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NIH funding notice PA-19-053

NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed)

Closed on May 24, 2020.

Posted
November 5, 2018
Close date
May 24, 2020
Activity codes
R21
Institutes taking part
NEI, NHGRI, NIA, NIAAA, NIAID, NIAMS, NIDCD, NIDCR, NIDA, NIEHS, NINR, NIMHD, NLM, NCCIH

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

  1. Reissues: PA-18-489 NIH Exploratory/Developmental Research Grant Program ( Parent R21 Clinical Trial Not Allowed)
  2. 2 steps back: PA-16-161 NIH Exploratory/Developmental Research Grant Program (Parent R21)
  3. 3 steps back: PA-13-303 NIH Exploratory/Developmental Research Grant Program (Parent R21)
  4. 4 steps back: PA-11-261 NIH Exploratory/Developmental Research Grant Program (Parent R21)
  5. 5 steps back: PA-10-069 NIH Exploratory Developmental Research Grant Program (Parent R21)
  6. 6 steps back: PA-09-164 NIH Exploratory/Developmental Research Grant Program (Parent R21)
  7. 7 steps back: PA-06-181 NIH Exploratory/Developmental Research Grant Program (Parent R21)
  8. 8 steps back: PA-03-107

Replaced by PA-20-195.

Who won it before

8,179 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $1,849,901,467 in first-year total cost, median $228,873.

Most frequent study sections

  1. Special Emphasis Panel[ZRG1 IDM-B (80)]348
  2. Special Emphasis Panel[ZRG1 IDM-B (81)]169
  3. Special Emphasis Panel[ZRG1 IDM-Y (82)]154
  4. Pathogenic Eukaryotes Study Section[PTHE]146
  5. Virology - B Study Section[VIRB]125

Most frequent institutions

  1. UNIVERSITY OF PITTSBURGH AT PITTSBURGH183
  2. JOHNS HOPKINS UNIVERSITY182
  3. UNIVERSITY OF WASHINGTON163
  4. UNIVERSITY OF PENNSYLVANIA149
  5. UNIVERSITY OF MICHIGAN AT ANN ARBOR142
Competing awards under PA-19-053 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2021Quantitative disease risk scores for common diseases, with applications to eMERGE1R21HG012345-01A1IONITA, IULIANACOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$445,500ZRG1
2021Effects of Age on Control of Recollected Content1R21AG071231-01RUGG, MICHAEL DUNIVERSITY OF TEXAS DALLAS, TX$426,750ZRG1
2021Pathway discovery for ubiquilin-associated ALS/Dementia1R21AG065896-01A1KIM, SANG HWAUNIVERSITY OF WISCONSIN-MADISON, WI$421,841MNG
2021Efficacy assessment of intraocular islet transplant in nonhuman primates1R21AI156131-01ABDULREDA, MIDHAT HBERMAN, DORA MUNIVERSITY OF MIAMI SCHOOL OF MEDICINE, FL$307,000ZRG1
2021The role of macrophage podosomes in Ebola virus pathogenesis1R21AI151717-01A1SHTANKO, OLENATEXAS BIOMEDICAL RESEARCH INSTITUTE, TX$297,000VIRB
2021HIGH THROUGHPUT SINGLE CELL TRANSCRIPTOMIC APPROACH TO IDENTIFY SUSCEPTIBLE CELL TYPES AND GENE EXPRESSION CHANGES IN HUMAN GLAUCOMA1R21EY032219-01SANES, JOSHUA RHARVARD UNIVERSITY, MA$295,750DPVS
2021Characterizing a potential role for TREM2 in modulating tau pathogenesis in response to Abeta1R21AG070676-01HUANG, TIMOTHY YIKAISANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, CA$292,500CMBG
2021Does post-transcriptional control of NLRP3 inflammasome activity impact development of type 1 diabetes?1R21AI149171-01A1SUBRAMANIAN, NAEHAINSTITUTE FOR SYSTEMS BIOLOGY, WA$292,384CADO
2021Live Imaging of Immunity to M. tuberculosis1R21AI156407-01ERNST, JOEL D.UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$289,901ZRG1
2021Global Gene Expression Responses of Francisella tularensis to intracellular Infection of Human Alveolar Macrophages1R21AI156263-01SKERRETT, SHAWN J.WALTERS, KATHIE ANNEUNIVERSITY OF WASHINGTON, WA$288,407ZRG1
2021Breath Volatile Metabolites for the Diagnosis of Coccidioidomycosis1R21AI156279-01KOO, SOPHIABRIGHAM AND WOMEN'S HOSPITAL, MA$278,671CRFS
2021Sex-specific Immune Responses to Severe Influenza Virus Infection1R21AI151418-01A1SHOEMAKER, JASON EDWARDUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$278,498MABS
2021Role of Neuroprotective Indoles in Delaying the Onset of Cognitive Decline1R21AG066060-01A1FANG, XIANGPAPPOLLA, MIGUELUNIVERSITY OF TEXAS MED BR GALVESTON, TX$278,200ASG
2021Development, Usability Evaluation, and Pilot Feasibility Study of an mHealth Application Supporting Self-Management of Accidental Bowel Leakage, "I'M ABLe"1R21NR019676-01BLISS, DONNA ZUNIVERSITY OF MINNESOTA, MN$277,692CMPC
2021Improving AAV-transduction efficiencies for skeletal muscle delivery1R21AI151537-01A1CHOE, HYERYUNSCRIPPS FLORIDA, FL$277,500GDD
