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NIH funding notice PAR-17-032

Translational Bioinformatics Approaches to Advance Drug Repositioning and Combination Therapy Development for Alzheimers Disease (R01)

Closed on March 31, 2020.

Posted
October 25, 2016
Close date
March 31, 2020
Activity codes
R01
Institutes taking part
NIA

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

Its page names no earlier notice: it is new, or it does not say.

Replaced by PAR-20-156.

Who won it before

26 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $23,682,354 in first-year total cost, median $787,389.

Most frequent study sections

  1. Special Emphasis Panel[ZAG1 ZIJ-6 (O3)]4
  2. Special Emphasis Panel[ZAG1 ZIJ-6 (J4)]3
  3. Special Emphasis Panel[ZAG1 ZIJ-6 (M2)]3
  4. ZAG1-ZIJ-6(M2)3
  5. ZAG1-ZIJ-6(O3)3

Most frequent institutions

  1. MASSACHUSETTS GENERAL HOSPITAL3
  2. BOSTON UNIVERSITY MEDICAL CAMPUS2
  3. HUNTER COLLEGE2
  4. ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI2
  5. UNIVERSITY OF PITTSBURGH AT PITTSBURGH2
Competing awards under PAR-17-032 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2021Drug repositioning for Alzheimer's disease via genetics, electronic health records, and human iPSC models1R01AG069900-01LI, BINGSHANWEI, WEI-QIWEN, ZHEXINGVANDERBILT UNIVERSITY, TN$838,304ZAG1
2021Advancing Drug Repositioning for Alzheimer’s Disease using Real-world Data1R56AG069880-01BIAN, JIANGCHEN, YONGWU, YONGHUIXU, HUAUNIVERSITY OF FLORIDA, FL$798,718ZAG1
2020Compound repositioning for Alzheimer's Disease using knowledge graphs, insurance claims data, and gene expression complementarity1R01AG066750-01SU, ANDREW ISCRIPPS RESEARCH INSTITUTE, THE, CA$885,874ZAG1
2020Novel Network Biology Approaches to Reposition FDA-approved Drugs for Alzheimer's Disease1R01AG068030-01BRENNAND, KRISTEN JENNIFERCAI, DONGMINGZHANG, BINICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$845,873ZAG1
2020Finding combinatorial drug repositioning therapy for Alzheimer's disease and related dementias1R01AG066749-01JIANG, XIAOQIANZHENG, WENJIN JIMUNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TX$781,522ZAG1
2020Endophenotype Network-based Approaches to Prediction and Population-based Validation of in Silico Drug Repurposing for Alzheimer’s Disease1R01AG066707-01CHENG, FEIXIONGCLEVELAND CLINIC LERNER COM-CWRU, OH$634,650ZAG1
2020Combine Genomics and Symptoms Data Driven Models to Discover Synergistic Combinatory Therapies for Alzheimer's Disease1R56AG065352-01A1LI, FUHAIWASHINGTON UNIVERSITY, MO$500,322ZAG1
2019Big data and small molecules for Alzheimer's disease1RF1AG063913-01GOLDSTEIN, LEE E.XIA, WEIMINGBOSTON UNIVERSITY MEDICAL CAMPUS, MA$2,035,223NIA
2019Predictive Networks-based in-silico approach for Precision Medicine-repurposing for Alzheimer's Disease1R56AG062620-01BRADSHAW, ELIZABETH MCHANG, RUIKANEKIYO, TAKAHISAUNIVERSITY OF ARIZONA, AZ$836,812ZAG1
2019The Alzheimer's Disease Resiliome: Pathway Analysis and Drug Discovery.1R01AG062547-01HIDE, WINSTON ALEXANDERKIM, DOO YEONTANZI, RUDOLPH EMILEMASSACHUSETTS GENERAL HOSPITAL, MA$686,190ZAG1
