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NIH funding notice PA-20-195

NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed)

Closed on January 7, 2025.

Posted
May 7, 2020
Close date
January 7, 2025
Activity codes
R21
Institutes taking part
NEI, NHGRI, NIA, NIAAA, NIAID, NICHD, NIDCD, NIDCR, NIDA, NIEHS, NINR, NLM, NCCIH, NIBIB

Read the notice on Grants.gov ยท NIH Guide page

The notices it replaced

  1. Reissues: PA-19-053 NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed)
  2. 2 steps back: PA-18-489 NIH Exploratory/Developmental Research Grant Program ( Parent R21 Clinical Trial Not Allowed)
  3. 3 steps back: PA-16-161 NIH Exploratory/Developmental Research Grant Program (Parent R21)
  4. 4 steps back: PA-13-303 NIH Exploratory/Developmental Research Grant Program (Parent R21)
  5. 5 steps back: PA-11-261 NIH Exploratory/Developmental Research Grant Program (Parent R21)
  6. 6 steps back: PA-10-069 NIH Exploratory Developmental Research Grant Program (Parent R21)
  7. 7 steps back: PA-09-164 NIH Exploratory/Developmental Research Grant Program (Parent R21)
  8. 8 steps back: PA-06-181 NIH Exploratory/Developmental Research Grant Program (Parent R21)
  9. 9 steps back: PA-03-107

Replaced by PA-25-304.

Who won it before

12,646 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $3,063,209,467 in first-year total cost, median $231,750.

Most frequent study sections

  1. Special Emphasis Panel[ZRG1 IDM-B (80)]360
  2. Pathogenic Eukaryotes Study Section[PTHE]239
  3. Special Emphasis Panel[ZRG1 IDM-B (81)]180
  4. Cellular and Molecular Immunology - B Study Section[CMIB]172
  5. Immunity and Host Defense Study Section[IHD]170

Most frequent institutions

  1. JOHNS HOPKINS UNIVERSITY271
  2. UNIVERSITY OF PITTSBURGH AT PITTSBURGH254
  3. UNIVERSITY OF WASHINGTON241
  4. WASHINGTON UNIVERSITY239
  5. MASSACHUSETTS GENERAL HOSPITAL216
Competing awards under PA-20-195 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2025Glymphatic MR Imaging and Biomarker Discovery in Aging with HIV Infection1R21AG096957-01MULLER-OEHRING, EVA MSRI INTERNATIONAL, CA$629,712HCCS
2025The Impact of Wildfire Exposure on the Human Methylome and Health1R21ES037100-01BARCELLOS, LISA FUNIVERSITY OF CALIFORNIA BERKELEY, CA$567,093SEDH
2025Identifying the molecular determinants of thermoadaptation and parasitic growth of Histoplasma capsulatum1R21AI190982-01BEYHAN, SINEMJ. CRAIG VENTER INSTITUTE, INC., CA$556,375GVE
2025Autoimmunity, calorie restriction, and core body temperature1R21AI194047-01BACCALA, ROBERTO GSAN DIEGO BIOMEDICAL RESEARCH INSTITUTE, CA$541,500ZRG1
2025Structure-based identification of pan-arenavirus sites of vulnerability1R21AI176379-01A1JOYCE, MICHAEL GORDONHENRY M. JACKSON FDN FOR THE ADV MIL/MED, MD$536,871MSFC
2025Lineage-Traced Single-Cell Analysis of Epigenetic Clocks1R21AG087016-01A1LAIRD, PETER WVAN ANDEL RESEARCH INSTITUTE, MI$528,000GVE
2025Architecture of a divergent bipartite internal ribosome entry site from Giardiavirus1R21AI193830-01WIMBERLY, BRIAN TNEW YORK STRUCTURAL BIOLOGY CENTER, NY$518,400MSFC
2025Evaluating the impact of pre-existing humoral immunity on hepatocyte death1R21AI194544-01KAUSHANSKY, ALEXISSEATTLE CHILDREN'S HOSPITAL, WA$516,175ZRG1
2025Role of hyaluronan in YAP signaling on TMJ health and pathology1R21DE034541-01A1KOYAMA, EIKICHILDREN'S HOSP OF PHILADELPHIA, PA$507,006ZRG1
2025Preparation and Investigation of Monoclonal Antibodies to Block Xylazine's Mechanism of Action and Adverse Effects1R21DA062132-01JANDA, KIMSCRIPPS RESEARCH INSTITUTE, THE, CA$506,000DMPB
2025Engineering Synthetic Biomolecular Condensates for Targeted Autophagy Modulation1R21AG093393-01LASKER, KERENSCRIPPS RESEARCH INSTITUTE, THE, CA$506,000EBIT
2025Development of siRNA-peptide libraries for delivery screening1R21AI194052-01MACRAE, IAN JOHNSCRIPPS RESEARCH INSTITUTE, THE, CA$506,000ZRG1
2025Defining the structure-interactome relationships of the basigin glycoprotein in endometriosis1R21HD119928-01HUANG, MIA LSCRIPPS RESEARCH INSTITUTE, THE, CA$506,000CBP
2025Cryo-ET structure of the Plasmodium basal complex1R21AI193598-01DVORIN, JEFFREY DBOSTON CHILDREN'S HOSPITAL, MA$501,800MSFC
2025Development of quantitative EEG biomarkers for Smith Magenis syndrome1R21HD117817-01SIDOROV, MICHAEL SCHILDREN'S RESEARCH INSTITUTE, DC$500,500NPAS
2025Arrays of bottomless picowells for the analysis of biological age using high-resolution imaging1R21AG095939-01GROISMAN, ALEXTERSKIKH, ALEXEY VUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$498,366ZRG1
