mediated transepithelial Ag transport to the NALT and Fc RI-enhanced Ag processing and presentation within the NALT.1R21AI139733-01GOSSELIN, EDMUND JZHU, XIAOPINGALBANY MEDICAL COLLEGE, NY$252,563VMD
2018Mechanisms of increased Shiga toxin production by commensal E. coli1R21AI130856-01A1DUDLEY, EDWARD G.PENNSYLVANIA STATE UNIVERSITY, THE, PA$252,025ZRG1
2018iPSC-derived astrocytes to model Vanishing White Matter Disease1R21NS104878-01PROSCHEL, CHRISTOPHUNIVERSITY OF ROCHESTER, NY$251,867CMBG
2018Personalized target selection for TMS therapy using functional vs. structural connectivity MRI1R21MH115280-01CAMPRODON, JOAN ANING, LIPENGBRIGHAM AND WOMEN'S HOSPITAL, MA$251,654NPAS
2018Identifying Kawasaki Disease-Specific Antibodies and Antigens1R21AI140029-01ROWLEY, ANNE HNORTHWESTERN UNIVERSITY AT CHICAGO, IL$251,484CRFS
2018Mixed-Reality Neuronavigation for Transcranial Magnetic Stimulation Treatment of Depression1R21MH116484-01A1MCNAB, JENNIFER ASTANFORD UNIVERSITY, CA$251,481BMIT
2018Impact of Metabolic Health in Type 2 Diabetes on Sperm Epigenetic Marks in Humans: A Novel Intergenerational Mechanism for Metabolic Disease Risk Transmission1R21HD091974-01A1ISGANAITIS, ELVIRA MARIEPATTI, MARY EJOSLIN DIABETES CENTER, MA$251,376CIDO
2018Antibody and viral determinants of protection against CMV infection following gB/MF59 vaccination1R21AI136556-01A1KOELLE, KATHARINA VPERMAR, SALLIE R.DUKE UNIVERSITY, NC$251,267VMD
2018Identification of Genes Important for Rejuvenation of Aged Hematopoietic Stem Cells1R21AG057977-01ZHANG, HONGUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$251,250CMAD
2018Combined Human Myeloid and Lymphoid Engraftment in MISTRG Mice for Transplantation Research1R21AI136017-01A1POBER, JORDAN STELLIDES, GEORGEYALE UNIVERSITY, CT$251,250TTT
2018Structural and Functional Characterization of the Salmonella Typhimurium Type III Secretion System Sorting Platform1R21AI126158-01A1BEWERSDORF, JOERGLARA-TEJERO, MARIAYALE UNIVERSITY, CT$251,250ZRG1
2018Protective function of virus-induced age-associated B cells1R21AI128606-01A1SWAIN, SUSAN LUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$251,250IHD
2018An innate immunity model of FSHD muscle pathology1R21NS101257-01A1EMERSON, CHARLES P.UNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$251,250SMEP
2018Functional and structural analysis of the Legionella pneumophila Dot/Icm apparatus1R21AI130671-01A1ROY, CRAIG R.YALE UNIVERSITY, CT$251,250ZRG1
2018Mechanisms of CD36-mediated parasitophorous vacuole maturation in macrophages infected with Leishmania amazonensis1R21AI136532-01SILVERMAN, NEALUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$251,250ZRG1
2018Identification of blood-brain-barrier pericyte-specific cis regulatory elements1R21NS105654-01LAWSON, NATHAN DUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$251,250CMBG
2018A comprehensive gene repair therapy for FKRP neuromuscular diseases1R21NS106122-01EMERSON, CHARLES P.WOLFE, SCOT AUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$251,250SMEP
2018In vivo genetic analysis of dendritic spine formation, plasticity and maintenance1R21NS101649-01A1BENARD, CLAIREFRANCIS, MICHAEL MUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$251,250NDPR
2018Retro-proteomics to identify misfolded proteins from the ER and their quality control pathways1R21AG056800-01A1MARIAPPAN, MALAIYALAMYALE UNIVERSITY, CT$251,250MBPP
2018Distinguishing Lipid Subtypes by Amplifying Contrast from J-Coupling1R21EB023414-01A1GALIANA, GIGIYALE UNIVERSITY, CT$251,250BMIT

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