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NIH funding notice PA-18-489

NIH Exploratory/Developmental Research Grant Program ( Parent R21 Clinical Trial Not Allowed)

Closed on February 7, 2019.

Posted
December 6, 2017
Close date
February 7, 2019
Activity codes
R21
Institutes taking part
NEI, NHGRI, NIA, NIAAA, NIAID, NIAMS, NIDA, NIDCD, NIDCR, NIEHS, NIMHD, NINR, NLM, NCCIH

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

  1. Reissues: PA-16-161 NIH Exploratory/Developmental Research Grant Program (Parent R21)
  2. 2 steps back: PA-13-303 NIH Exploratory/Developmental Research Grant Program (Parent R21)
  3. 3 steps back: PA-11-261 NIH Exploratory/Developmental Research Grant Program (Parent R21)
  4. 4 steps back: PA-10-069 NIH Exploratory Developmental Research Grant Program (Parent R21)
  5. 5 steps back: PA-09-164 NIH Exploratory/Developmental Research Grant Program (Parent R21)
  6. 6 steps back: PA-06-181 NIH Exploratory/Developmental Research Grant Program (Parent R21)
  7. 7 steps back: PA-03-107

Replaced by PA-19-053.

Who won it before

6,975 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $1,559,914,130 in first-year total cost, median $228,750.

Most frequent study sections

  1. Special Emphasis Panel[ZRG1 IDM-B (80)]280
  2. Pathogenic Eukaryotes Study Section[PTHE]121
  3. Special Emphasis Panel[ZRG1 IDM-B (81)]121
  4. Virology - B Study Section[VIRB]107
  5. Cellular and Molecular Immunology - B Study Section[CMIB]102

Most frequent institutions

  1. JOHNS HOPKINS UNIVERSITY161
  2. UNIVERSITY OF PITTSBURGH AT PITTSBURGH156
  3. UNIVERSITY OF PENNSYLVANIA133
  4. UNIVERSITY OF WASHINGTON130
  5. UNIVERSITY OF MICHIGAN AT ANN ARBOR127
Competing awards under PA-18-489 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2021Mimicking evolution to define mechanisms of airborne transmission of H7N9 viruses1R21AI144135-01SUTTON, TROY CLAVELLPENNSYLVANIA STATE UNIVERSITY, THE, PA$226,169VIRB
2020Extrahypothalamic PPARs and compulsive food intake1R21DA046865-01A1ZORRILLA, ERIC PSCRIPPS RESEARCH INSTITUTE, THE, CA$290,250NMB
2020The Pathogenic Role of Pb in Cerebral Amyloid Angiopathy and AD1R21AG067923-01DU, YANSHENGTERRITO, PAUL RICHARDINDIANA UNIVERSITY INDIANAPOLIS, IN$251,595CDIN
2020Obtaining population-based estimates of the timing of antiretroviral therapy initiation using HIV surveillance data: Change-point model development, validation, and dissemination1R21AI147933-01ZHANG, HONGBINGRADUATE SCHOOL OF PUBLIC HEALTH AND HEALTH POLICY, NY$243,230BMRD
2020Developing a public health measure of built environment to assess risk of nonmedical opioid use and related mortality in urban and non-urban areas in New Jersey1R21DA046739-01A1TEMPALSKI, BARBARANDRI-USA, INC., NY$224,533CIHB
2020A Role for IL-1Beta in Ethanol Withdrawal-Induced Increase of PTSD-Like Phenotype1R21AA027463-01A1LYSLE, DONALD TTHIELE, TODD ERICUNIV OF NORTH CAROLINA CHAPEL HILL, NC$223,531ZAA1
2020hiPSC-derived tissue mimetics of the retina blood barrier1R21EY030817-01BENOIT, DANIELLE S.SINGH, RUCHIRAUNIVERSITY OF ROCHESTER, NY$192,500CMT
2020Multiparameter optimization of new phenothiazines for proteasome activation1R21AG061306-01TEPE, JETZE J.MICHIGAN STATE UNIVERSITY, MI$181,586DDNS
2019Population level characterization of human immunoglobulin heavy chain germline variants with impacts on variability in the Ab repertoire of healthy adults1R21AI142590-01MARASCO, WAYNE A.WATSON, COREY TAYLORUNIVERSITY OF LOUISVILLE, KY$357,431GHD
2019Role of viral mitophagosomes in driving sex differences in myocarditis1R21AI145356-01FAIRWEATHER, DELISASIN, JONMAYO CLINIC JACKSONVILLE, FL$340,625ZRG1
2019Role of the Oral Microbiome in Oral Squamous Cell Carcinoma Progression1R21DE028063-01A1STASHENKO, PHILIPBOSTON UNIVERSITY MEDICAL CAMPUS, MA$328,422TME
2019Associating retinal nerve fiber layer thickness with glucose metabolism and diabetic retinopathy1R21EY030631-01ELZE, TOBIASSCHEPENS EYE RESEARCH INSTITUTE, MA$313,837DPVS
2019Dark adaptation measurement with a mobile device1R21EY029847-01A1PUNDLIK, SHRINIVASSCHEPENS EYE RESEARCH INSTITUTE, MA$312,190BNVT
2019Nasal cytokine responses in children with viral upper respiratory infection1R21AI144744-01WALD, ELLENUNIVERSITY OF WISCONSIN-MADISON, WI$309,167ZRG1
2019Structural characterization of nucleoprotein cores of human adenoviruses1R21AI146644-01REDDY, VIJAY SSCRIPPS RESEARCH INSTITUTE, THE, CA$305,000VIRA