2025Role of Mast cells in regulating inflammatory pathology of secondary lymphedema1R21AI190542-01KATARU, RAGHU PRASADSLOAN-KETTERING INST CAN RESEARCH, NY$497,136IVPP
2025Mechanisms of Mitral Cell Regeneration in Zebrafish1R21DC022365-01A1POSS, KENNETH DMORGRIDGE INSTITUTE FOR RESEARCH, INC., WI$495,000NDPR
2025Determining if Tregs are Dysfunctional in Alzheimer's Diseases1R21AG091064-01A1BAECHER-ALLAN, CLARE MARYBRIGHAM AND WOMEN'S HOSPITAL, MA$492,250ZRG1
2025Overcoming obstacles in structural elucidation of B cell antigen receptor assembly and lateral interaction1R21AI188071-01WU, HAOBOSTON CHILDREN'S HOSPITAL, MA$489,500CMIA
2025C. albicans cell wall stress responses and TOR signaling1R21AI180611-01A1KOEHLER, JULIA RBOSTON CHILDREN'S HOSPITAL, MA$489,500AIRT
2025Oral Fluid Testing to Assess Cannabis Non-Use in Remote Clinical Trials1R21DA062872-01SHRIER, LYDIA A.BOSTON CHILDREN'S HOSPITAL, MA$489,500IPTA
2025Unravelling the role of aDb2 as a novel complement receptor in lung injury1R21AI185295-01A1KOUTSOGIANNAKI, SOPHIAYUKI, KOICHIBOSTON CHILDREN'S HOSPITAL, MA$489,500LII
2025Antimicrobial Blue Light for the Treatment of Otitis Media1R21DC021785-01A1DAI, TIANHONGSABHARWAL, VISHAKHAMASSACHUSETTS GENERAL HOSPITAL, MA$489,500ZRG1
2025Cellular Identity of the Intact HIV Reservoir1R21AI189303-01A1VELLA, LAURA ACHILDREN'S HOSP OF PHILADELPHIA, PA$489,500HVCD
2025Human cellular models of TB and innate immunity1R21AI194232-01GOLDFELD, ANNEBOSTON CHILDREN'S HOSPITAL, MA$489,500ZRG1
2025Structural studies of the full-length nucleocapsid protein of SARS-CoV-21R21AI180552-01A1CHEN, BINGBOSTON CHILDREN'S HOSPITAL, MA$489,500MSFC
2025Identification and characterization of the class I and class II MHC molecules of the Syrian hamster to enable advanced studies of T cell immunity1R21AI193903-01DILORENZO, TERESA PALBERT EINSTEIN COLLEGE OF MEDICINE, NY$486,200MSI
2025Type 2 Immune Responses in Endotoxemia-induced Lung Injury1R21AI193181-01JACOBSEN, ELIZABETH AMAYO CLINIC ARIZONA, AZ$486,109PIRR
2025Mechanism of HIV-1 Env neutralization by antibodies targeting the membrane-proximal external region1R21AI195146-01QIN, ZHUANYALE UNIVERSITY, CT$483,825HIVD
2025Inhibition of lipoprotein synthesis in Helicobacter pylori1R21AI187891-01MCCLAIN, MARK SVANDERBILT UNIVERSITY MEDICAL CENTER, TN$481,250AIRT
2025Human rotavirus egress and infection in association with extracellular vesicles1R21AI190445-01OGDEN, KRISTEN MVANDERBILT UNIVERSITY MEDICAL CENTER, TN$481,250VDT
2025ADAMTS10 Regulation of Transforming Growth Factor Beta1R21EY037409-01KUCHTEY, JOHN GVANDERBILT UNIVERSITY MEDICAL CENTER, TN$481,250PED1
2025Development of antimicrobials based on principles of induced proximity1R21AI190536-01CHOUDHARY, AMITBROAD INSTITUTE, INC., MA$481,250CBP
2025Imbalanced RF Receive Coil Array for Magnetic Resonance-guided Focused Ultrasound Neuromodulation1R21EB037763-01YAN, XINQIANGVANDERBILT UNIVERSITY MEDICAL CENTER, TN$481,250ITD
2025Mechanisms by which Glp-1 and Gip receptor signaling enhance airway epithelial barrier function1R21AI190446-01CAHILL, KATHERINE NNEWCOMB, DAWN CVANDERBILT UNIVERSITY MEDICAL CENTER, TN$481,249ZRG1
2025Defining high-risk genomic groups of Stenotrophomonas maltophilia1R21AI185663-01A1DOI, YOHEIUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$481,214EDIT
2025The Extracellular Matrix as a Determinant of Filovirus Infectivity.1R21AI187982-01HARTY, RONALD NUNIVERSITY OF PENNSYLVANIA, PA$480,249VDT
2025Developing cross-platform fluorescent reporters for measuring the 26S proteasome and the VCP activities1R21AG093262-01LU, YINGSONG, YUYUHARVARD MEDICAL SCHOOL, MA$478,624CMAD
2025Biological and clinical significance of spatial immune heterogenenity in non-small cell lung cancer1R21CA297430-01SCHALPER, KURT AYALE UNIVERSITY, CT$478,532MCDC
2025Quantifying the impact of hyperglycemia on embryonic metabolism and development in C. elegans.1R21HD117015-01A1ZACHARIAS, AMANDA LUCILLECINCINNATI CHILDRENS HOSP MED CTR, OH$474,878ZRG1
2025Novel point-of-care liquid biopsy for early detection of sepsis-associated organ damage1R21AI188227-01BHATTACHARYYA, ROBY PAULKARABACAK, NEZIHI MURATMASSACHUSETTS GENERAL HOSPITAL, MA$473,937SAT
2025Functional and Molecular Dissection of Marmoset Face Areas1R21EY037066-01A1CHEN, JERRY LFREIWALD, WINRICHBOSTON UNIVERSITY (CHARLES RIVER CAMPUS), MA$473,750NBVP
2025In-silico screen and in-vivo evaluation of FDA-approved drugs to treat noise-induced hearing loss1R21DC022085-01A1INDZHYKULIAN, ARTURMASSACHUSETTS EYE AND EAR INFIRMARY, MA$473,749AUD