2019Personalized Combination Therapy for AD with Common Comorbidities1R56AG062493-01WANG, LIRONGXIE, XIANG-QUNUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$377,443ZAG1
2018SYSTEMATIC DRUG REPURPOSING TARGETING IMMUNE ACTIVATION NETWORKS IN ALZHEIMER'S DISEASE (AD)1RF1AG059319-01EHRLICH, MICHELLE EGANDY, SAMUEL E.ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$4,186,456ZAG1
2018Harnessing Diverse BioInformatic Approaches to Repurpose Drugs for Alzheimers Disease1R01AG058063-01A1ALBERS, MARK WMASSACHUSETTS GENERAL HOSPITAL, MA$828,046ZAG1
2018Quantitative systems pharmacology and translational study of pramlintide for Alzheimer's disease1R56AG059805-01QIU, WEI QIAO WENDYBOSTON UNIVERSITY MEDICAL CAMPUS, MA$810,558ZAG1
2018Drug repurposing for Alzheimer's disease using both observational and chemical genomics data1R56AG059428-01TROPSHA, ALEXANDERUNIV OF NORTH CAROLINA CHAPEL HILL, NC$794,078ZAG1
2018A knowledge map to find Alzheimer's disease drugs1R01AG061105-01LICHTARGE, OLIVIERBAYLOR COLLEGE OF MEDICINE, TX$792,498ZAG1
2018Phenotypic screening and computational modeling for development of combination therapies for Alzheimer's disease1R56AG059612-01LEZON, TIMOTHY RSCHURDAK, MARK EUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$782,279ZAG1
2018Drug repurposing for Alzheimer's disease using structural systems pharmacology.1R01AG057555-01A1XIE, LEIHUNTER COLLEGE, NY$779,392ZAG1
2018Leveraging the Human Non-Coding Transcriptome to Identify Therapeutics for Healthy Aging and Alzheimers Disease1R56AG061911-01VOLMAR, CLAUDE-HENRYWAHLESTEDT, CLAES ROBERTUNIVERSITY OF MIAMI SCHOOL OF MEDICINE, FL$749,747ZAG1
2018Systematic Alzheimer's disease drug repositioning (SMART) based on bioinformatics-guided phenotype screening and image-omics1R01AG057635-01A1WONG, STEPHEN TCMETHODIST HOSPITAL RESEARCH INSTITUTE, TX$694,058ZAG1
2018Omic analyses for stratifying Alzheimer's subtypes and identifying novel drug targets1R56AG061163-01CHEN, CHI-HUAUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$560,128ZAG1
2018A Translational Bioinformatics Approach to Rescuing Synaptic and Neurophysiologic Dysfunction in Alzheimer's Disease1R01AG059854-01TEICH, ANDREW FRANKLINCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$460,731ZAG1
2017ApoE Genotype-Directed Drug Repositioning and Combination Therapy for Alzheimer's Disease1R01AG057683-01HUANG, YADONGSIROTA, MARINAJ. DAVID GLADSTONE INSTITUTES, CA$875,721ZAG1
2017Harnessing Diverse BioInformatic Approaches to Repurpose Drugs for Alzheimer's Disease1R56AG058063-01ALBERS, MARK WSORGER, PETER KARLMASSACHUSETTS GENERAL HOSPITAL, MA$835,424ZAG1
2017Drug repurposing for Alzheimer's disease using structural systems pharmacology1R56AG057555-01XIE, LEIHUNTER COLLEGE, NY$770,770ZAG1
2017An Integrated Reverse Engineering Approach Toward Rapid drug Re positioning for Alzheimer's Disease1R01AG057557-01XU, RONGYAN, RIQIANGCASE WESTERN RESERVE UNIVERSITY, OH$541,537ZAG1

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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PAR-17-032: Translational Bioinformatics Approaches to Advance Drug Repositioning and Combination Therapy Development for Alzheimers Disease (R01) | ScienceDex | ConductScience