2021Longitudinal Antibody Profiles Correlated with Protection from Malaria in Malawi1R21AI151459-01A1BEESON, JAMESVALIM, CLARISSABOSTON UNIVERSITY MEDICAL CAMPUS, MA$276,326CRFS
2021The rectal microbiome and incident rectal sexually transmitted infections1R21AI156765-01TUDDENHAM, SUSAN ANNEJOHNS HOPKINS UNIVERSITY, MD$271,600ZRG1
2021Role of β-lactamase encoding gene amplification in the development of non-carbapenemase producing, carbapenem-resistant Enterobacteriaceae1R21AI151536-01A1SHELBURNE, SAMUEL AUNIVERSITY OF TX MD ANDERSON CAN CTR, TX$270,079ZRG1
2021Preventing alcohol seeking with a nonmuscle myosin II inhibitor under clinical development1R21AA028727-01A1GILPIN, NICHOLAS WARRENMILLER, COURTNEY ASCRIPPS FLORIDA, FL$267,975AA
2021The Maternal Immune Legacy of In Utero HIV Exposure1R21AI157821-01HARRINGTON, WHITNEY ELIZABETHSEATTLE CHILDREN'S HOSPITAL, WA$267,804HIVD
2021Predictive biomarkers of treatment response in kidney transplant rejection1R21AI151491-01A1COLEY, SHANA M.COLUMBIA UNIVERSITY HEALTH SCIENCES, NY$266,691TTT
2021Distal gut microbiome targets of host anti-proteolytic proteins during colitis1R21AI156674-01HANG, HOWARD CSCRIPPS RESEARCH INSTITUTE, THE, CA$266,250GMPB
2021Mechanisms of acute kidney injury in malaria - Resubmission - 11R21AI151349-01A1RODRIGUEZ, ANANEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$265,840PBKD
2021Subversion of Syndecan-1 Functions in Listeriosis1R21AI156284-01PARK, PYONG WOOBOSTON CHILDREN'S HOSPITAL, MA$265,500ZRG1
2021MiR-23/27/24 Control of Adipose Tissue Macrophage Activation1R21AI156292-01PUA, HEATHER HVANDERBILT UNIVERSITY MEDICAL CENTER, TN$265,223III
2021Roles and regulation of polyamines during HCMV infection1R21AI156152-01GEBALLE, ADAM P.FRED HUTCHINSON CANCER RESEARCH CENTER, WA$264,000VIRA
2021Structure-Based Designs of HIV-1 Immunogens Targeting Germline Precursors of Broadly Neutralizing Antibodies1R21AI157799-01PANCERA, MARIEFRED HUTCHINSON CANCER RESEARCH CENTER, WA$264,000HIVD
2021Historic Violence and Contemporary Racial Disparities in Birth Outcomes1R21MD015813-01BAILEY, AMY KATEUNIVERSITY OF ILLINOIS AT CHICAGO, IL$263,600HDEP
2021Osteoblast Dopamine Receptor Mediates Diabetic Bone Disease1R21AR077260-01A1TRACKMAN, PHILIP CADA FORSYTH INSTITUTE, INC., MA$262,680SBDD
2021Identification of potentiators of antimicrobial activity against multidrug-resistant Burkholderia cepacia complex infections in cystic fibrosis1R21AI156039-01BRENNAN-KROHN, THEABETH ISRAEL DEACONESS MEDICAL CENTER, MA$262,500ZRG1
2021Development of Blood Delivery Networks for Silicon Nanomembrane-Enabled Low-Volume Membrane Oxygenators1R21HL156143-01DAY, STEVENROUSSIE, JAMES ANDREWROCHESTER INSTITUTE OF TECHNOLOGY, NY$262,405BTSS
2021Exploiting the Salivary Arsenal to Inhibit Diarrheal Disease1R21AI156236-01BULLITT, ESTHERBOSTON UNIVERSITY MEDICAL CAMPUS, MA$261,875ZRG1
2021Foxp3DEx2 isoform expression leads to Treg dysfunction and SLE1R21AI152444-01A1ZIEGLER, STEVEN FBENAROYA RESEARCH INST AT VIRGINIA MASON, WA$261,150HAI
2021Control of CD8+ T cell migration and activation by Flightless-11R21AI157440-01CAMPBELL, DANIEL JBENAROYA RESEARCH INST AT VIRGINIA MASON, WA$261,150ZRG1
2021Epigenetic Determinants and Mechanisms Influencing Genital Chlamydia trachomatis Reinfection in African American Women1R21AI156142-01GEISLER, WILLIAM MTIWARI, HEMANT K.UNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$259,875ZRG1
2021Structure-Based Design of Peptide Entry Inhibitors against Ebola Virus Infection1R21AI151483-01A1XIANG, SHI-HUAUNIVERSITY OF NEBRASKA LINCOLN, NE$259,074ZRG1
2021In Vivo Detection of Chronic Traumatic Encephalopathy with 18F-MK-6240 Tau PET1R21NS120629-01ALOSCO, MICHAELRABINOVICI, GIL DANUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$258,483ZRG1
2021Macrolide resistance transfer in Streptococcus pyogenes1R21AI156226-01BESSEN, DEBRA ENEW YORK MEDICAL COLLEGE, NY$258,248ZRG1
2021Major Depression and Molecular Senescence: The Role of Sleep1R21AG060732-01A1HALL, MARTICA HELONUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$258,015ZRG1
2021Polyclonality of carbapenem resistant Enterobacteriaceae bloodstream infections1R21AI152018-01A1CLANCY, CORNELIUS JUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$257,115ZRG1
2021Patterns of Aging and the Role of Biomarkers of Senescence1R21AG070356-01TSYGANKOV, DENISGEORGIA INSTITUTE OF TECHNOLOGY, GA$255,648ASG