2025Quantifying Selective Motor Control in Preterm Infants: A Computer Vision Approach1R21HD117074-01COTTON, RONALD JAMESPEYTON, COLLEENREHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB, IL$472,325CIDH
2025The anatomy of T-cell mediated neutrophil recruitment during lung infection1R21AI191650-01MIZGERD, JOSEPH PQUINTON, LEEUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$472,210ZRG1
2025Regulation of brain vascular endothelial cell ferroptosis by hyaluronan1R21AG089920-01A1SHERMAN, LARRY S.OREGON HEALTH & SCIENCE UNIVERSITY, OR$471,885BINP
2025Genetic Regulation of Factor VIII Inhibitor Development1R21AI188271-01PATEL, SEEMA RAJNIKANTEMORY UNIVERSITY, GA$470,553HTBT
2025Deep learning-based regional radiomics analysis in placenta accreta spectrum evaluation1R21HD119601-01DO, QUYEN NGOCUT SOUTHWESTERN MEDICAL CENTER, TX$467,542ZRG1
2025Decoding the Molecular and Antigenic Interactions in Orthopox Virus Entry1R21AI190491-01DUERR, RALFNEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$466,125VPI
2025Aging in the Liver: Alcohol and the Retinoic Acid Pathway1R21AG093343-01MELIS, MARTAWEILL MEDICAL COLL OF CORNELL UNIV, NY$466,125HBPP
2025Genetic basis of incomplete penetrance of RPSA haploinsufficiency for congenital asplenia1R21AI186048-01A1BOISSON, BERTRANDROCKEFELLER UNIVERSITY, NY$466,125ZRG1
2025PUFA partitioning into condensates as a new mechanism for gene regulation1R21AT013302-01A1DUMELIE, JASONWEILL MEDICAL COLL OF CORNELL UNIV, NY$466,125NMHD
2025Synaptic development of the retinogeniculate pathway1R21EY036568-01A1WILDENBERG, GREGGUNIVERSITY OF CHICAGO, IL$464,903NBVP
2025The role of the mRNA-based or Newcastle disease virus (NDV)-based vaccine platform in mucosal B cell priming and recirculation1R21AI188112-01SUN, WEINAICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$464,750VID
2025Genetic determinants of TF binding in pooled microglia1R21AG091272-01RAJ, TOWFIQUEICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$464,750MNG
2025The Role of Lineage in Development of Chicken Retina and High Acuity Area1R21EY037867-01CEPKO, CONSTANCE LHARVARD MEDICAL SCHOOL, MA$464,750NCF
2025Differentiating chronic sleep disruption from intermittent hypoxia in OSA on tau pathology and spread1R21AG088736-01A1KAM, KOREYVARGA, ANDREW WICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$464,750CDIN
2025Kinase activity rewiring in T cell trans-differentiation1R21AI187947-01A1FRIBOURG, MIGUELFUEYO GONZALEZ, FRANCISCO JOSEICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$464,750AI
2025The Context of Food Allergy Management for Latino Children: Identifying Drivers of Health Disparities1R21AI190745-01ESETBAN, CYNTHIAMCQUAID, ELIZABETH LRHODE ISLAND HOSPITAL, RI$464,615CIHB
2025Cell Specific Proteomics highlights Molecular signatures of Manganese neurotoxicity in Dopaminergic neurons in vivo1R21ES037434-01RANGARAJU, SRIKANTSARKAR, SOUVARISHUNIVERSITY OF ROCHESTER, NY$464,133NAL
2025The ANKosome: a cytoplasmic activation platform for caspase-21R21AG095696-01SIDI, SAMUELICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$463,916CSRS
2025Associations of Prenatal PFAS Mixtures With Adult Metabolic, Vascular, and Bone Health1R21ES036946-01BRAUN, JOSEPH MBUCKLEY, JESSIE PBROWN UNIVERSITY, RI$463,850RPPH
2025Understanding the effect of aging on the lung adenocarcinoma tumor microenvironment1R21AG095627-01TSANKOV, ALEXANDER MINCHEVICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$463,625BCIB
2025VIOLA: Study of Viremia on Long-acting Antiretroviral Therapy with Cabotegravir and Rilpivirine1R21AI195092-01KOSS, CATHERINE ANNE STIMETSUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$463,615HCCS
2025Pathogenicity of ethanol tolerant strains of Candida albicans in the oral cavity1R21DE034446-01A1DONGARI-BAGTZOGLOU, ANNA IKUMAMOTO, CAROL A.TUFTS UNIVERSITY BOSTON, MA$463,530ODCS
2025Designing better T cell epitopes for improved T cell vaccines and therapies1R21AI193429-01FISER, ANDRASLAUVAU, GREGOIRE STEPHANEALBERT EINSTEIN COLLEGE OF MEDICINE, NY$462,000MSI
2025Regulation of thymus function and aging by the sympathetic nervous system1R21AG091008-01A1KARAGIANNIS, GEORGE SMARIANOVICH, MARIAALBERT EINSTEIN COLLEGE OF MEDICINE, NY$462,000ZRG1
2025Mechanisms underlying TDP-43 dependent structural deficits in ALS muscles1R21AG093032-01PASINELLI, PIERAZARNESCU, DANIELA CPENNSYLVANIA STATE UNIV HERSHEY MED CTR, PA$461,900CMND
2025Characterizing Metals and PFAS leaching from Tampons and their Adverse Effects on a Human Vaginal Mucosa Cell Model1R21ES037785-01SCHILLING, KATHRINCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$461,758EDD
