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NIH funding notice PAR-17-045

Focused Technology Research and Development (R01)

Closed on April 12, 2019.

Posted
November 1, 2016
Close date
April 12, 2019
Activity codes
R01
Institutes taking part
NIGMS

Read the notice on Grants.gov ยท NIH Guide page

The notices it replaced

Its page names no earlier notice: it is new, or it does not say.

Replaced by PAR-19-253.

Who won it before

103 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $40,101,514 in first-year total cost, median $351,520.

Most frequent study sections

  1. Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]25
  2. Cellular and Molecular Technologies Study Section[CMT]14
  3. Instrumentation and Systems Development Study Section[ISD]11
  4. Synthetic and Biological Chemistry B Study Section[SBCB]6
  5. Special Emphasis Panel[ZRG1 EBIT-A (90)]5

Most frequent institutions

  1. JOHNS HOPKINS UNIVERSITY4
  2. UNIVERSITY OF CALIFORNIA-IRVINE4
  3. UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN4
  4. YALE UNIVERSITY4
  5. BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)3
Competing awards under PAR-17-045 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2020Open data-driven infrastructure for building biomolecular force fields for predictive biophysics and drug design1R01GM132386-01A1SHIRTS, MICHAEL RUNIVERSITY OF COLORADO, CO$675,565MSFD
2020Integrated Acoustofluidic Plasmonic Molecular Diagnostic System for Detecting MicroRNA Biomarkers1R01GM135486-01VO-DINH, TUANDUKE UNIVERSITY, NC$476,407ZRG1
2020Multi-tiered containment system for engineered microbes1R01GM135483-01VAN PIJKEREN, JAN-PETERUNIVERSITY OF WISCONSIN-MADISON, WI$304,720PCMB
2020Nucleic Acid-Based Anti-CRISPR Inhibitors of Cas91R01GM135646-01GAGNON, KEITH THOMASSOUTHERN ILLINOIS UNIVERSITY CARBONDALE, IL$281,595SBCA
2019High-Throughput Platform for Thermodynamic Characterization of Biomolecular Interactions1R01GM132324-01A1RECHT, MICHAELPALO ALTO RESEARCH CENTER, CA$869,597EBIT
2019A Biophotonics Platform for Mechanotransduction and Metabolic Microscopy1R01GM129426-01A1VENUGOPALAN, VASANUNIVERSITY OF CALIFORNIA-IRVINE, CA$709,000ISD
2019Ultra-High Resolution Gas Phase Separation and Analysis Platform for Metabolomics1R01GM130709-01IBRAHIM, YEHIABATTELLE PACIFIC NORTHWEST LABORATORIES, WA$609,886EBIT
2019Development of Single Molecule Chromatin Interaction Assays (smChIA) in Single Nuclei1R01GM127531-01A1WEI, CHIA-LINJACKSON LABORATORY, ME$608,297EBIT
2019Tools to probe the biophysical properties of cells1R01GM132447-01HOLT, LIAM JNEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$575,450CMT
2019Molecular Diagnostics using a Nanopore to Analyze Secretions from Single Cells1R01GM127537-01A1LI, JUNTIMP, GREGORY LOUISUNIVERSITY OF NOTRE DAME, IN$533,474NANO
2019Development of Multidimensional, Linear and Differential Ion Mobility MS Separations for Middle-Down Proteoforms1R01GM134247-01FERNANDEZ-LIMA, FRANCISCOFLORIDA INTERNATIONAL UNIVERSITY, FL$523,560ZRG1
2019Next Generation Elemental Mass Spectrometry of Non-Metals1R01GM132112-01A1JORABCHI, KAVEHGEORGETOWN UNIVERSITY, DC$478,211EBIT
2019Robust microdroplet-based mechanical probes for wide-ranging mechanobiology applications1R01GM135380-01CAMPAS, OTGERSLETTEN, ELLEN MAYZINK, JEFFREY IUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$468,508CMT
2019Universal Metabolite Tagging1R01GM134081-01ARNATT, CHRISTOPHER KBYTHELL, BENJAMIN J.EDWARDS, JAMES LPATTI, GARY JSAINT LOUIS UNIVERSITY, MO$465,781EBIT
2019High-Throughput De Novo Glycan Sequencing1R01GM132675-01HONG, PENGYULIN, CHENGBOSTON UNIVERSITY MEDICAL CAMPUS, MA$462,286EBIT
2019Multiplexed Imaging in the Near Infrared with Indium Phosphide Quantum Shells1R01GM129437-01A1DENNIS, ALLISON MARIEBOSTON UNIVERSITY (CHARLES RIVER CAMPUS), MA$462,000NANO
2019High accuracy optical growth assay of 3D cellular systems1R01GM129709-01A1POPESCU, GABRIELUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$443,191CMT