2019QUANTIFYING THE IMPACT OF CIRCADIAN DISRUPTION ON GENOME STABILITY1R21ES031000-01LAMIA, KATJA ALOHMUELLER, KIRKSCRIPPS RESEARCH INSTITUTE, THE, CA$301,403ZRG1
2019Genetically Modified NKT Cells to Target Viral Reservoirs1R21AI145642-01BRAUN, STEPHEN EDWARDKAUR, AMITINDERTULANE UNIVERSITY OF LOUISIANA, LA$297,500HIVD
2019Towards noninvasive diagnosis of malaria1R21AI144472-01ODOM JOHN, AUDREY RAGANWASHINGTON UNIVERSITY, MO$297,059CRFS
2019Uncoupling caspase 8-mediated-apotosis from caspase 8-mediated-inflammation in glaucoma.1R21EY030276-01GREGORY-KSANDER, MEREDITHSCHEPENS EYE RESEARCH INSTITUTE, MA$295,500DPVS
2019Associations of Exposure to Marijuana Outlets and Advertising with Marijuana Use Outcomes Among Young Adults1R21DA047501-01A1PEDERSEN, ERIC R.RAND CORPORATION, CA$294,912CIHB
2019Proteogenomic resource for the development of novel markers for Lyme disease1R21AI142302-01MORITZ, ROBERT LINSTITUTE FOR SYSTEMS BIOLOGY, WA$293,522EBIT
2019Cellular Mediators of Cardiac Aging and Arrhythmia in Drosophila1R21AG061598-01OCORR, KARENSANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, CA$292,500ESTA
2019Transcriptomic and epigenetic regulators of Drosophila heart aging1R21AG058075-01A1ADAMS, PETER D.SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, CA$292,500CMAD
2019Effect of HIV infection on M.tuberculosis granuloma formation and evolution1R21AI145539-01KULKARNI, SMITASCHLESINGER, LARRY S.TEXAS BIOMEDICAL RESEARCH INSTITUTE, TX$292,500HCAC
2019Pathogenesis and Novel Therapeutics to Reverse T Cell Exhaustion in Persistent Viral Infections1R21AI141842-01LAIRSON, LUKE LEESCRIPPS RESEARCH INSTITUTE, THE, CA$290,250IHD
2019Enhancement of VIPERdb, a virus structure knowledgebase1R21AI137580-01A1REDDY, VIJAY SSCRIPPS RESEARCH INSTITUTE, THE, CA$290,250VIRA
2019TLR-dependent B cells in Lupus1R21AI138512-01A1KONO, DWIGHT HSCRIPPS RESEARCH INSTITUTE, THE, CA$290,250HAI
2019Novel Regulators of B Cell Tolerance1R21AI143529-01XIAO, CHANGCHUNSCRIPPS RESEARCH INSTITUTE, THE, CA$290,250CMIA
2019Gamma delta IEL control of intestinal infection: roles for CD100 and JAML1R21AI144825-01WITHERDEN, DEBORAH ASCRIPPS RESEARCH INSTITUTE, THE, CA$290,250IHD
2019Characterizing Bilingual Speech Sound Production in Jamaican Creole and English-Speaking Preschoolers1R21DC018170-01A1WASHINGTON, KARLA NUNIVERSITY OF CINCINNATI, OH$289,035LCOM
2019Variable adaptive responses to weight loss in older adults (VARIA)1R21AG061344-01A1BEAVERS, DANIEL PBEAVERS, KRISTEN MARIEWAKE FOREST UNIVERSITY HEALTH SCIENCES, NC$282,777NAME
2019New Approaches for the Identification of Critical Signals for Mast Cell Function1R21AI144231-01PILIPONSKY, ADRIAN MSEATTLE CHILDREN'S HOSPITAL, WA$282,450ZRG1
2019A pipeline for prioritizing and evaluating multidrug regimens for Mycobacterium abscessus1R21AI144536-01HERNANDEZ, RAFAEL ESEATTLE CHILDREN'S HOSPITAL, WA$280,873ZRG1
2019The effects of amyloid beta on pericyte remodeling and brain capillary function in vivo1R21AG063031-01SHIH, ANDY YSEATTLE CHILDREN'S HOSPITAL, WA$279,000ANIE
2019Decoding the neural time-course of spoken word recognition1R21DC017596-01ASLIN, RICHARD N.MCMURRAY, BOBHASKINS LABORATORIES, INC., CT$277,714LCOM
2019Immune Regulation by Bacteroides Polysaccharide Capsules1R21AI142257-01ALLEN, PAUL MMARTENS, ERIC CWASHINGTON UNIVERSITY, MO$277,680ZRG1
2019Imaging biomarkers of early synaptic changes in a preclinical model of Alzheimer’s disease1R21AG064599-01CHAUDHARI, ABHIJIT JLEIN, PAMELA JUNIVERSITY OF CALIFORNIA AT DAVIS, CA$274,750EITN
2019Role of Hhip signaling in parallel circuit formation1R21EY029874-01TRIPLETT, JASONCHILDREN'S RESEARCH INSTITUTE, DC$274,126SPC
2019Translational Reprogramming by Regulatory T Cells1R21AI143227-01A1SAVAN, RAMZIEGLER, STEVEN FBENAROYA RESEARCH INST AT VIRGINIA MASON, WA$272,888CMIA
2019Islet Autoimmunity Reversion as a Model of T1D Resiliency1R21AI142483-01NORRIS, JILL MUNIVERSITY OF COLORADO DENVER, CO$272,125KNOD
2019EEG Telemetry in Monkeys: Potential Markers of Benzodiazepine Action1R21DA046778-01A1ROWLETT, JAMES KUNIVERSITY OF MISSISSIPPI MED CTR, MS$271,250NNRS
2019A urine tenofovir immunoassay to distinguish adherence versus resistance-based HIV treatment failure1R21AI145537-01MCCLUSKEY, SUZANNEMASSACHUSETTS GENERAL HOSPITAL, MA$270,448PPAH