2025Developing a Service Planning Tool to Address the Combined HIV and Opioid Epidemics1R21DA063450-01ZELENEV, ALEXEIYALE UNIVERSITY, CT$461,491PPAH
2025Systematic identification of interactions between Lyme Borrelia and Ixodes scapularis1R21AI187882-01A1FIKRIG, EROLYALE UNIVERSITY, CT$461,375ZRG1
2025Selective Recruitment of RSK Protein Kinases Through Non-Catalytic Docking Interactions1R21DE035244-01TURK, BENJAMIN EYALE UNIVERSITY, CT$461,375CSRS
2025Investigating the role of CSPalpha in presynaptic autophagy1R21AG093151-01CHANDRA, SREEGANGA SYALE UNIVERSITY, CT$461,313NC
2025An Immunological investigation of Meniere's disease1R21DC021400-01A1KVETON, JOHN F.NAVARATNAM, DHASAKUMAR SO'CONNOR, KEVIN CTOMAYKO, MARYYALE UNIVERSITY, CT$461,250CNBT
2025Single-cell phenotyping for better drug discovery1R21AI187955-01A1REGO, ELIZABETH HESPERYALE UNIVERSITY, CT$461,250AIRT
2025Targeting Isoform-specific FGFR Signaling in Idiopathic Pulmonary Fibrosis1R21AG093265-01LEE, SANGWONYALE UNIVERSITY, CT$461,146PIRR
2025Toward developing a navigation model of the aging brain in the marmoset1R21AG088866-01A1ARNSTEN, AMY F.T.CHANG, STEVE W. C.JADI, MONIKA P.NANDY, ANIRVAN S.YALE UNIVERSITY, CT$461,146LMDN
2025Association of LOY with Other Forms of Genome Instability1R21AG093047-01MONTAGNA, CRISTINAZHANG, ZHENGDONGRUTGERS BIOMEDICAL AND HEALTH SCIENCES, NJ$460,849CMAD
2025Platelet-MLKL role in S100 Release with Age and Infection1R21AG093333-01KOUPENOVA, MILKAUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$460,625HTBT
2025Role of post-sepsis exercise therapy in regulating CD4 T cell immunity against secondary Pseudomonas aeruginosa infection1R21AI182698-01A1DENG, MEIHONGFEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, NY$460,625SAT
2025Mechanisms of Hematopoietic stem cell development during fetal life1R21HD117517-01A1PEREIRA, JOAOYALE UNIVERSITY, CT$460,625BBHV
2025Reverse electron transport inhibition to suppress fibroblast activation in aging1R21AG093042-01BHATTACHARYA, MALLARUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$460,283PIRR
2025Exposure to endocrine disrupting chemicals via consumption of ultraprocessed foods: implications for maternal metabolic health in pregnancy1R21ES036628-01A1BRAUN, JOSEPH MSTRAKOVSKY, RITA S.MICHIGAN STATE UNIVERSITY, MI$459,522RPPH
2025Bringing alloreactivity into focus with the lens of TCR cross-reactivity1R21AI191060-01BAKER, BRIAN MHILDEMAN, DAVID AUNIVERSITY OF NOTRE DAME, IN$459,439MSI
2025Synoviocyte endothelial cell cross talk in rheumatoid arthritis1R21AI190985-01BOTTINI, NUNZIOCEDARS-SINAI MEDICAL CENTER, CA$459,250SCTS
2025Elucidating the mechanisms of stress and resilience to cognitive aging and Alzheimer's disease1R21AG088163-01A1VANNINI, PATRIZIAMASSACHUSETTS GENERAL HOSPITAL, MA$459,250MESH
2025Role of HMGB1 in an experimental model of Bacterial ligand induced Vasculitis1R21AI193709-01ARDITI, MOSHECEDARS-SINAI MEDICAL CENTER, CA$459,250AVI
2025Multi-Ancestry Genome-wide Association Analysis and Polygenic Risk Score of Moderate-to-Severe Asthma1R21AI193971-01MENDY, ANGELICOMERSHA, TESFAYE B.UNIVERSITY OF CINCINNATI, OH$458,634CRD
2025A VP4-Based Pseudovirus Nanoparticle Rotavirus Vaccine for Oral Immunization1R21AI190243-01TAN, MINGYUAN, LIJUANCINCINNATI CHILDRENS HOSP MED CTR, OH$458,250VID
2025SOLUBLE LYMPHOCYTE ACTIVATION GENE-3 (s-LAG-3) AND INSULIN m-RNA: A POTENTIAL SURROGATE MARKERS FOR DISEASE PROGRESSION AND IMMUNOTHERAPY1R21AI193399-01PIGANELLI, JON DINDIANA UNIVERSITY INDIANAPOLIS, IN$457,877ZRG1
2025Contribution of RpoS to persistence of Borrelia burgdorferi in mammals1R21AI187932-01CAIMANO, MELISSA JRADOLF, JUSTIN DUNIVERSITY OF CONNECTICUT SCH OF MED/DNT, CT$457,875BV
2025Bioengineering a human microphysiological system for elucidation of viral peripheral neurotropism of RSV and SARS-CoV-21R21AI188371-01A1MOORE, MICHAEL JPIEDIMONTE, GIOVANNITULANE UNIVERSITY OF LOUISIANA, LA$457,778BTEN
2025Evaluating EHR-based Prediction of Obesity using WHO Weight Velocity Standards and Peak BMI1R21HD115788-01A1WOO, JESSICA GWOOD, CHARLES TCINCINNATI CHILDRENS HOSP MED CTR, OH$456,914ASPB
2025Innovative Antibiotic Combinations for Hypervirulent Klebsiella pneumoniae1R21AI190454-01BULMAN, ZACKERY P.CHEN, LIANGUNIVERSITY OF ILLINOIS AT CHICAGO, IL$456,911AIRT
2025Elucidating mechanisms underlying the pathogenesis of Hao Fountain Syndrome, a rare disease caused by USP7 variants1R21HD119902-01GALPERIN, EMILIAVARSHNEY, GAURAV KUNIVERSITY OF KENTUCKY, KY$456,892ZRG1