2021Features of PMN Senescence that Lead to Susceptibility to Pneumococcal Infection1R21AG071268-01LEONG, JOHN MMECSAS, JOAN CTUFTS UNIVERSITY BOSTON, MA$255,291ZRG1
2021Falls Related Injuries and Hearing Loss: Understanding the role of hearing healthcare intervention1R21DC018616-01A1RISKA, KRISTAL MILLSDUKE UNIVERSITY, NC$254,400NAME
2021The roles of the Pseudomonas aeruginosa Prc/AlgO protease - Resubmission - 11R21AI151097-01A1DARWIN, ANDREW J.NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$254,250ZRG1
2021Identification of host factors required by the tick-borne Powassan virus1R21AI153927-01A1RICE, CHARLES MROCKEFELLER UNIVERSITY, NY$254,250ZRG1
2021Microbiota, Tertiary Lymphoid Structures and Chronic Inflammation in the Human Gut1R21AI157369-01BOGUNOVIC, MILENAMORGUN, ANDRIYUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$253,875GMPB
2021A novel mechanism for synapse localization in the retina1R21EY032392-01GOODRICH, LISAHARVARD MEDICAL SCHOOL, MA$253,500SYN
2021Bordetella cell surface modification and pathogenesis1R21AI156732-01DEORA, RAJENDAR KOHIO STATE UNIVERSITY, OH$253,250ZRG1
2021In vivo real-time monitoring of reactive oxygen species and opioid signaling in a model for opioid receptor activity.1R21DA051193-01A1BERNDT, ANDREUNIVERSITY OF WASHINGTON, WA$252,894MNPS
2021Microfluidic Assays for Probing Neutrophil-Borrelia Interactions in Blood during Acute Lyme Disease1R21AI156723-01IRIMIA, DANIELMASSACHUSETTS GENERAL HOSPITAL, MA$252,000ISD
2021Targeted delivery of TB therapeutics1R21AI151842-01A1SASSETTI, CHRISTOPHER MUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$251,250ZRG1
2021Mitochondrial regulation of the NLRP3 inflammasome in myocardial ischemia-reperfusion injury and heart transplantation1R21AI156919-01SUTTERWALA, FAYYAZ S.CEDARS-SINAI MEDICAL CENTER, CA$250,500SAT
2021Immune-induction of lipid droplets in Drosophila larval hemocytes1R21AI156088-01WELTE, MICHAEL ANDREASUNIVERSITY OF ROCHESTER, NY$248,815CSRS
2021Fungal natural products targeting antimicrobial resistant Mycoplasma genitalium1R21AI153863-01A1CICHEWICZ, ROBERT HENRYWOOD, GWENDOLYNUNIVERSITY OF OKLAHOMA, OK$246,625SBCB
2021HEMOGLOBIN-INDUCED VIRULENCE IN STREPTOCOCCUS PNEUMONIAE1R21AI151571-01A1AKERLEY, BRIANEICHENBAUM, ZEHAVAVIDAL, JORGE EUGENIOUNIVERSITY OF MISSISSIPPI MED CTR, MS$246,625ZRG1
2021Infection and prevalence of a new segmented flavivirus in the United States1R21AI156406-01KAPOOR, AMITRESEARCH INST NATIONWIDE CHILDREN'S HOSP, OH$246,525CRFS
2021Computational de novo design of a disulfide-rich miniprotein synthetic library and its application to engineer binders to neutralizing epitopes on Clostridium difficile toxins TcdA and TcdB1R21AI156570-01BAHL, CHRISTOPHER DAVIDINSTITUTE FOR PROTEIN INNOVATION, INC., MA$246,300MSFD
2021Resistance-gene-guided genome mining for novel antifungal compounds1R21AI156320-01OAKLEY, BERL RAYUNIVERSITY OF KANSAS LAWRENCE, KS$245,768ZRG1
2021Identifying gene regulatory networks controlling photoreceptor specification by transcriptomic and epigenomic analysis of retinal development in cone-dominant retina1R21EY032281-01BLACKSHAW, SETHJOHNS HOPKINS UNIVERSITY, MD$245,625BVS
2021Acetylation and contraction-mediated glucose uptake1R21AG067495-01A1SCHENK, SIMONUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$245,605ZRG1
2021Systematic in vitro and in vivo genetic analysis of C.albicans protein kinases1R21AI157341-01KRYSAN, DAMIAN JUNIVERSITY OF IOWA, IA$244,071ZRG1
2021Characterizing the Pan-genome of a Rickettsia Infecting the Eastern Black-legged Tick1R21AI156762-01DRISCOLL, TIMOTHY PGILLESPIE, JOSEPH JUNIVERSITY OF MARYLAND BALTIMORE, MD$243,797GVE
2021Optogenetic modulation of inhibition in cat visual cortex1R21EY032232-01CONTRERAS, DIEGOUNIVERSITY OF PENNSYLVANIA, PA$243,542SPC
2021Oncolytic virus targeting Schistosomes1R21AI151334-01A1BAIS, SWARNAFREEDMAN, BRUCE DUNIVERSITY OF PENNSYLVANIA, PA$243,500PTHE
2021Identification of the agent of Southern Tick Associated Rash Illness1R21AI156475-01TOKARZ, RAFALCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$243,000CRFS
2021Determining the role of microtubules and motor proteins during early HIV-1 replication1R21AI152869-01A1CIANFROCCO, MICHAELUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$242,404HVCD