2019A LINE-1 Retrotransposition-Deficient Mouse Genome1R21HG010512-01BORTVIN, ALEXWHEELAN, SARAH JCARNEGIE INSTITUTION OF WASHINGTON, D.C., DC$270,428GHD
2019Role of sumoylation in aging1R21AG064519-01SAMUELSON, ANDREW VAUGHNUNIVERSITY OF ROCHESTER, NY$269,500CMAD
2019A novel genetic tool to investigate T cell development and function1R21AI146614-01FENG, YONGQIANGST. JUDE CHILDREN'S RESEARCH HOSPITAL, TN$269,250CMIB
2019Single cell activation dynamics as a predictor and regulator of aged MuSC dysfunction.1R21AG063416-01BRACK, ANDREW SUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$268,627CMAD
2019Correcting genetic disorders using predictable CRISPR/Cas9-induced exon skipping1R21HG010391-01CASSA, CHRISTOPHERSHERWOOD, RICHARD IBRIGHAM AND WOMEN'S HOSPITAL, MA$268,500TAG
2019Novel diffusion-weighted MRI assessment of cortical microstructural changes and their relationship to amyloid, tau and cognition in aging and Alzheimer's disease.1R21AG064348-01VANNINI, PATRIZIABRIGHAM AND WOMEN'S HOSPITAL, MA$268,500CNN
2019Quantitative Tactile Assessment of Human Manual Dexterity1R21AG064452-01GARDNER, ESTHER P.NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$268,438SPS
2019Host Glycomic Determinants of HIV Persistence in vivo1R21AI143385-01A1ABDEL MOHSEN, MOHAMEDWISTAR INSTITUTE, PA$267,900HIVD
2019Photo-enhanced messaging to address dietary sugars as a common risk factor for chronic disease1R21DE028993-01HEATON, BRENDAQUINTILIANI, LISA M.BOSTON UNIVERSITY MEDICAL CAMPUS, MA$267,651PRDP
2019The role of Ig Polymorphism in shaping the Broadly Neutralizing Antibody Response to Hemagglutinin HA stem domain(s) of Influenza A, Group 1 and 2 Viruses1R21AI142502-01MARASCO, WAYNE A.DANA-FARBER CANCER INST, MA$267,000CMIB
2019The Risk and Risk Factors of Incident Hydroxychloroquine Retinopathy Among Long-Term Users1R21AR074754-01A1CHOI, HYON KMELLES, RONALDMASSACHUSETTS GENERAL HOSPITAL, MA$266,507NAME
2019Understanding disparities in the adoption and use of assistive technology by older Hispanics1R21NR018039-01A1ORELLANO-COLON, ELSA MUNIVERSITY OF PUERTO RICO MED SCIENCES, PR$266,467HDEP
2019A Novel Personalized Approach Towards Treating Negative Symptoms and Reducing Alcohol Abuse in patients with Comorbid AUD and Schizophrenia.1R21AA027392-01A1CLELLAND, CATHERINE LCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$266,464AA
2019Apramycin scaffold exploration using novel glycochemistry and SAR studies to enhance activity against Acinetobacter baumannii and other multidrug-resistant Gram-negative pathogens1R21AI142040-01KIRBY, JAMES EO'DOHERTY, GEORGE ABETH ISRAEL DEACONESS MEDICAL CENTER, MA$266,324ZRG1
2019Fusidic acid derivatization to enhance entry into Gram-negative pathogens1R21AI146485-01KIRBY, JAMES EO'DOHERTY, GEORGE ABETH ISRAEL DEACONESS MEDICAL CENTER, MA$266,130ZRG1
2019Skin Microbiome of Monogenic Skin Disorders1R21AR075174-01A1OH, JULIAJACKSON LABORATORY, ME$266,054ACTS
2019Mutagenesis screen to functionally characterize essential genes in Plasmodium falciparum1R21AI144890-01DVORIN, JEFFREY DBOSTON CHILDREN'S HOSPITAL, MA$265,500PTHE
2019A signaling pathway governing growth and antibiotic sensitivity in Pseudomonas aeruginosa1R21AI146515-01DOVE, SIMON LBOSTON CHILDREN'S HOSPITAL, MA$265,500ZRG1
2019Modeling poly-genomic risk in the relationship between brain structure and alcohol involvement from adolescence through adulthood1R21AA027827-01BOGDAN, RYAN HWASHINGTON UNIVERSITY, MO$264,938AA
2019Liver-stage Plasmodium protein export to the host cell to inform vaccine design.1R21AI137748-01A1MURPHY, SEAN CUNIVERSITY OF WASHINGTON, WA$264,688VMD
2019Role of cannabinoid receptor 1 in lung injury and resolution1R21AI147536-01ALTEMEIER, WILLIAM AGHARIB, SINA AMANICONE, ANNE M.UNIVERSITY OF WASHINGTON, WA$264,688ZRG1
2019Novel approaches to study the intersection of cellular heterogeneity and tissue microanatomy1R21AI142667-01GERNER, MICHAELUNIVERSITY OF WASHINGTON, WA$264,500CMT
2019Exploring the Role of RAG1 in Post-transcriptional Gene Regulation1R21AI135435-01A1BASSING, CRAIG HCHILDREN'S HOSP OF PHILADELPHIA, PA$264,000ZRG1
2019Using Genetics and Genomics to Dissect Coccidioides Spherulation1R21AI144855-01BREM, RACHEL BETHSIL, ANITAUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$262,780PTHE
2019Novel approaches to map DNA replication traffic in a genome-wide scale1R21HG010165-01A1EGLI, DIETER MEINRADWANG, KAICOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$262,177GCAT
