Skip to main content
NIH funding notice PAR-16-121

Early-Stage Preclinical Validation of Therapeutic Leads for Diseases of Interest to the NIDDK (R01)

Closed on May 7, 2019.

Posted
March 9, 2016
Close date
May 7, 2019
Activity codes
Not stated on the notice page
Institutes taking part
Not stated on the notice page

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

Its page was not saved, so the notices it replaced are not known.

Who won it before

20 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $9,661,154 in first-year total cost, median $490,001.

Most frequent study sections

  1. Special Emphasis Panel[ZRG1 EMNR-B (50)]13
  2. Special Emphasis Panel[ZRG1 EMNR-F (50)]4
  3. Special Emphasis Panel[ZRG1-EMNR-B(50)R]2
  4. Special Emphasis Panel[ZRG1 EMNR-F (07)]1

Most frequent institutions

  1. ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI2
  2. STANFORD UNIVERSITY2
  3. YALE UNIVERSITY2
  4. BETH ISRAEL DEACONESS MEDICAL CENTER1
  5. BRIGHAM AND WOMEN'S HOSPITAL1
Competing awards under PAR-16-121 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2020Novel therapeutic strategy for renal fibrosis by targeting RNA-binding protein HuR1R01DK123727-01HUANG, YUFENGUNIVERSITY OF UTAH, UT$366,700ZRG1
2020ENZYME THERAPY FOR CKD-MBD: BREAKING THE BARRIER OF VASCULAR CALCIFICATION1R01DK121326-01A1BRADDOCK, DEMETRIOSYALE UNIVERSITY, CT$238,800ZRG1
2019Small molecules targeting hepatic glucose production and insulin resistance1R01DK117655-01A1GRIFFIN, PATRICK ROBERTPUIGSERVER, PEREDANA-FARBER CANCER INST, MA$661,093ZRG1
2019Development of Controlled Release Mitochondrial Protonophore (CRMP) as a Novel Treatment for Type-2 Diabetes and Non-Alcoholic Steatohepatitis in Dysmetabolic Non-Human Primates1R01DK119968-01SHULMAN, GERALD IYALE UNIVERSITY, CT$557,732ZRG1
2019The Development of TGR5 Antagonists for the Treatment of Cholangiopathies1R01DK117133-01A1LARUSSO, NICHOLAS F.OLSON, STEVEN HSANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, CA$537,612ZRG1
2019Small molecule inhibitors of LMPTP: an obesity drug target2R01DK106233-06BOTTINI, NUNZIOPINKERTON, ANTHONY BRUCEUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$518,066ZRG1
2019Development of Beta-Cell-Targeted Regenerative Therapeutics Using A Novel Prodrug Strategy1R01DK119955-01A1ANNES, JUSTIN PIERCESTANFORD UNIVERSITY, CA$426,790ZRG1
2019Optimization of Novel Small Molecules to Antagonize FGF-231R01DK121132-01QUARLES, L DARRYLUNIVERSITY OF TENNESSEE HEALTH SCI CTR, TN$304,000ZRG1
2018Novel Selective Type II kinase Inhibitors to treat Diabetes1R01DK116904-01DEVITA, ROBERT JSTEWART, ANDREW F.ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$674,446ZRG1
2018Therapeutic Protein Engineering of Single-Chain Insulin Analogs1R01DK118536-01CHERRINGTON, ALAN DISMAIL-BEIGI, FARAMARZPHILLIPS, NELSON F BWEISS, MICHAEL AARONINDIANA UNIVERSITY INDIANAPOLIS, IN$554,879ZRG1
2018Developing UPR inhibitory KIRAs into oral antidiabetic beta cell-sparing drugs2R01DK100623-05BACKES, BRADLEY JMALY, DUSTIN JPAPA, FEROZ RUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$502,298ZRG1
2018Inhibiting Bcl-2-regulated intestinal fibrosis in models of Crohn’s Disease1R01DK118154-01HIGGINS, PETER D.R.UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$467,340ZRG1
2018The Development of 4-methylumbelliferone Pro-drugs to Prevent Autoimmune Diabetes1R01DK114174-01A1BOLLYKY, PAUL LSTANFORD UNIVERSITY, CA$419,389ZRG1
2018Targeting Diabetes With Novel SERCA Allosteric Activators1R01DK111417-01A1LEBECHE, DJAMELICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$381,375ZRG1
2018Preclinical therapeutic validation of a novel therapeutic lead for treating glomerular diseases such as focal and segmental glomerulosclerosis1R56DK116887-01A1NIHALANI, DEEPAKSCHNELLMANN, RICK GMEDICAL UNIVERSITY OF SOUTH CAROLINA, SC$100,000ZRG1
2017Preclinical Studies of Novel Anti-Diabetic Lipids1R56DK110150-01A1KAHN, BARBARA B.SAGHATELIAN, ALANSIEGEL, DIONICIO RBETH ISRAEL DEACONESS MEDICAL CENTER, MA$903,077ZRG1
2017L-Cystine Diamides as Inhibitors of L-Cystine Stone Formation in Cystinuria1R01DK112782-01HU, LONGQINSAHOTA, AMRIKRUTGERS, THE STATE UNIV OF N.J., NJ$621,145ZRG1
2017Targeting the orphan nuclear receptor LRH-1 with small molecules1R01DK115213-01CALVERT, JOHN WINTERJUI, NATHAN THOMASORTLUND, ERIC AEMORY UNIVERSITY, GA$490,001ZRG1
2017ALDH1a1 Inhibition As A Therapeutic Target In Visceral Adiposity and Type 2 Diabetes1R01DK107239-01A1GRIFFIN, PATRICK ROBERTPLUTZKY, JORGEBRIGHAM AND WOMEN'S HOSPITAL, MA$490,000ZRG1
2017Relaxin receptor agonists for treatment of liver fibrosis1R01DK110167-01A1AGOULNIK, ALEXANDER IFLORIDA INTERNATIONAL UNIVERSITY, FL$446,411ZRG1

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

ScienceDex for faculty

Your academic CV and NIH biosketch

Make your CV in your school's format and your NIH biosketch from it, then download both as Word files.