Skip to main content
NIH funding notice PAR-15-357

Understanding Alzheimer's Disease in the Context of the Aging Brain (R01)

Closed on January 7, 2019.

Posted
September 24, 2015
Close date
January 7, 2019
Activity codes
Not stated on the notice page
Institutes taking part
Not stated on the notice page

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

Its page was not saved, so the notices it replaced are not known.

Who won it before

46 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $70,702,486 in first-year total cost, median $827,478.

Most frequent study sections

  1. Special Emphasis Panel[ZRG1 BDCN-A (55)]40
  2. Special Emphasis Panel[ZRG1-BDCN-A(55)R]3
  3. Special Emphasis Panel[ZRG1 BDCN-K (56)]2
  4. Special Emphasis Panel[ZRG1-BDCN-K(56)R]1

Most frequent institutions

  1. MASSACHUSETTS GENERAL HOSPITAL5
  2. BAYLOR COLLEGE OF MEDICINE3
  3. J. DAVID GLADSTONE INSTITUTES2
  4. MEDICAL UNIVERSITY OF SOUTH CAROLINA2
  5. UNIVERSITY OF CALIFORNIA SANTA BARBARA2
Competing awards under PAR-15-357 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2020The complex interaction between Alzheimer drivers and aging1RF1AG062479-01KOSIK, KENNETH STEPHENUNIVERSITY OF CALIFORNIA SANTA BARBARA, CA$2,591,132ZRG1
2019Assessing cholinergic circuits and spatial memory loss: a translational study of Alzheimer's disease and a model of cognitive decline1RF1AG064245-01DELORENZO, CHRISTINESTATE UNIVERSITY NEW YORK STONY BROOK, NY$4,279,020ZRG1
2019Are mechanisms leading to FAD, SAD and age-associated cognitive decline similar?1RF1AG064821-01D'ADAMIO, LUCIANORBHS-NEW JERSEY MEDICAL SCHOOL, NJ$2,126,894ZRG1
2019Mechanisms of Alzheimer's Disease Progression in the Aging Brain1R01AG062542-01JAGUST, WILLIAM J.UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB, CA$848,137ZRG1
2019Tracking the origin of tau pathology1R01AG062559-01JACOBS, HEIDI IRMAMASSACHUSETTS GENERAL HOSPITAL, MA$815,700ZRG1
2019The complex interaction between Alzheimer drivers and aging1R56AG062479-01KOSIK, KENNETH STEPHENUNIVERSITY OF CALIFORNIA SANTA BARBARA, CA$732,363ZRG1
2019Understanding Alzheimer's Disease in the Context of the Aging1R01AG062623-01A1OUKRAINTSEVA, SVETLANA V.DUKE UNIVERSITY, NC$724,888ZRG1
2019Apolipoprotein E4-related Electrophysiological and Metabolic Impairments in Aging and Alzheimer's Disease1R01AG061150-01ZILBERTER, MISHA YURIJ. DAVID GLADSTONE INSTITUTES, CA$655,674ZRG1
2019Dissecting the molecular mediators of the neuroprotective effects of exercise in Alzheimer's Disease1R56AG064580-01WRANN, CHRISTIANE D.MASSACHUSETTS GENERAL HOSPITAL, MA$590,331ZRG1
2019Mechanisms of tau- and aging-induced neurological dysfunction: Focus on the nucleus1R01AG057896-01A1FROST, BESSUNIVERSITY OF TEXAS HLTH SCIENCE CENTER, TX$553,007ZRG1
2019Genetic Profiles of the Spatiotemporal Causality of Tau and Amyloid in the Elderly Brain1R01AG061445-01A1SEPULCRE, JORGEMASSACHUSETTS GENERAL HOSPITAL, MA$416,600ZRG1
2019mTOR at the crossroad between aging and Alzheimer's disease1RF1AG063454-01ODDO, SALVATOREARIZONA STATE UNIVERSITY-TEMPE CAMPUS, AZ$146,409ZRG1