2019C. trachomatis within-host genomic diversity and transmission between female anatomic sites1R21AI138079-01A1DEAN, DEBORAH ANNEREAD, TIMOTHY D.EMORY UNIVERSITY, GA$261,773CRFS
2019Pilot mobile-wearable just-in-time adaptive intervention (JITAI) for sun safety among children1R21ES029570-01A1HUH, JIMIUNIVERSITY OF SOUTHERN CALIFORNIA, CA$261,678PRDP
2019Molecular mechanisms governing the regulation of innate antiviral immunity by the SRMS kinase1R21AI142044-01LI, KUIPOTTS, MALIA BUNIVERSITY OF TENNESSEE HEALTH SCI CTR, TN$261,625IHD
2019Population-Level Effects of Increasing PrEP Uptake on HIV and Bacterial STIs1R21AI143386-01A1MARCUS, JULIA L.YOUNG, JESSICA GERALDHARVARD PILGRIM HEALTH CARE, INC., MA$261,623PPAH
2019Initiating translation in mycobacteria: ribosome complexity in a leaderless bacterium1R21AI147608-01DERBYSHIRE, KEITH MGRAY, TODDWADE, JOSEPH THOMASWADSWORTH CENTER, NY$261,486MGA
2019Leveraging immunostimulatory pathways that enhance BCG vaccination for the rational design of synthetic neonatal vaccine formulations1R21AI137932-01A1DOWLING, DAVID JAMESSCOTT, EVAN ALEXANDERNORTHWESTERN UNIVERSITY, IL$261,000VMD
2019Developmental origins of child liver injury: Effects of prenatal environmental exposures1R21ES029681-01A1CHATZI, VAIA LIDAUNIVERSITY OF SOUTHERN CALIFORNIA, CA$260,715KNOD
2019Targeting viral alkaline nucleases for the development of broad spectrum anti-herpesvirus therapeutics1R21AI143272-01A1WELLER, SANDRA KWRIGHT, DENNIS L.UNIVERSITY OF CONNECTICUT SCH OF MED/DNT, CT$260,500ZRG1
2019Investigation of chromosomally integrated Human Herpesvirus 6 as a risk factor for Alzheimer's disease1R21AG063068-01READHEAD, BENJAMINARIZONA STATE UNIVERSITY-TEMPE CAMPUS, AZ$260,020GHD
2019HBD-3: A novel factor orchestrating microbial persistence in suspicious oral lesions1R21DE028416-01A1WEINBERG, AARONCASE WESTERN RESERVE UNIVERSITY, OH$259,606ODCS
2019Contribution of Cerebral Iron Load to Elderly Individuals with High Risk to Develop Alzheimer's Disease.1R21AG061668-01LI, XUQIAO, YEJOHNS HOPKINS UNIVERSITY, MD$258,854ASG
2019Before the Fall: Anticipatory Brain Roles in Reactive Balance Control1R21AG061688-01BOLTON, DAVID AUTAH STATE UNIVERSITY, UT$258,430SMI
2019Receptor Specific Retinoids Probes to Study the Brain Damage Caused by Developmental Alcohol Exposure1R21AA027374-01A1DAS, BHASKAR CHANDRASAITO, MARIKOICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$258,251AA
2019Congenital abnormalities resulting from fetal thyrotoxicosis1R21DE028732-01A1HERNANDEZ, ARTUROMAINEHEALTH, ME$258,000ZRG1
2019A State-of-Art NMR technique to Investigate Biologicals Effects of Electronic Nicotine Delivery Systems1R21ES029778-01A1HU, JIAN ZHIBATTELLE PACIFIC NORTHWEST LABORATORIES, WA$257,616EBIT
2019Solid-State MRI as a Noninvasive Alternative to Computed Tomography for Craniofacial Imaging1R21DE028417-01WEHRLI, FELIX WUNIVERSITY OF PENNSYLVANIA, PA$257,457MEDI
2019Fbxw7 as a target to promote muscle stem cell expansion1R21AR075205-01SACCO, ALESSANDRASANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, CA$257,400SMEP
2019Distinguishing immunomodulatory intestinal viruses through examination of viruses attached to RIG-I and MDA-51R21AI144877-01JEFFREY, KATE LOUISAMASSACHUSETTS GENERAL HOSPITAL, MA$257,027GMPB
2019R21: Acidic Nanoparticles for Restoration of Autophagy in Age-associated NAFLD1R21AG063373-01GRINSTAFF, MARK W.SHIRIHAI, ORIAN SBOSTON UNIVERSITY (CHARLES RIVER CAMPUS), MA$257,000NANO
2019iNKT cells hyperactivate DCs1R21AI144139-01BRENNER, MICHAEL B.BRIGHAM AND WOMEN'S HOSPITAL, MA$256,650III
2019Exploiting Natural Post-Integration Barriers to Restrict HIV-1 Replication1R21AI143800-01KUMAR, PRITISHERER, NATHAN MUNIVERSITY OF WISCONSIN-MADISON, WI$256,604ZRG1
2019Bispecific Antibody-Based PET Ligands for Imaging Tauopathies1R21AG064474-01DING, YU-SHINNEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$256,250IPCA
2019Using Behavioral Science to Improve the Appropriateness of Surgery for Degenerative Lumbar Scoliosis1R21AG059214-01A1NUCKOLS, TERYLRAND CORPORATION, CA$256,152DIRH
2019Humoral immune correlates of protection against congenital CMV and HSV transmission in HIV-infected women1R21AI147992-01HUGHES, BRENNA L.PERMAR, SALLIE R.DUKE UNIVERSITY, NC$255,813HCAC
2019Alu RNAs and double-stranded RNA sensors1R21AI144193-01AUNE, THOMAS M.VANDERBILT UNIVERSITY MEDICAL CENTER, TN$255,000III