2025Drosophila Nse5/6: a missing link for heterochromatin repair1R21ES036346-01A1CHIOLO, IRENE EUNIVERSITY OF SOUTHERN CALIFORNIA, CA$456,500ZRG1
2025Periodontal Regeneration with Supramolecular Nanomaterials1R21DE034150-01A1ZHOU, YANUNIVERSITY OF SOUTHERN CALIFORNIA, CA$456,500MTE
2025Patterns of Autoimmune Biomarkers among Metal/Metalloid and Organochemical-Exposed Native American/Alaska Native Tribal members1R21ES037735-01ERDEI, ESTHERPOLLITT, KRYSTALUNIVERSITY OF NEW MEXICO HEALTH SCIS CTR, NM$456,328ZRG1
2025Uncovering mechanisms that underpin bat virus virulence1R21AI188400-01A1BROOK, CARAUNIVERSITY OF CALIFORNIA BERKELEY, CA$455,692TVZ
2025Exercise Protection of the Aging Nervous System: Defining Exercise Impact on Cell and System1R21AG095865-01DRISCOLL, MONICA A.GABEL, CHRISTOPHER VRUTGERS, THE STATE UNIV OF N.J., NJ$454,938ZRG1
2025Investigating unknown yet essential mechanisms of gene regulation for tick-borne relapsing fever spirochetes.1R21AI179603-01A1LOPEZ, JOB EBAYLOR COLLEGE OF MEDICINE, TX$454,791ZRG1
2025Elucidating the immune function of the RNA helicase DDX61R21AI193649-01DI STEFANO, BRUNOBAYLOR COLLEGE OF MEDICINE, TX$454,288BBHV
2025Adjuvanted Intranasal influenza vaccine to generate lung resident-memory T cells1R21AI185450-01A1GANDHAPUDI, SIVA KUMARUNIVERSITY OF KENTUCKY, KY$454,278VID
2025Pseudomonas aeruginosa Microcolony Aggregates Elicit Neutrophil Swarming1R21AI187948-01HURLEY, BRYAN PMASSACHUSETTS GENERAL HOSPITAL, MA$453,750BV
2025Mechanism of evasion of cyclic oligonucleotide-based anti-phage signaling system1R21AI182853-01A1NG, WAI-LEUNGTUFTS UNIVERSITY BOSTON, MA$453,750PCMB
2025Role of ZNF proteins in the establishment and maintenance of HIV latency1R21AI189231-01LICHTERFELD, MATHIASMASSACHUSETTS GENERAL HOSPITAL, MA$453,750HVCD
2025A CRISPR based organoid screen for mediators of epithelial-myeloid interactions1R21AI193274-01MEDOFF, BENJAMIN DAVIDMASSACHUSETTS GENERAL HOSPITAL, MA$453,750PIRR
2025Finessing the details: subclasses of LGN neurons and the richness of spatial transcriptomics1R21EY037012-01A1PEZARIS, JOHN S.MASSACHUSETTS GENERAL HOSPITAL, MA$453,750NBVP
2025Phage-Seq phenotyping of the Pseudomonas aeruginosa surface-ome1R21AI194588-01KAZMIERCZAK, BARBARA IYALE UNIVERSITY, CT$453,629PCMB
2025Dimensions of Emotion Regulation in PTSD-Related Drinking Risk: A Proof of Concept Study1R21AA032370-01READ, JENNIFER PSTATE UNIVERSITY OF NEW YORK AT BUFFALO, NY$453,085AA
2025Intraoperative stereo imaging for oral specimen orientation and margin visualization1R21DE034090-01A1HALTER, RYAN JOSEPHDARTMOUTH COLLEGE, NH$452,967IGIS
2025Environmental exposure modulation of the ovarian lipidome1R21ES037063-01A1VEIGA-LOPEZ, ALMUDENAUNIVERSITY OF ILLINOIS AT CHICAGO, IL$452,945ICER
2025Impact of BDGR-49 treatment on VEEV induced neurological sequelae1R21AI194034-01GOLDEN, JENNIFER E.JONSSON, COLLEEN BKEHN-HALL, KYLENEVIRGINIA POLYTECHNIC INST AND ST UNIV, VA$452,769CNBT
2025Neurosteroid regulation of placental inflammation1R21HD119466-01PENN, ANNA AVACHER, CLAIRE-MARIECOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$452,375PN
2025Identification of a cellular immune signature unique to clinically-significant villitis of unknown etiology1R21HD117178-01A1PARAST, MANA MUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$452,000PN
2025Manipulation of antibody responses by a retrovirus1R21AI187838-01GOLOVKINA, TATYANA VUNIVERSITY OF CHICAGO, IL$451,000VPI
2025Molecular mechanisms of signal transduction by the Campylobacter jejuni BumSR two-component system1R21AI188117-01HENDRIXSON, DAVID RUT SOUTHWESTERN MEDICAL CENTER, TX$451,000PCMB
2025Unraveling the Regulation of Transcription and Activity of Calcium Transporter SLC24A4 in Enamel Formation1R21DE033833-01A1ZHANG, YANUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$451,000ODCS
2025Programming Offspring Immunity By In Utero Exposure to Maternal Helminth Infection1R21AI190719-01REESE, TIFFANY ANNEUT SOUTHWESTERN MEDICAL CENTER, TX$451,000IMII
2025Rescue T cell aging to improve CAR T cell production for elderly cancer patients1R21AG093249-01WU, TUOQIUT SOUTHWESTERN MEDICAL CENTER, TX$451,000CIC
2025The Development of the RGC Projectome1R21EY037490-01KASTHURI, NARAYANANUNIVERSITY OF CHICAGO, IL$451,000ZRG1
2025Using Chemical Synthetic Lethality to Identify New Antimicrobial Targets in Gram-Negative Bacterial Pathogens1R21AI190827-01SEYEDSAYAMDOST, MOHAMMAD RPRINCETON UNIVERSITY, NJ$451,000CBP