2021Proteomic interrogation of the parasite vacuole using autoSTOMP1R21AI156153-01EWALD, SARAH E.UNIVERSITY OF VIRGINIA, VA$242,250PTHE
2021Subunit Vaccine for Cryptosporidiosis1R21AI154862-01A1PETRI, WILLIAM AUNIVERSITY OF VIRGINIA, VA$242,250VMD
2021Neutrophil Activation Phenotypes in Healthy Subjects and Implications for Bacterial Clearance1R21AI156143-01LEE, GRACE MINGDUKE UNIVERSITY, NC$241,500IHD
2021The effects of BTNL2 on experimental autoimmune encephalomyelitis1R21AI156779-01LAI, LAIJUNUNIVERSITY OF CONNECTICUT STORRS, CT$241,500HAI
2021Plasmodium ovale hypnozoite development and relapse: a coordinated in vivo in vitro study1R21AI152260-01A1ADAMS, JOHN HLIN, JESSICAUNIV OF NORTH CAROLINA CHAPEL HILL, NC$240,758ZRG1
2021Mechanisms of exacerbation of COVID-19 pathogenesis in mice expressing human ACE2 by polycyclic aromatic hydrocarbons (PAHs), and its protection by inhibition of soluble epoxide hydrolase (sEH)1R21ES032739-01MOORTHY, BHAGAVATULARONCA, SHANNONBAYLOR COLLEGE OF MEDICINE, TX$240,720SIEE
2021The Role of Tuberculosis Disease on Non-Communicable Disease Risk: Comparative Analysis of Large Healthcare Databases1R21AI156161-01CRITCHLEY, JULIA ALISONMAGEE, MATTHEW JAMESEMORY UNIVERSITY, GA$240,091ZRG1
2021Mechanisms by which rickettsiae subvert autophagy pathway in macrophages1R21AI151904-01A1FANG, RONG MEGANUNIVERSITY OF TEXAS MED BR GALVESTON, TX$239,750ZRG1
2021Function and Regulation of Sema3 Genes in Palate Development and Innervation1R21DE030193-01LAN, YUCINCINNATI CHILDRENS HOSP MED CTR, OH$238,500SBDD
2021Regulation of B cell development by ABCB71R21AI157328-01SHAPIRO, VIRGINIA SMITHMAYO CLINIC ROCHESTER, MN$238,500CMIA
2021Activity-Dependent Tagging of Cerebellar Neurons for Studying Signal Processing and Learning1R21EY031639-01A1RAYMOND, JENNIFER LSTANFORD UNIVERSITY, CA$238,259ZRG1
2021Siderophore secretion by Mycobacterium tuberculosis1R21AI151239-01A1NIEDERWEIS, MICHAELUNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$238,240ZRG1
2021Reversal of epigenetic silencing rescues integrase-deficient HIV-1 replication1R21AI157616-01CULLEN, BRYAN R.DUKE UNIVERSITY, NC$237,775HVCD
2021Sex separation through targeting of conserved female-specific lethal genes in disease vector mosquitoes1R21AI156170-01SCHEEL, MOLLY DUMANINDIANA UNIVERSITY INDIANAPOLIS, IN$237,750VB
2021A mouse model and iPS cells to study hyperactive ABCA1 in the eye in age-related macular degeneration1R21EY032235-01LYSSENKO, NICHOLASTEMPLE UNIV OF THE COMMONWEALTH, PA$237,750DPVS
2021Mincle and STING Activation in Proinflammatory Responses to Orientia Infection1R21AI156536-01SOONG, LYNNUNIVERSITY OF TEXAS MED BR GALVESTON, TX$237,000ZRG1
2021Defining the roles of an enhancer long non-coding RNA eIncRNA-ID2 in rickettsial pathogenesis and immunity1R21AI146681-01A1SAHNI, ABHAUNIVERSITY OF TEXAS MED BR GALVESTON, TX$237,000ZRG1
2021Mechanisms of IncRNA/RBP regulation of macrophage function for control of T. cruzi infection1R21AI151305-01A1CHOWDHURY, IMRAN HUSSAINGARG, NISHA JAINUNIVERSITY OF TEXAS MED BR GALVESTON, TX$237,000III
2021Restorative gene therapy on hippocampal spino-dendritic abnormalities: a focus on Alzheimer’s disease1R21AG071133-01BARRIENTOS, RUTH MOHIO STATE UNIVERSITY, OH$236,833CDIN
2021Development of precision genome editing tools in Ae. albopictus for functional genetics and mosquito control technologies1R21AI156078-01AKBARI, OMAR SULTANUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$236,750VB
2021Targeting protein-protein interactions as drug targets1R21AI156484-01BURKART, MICHAEL D.UNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$236,563MSFA
2021Tetrahydrothieno[2,3-c]pyridines as Vaccine Co-adjuvants1R21AI156558-01CARSON, DENNISSHUKLA, NIKUNJUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$236,500VMD
2021A novel microfluidic platform to study exosome biology in PAH.1R21HL156761-01DE JESUS PEREZ, VINICIO ADEMIRCI, UTKANSTANFORD UNIVERSITY, CA$236,363ZRG1
2021Gene regulatory architecture of CD56 bright natural killer cells1R21AI156411-01COLLINS, PATRICK LEONARDOHIO STATE UNIVERSITY, OH$235,688CMIB
2021Development of Precision Analyses to Reveal "Hit&Run" Effects1R21AI155515-01IZUMIYA, YOSHIHIROUNIVERSITY OF CALIFORNIA AT DAVIS, CA$235,500VIRA
2021Mechanisms underlying lncRNA SAF-mediated survival and persistence of HIV-1 infected macrophages1R21AI157759-01BOLIAR, SAIKATCORNELL UNIVERSITY, NY$235,500HVCD