2019The Macrophage Reverse Transsulfuration Pathway: A Novel Mediator of Helicobacter pylori Immunopathogenesis1R21AI142042-01A1WILSON, KEITH T.VANDERBILT UNIVERSITY MEDICAL CENTER, TN$255,000GMPB
2019A novel approach for reversal of autophagic defects using lysosome-targeted nanoparticles1R21AG060456-01A1GRINSTAFF, MARK W.SHIRIHAI, ORIAN SUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$254,750MBPP
2019ARCHAEAL-DERIVED SELF ADJUVANTING NANOPARTICLE MALARIA VACCINE1R21AI139808-01A1SRINIVASAN, PRAKASHJOHNS HOPKINS UNIVERSITY, MD$254,625VMD
2019Copper tolerance and homeostasis in Pneumocystis species1R21AI143467-01A1POROLLO, ALEXEYCINCINNATI CHILDRENS HOSP MED CTR, OH$254,418HCAC
2019Novel Nutrient-sensing Pathway Suppresses Pathologic Tissue Remodeling1R21AI142343-01WHITMAN, MALCOLM R.HARVARD MEDICAL SCHOOL, MA$254,250CSRS
2019Structure guided discovery of chemical probes for targeting Zika methyltransferase1R21AI142337-01AGGARWAL, ANEEL K.ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$254,250MSFB
2019Microbiota-dependent regulation of the gut-brain axis1R21AI142213-01ARTIS, DAVIDWEILL MEDICAL COLL OF CORNELL UNIV, NY$254,250CIMG
2019Stress hormone, calcium spikes and synapse loss in Alzheimer’s disease1R21AG061751-01CHAO, MOSES VICTORGAN, WENBIAONEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$254,250NDPR
2019Adapting hepatitis C virus to infect ferrets1R21AI144525-01EVANS, MATTHEW JICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$254,250VIRB
2019SERPINs as a novel family of innate antiviral molecules - Resubmission - 11R21AI139374-01A1DITTMANN, MEIKENEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$254,250VIRA
2019Determination of the GIRK channel proteome1R21DA048623-01SLESINGER, PAUL AICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$254,250SYN
2019Mechanisms and therapeutics of calcium dysregulation and synapse loss in Alzheimer's disease1R21AG064273-01GAN, WENBIAOZIFF, EDWARD BNEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$254,250NTRC
2019Investigation of commensal bacteria-produced metabolites with activity towards mycobiota.1R21AI146957-01ILIEV, ILIYAN DIMITROVWEILL MEDICAL COLL OF CORNELL UNIV, NY$254,250IHD
2019Neurocomputational Mechanisms for Addiction Heterogeneity, Impulsivity and Perseverance1R21DA049243-01GU, XIAOSIICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$254,250NPAS
2019Novel genetic tools for the analysis of plasmacytoid dendritic cell function in vivo1R21AI147501-01REIZIS, BORISNEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$254,250III
2019Discovery of genetic elements regulating intraepithelial lymphocytes1R21AI144827-01A1MUCIDA, DANIEL SROCKEFELLER UNIVERSITY, NY$254,250ZRG1
2019Palmitoylation-dependent Control of Glaucomatous Neurodegeneration1R21EY029386-01A1THOMAS, GARETHTEMPLE UNIV OF THE COMMONWEALTH, PA$253,798DPVS
2019Elucidation of a novel mechanism of macrolide resistance in Mycobacterium abscessus1R21AI146774-01GHOSH, PALLAVIWADSWORTH CENTER, NY$253,738ZRG1
2019Single cell analysis of transplant rejection1R21AI142264-01HILDEMAN, DAVID ACINCINNATI CHILDRENS HOSP MED CTR, OH$253,473TTT
2019Innate Immune Training by Human Malaria1R21AI139898-01A1DENT, ARLENEMITREVA, MAKEDONKACASE WESTERN RESERVE UNIVERSITY, OH$252,924III
2019Gating-Free Ultra-Fast Fetal Cardiac MRI with Sub-Nyquist Sampling for Live in Utero Imaging and Cardiovascular Phenotyping of Fetal Mice1R21EB023507-01A1 · under PA-16-161WU, YIJEN LINUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$252,859BMIT
2019Effects of boosting mucosal immunity by microbiota manipulation on B cell responses to HIV-1 vaccine1R21AI140788-01A1LYNCH, REBECCA MARIEGEORGE WASHINGTON UNIVERSITY, DC$252,788ZRG1
2019Transposable elements as drivers of normal and accelerated aging in Vertebrates1R21AG063739-01BENAYOUN, BERENICE ANATHUNIVERSITY OF SOUTHERN CALIFORNIA, CA$252,709CMAD
2019Exploring the Ethanol Engram: From Initiation to Excessive Ethanol Drinking1R21AA027330-01MULHOLLAND, PATRICK J.MEDICAL UNIVERSITY OF SOUTH CAROLINA, SC$252,281AA
2019High Quality Long Term Preservation of Sporozoites via Deep Supercooling1R21AI142415-01SANDLIN, REBECCAUSTA, OSMAN BERKMASSACHUSETTS GENERAL HOSPITAL, MA$252,000CMT
2019Cryogenic purification of Plasmodium parasites from blood1R21AI137558-01A1SANDLIN, REBECCAMASSACHUSETTS GENERAL HOSPITAL, MA$252,000CMT