2025Deciphering the mechanism of response to novel HPV-specific viral immune therapy in HPV associated head and neck cancer1R21DE034942-01IZUMCHENKO, EVGENY (EUGENE) GMIAO, YUXUAN PHOENIXROSENBERG, ARIUNIVERSITY OF CHICAGO, IL$451,000TIO
2025Estrogen modulation of chondrocyte mechanotransduction via PIEZO1 and TRPV41R21AG089130-01A1HERNANDEZ, PAULA ANDREAUT SOUTHWESTERN MEDICAL CENTER, TX$451,000SBSR
2025Alveolus on a chip model of non-tuberculous mycobacteria infection1R21AI186020-01A1SHILOH, MICHAELUT SOUTHWESTERN MEDICAL CENTER, TX$451,000IHD
2025Development and characterization of metastatic Myb-NFIB fusion adenoid cystic carcinoma cell line models1R21DE035273-01HA, PATRICK KYONGMINUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$451,000TEHM
2025Comprehensive, high-resolution arrays to trace the development of antibody responses to variant Plasmodium falciparum antigens in naturally exposed cohorts1R21AI193813-01GREENHOUSE, BRYAN RUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$451,000PRID
2025Sex and circadian influences on olfactory behavior and neurophysiology1R21DC023035-01KAY, LESLIE MUNIVERSITY OF CHICAGO, IL$451,000NIC
2025Multimodal Characterization of a Novel Inherited Mouse Model of Glaucoma1R21EY038004-01NAIR, KAYARAT SAIDASUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$451,000PED2
2025Remodeling of inter-organelle communication during Chlamydia infection1R21AI193265-01DERRE, ISABELLEUNIVERSITY OF VIRGINIA, VA$450,766BHI
2025Understanding heterogeneity of necroptotic cell death and mechanism(s) of necroptosis escape1R21AI185601-01A1BATORSKY, REBECCADEGTEREV, ALEXEITAI, ALBERT KTUFTS UNIVERSITY BOSTON, MA$450,764CSRS
2025Spatiotemporal interrogation of interactions of pneumolysin, pulmonary epithelium, and PMNs that result in age-associated susceptibility to Streptococcus pneumoniae disease1R21AI193724-01LEONG, JOHN MTAN, SHUMINTUFTS UNIVERSITY BOSTON, MA$450,630BHI
2025Single-cell spatial-temporal understanding of the role of macrophage subsets in maintenance of lesion biology and local Mycobacterium tuberculosis infection outcome1R21AI188044-01A1HUANG, LUTAN, SHUMINUNIV OF ARKANSAS FOR MED SCIS, AR$450,500BHI
2025Enhancing Clinical Research Data Interoperability, Submission, and Sharing with Embedded Electronic Case Report Form Standards Mapping1R21AI189358-01A1CHENG, ALEXCOLE, MATTHEWVANDERBILT UNIVERSITY MEDICAL CENTER, TN$450,472PPAH
2025Understanding corneal limbal stem cells during wound healing1R21EY037961-01KNOX, SARAH MONICAMCNAMARA, NANCY AUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$450,300PED2
2025The impact of early life stress on vascular aging1R21AG091052-01A1EBERTH, JOHN FMARVAR, PAUL JGEORGE WASHINGTON UNIVERSITY, DC$450,250IVPP
2025Practitioners Approach to Oral Appliance Therapy for Obstructive Sleep Apnea and the Impact on Patients Outcomes1R21DE034099-01A1GALANG-BOQUIREN, MARIA THERESE SMUNGIA, RAHMAUNIVERSITY OF TEXAS HLTH SCIENCE CENTER, TX$449,861ZRG1
2025siRNA-based treatment approach to enhance Gs alpha-mediated hormone signaling1R21HD117132-01A1BASTEPE, MURATMASSACHUSETTS GENERAL HOSPITAL, MA$449,636CSME
2025Human cutaneous responses to arthropod-mediated viral transmission1R21AI193648-01DOUAM, FLORIANBOSTON UNIVERSITY MEDICAL CAMPUS, MA$449,625TVZ
2025Virion, nucleocapsid, and inclusion body structures of Lloviu and Ebola viruses1R21AI188100-01A1BULLITT, ESTHERBOSTON UNIVERSITY MEDICAL CAMPUS, MA$449,625MSFC
2025Development of Diagnostic Antibodies for Acute and Chronic Chagas Disease1R21AI180397-01A1GUNN, MICHAEL DDUKE UNIVERSITY, NC$449,408EDIT
2025Notch regulation of airway epithelial-immune cell cross-talk in SARS-CoV-2 infection1R21AI194204-01DESHMUKH, UMESH SWALTERS, MATTHEW STUARTOKLAHOMA MEDICAL RESEARCH FOUNDATION, OK$448,688LII
2025PRG4/Lubricin glycoform variants associated with endocardial infections and sepsis1R21AI190343-01BENSING, BARBARA ANNEMALAKER, STACY ALYSENORTHERN CALIFORNIA INSTITUTE/RES/EDU, CA$448,375SAT
2025Composition and function of Optix-Cofactor transcription complexes in the eye.1R21EY035492-01A1PIGNONI, FRANCESCAUPSTATE MEDICAL UNIVERSITY, NY$448,250BDE
2025Yki-Mitf-ECM regulation of eye progenitor epithelium morphology.1R21EY037057-01A1NEAL, SCOTT JEFFREYUPSTATE MEDICAL UNIVERSITY, NY$448,250BDE
2025Transcriptional Dynamics of Photoreceptor Gene Regulation.1R21EY037020-01A1CALVERT, PETER DEANEKNOX, BARRY EUPSTATE MEDICAL UNIVERSITY, NY$448,250BDE
2025Preclinical Research to Determine Prosthetic Joint Infection Pathophysiology Needed to Direct Clinical Bacteriophage Therapy1R21AI188355-01DOUB, JAMES B.URISH, KENNETH LUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$447,783ZRG1