2021Immunoregulatory effect of microparticle delivered STING agonist in the control of experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS)1R21AI154772-01A1MARKOVIC-PLESE, SILVATHOMAS JEFFERSON UNIVERSITY, PA$234,966HAI
2021Investigating the molecular requirements for ESX-1-lytic activity in pathogenic mycobacteria1R21AI156229-01CHAMPION, PATRICIA AUNIVERSITY OF NOTRE DAME, IN$234,750ZRG1
2021Pooled and dual-guided CRISPRi, a genome-wide tool for genetic interaction mapping in high-throughput1R21AI156203-01VAN OPIJNEN, TIMBOSTON COLLEGE, MA$234,750PCMB
2021Analysis of cellular factors limiting productive JC virus infections1R21AI151612-01A1PIPAS, JAMES MUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$234,750VIRB
2021Use of site-specific pharmacokinetics to optimize antibiotic combinations and prevent the emergence of resistance against CRE1R21AI151363-01A1SHIELDS, RYAN KUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$234,750ZRG1
2021Epigenetic Study of Resistance to Infection by Mycobacterium tuberculosis1R21AI152031-01A1GANDHI, NEEL RAJNIKANTSUN, YANEMORY UNIVERSITY, GA$234,563ZRG1
2021Improving oral health awareness and dental referrals for adult patients receiving palliative care1R21DE030248-01CHEN, XIUNIVERSITY OF IOWA, IA$234,020CMPC
2021Susceptibility determinants to Legionella pneumophila infection in smokers1R21AI156379-01AMER, AMAL OCORMET-BOYAKA, ESTELLE AGAVRILIN, MIKHAIL AOHIO STATE UNIVERSITY, OH$234,000ZRG1
2021The Role of DIRAS Proteins in Neuronal Autophagy1R21AG067282-01A1TSVETKOV, ANDREYUNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TX$234,000CMND
2021Urine TB diagnostic by amplicon reconstruction for PCR detection of DNA fragments1R21AI152497-01A1HASELTON, FREDERICK RVANDERBILT UNIVERSITY, TN$233,816ZRG1
2021Single molecule kinetic studies of gamma-secretase/substrate interaction and the effects of AD-causing mutations1R21AG067436-01A1FORTH, SCOTT THOMASWANG, CHUNYURENSSELAER POLYTECHNIC INSTITUTE, NY$233,776MSFC
2021Microscale System for Functional T Cell Transcriptomics1R21AI154867-01A1KAM, LANCE CCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$233,352ZRG1
2021Genetically Encoded Optical Biosensors for Dissecting Brain Distribution and Metabolism of Cannabinoids1R21DA051555-01GU, LIANGCAIUNIVERSITY OF WASHINGTON, WA$233,250MNPS
2021Dissecting Hem-1 functions in B lymphocyte Development and Primary Immunodeficiency Disease1R21AI156243-01IRITANI, BRIAN MUNIVERSITY OF WASHINGTON, WA$233,250CMIA
2021MOLECULAR BASIS OF PILUS-MEDIATED GONOCOCCAL ADHESION1R21AI155991-01MERZ, ALEXEY JARRELLUNIVERSITY OF WASHINGTON, WA$233,250ZRG1
2021Regulation of DNA Damage and Innate Immunity During the Productive Phase of the HPV Life Cycle1R21AI156158-01MOODY, CARY AUNIV OF NORTH CAROLINA CHAPEL HILL, NC$233,250VIRA
2021Exploring the Ethical Dimensions of Peanut Allergy Immunotherapy Research1R21AI156709-01FISHER, JILL AUNIV OF NORTH CAROLINA CHAPEL HILL, NC$233,250ZRG1
2021Inflammatory Bowel Disease Susceptibility Gene Regulation of Anemia1R21AI152017-01A1MCCOLE, DECLANUNIVERSITY OF CALIFORNIA RIVERSIDE, CA$233,250ZRG1
2021HERV-K immunity, a trigger of citrullination in rheumatoid arthritis?1R21AR077266-01A1MUSTELIN, TOMAS MUNIVERSITY OF WASHINGTON, WA$232,980ACTS
2021Consequences of fentanyl self-administration during pregnancy1R21DA052801-01RÜEDI-BETTSCHEN, DANIELAUNIVERSITY OF MISSISSIPPI MED CTR, MS$232,500BRLE
2021CAUSALITY CONSTRAINTS ON EAR-CANAL TESTS OF ACOUSTIC REFLECTION FUNCTION AND REFLECTANCE1R21DC018637-01A1KEEFE, DOUGLAS HFATHER FLANAGAN'S BOYS' HOME, NE$232,500AUD
2021NK cell and interferon gamma deficiency in infant susceptibility to pertussis1R21AI156042-01CARBONETTI, NICHOLAS HUNIVERSITY OF MARYLAND BALTIMORE, MD$231,750III
2021CD4 T cell intrinsic signaling defects during viral exhaustion1R21AI157121-01HOUTMAN, JON C.D.VARGA, STEVEN MUNIVERSITY OF IOWA, IA$231,750ZRG1
2021Salmonella chronic infection: Biofilm matrix factors and innate immune tolerance1R21AI156328-01GUNN, JOHN SRESEARCH INST NATIONWIDE CHILDREN'S HOSP, OH$231,000ZRG1
2021Role of ACAT1 in Pathological Retinal Neovascularization1R21EY032265-01CALDWELL, RUTH BROJAS, MODESTO ANTONIOAUGUSTA UNIVERSITY, GA$231,000DPVS
2021A Small Molecule That Blocks Salmonella Replication in Macrophages1R21AI151979-01A1DETWEILER, CORRELLA SUNIVERSITY OF COLORADO, CO$231,000ZRG1
2021Deciphering the tau phosphorylation code1R21AG070673-01PAK, DANIEL TGEORGETOWN UNIVERSITY, DC$230,920CMND