2018Brainstem connectomes related to Alzheimer's disease1RF1AG056573-01A1SHI, YONGGANGUNIVERSITY OF SOUTHERN CALIFORNIA, CA$2,457,284ZRG1
2018Maternal lifestyle, brain aging and Alzheimer's disease1RF1AG060711-01PRATICO, DOMENICOTEMPLE UNIV OF THE COMMONWEALTH, PA$1,981,250ZRG1
2018Interrogating the Interferon Pathway in Aging and Alzheimer's Disease1RF1AG057587-01A1CAO, WEIZHENG, HUIBAYLOR COLLEGE OF MEDICINE, TX$1,803,164ZRG1
2018Light, metabolic syndrome and Alzheimer’s disease: a non-pharmacological approach1R01AG060716-01BUETTNER, CHRISTOPHFIGUEIRO, MARIANA GROSSRENSSELAER POLYTECHNIC INSTITUTE, NY$839,256ZRG1
2018Age-related lymphatic dysfunction enhances the pathogenesis of Alzheimer's disease1R56AG057581-01A1SEVICK, EVA M.SOTO, CLAUDIOUNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TX$728,056ZRG1
2018Sex Differences in Pain Reports and Brain Activation in Older Adults with Alzheimers Disease1R01AG059861-01MONROE, TODD BRYANTOHIO STATE UNIVERSITY, OH$718,664ZRG1
2018Defining the Mechanistic Link between C5aR1 signaling and cognitive loss in Alzheimer's diseases1R01AG060148-01MORTAZAVI, SEYED ALITENNER, ANDREA JOANUNIVERSITY OF CALIFORNIA-IRVINE, CA$629,464ZRG1
2018Building a pathology-validated neuroimaging tool for Alzheimer's Disease1R01AG057672-01A1AUGUSTINACK, JEANMASSACHUSETTS GENERAL HOSPITAL, MA$490,054ZRG1
2018Cellular Senescence and Alzheimer’s disease1R56AG056696-01TORRES, CLAUDIO AURELIODREXEL UNIVERSITY, PA$391,250ZRG1
2017Tau pathology, sleep disruption, and hippocampal memory decline in older adults1RF1AG054106-01A1WALKER, MATTHEW PUNIVERSITY OF CALIFORNIA BERKELEY, CA$4,378,782ZRG1
2017Heterogeneity of Multi-modal Imaging Signatures of Aging, MCI, Alzheimer's disease via Pattern Analysis1RF1AG054409-01DAVATZIKOS, CHRISTOSUNIVERSITY OF PENNSYLVANIA, PA$3,791,182ZRG1
2017The Contribution of Old Age-Associated Proteotoxicity to Inflammation and Dementia1RF1AG054714-01A1FISCHER, WOLFGANG HMAHER, PAMELA ANNESALK INSTITUTE FOR BIOLOGICAL STUDIES, CA$3,644,970ZRG1
2017Roles of ApoE4 in Brain Aging and Alzheimer's Disease1RF1AG055421-01HUANG, YADONGJ. DAVID GLADSTONE INSTITUTES, CA$3,284,440ZRG1
2017Single cell RNA-seq analyses of age-related changes in glial cells and in AD1RF1AG055521-01A1YUAN, JUNYINGHARVARD MEDICAL SCHOOL, MA$2,885,990ZRG1
2017Mechanisms of Synaptic Aging Mediating Cognitive and Behavioral Symptoms of AD1RF1AG055974-01SAVONENKO, ALENAJOHNS HOPKINS UNIVERSITY, MD$2,045,937ZRG1
2017Quantitative Neuroimaging Assessment of White Matter Integrity in the Context of Aging and AD1R01AG054159-01A1HELPERN, JOSEPH A.MINTZER, JACOBOMEDICAL UNIVERSITY OF SOUTH CAROLINA, SC$856,753ZRG1
2017Role of age, dopamine, and tau related network disruption in setting a context for progression toward Alzheimer's Disease1R01AG054110-01A1HEDDEN, JULIUS CMASSACHUSETTS GENERAL HOSPITAL, MA$854,701ZRG1
2017Mechanisms of Gonadotropin Action on Cognition and Neuronal Remodeling in Aging and Alzheimer's Disease1RF1AG054654-01CASADESUS, GEMMAKENT STATE UNIVERSITY, OH$806,713ZRG1