2025Controlled delivery of mitochondria for craniofacial bone healing1R21DE034938-01TEMENOFF, JOHNNA SGEORGIA INSTITUTE OF TECHNOLOGY, GA$447,009MTE
2025Do Genetic Risk Variants for Alzheimer's Disease have a Pleotropic Effect on Sleep?1R21AG091081-01PACK, ALLAN IUNIVERSITY OF PENNSYLVANIA, PA$446,875ZRG1
2025Fibroblast activating protein PET-CT imaging of TB-associated fibrosis1R21AI179016-01A1BISSON, GREGORY P.SELLMYER, MARK AUNIVERSITY OF PENNSYLVANIA, PA$446,875CTIS
2025Nuclear Localization and Function of the Ebola Virus VP40 Protein1R21AI193179-01HARTY, RONALD NUNIVERSITY OF PENNSYLVANIA, PA$446,875VDT
2025Genetic insight into senescence from the Drosophila brain1R21AG095657-01BONINI, NANCY MUNIVERSITY OF PENNSYLVANIA, PA$446,875MNG
2025Multimodality and Longitudinal Artificial Intelligence for Diagnosis and Prognosis in Hepatic Steatosis1R21EB036734-01A1EATON, ERIC ROBERTSAGREIYA, HERSHWITSCHEY, WALTER R.T.UNIVERSITY OF PENNSYLVANIA, PA$446,875CDMA
2025Mast Cell G-protein Coupled Receptors in Immune Modulation of colitis1R21AI190597-01A1ALI, HYDARUNIVERSITY OF PENNSYLVANIA, PA$446,875DHMI
2025A novel role of corpus luteum in female reproduction1R21HD117555-01A1SUN, JIANJUNUNIVERSITY OF CONNECTICUT STORRS, CT$446,875ZRG1
2025Novel olfactory-based approach to measure risks of Alzheimer's disease and related dementias in diverse populations1R21AG091261-01FRANKENBERG, ELIZABETH ATHOMAS, DUNCANUNIV OF NORTH CAROLINA CHAPEL HILL, NC$446,619SSPA
2025GenePAL: A Portable Approach to Longitudinal Genomic Healthcare for Infants1R21HG014064-01SMITH, HADLEY STEVENSWOJCIK, MONICA HSIUNGBOSTON CHILDREN'S HOSPITAL, MA$446,042ZRG1
2025Effects of a natural experiment on maternal and infant health1R21HD118668-01BRUCKNER, TIM ALLENMARGERISON, CLAIRE EHENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES, MI$446,000SSPB
2025Molecular and physiologic architecture of the human inner ear1R21DC023019-01JAN, TAHA AVANDERBILT UNIVERSITY MEDICAL CENTER, TN$445,956ZRG1
2025Characterization of Plasmodium falciparum long non-coding RNAs and their roles in gene regulation1R21AI194421-01LLINAS, MANUELSERRE, DAVIDUNIVERSITY OF MARYLAND BALTIMORE, MD$445,488ZRG1
2025Mechanisms of age-related lung inflammation in pulmonary melioidosis1R21AI193374-01WRIGHT, SHELTON WILEYUNIVERSITY OF WASHINGTON, WA$445,338LII
2025Prenatal metal exposures and childhood telomere length attrition1R21ES037112-01EGGERS, SHOSHANNAH IYLENEMIDYA, VISHALICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$445,240RPPH
2025Characterization of cAMP signaling microdomains in the human pathogen Trypanosoma cruzi1R21AI182544-01A1LANDER, NOELIAUNIVERSITY OF CINCINNATI, OH$444,688PTHE
2025Modulation of Neutrophil Function by Red Cell Exchange in SCD Patients1R21AI182883-01A1LEE, GRACE MINGDUKE UNIVERSITY, NC$444,125HTBT
2025Streptococcal virulence regulation by a novel intercellular signaling pathway1R21AI187915-01A1KUMARASWAMI, MUTHIAHMETHODIST HOSPITAL RESEARCH INSTITUTE, TX$444,125BV
2025Simultaneous Targeting of Immunoglobulin G and M Using Endopeptidase for Humoral Rejection in Xenotransplantation1R21AI188089-01A1KWUN, JEANDUKE UNIVERSITY, NC$444,125ITA
2025Defining the role of haplotypes and rejection pathways in placental villitis1R21HD116957-01ENNINGA, ELIZABETH ANN LIESERNORGAN, ANDREW PAULMAYO CLINIC ROCHESTER, MN$443,850PN
2025G-Quadruplex-Based Supramolecular Assemblies as Activatable Contrast Agents for In Vitro and In Vivo Fluorescence Imaging of Estrogen Receptor1R21EB037399-01HAWSE, JOHN R.MUTHYALA, RAJEEV SRINIVASMAYO CLINIC ROCHESTER, MN$443,850IPCA
2025Determining the Utilization, Cost, and Safety of Antipsychotics Among the Elderly with Dementia Post-Brexpiprazole Approval for Agitation in Alzheimer's Disease1R21AG091282-01KIM, YOUNGRANTEIXEIRA, ANTONIO LUCIOUNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TX$443,838ODHS
2025A Chairside Diagnostic to Reduce the Need for Endodontic Retreatment1R21DE035344-01JOKERST, JESSE VINCENTUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$443,490EBIT
2025Probing sleep and memory as targets for rejuvenation1R21AG091327-01L 'ETOILE, NOELLE DUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$442,938LMDN
2025Systematic identification of drivers controlling Fusobacterium and oral squamous cell carcinoma interactions1R21DE035242-01MCGRAIL, DANIEL JAMESSTACY, APOLLOCLEVELAND CLINIC LERNER COM-CWRU, OH$442,750CG