2021Analyzing the expression and activation of Perforin-2 -a bactericidal pore-forming protein- with single domain antibodies1R21AI156567-01MUNSON, GEORGE PATRICKUNIVERSITY OF MIAMI SCHOOL OF MEDICINE, FL$230,250ZRG1
2021Establishing Behavioral and Biological Predictors of Problematic Cannabis Use1R21DA051689-01A1MCLAUGHLIN, RYAN JOSEPHWASHINGTON STATE UNIVERSITY, WA$230,028BRLE
2021Arsenite-induced necroptosis1R21ES030838-01A1JACOBS, BERTRAM L.ARIZONA STATE UNIVERSITY-TEMPE CAMPUS, AZ$229,492CSRS
2021Reconstructing positional information in the eye from scRNA-seq and relating it to signal transduction1R21EY032233-01CARTHEW, RICHARD W.NORTHWESTERN UNIVERSITY, IL$228,925DEV2
2021A versatile "pan-spike-in" internal reference genome methodology for quantitative ChIP-seq normalization1R21HG011520-01CHANDRASEKHARAN, MAHESH BUNIVERSITY OF UTAH, UT$228,750GCAT
2021How Cd1d protects mice during natural infection1R21AI150158-01A1HOGQUIST, KRISTIN A.UNIVERSITY OF MINNESOTA, MN$228,604CMIB
2021Computational Modeling of Right Ventricular Intracardiac Flow in Tetralogy of Fallot1R21HL156045-01LOKE, YUE-HINCHILDREN'S RESEARCH INSTITUTE, DC$228,500BTSS
2021Mathematical Modeling of Influenza Severity in Outbred Mice1R21AI153882-01A1ALCORN, JOHN FSHOEMAKER, JASON EDWARDUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$228,212LCMI
2021Effects of Light at Night and Disrupted Circadian Rhythms on Pain1R21AT011238-01NELSON, RANDY J.WEST VIRGINIA UNIVERSITY, WV$228,000NNRS
2021Therapeutic modulation of tissue nonspecific alkaline phosphatase activity in acute inflammation and sepsis1R21AG070443-01BROWN, CANDICEWEST VIRGINIA UNIVERSITY, WV$228,000CNBT
2021Examining the importance of folate biosynthetic enzymes in infectious fungi1R21AI156611-01PALMER, GLENUNIVERSITY OF TENNESSEE HEALTH SCI CTR, TN$228,000ZRG1
2021Kinetics of neo-vascularization during pulp regeneration1R21DE029605-01A1HUANG, GEORGE T.JUNIVERSITY OF TENNESSEE HEALTH SCI CTR, TN$228,000ODCS
2021Molecular tracking of antigen following vaccination1R21AI155929-01TAMBURINI, BETH ANNUNIVERSITY OF COLORADO DENVER, CO$227,700CMIB
2021The effect of HIV infection on CD4 T cell immunity to Mycobacterium tuberculosis1R21AI155221-01A1DAY, CHERYL LIANEEMORY UNIVERSITY, GA$227,500HCAC
2021Chromosome scale genome assemblies for Culex pipiens mosquitoes1R21AI156280-01SHARAKHOVA, MARIAVIRGINIA POLYTECHNIC INST AND ST UNIV, VA$227,369ZRG1
2021T cell regulation by adult prostate stem cells1R21AI151723-01A1RATLIFF, TIMOTHY L.PURDUE UNIVERSITY, IN$226,841ZRG1
2021Ketone ester diet to ameliorate age-related decline in memory and muscle mass1R21AG071156-01RAMSEY, JON J.SLUPSKY, CAROLYNTAHA, AMEERUNIVERSITY OF CALIFORNIA AT DAVIS, CA$226,781CMAD
2021Identification and validation of Zika virus receptor(s) in the midgut lumen of Aedes aegypti1R21AI151475-01A1PUJHARI, SUJIT KUNIVERSITY OF SOUTH CAROLINA AT COLUMBIA, SC$226,756ZRG1
2021Integrating a pre-erythrocytic component into a multistage malaria vaccine1R21AI151765-01A1BURNS, JAMES MATTHEWDREXEL UNIVERSITY, PA$226,750VMD
2021Are acellular vaccines driving the rise of pertactin-deficient Bordetella pertussis1R21AI156293-01HARVILL, ERIC TUNIVERSITY OF GEORGIA, GA$226,500ZRG1
2021Mimicking evolution to define mechanisms of airborne transmission of H7N9 viruses1R21AI144135-01 · under PA-18-489SUTTON, TROY CLAVELLPENNSYLVANIA STATE UNIVERSITY, THE, PA$226,169VIRB
2021Sensitive and quantitative malaria diagnostic using nanoscale porous silicon.1R21AI156693-01WEISS, SHARON MVANDERBILT UNIVERSITY, TN$226,052NANO
2021Development of an emulsion-based method for repertoire-scale paired-chain T cell receptor sequencing1R21AI156664-01BIRNBAUM, MICHAELMASSACHUSETTS INSTITUTE OF TECHNOLOGY, MA$225,868CMIA
2021Quantifying data-driven metrics of meaningful cannabis reduction1R21DA052661-01BAKER, NATHANIEL LEEMCCLURE, ERIN AMEDICAL UNIVERSITY OF SOUTH CAROLINA, SC$225,750ARM
2021Multisensory integration in the mouse superior colliculus1R21EY032230-01FELDHEIM, DAVID AUNIVERSITY OF CALIFORNIA SANTA CRUZ, CA$225,600SPC
2021PfVP1, a battery of the malaria parasite, is critical for ring stage development1R21AI156735-01KE, HANGJUNDREXEL UNIVERSITY, PA$225,586PTHE
2021Oral Health Education and Navigation Program for Older Immigrants with Limited English Proficiency1R21DE029579-01A1JANG, YURIUNIVERSITY OF SOUTHERN CALIFORNIA, CA$225,459HDEP