2019Identification of novel HIV-derived antigens1R21AI143449-01A1LE GALL, SYLVIEMASSACHUSETTS GENERAL HOSPITAL, MA$252,000HIVD
2019Physiology of Mycobacterium Tuberculosis with Hibernating Ribosomes1R21AI144474-01OJHA, ANIL KUMARWADSWORTH CENTER, NY$251,879ZRG1
2019Unveiling the chromosomal address of intact HIV clones to provide insights into persistence1R21AI143564-01A1O'DOHERTY, UNA TUNIVERSITY OF PENNSYLVANIA, PA$251,788HIVD
2019RNA Pseudouridylation During Flavivirus Infection1R21AI142463-01GILBERT, WENDY VICTORIAYALE UNIVERSITY, CT$251,250ZRG1
2019Suppression of the type I IFN gene signature by the long non-coding RNA-Lucat-11R21AI142231-01FITZGERALD, KATHERINE A.UNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$251,250III
2019Generation of Macrophage Activation State-Specific Genetic Tools by A Synthetic Biology Approach1R21AI142316-01CANTLEY, LLOYD GGUO, JIANKANYALE UNIVERSITY, CT$251,250PBKD
2019Focusing the vaccine-elicited T cell response on the recognition of Mtb-infected cells1R21AI136922-01A1BEHAR, SAMUEL MUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$251,250VMD
2019Aging and clonality in atherosclerosis1R21AG062202-01FERNANDEZ HERNANDO, CARLOSGREIF, DANIELYALE UNIVERSITY, CT$251,250AICS
2019Testing the role of Glucose deprivation during secondary cone death in Retinitis Pigmentosa1R21EY030166-01PUNZO, CLAUDIOUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$251,250DPVS
2019IgA-Glycosylation: Mediator of Microbial Homeostasis and Intestinal Health?1R21AI137935-01A1PALM, NOAH WOLCOTTYALE UNIVERSITY, CT$251,250ZRG1
2019Mechanisms by which TLR9-deficiency and FasL Promote Cutaneous Lupus1R21AI145097-01MARSHAK-ROTHSTEIN, ANNUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$251,250ZRG1
2019Innate T cells learn to find their activating ligands in the skin during their thymic education using cholesterol byproducts1R21AI143225-01A1KANG, JOONSOOUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$251,250CMIA
2019Lymphopoietic niche editing by B-lineage leukemic cells and its implications for B cell progenitor and leukemic cell growth1R21AI146648-01PEREIRA, JOAOYALE UNIVERSITY, CT$251,250CMIB
2019Molecular Mechanisms of Visual Circuit Formation between Superior Colliculus and Thalamus1R21EY029820-01A1KIM, IN-JUNGYALE UNIVERSITY, CT$251,250NDPR
2019Modeling CRB1-related retinal disease using 3-D human retinal organoids1R21EY029806-01A1LIU, WEIALBERT EINSTEIN COLLEGE OF MEDICINE, NY$250,938BVS
2019A CCR5 Blocking Antibody as HIV Pre-exposure Prophylaxis1R21AI147723-01SACHA, JONAH B.OREGON HEALTH & SCIENCE UNIVERSITY, OR$250,898HIVD
2019Molecular imaging of PS1/gamma-secretase and analysis of Alzheimer's disease.1R21AG062913-01WANG, CHANGNINGZHANG, CAN MARTINMASSACHUSETTS GENERAL HOSPITAL, MA$250,640CNN
2019Impacts of the 2017 Hurricanes on Emergency Department Admissions and Outcomes in St. Thomas, USVI1R21MD013762-01MORRIS, JOHN GLENNUNIVERSITY OF FLORIDA, FL$250,565NRCS
2019A Novel Human Regulatory B Cell Subset1R21AI145323-01DITTEL, BONNIE NVERSITI WISCONSIN, INC., WI$250,500CMIB
2019Impact of a novel emm-enn gene fusion event on epidemic behavior of group A streptococcus1R21AI142126-01FLORES, ANTHONY RICHARDSHELBURNE, SAMUEL AUNIVERSITY OF TX MD ANDERSON CAN CTR, TX$250,320ZRG1
2019Early Life Brain Injury and Neurodegenerative Disorders of Aging1R21AG061643-01NORTHINGTON, FRANCES JJOHNS HOPKINS UNIVERSITY, MD$250,113DBD
2019Retrospective assessment of radon progeny and pollution effects in COPD1R21ES029637-01A1GARSHICK, ERICHARVARD MEDICAL SCHOOL, MA$249,996ZRG1
2019Exploring MetAP2 as a viable drug target for Entamoeba and Naegleria1R21AI142487-01A1SINGH, UPINDERSTANFORD UNIVERSITY, CA$249,275ZRG1
2019Multimorbidity, Rurality, and Outcomes in Atrial Fibrillation in the Community1R21AG062580-01CHAMBERLAIN, ALANNA MMAYO CLINIC ROCHESTER, MN$249,245CHSA
2019Regulation of salivary gland inflammation in Sjogren's Syndrome by Annexin 11R21DE029003-01HARDT, MARKUSADA FORSYTH INSTITUTE, INC., MA$248,750ODCS
2019Are all sporozoites equal? Analyses of transcriptomes from individual Plasmodium sporozoites using single cell RNA-seq1R21AI143932-01SERRE, DAVIDUNIVERSITY OF MARYLAND BALTIMORE, MD$248,150ZRG1
2019Synthetic Genomics to Improve a Phage-Based Diagnostic for Multi-Drug Resistant Bacteria1R21AI146703-01VASHEE, SANJAYJ. CRAIG VENTER INSTITUTE, INC., CA$248,114CRFS