2025Novel Therapies for Congenital Hyperinsulinism1R21HD117270-01A1SHYNG, SHOW-LINGOREGON HEALTH & SCIENCE UNIVERSITY, OR$442,071TAG
2025Perfusion-based renal allograft modification to attenuate ischemia/reperfusion injury1R21AI193316-01KANE, BOB RBAYLOR UNIVERSITY, TX$441,522ZRG1
2025Utilization of JAK inhibitor therapy in a transplant model of STAT1 GOF disease1R21AI173539-01A1FORBES, LISABAYLOR COLLEGE OF MEDICINE, TX$441,375TTT
2025Intein technology to deliver CFTR to CF airway using AAV1R21HL179437-01BREWINGTON, JOHN JOSEPHMAEDA, YUTAKACINCINNATI CHILDRENS HOSP MED CTR, OH$441,375ZRG1
2025Cell specific roles of CD153 and CD30 in regulation of immune responses1R21AI190579-01HILDEMAN, DAVID ACINCINNATI CHILDRENS HOSP MED CTR, OH$441,375AI
2025Transcriptional mechanisms of chronic inflammation in genetically diverse tissue macrophages1R21AI187803-01A1TROUTMAN, TY DALECINCINNATI CHILDRENS HOSP MED CTR, OH$441,375HBPP
2025Testing the contribution of ex-Tregs to autoimmunity and cancer immunity1R21AI191077-01DUPAGE, MICHELUNIVERSITY OF CALIFORNIA BERKELEY, CA$441,202BCIB
2025Ebola Virus Life Cycle Modeling In Vivo1R21AI188373-01BARRY, MICHAEL AMAYO CLINIC ROCHESTER, MN$441,100VDT
2025Multiomic analysis of downstream molecular effect of teloemre length in individual chromosome arms1R21AG093316-01FERRER, ALEJANDROMAYO CLINIC ROCHESTER, MN$441,100ZRG1
2025Antagonistic actions of IRF4 and BACH2 in regulating Germinal Center B cell fates and promoting Lymphomagenesis1R21AI187691-01A1MONDELLO, PATRIZIAMAYO CLINIC ROCHESTER, MN$441,098CG
2025Scorching Circumstances: The Role of Extreme Heat in Disability Among Older Workers in Heat Sensitive Jobs1R21ES037897-01BALK, DEBORAH LSHEFTEL, MARA GETZBERNARD M. BARUCH COLLEGE, NY$441,027SSPB
2025Engineering In Vitro Models of Pregnancy-Induced Liver Changes1R21HD116135-01A1KHETANI, SALMAN RLAYDEN, BRIAN THOMASUNIVERSITY OF ILLINOIS AT CHICAGO, IL$440,908HBPP
2025Advancing the Treatment of Alcohol Associated Liver Disease by Precision Targeting Methyltransferase-like Protein family1R21AA032088-01OUYANG, XINSHOUYALE UNIVERSITY, CT$440,566AA
2025Determining function and mechanism of lncRNA Chast in Trypanosoma cruzi infection and dissemination1R21AI173895-01A1GARG, NISHA JAINUNIVERSITY OF TEXAS MED BR GALVESTON, TX$440,000PTHE
2025Defining the role of TRIM proteins in vector-borne bunyavirus infection1R21AI190681-01LI , MINGHUAUNIVERSITY OF TEXAS MED BR GALVESTON, TX$440,000VPI
2025Robotic Augmentation of Physical Therapists for Locomotor Rehabilitation1R21HD118499-01HASSON, CHRISTOPHER JAMESNORTHEASTERN UNIVERSITY, MA$440,000MFSR
2025Developing and validating natural language processing tools for memory assessment1R21AG085061-01A1VAN GENUGTEN, RUBENNORTHEASTERN UNIVERSITY, MA$440,000HCMF
2025A new deep learning approach to probe the molecular basis of inhalation allergens1R21AI193195-01BRAUN, WERNER AMIDORO-HORIUTI, TERUMIUNIVERSITY OF TEXAS MED BR GALVESTON, TX$440,000BDMA
2025Creation of a transgenic pig model permissive to HBV infection1R21AI193714-01KRUSE, ROBERT LAYNEUNIVERSITY OF TEXAS MED BR GALVESTON, TX$440,000VPI
2025Rickettsial CspA proteins and host microRNAs in exosome formation and pathogenesis1R21AI193808-01GONG, BINSOONG, LYNNUNIVERSITY OF TEXAS MED BR GALVESTON, TX$440,000BHI
2025Patient Voices from an Advance Care Planning Intervention and Optimizing Care for Serious Illness1R21AG091135-01A1MADDEN, JEANNE MNORTHEASTERN UNIVERSITY, MA$440,000ICSC
2025Targeting Multidrug-Resistant Pseudomonas aeruginosa with R Pyocins1R21AI193182-01KIRIENKO, NATASHARICE UNIVERSITY, TX$439,896AIRT
2025Role of cholinergic neuroimmune signaling pathway disruption in the pathogenesis of Hirschsprung-associated enterocolitis1R21AI183051-01A1HOTTA, RYOMASSACHUSETTS GENERAL HOSPITAL, MA$439,216DNPD
2025Sex differences in a cytokine controlling antibody class switch recombination1R21AI193280-01LINGWOOD, DANIELMASSACHUSETTS GENERAL HOSPITAL, MA$439,088MSI
2025Targeting TGFBeta-mediated IOP dysregulation in a large animal model of glaucoma1R21EY037150-01A1MAO, WEIMINGMCLELLAN, GILLIAN JANEUNIVERSITY OF WISCONSIN-MADISON, WI$439,016PED1
2025Formation of a Novel SARS-CoV-2 Nucleocapsid Dimer: Impacts on Viral and Cellular Processes1R21AI183054-01A1BRUCE, EMILY A.UNIVERSITY OF VERMONT & ST AGRIC COLLEGE, VT$438,983VDT
2025Prevalence, Risk Factors, and Clinical Presentation of Uterine Leiomyomas by HIV Status1R21HD120187-01STOCKMAN, JAMILA KINSHASAUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$438,926HCCS

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