2017Using connectomics to characterize risk for Alzheimer's Disease1R01AG055132-01JOSEPH, JANE EMINTZER, JACOBOMEDICAL UNIVERSITY OF SOUTH CAROLINA, SC$745,391ZRG1
2017Role of slow waves and sleep apnea in memory and risk for Alzheimer disease1R01AG056682-01VARGA, ANDREW WICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$713,857ZRG1
2017Linking Connectomics to Biochemical Trajectories of Aging: How the Human Brain Ages Differentially in Key Regions of the Default Mode Network1R01AG055591-01A1MANGIA, SILVIATERPSTRA, MELISSA JUNIVERSITY OF MINNESOTA, MN$706,118ZRG1
2017Epigenetic-Genetic Modulations in Aging and Alzheimer's Disease Neurons1R01AG054712-01A1ROGAEV, EVGENY IUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$670,000ZRG1
2017Systems Control of Normal Aging and Alzheimer's Disease1R01AG054180-01A1KACZOROWSKI, CATHERINE COOKJACKSON LABORATORY, ME$649,874ZRG1
2017Essential Function of miR-29 in the Mature Brain1R01AG055304-01A1DESHMUKH, MOHANISH PUNIV OF NORTH CAROLINA CHAPEL HILL, NC$527,934ZRG1
2017Contributions of Alzheimer's Pathology and Cerebrovascular Factors to Cognitive Aging1R01AG055449-01A1GOLD, BRIAN TIMOTHYUNIVERSITY OF KENTUCKY, KY$487,978ZRG1
2017Role of the CX3CL1 C-terminus in reversing age-dependent Alzheimers neurodegeneration1RF1AG058261-01YAN, RIQIANGCLEVELAND CLINIC LERNER COM-CWRU, OH$108,656ZRG1
2016Demystifying Microglia in Aging and Alzheimer's Disease1RF1AG054321-01DE JAGER, PHILIP LLEVIN, JOSHUA ZVITSAI, LI-HUEIMASSACHUSETTS INSTITUTE OF TECHNOLOGY, MA$4,028,422ZRG1
2016Decoding the role of diverse astrocyte populations in aging and AD1RF1AG054111-01DENEEN, BENJAMINZHENG, HUIBAYLOR COLLEGE OF MEDICINE, TX$3,145,948ZRG1
2016Short Sleep: Locus Coeruleus Metabolics and the Temporal Progression of Alzheimers1RF1AG054104-01VEASEY, SIGRID CUNIVERSITY OF PENNSYLVANIA, PA$3,136,625ZRG1
2016Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer's disease pathologies andcognitive decline1RF1AG054156-01AU, RHODARYU, HOONSTEIN, THORBOSTON UNIVERSITY MEDICAL CAMPUS, MA$3,047,094ZRG1
2016Interrogating the link between aging and AD with temporally-controlled transgenes1RF1AG054160-01JANKOWSKY, JOANNA LBAYLOR COLLEGE OF MEDICINE, TX$2,538,799ZRG1
2016Proteostasis in the aging and Alzheimer's disease brain: are the ATases novel targets?1RF1AG053937-01PUGLIELLI, LUIGIUNIVERSITY OF WISCONSIN-MADISON, WI$1,880,700ZRG1
2016Understanding Alzheimer's Disease in the Context of the Aging Brain1RF1AG054108-01CUERVO, ANA MARIAALBERT EINSTEIN COLLEGE OF MEDICINE, INC, NY$855,775ZRG1
2016The role of aging-associated microRNAs in Alzheimer's disease1R01AG054102-01KIM, JUNGSUMAYO CLINIC JACKSONVILLE, FL$391,250ZRG1

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

ScienceDex for faculty

Your academic CV and NIH biosketch

Make your CV in your school's format and your NIH biosketch from it, then download both as Word files.

PAR-15-357: Understanding Alzheimer's Disease in the Context of the Aging Brain (R01) | ScienceDex | ConductScience