2019Transcriptomic and Genetic Differences of Group A Streptococcus in Humans: Acute Infection versus Carriage1R21AI147502-01COOK, LAURA CAROL CASEWALD, ELLENSTATE UNIVERSITY OF NY,BINGHAMTON, NY$247,805ZRG1
2019Studies of translational regulatory networks in macrophage-mediated inflammatory responses1R21AI146431-01HU, WENQIANMAYO CLINIC ROCHESTER, MN$247,694III
2019Targeting the host NDP kinase to abrogate viral dissemination1R21DE028256-01FENG, PINGHUILIANG, CHENGYUUNIVERSITY OF SOUTHERN CALIFORNIA, CA$247,500ZRG1
2019Mapping the Transcriptome of Age-Related Hippocampal Trisynaptic Circuit Dysfunction in a Rat Model for Alzheimer's Disease1R21AG061553-01FARB, DAVID HRUSSEK, SHELLEY JBOSTON UNIVERSITY MEDICAL CAMPUS, MA$247,500CDIN
2019White Matter Pathology and Infiltrating T cells in the Brain of Cognitively Impaired Aging Rhesus Monkeys1R21AG061678-01ROSENE, DOUGLAS LBOSTON UNIVERSITY MEDICAL CAMPUS, MA$247,500ASG
2019Role of DdIR-regulated D-Ala-D-Ala biosynthesis in peptidoglycan synthesis and virulence1R21AI137641-01A1BELITSKY, BORIS RTUFTS UNIVERSITY BOSTON, MA$247,500ZRG1
2019Calcium oscillations and cell motility with corneal injury1R21EY029097-01A1TRINKAUS-RANDALL, VICKERY EBOSTON UNIVERSITY MEDICAL CAMPUS, MA$247,500ZRG1
2019Modulation of Runx2 activity by arginine methylation1R21DE028617-01XU, JIANUNIVERSITY OF SOUTHERN CALIFORNIA, CA$247,500SBDD
2019Metabolic compensation in Mycobacterium tuberculosis for the formation of persisters1R21AI139386-01A1EOH, HYUNGJINUNIVERSITY OF SOUTHERN CALIFORNIA, CA$247,500ZRG1
2019Psychosocial stressors and the hippocampal memory system in African American seniors1R21AG060269-01A1SCHON, KARINBOSTON UNIVERSITY MEDICAL CAMPUS, MA$247,500CP
2019Gene-Education Interactions and Psychological Health1R21AG060447-01A1BARCELLOS, SILVIA HELENAUNIVERSITY OF SOUTHERN CALIFORNIA, CA$247,500SSPA
2019Endogenous and Environmental AHR Ligands in Head and Neck Cancer Aggression and Immunosuppression1R21ES029624-01A1SHERR, DAVID HBOSTON UNIVERSITY MEDICAL CAMPUS, MA$247,500SIEE
2019Development in a dish: an ex-vivo fetal mammary assay for toxicological research1UH2ES030045-01A1SOTO, ANATUFTS UNIVERSITY BOSTON, MA$247,500SIEE
2019Role of Gamma delta-17 T Cells in Asthma Protection by Amish Farm Exposure .1R21AI144722-01VERCELLI, DONATAUNIVERSITY OF ARIZONA, AZ$247,298ZRG1
2019Retinal inputs signal through astrocytes to recruit interneurons into visual thalamus1R21EY030568-01FOX, MICHAEL AVIRGINIA POLYTECHNIC INST AND ST UNIV, VA$247,117NDPR
2019Establishing immunoprivileged scaffolds for transplantation of immature beta cells1R21AI147677-01SHEA, LONNIE DSHIRWAN, HAVALUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$246,500BMBI
2019An imaging approach to understanding the impact of heterogeneity in microenvironments and lesion properties during Mycobacterium tuberculosis infection1R21AI137759-01A1TAN, SHUMINTUFTS UNIVERSITY BOSTON, MA$246,200ZRG1
2019Liquid liquid phase separation and tau biology1R21AG063347-01HYMAN, BRADLEY T.MASSACHUSETTS GENERAL HOSPITAL, MA$246,184BPNS
2019Tafenoquine as a potential revolutionary treatment for babesiosis1R21AI142523-01MORDUE, DANA GNEW YORK MEDICAL COLLEGE, NY$246,000ZRG1
2019Mechanisms of Phagocyte Interactions with Pseudomonas Mediated by Polyanions1R21AI137656-01A1O'TOOLE, GEORGE A.DARTMOUTH COLLEGE, NH$246,000ZRG1
2019Direct ligand-based control of C. albicans zinc cluster transcription factors1R21AI146514-01MYERS, LAWRENCE CHRISTOPHERDARTMOUTH COLLEGE, NH$246,000ZRG1
2019Monoclonal antibody therapy for neonatal HSV infections1R21AI147714-01LEIB, DAVID ADARTMOUTH COLLEGE, NH$246,000ZRG1
2019Monitoring seizure activity following BACE1 inhibition for Alzheimer's disease treatment1R21AG059124-01A1HU, XIANG-YOUUNIVERSITY OF CONNECTICUT SCH OF MED/DNT, CT$245,813CDIN
2019Study of responses to CD44 targeted nanovectors to design a novel adjunctive anti-tuberculosis host-directed therapy1R21AI137533-01A1CHATTERJEE, SOUMYAGODIN, BIANASAINT LOUIS UNIVERSITY, MO$245,811LCMI
2019The Neisseria Type IV pilus as a mediator of persistent colonization1R21AI144763-01SO, MAGDALENE YUNIVERSITY OF ARIZONA, AZ$245,755ZRG1
2019Site-specific DNA recombinase and A/E pathogen virulence1R21AI137719-01A1WAN, FENGYIJOHNS HOPKINS UNIVERSITY, MD$245,625ZRG1
2019Exploratory Studies of SPPL31R21AI143053-01POMERANTZ, JOEL LJOHNS HOPKINS UNIVERSITY, MD$245,625MBPP