2021Generation of Novel Osteolineage VHL Conditional Knockout Mice to Study B Cell Microenvironments1R21AI156469-01MANILAY, JENNIFER OSPENCER, JOEL A.UNIVERSITY OF CALIFORNIA, MERCED, CA$225,449ZRG1
2021Evaluating hepatitis E virus ribavirin resistance clinical outcomes in the immunosuppressed pig model1R21AI151736-01A1JUNG, KWONILKENNEY, SCOTT PSTEINMANN, EIKEOHIO STATE UNIVERSITY, OH$224,763HBPP
2021Optimizing functional synergies between local and systemic memory CD4 T cell responses to influenza1R21AI148882-01A1MCKINSTRY, KARL KAIUNIVERSITY OF CENTRAL FLORIDA, FL$224,404ZRG1
2021Lnc-PINK regulation of innate immunity in lung epithelial cells1R21AI152004-01A1LIU, LINOKLAHOMA STATE UNIVERSITY STILLWATER, OK$224,400LCMI
2021Intervertebral Disc Mechanics with Functional GRASP-MRI1R21AR078357-01REGATTE, RAVINDERNEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$223,740CTIS
2021Regulation of Inflammation by IL1RN polymorphisms1R21AR078466-01ABRAMSON, STEVEN BNEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$223,740ACTS
2021Small molecule biomarkers of cardiac Chagas disease progression1R21AI156669-01BOWMAN, NATALIE MCCARTERGILMAN, ROBERT HMCCALL, LAURA-ISOBELUNIVERSITY OF OKLAHOMA, OK$223,523CRFS
2021The role of the Type IV pili ATPase PilT as a surface sensor in regulating cell division1R21AI149177-01A1MELVILLE, STEPHENVIRGINIA POLYTECHNIC INST AND ST UNIV, VA$222,764ZRG1
2021In vivo photoacoustic imaging of prefrontal cortex in rats undergoing fentanyl self-administration1R21DA052657-01AVANAKI, KAMRANPERRINE, SHANE ALANWAYNE STATE UNIVERSITY, MI$222,274NMB
2021NON-NUCLEASE BASED GENE EDITING FOR HUTCHINSON-GILFORD PROGERIA1R21AG067347-01A1BRADDOCK, DEMETRIOSYALE UNIVERSITY, CT$221,375DMP
2021Role of gasderminD in ganglion cell dysfunction and injury1R21EY032261-01SHESTOPALOV, VALERY IUNIVERSITY OF MIAMI SCHOOL OF MEDICINE, FL$221,345NTRC
2021An ounce of prevention: stopping menopausal bone loss before it starts1R21AR078538-01INSOGNA, KARL LEONARDYALE UNIVERSITY, CT$221,100ZRG1
2021A Novel Approach to Restore Sight after Corneal Chemical Injury1R21EY031031-01A1BAZAN, HAYDEE E.P.HE, JIUCHENGLSU HEALTH SCIENCES CENTER, LA$220,500ZRG1
2021Ubiquitination during infection with Mouse Adenovirus1R21AI157416-01WEITZMAN, MATTHEW D.CHILDREN'S HOSP OF PHILADELPHIA, PA$220,000ZRG1
2021Pharmacologic Intervention for Ectopic Calcification1R21AR077332-01A1LI, QIAOLITHOMAS JEFFERSON UNIVERSITY, PA$218,929TAG
2021PGC-1α, Purines and the Postmenopausal Heart1R21AG065923-01A1MATYAL, ROBINAROBSON, SIMON C.BETH ISRAEL DEACONESS MEDICAL CENTER, MA$218,750MIM
2021Amyloidogenic Antibiotics1R21AI156565-01NOWICK, JAMES SUNIVERSITY OF CALIFORNIA-IRVINE, CA$217,649SBCB
2021Sex-related variations in the response of drug therapies targeting purinergic signaling pathways in sepsis1R21AI156627-01LIVERANI, ELISABETTANORTH DAKOTA STATE UNIVERSITY, ND$217,500HT
2021Development and maintenance of plantar skin1R21AR078511-01MORGAN, BRUCE AMASSACHUSETTS GENERAL HOSPITAL, MA$217,078ACTS
2021Rational Structure-Based Design of Broad Neutralizing Humanized svMP mAbs1R21AI156156-01GALAN, JACOB ANTHONYGE, XINSANCHEZ, ELDA E.TEXAS A&M UNIVERSITY-KINGSVILLE, TX$216,935CMIA
2021Discovery of novel smHDAC8 inhibitors for the treatment of schistosomiasis1R21AI146512-01A1ANGELUCCI, FRANCESCOPETUKHOV, PAVEL AWILLIAMS, DAVID LEEUNIVERSITY OF ILLINOIS AT CHICAGO, IL$216,651ZRG1
2021Investigating the small peptide Tsr37, its role in virulence, and activation of the SaeRS two component system in Staphylococcus aureus1R21AI156391-01CARROLL, RONANOHIO UNIVERSITY ATHENS, OH$216,300ZRG1
2021In vivo modeling of autoantibody-induced optic neuritis1R21EY032399-01BENNETT, JEFFREY LGRAMLICH, OLIVER WUNIVERSITY OF IOWA, IA$214,451ZRG1
2021Dynamic heterogeneity of nucleus pulposus cells from development to degeneration1R21AR077261-01A1MALHOTRA, NEILSMITH, LACHLAN JAMESUNIVERSITY OF PENNSYLVANIA, PA$214,390MTE
2021Deciphering DNA sequence selectivity in V(D)J recombination1R21AI156351-01RODGERS, KARLA KUNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR, OK$214,125CMIB
2021A Metabolic Strategy Utilizing a Zein Scaffold for Bone Repair1R21AR078399-01ARINZEH, TREENA LYNNENEW JERSEY INSTITUTE OF TECHNOLOGY, NJ$213,424MTE
2021The role of NBEAL2 in the cornea1R21EY032109-01CHAKRAVARTI, SHUKTINEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$211,875ZRG1