2019PpiA, a multitasking mycobacterial virulence protein1R21AI143610-01BISHAI, WILLIAM RAMSESJOHNS HOPKINS UNIVERSITY, MD$245,625AOIC
2019Discovery of cryptic open reading frames in Alzheimer's brain1R21AG064536-01NA, CHAN-HYUNJOHNS HOPKINS UNIVERSITY, MD$245,625EBIT
2019Antibiotic Knowledge and Attitudes among Nursing Home Patients, Family and Staff.1R21AG061482-01A1ZENILMAN, JONATHAN MJOHNS HOPKINS UNIVERSITY, MD$245,625DIRH
2019Cerebellar Modulation of Auditory Function1R21DC017600-01A1DU LAC, SASCHAJOHNS HOPKINS UNIVERSITY, MD$245,625SMI
2019Clostridium innocuum as an emerging multidrug-resistant antibiotic-associated diarrheal pathogen1R21AI144549-01KOCIOLEK, LARRY KLURIE CHILDREN'S HOSPITAL OF CHICAGO, IL$245,586CRFS
2019Identification of candidate genes conditioning mosquito immune response to arboviruses1R21AI144095-01SEVERSON, DAVID WUNIVERSITY OF NOTRE DAME, IN$245,500VB
2019Genetically Modified T cells as Probes and Therapy for Lupus1R21AI142137-01A1KONO, DWIGHT HSCRIPPS RESEARCH INSTITUTE, THE, CA$245,480ACTS
2019Endoscopic nasal sinus surgery simulator to optimize treatment outcome1R21DC017530-01ZHAO, KAIOHIO STATE UNIVERSITY, OH$245,020BTSS
2019Pathophysiology of Lower Urinary Tract Dysfunction in a Mouse Model of Alzheimer's Disease1R21AG061609-01HU, XIANG-YOUSMITH, PHILLIP PAULUNIVERSITY OF CONNECTICUT SCH OF MED/DNT, CT$244,875ASG
2019Does the senescent environment contribute to age-related changes in T cell function?1R21AG060707-01A1HAYNES, LAURAUNIVERSITY OF CONNECTICUT SCH OF MED/DNT, CT$244,875CMAD
2019Regulation of innate immunity by a novel protein interaction network1R21AI132827-01A1ALPER, SCOTTNATIONAL JEWISH HEALTH, CO$244,750III
2019Structural mechanism of a DNA polymerase critical for developing antibiotic-resistance1R21AI144637-01KELCH, BRIAN ANTHONYUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$244,500MSFA
2019Sleep in children with fetal alcohol spectrum disorders1R21AA026697-01A1THOMAS, JENNIFER DSAN DIEGO STATE UNIVERSITY, CA$244,457AA
2019Development of novel viral vectors to study and treat neuroinflammation1R21AG064221-01MANFREDSSON, FREDRICSANDOVAL, IVETTEST. JOSEPH'S HOSPITAL AND MEDICAL CENTER, AZ$244,201CMBG
2019A Pluripotent Stem Cell-Based Model to Investigate the Mechanisms of TBI-Induced AD1R21AG063358-01BRAFMAN, DAVID ASTABENFELDT, SARAH EARIZONA STATE UNIVERSITY-TEMPE CAMPUS, AZ$243,975BNVT
2019Exploring the Ecological Roles of Mutanic Acid and Mutanicyclin; Two Novel Small Molecules Produced by Streptococcus mutans1R21DE028609-01EDLUND, ANNA ELISABETJ. CRAIG VENTER INSTITUTE, INC., CA$243,750ODCS
2019Carbon Regulation of Virulence in Oropharyngeal Candidiasis1R21AI144878-01MITCHELL, AARON PCARNEGIE-MELLON UNIVERSITY, PA$243,094PTHE
2019Microbial effects on Acute Lung Injury1R21AI142360-01HRUSCH, CARA LYNNSPERLING, ANNE I.UNIVERSITY OF CHICAGO, IL$243,000LIRR
2019Role of astrocyte infection in viral neurovirulence1R21AI137613-01A1RACANIELLO, VINCENT RCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$243,000VIRB
2019Genetic network regulating eye formation1R21EY029114-01A1VICZIAN, ANDREA SUPSTATE MEDICAL UNIVERSITY, NY$243,000BVS
2019Adrenergic Control of Memory T Cells by Circadian Rhythms1R21AI143248-01FARRAR, JOHN DAVIDUT SOUTHWESTERN MEDICAL CENTER, TX$243,000NNRS
2019Specificity and dynamics of transcriptional repression in retinal development1R21EY030199-01REBAY, ILARIAUNIVERSITY OF CHICAGO, IL$243,000BVS
2019Rickettsia conorii transposon mutagenesis and Spotted Fever pathogenesis1R21AI144136-01KIM, HWAN KEUNUNIVERSITY OF CHICAGO, IL$243,000ZRG1
2019A droplet microfluidics approach to measuring protein aggregation1R21AG062874-01DIAMOND, MARC IUT SOUTHWESTERN MEDICAL CENTER, TX$243,000BPNS
2019Defining Arbovirus-Host Interactions Using a Novel Caenorhabditis elegans-based System1R21AI144203-01GAMMON, DON BRADUT SOUTHWESTERN MEDICAL CENTER, TX$243,000VIRB
2019The Persistence of Longevity Across Generations: An Exploratory Investigation of Grandchildren of ex-POWs1R21AG064460-01COSTA, DORA LNATIONAL BUREAU OF ECONOMIC RESEARCH, MA$243,000SSPB
2019Investigating a positive biological role for the A Beta peptide1R21AG064618-01JONGENS, THOMAS AUNIVERSITY OF PENNSYLVANIA, PA$243,000CMND
2019Role of Maturin in retinal development and homeostasis1R21EY030654-01ZUBER, MICHAEL EUPSTATE MEDICAL UNIVERSITY, NY$243,000BVS

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