2021Diversification of cell types in the Drosophila retina - Resubmission - 11R21EY031442-01A1TREISMAN, JESSICA ENEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$211,875BVS
2021Characterizing malaria vector competence among natural populations of Anopheles1R21AI156297-01LAUFER, MIRIAM K.MZILAHOWA, THEMBAUNIVERSITY OF MARYLAND BALTIMORE, MD$211,567VB
2021Engineering a denaturant-resistant polymerase for direct nucleic acid diagnostics1R21AI156017-01LUTZ, BARRY RYANUNIVERSITY OF WASHINGTON, WA$211,050EBIT
2021The impact of early antiretroviral treatment initiation on measles immunity among children living with HIV1R21AI152847-01A1SUTCLIFFE, CATHERINE GAYLEJOHNS HOPKINS UNIVERSITY, MD$210,372HCCS
2021Effect of B-cell depletion on vaginal microbiota and mucosal immunity1R21AI156038-01MITCHELL, CAROLINE MMASSACHUSETTS GENERAL HOSPITAL, MA$210,000CMIB
2021Identifying mechanisms that detect and eliminate aneuploid cells1R21EY032256-01BAKER, NICHOLAS EALBERT EINSTEIN COLLEGE OF MEDICINE, NY$210,000DEV1
2021Host response-based screening for unexpected or emerging respiratory viruses1R21AI156208-01FOXMAN, ELLEN FLESCHERYALE UNIVERSITY, CT$209,375CRFS
2021Reference strains of Mycobacteroides abscessus1R21AI156302-01LAMICHHANE, GYANUJOHNS HOPKINS UNIVERSITY, MD$209,151ZRG1
2021Role of Rip2 in the Generation of Pathogenic Th17/Th1 T-cells and Ileitis1R21AI156311-01CROTHER, TIMOTHY ROBERTCEDARS-SINAI MEDICAL CENTER, CA$208,750GMPB
2021Novel nanoparticles function as chemo- and adjunctive-therapy against experimental cerebral malaria1R21AI151767-01A1VAN DER HEYDE, HENRI CLA JOLLA INFECTIOUS DISEASE INSTITUTE, CA$208,500CNBT
2021Pathogenesis of LRP6 High Bone Mass1R21AR077291-01A1MUMM, STEVEN RWASHINGTON UNIVERSITY, MO$207,900SBDD
2021P2X7 Receptor Splice Variants in Psoriasis Pathophysiology1R21AR078349-01MATHERS, ALICIA RUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$206,580ACTS
2021Mycobacterium tuberculosis aerobiology and novel tools to assess infectiousness1UH2AI152621-01A1HORNE, DAVID J.UNIVERSITY OF WASHINGTON, WA$205,391HCAC
2021A critical role for UBXN3B in IgG homeostasis and maternal transfer1R21AI155820-01WANG, PENGHUAUNIVERSITY OF CONNECTICUT SCH OF MED/DNT, CT$205,000CMIA
2021Antimicrobial peptide mimetic activity against Candida auris1R21AI146542-01A1DIAMOND, GILLUNIVERSITY OF LOUISVILLE, KY$205,000ZRG1
2021Defining Corneal Schwann cells in Injury1R21EY031113-01A1MOHAN, ROYCEUNIVERSITY OF CONNECTICUT SCH OF MED/DNT, CT$205,000ZRG1
2021Characterization of plasma virome in people who inject drugs to identify early transmission networks of HIV and other bloodborne infections1R21DA053145-01KANDATHIL, ABRAHAMJOHNS HOPKINS UNIVERSITY, MD$204,688HCAC
2021Targeting Cardiovascular Disease with SIRT6 Activators1R21AG070740-01FRANZINI, RAPHAEL M.UNIVERSITY OF UTAH, UT$204,650MIM
2021Targeting vascular endothelium for muscular dystrophy therapy1R21AR078400-01ASAKURA, ATSUSHIUNIVERSITY OF MINNESOTA, MN$204,270SMEP
2021A State-Feedback Neurodynamic Model of Echolocation in Blind Humans1R21EY032282-01TENG, SANTANISMITH-KETTLEWELL EYE RESEARCH INSTITUTE, CA$204,034CP
2021TNF and caspase-8-mediated control of Legionella pneumophila infection1R21AI151476-01A1SHIN, SUNNYUNIVERSITY OF PENNSYLVANIA, PA$202,917ZRG1
2021Engineered Biomaterial for Endoscopic Treatment of Airway Fibrosis1R21AR077163-01A1DANIERO, JAMES J.GRIFFIN, DONALD RICHIERIUNIVERSITY OF VIRGINIA, VA$202,789BMBI
2021Single-cell characterization of antibiotic-induced heteroresistance1R21AI157298-01TAVAZOIE, SAEED FCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$202,500GCAT
2021Diabetes Evaluation in TB Patients in Eswatini for Improving TB/HIV Care and Treatment (DETECT) Study1R21AI152862-01A1HIRSCH-MOVERMAN, YAEL RCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$201,492PPAH
2021Opioid-induced dysregulation of lateral mesolimbic dopamine circuits and motivated behavior1R21DA052706-01HEARING, MATTHEW CARLMARQUETTE UNIVERSITY, WI$199,899NMB
2021Health Determinants of Mental Health Disorders among Sexual and Gender Minority Firefighters1R21MD015136-01A1KAIPUST, CHRISTOPHER MNDRI-USA, INC., NY$199,800HDEP
2021Cyclic di-GMP Second Messenger Signaling in the Tickborne Relapsing Fever Spirochete, Borrelia turicatae1R21AI156101-01BLEVINS, JON SCOTTUNIV OF ARKANSAS FOR MED SCIS, AR$199,611ZRG1

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