2019Enabling exosome biomarker development via digitized single vesicle analysis1R01GM130923-01DEVOE, DON LWHITE, IAN MUNIV OF MARYLAND, COLLEGE PARK, MD$428,266ISD
2019Methods for determination of glycoprotein glycosylation similarities among disease states1R01GM133963-01ZAIA, JOSEPHBOSTON UNIVERSITY MEDICAL CAMPUS, MA$420,750BDMA
2019New biosensor tools for Diaphanous related formin mDia 1 and 2, useful for multiplex imaging1R01GM132098-01HODGSON, LOUISALBERT EINSTEIN COLLEGE OF MEDICINE, NY$407,639CMT
2019Development of 3D interferometric super-resolution methods for imaging dynamic, multi-component molecular systems, in single cells and in multi-cellular environments1R01GM135545-01PERTSINIDIS, ALEXANDROSSLOAN-KETTERING INST CAN RESEARCH, NY$399,719ISD
2019Ultra-Sensitive Multiplexed Quantification of Proteins Secreted from Single-Cells - Resubmission 011R01GM127527-01A1TAY, SAVASUNIVERSITY OF CHICAGO, IL$395,280EBIT
2019Develop General Methods for the Synthesis of Proteins with Posttranslational Lysine Modifications1R01GM127575-01A1LIU, WENSHE RAYTEXAS A&M UNIVERSITY, TX$394,016SBCB
2019Native Cell Membrane Nanoparticles System1R01GM132329-01GUO, YOUZHONGVIRGINIA COMMONWEALTH UNIVERSITY, VA$382,600BBM
2019High-resolution molecular recognition of ligands using solution X-ray scattering1R01GM133998-01GRANT, THOMAS D.STATE UNIVERSITY OF NEW YORK AT BUFFALO, NY$376,637MSFD
2019Lagrangian computational modeling for biomedical data science1R01GM130825-01ROHDE, GUSTAVO KUNDEUNIVERSITY OF VIRGINIA, VA$375,602BDMA
2019Development of an improved core technology for efficient genetic code expansion in biomedical research1R01GM131168-01MEHL, RYAN AOREGON STATE UNIVERSITY, OR$370,856MSFB
2019Synthetic adenovirus libraries for vector optimization1R01GM135485-01BUNZ, FREDJOHNS HOPKINS UNIVERSITY, MD$368,438GDD
2019Calibration nanotemplates as universal standards for determining protein copy number in super-resolution microscopy1R01GM133842-01A1LAKADAMYALI, MELIKEUNIVERSITY OF PENNSYLVANIA, PA$364,500CMT
2019Toolkit for Fast, Multipurpose and Inducible Bioorthogonal Chemistry1R01GM132460-01FOX, JOSEPH MUNIVERSITY OF DELAWARE, DE$358,800SBCA
2019A high-throughput, comprehensive, and quantitative approach for measuring nucleosome-protein binding1R01GM132199-01A1BUCK, MICHAEL JOSEPHSTATE UNIVERSITY OF NEW YORK AT BUFFALO, NY$352,755GCAT
2019Building Bridges to New Fluorophores1R01GM135474-01MILLER, STEPHEN C.UNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$351,520SBCA
2019Development of Photoreversible 4D Cell Culture Technologies1R01GM132677-01A1KALOW, JULIA ANNNORTHWESTERN UNIVERSITY, IL$347,754BMBI
2019Mesoscale spatial kinetic modeling of cell systems1R01GM132859-01A1LOEW, LESLIE MUNIVERSITY OF CONNECTICUT SCH OF MED/DNT, CT$344,400MABS
2019A universal multiplexing approach to unlock the hidden proteome1R01GM133981-01SWANEY, DANIELLE LUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$341,727EBIT
2019Advanced Molecular Probes and Cell Engineering Tools for Accurate Single-Molecule Analysis of Signaling in Individual Cells1R01GM131272-01SMITH, ANDREW MICHAELUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$338,776CMT
2019MEMS Acoustic Tweezers for Micromanipulation of Living Cells1R01GM134352-01KIM, EUN SOKUNIVERSITY OF SOUTHERN CALIFORNIA, CA$337,970ISD
2019Strategies for N to C solid-phase peptide synthesis1R01GM129475-01A1STOCKDILL, JENNIFER LYNNWAYNE STATE UNIVERSITY, MI$336,966SBCB
2019Precise regulation of native transcription factor at the single-cell level1R01GM132438-01A1ZHANG, KAIUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$336,767CMT
2019A Nanomechanical Toolkit to Guide Membrane Structure and Dynamics1R01GM132114-01LIN, CHENXIANGYALE UNIVERSITY, CT$335,000NANO
2019Molecular imaging technologies for mechanobiology1R01GM131099-01MATTHEYSES, ALEXA LYNNSALAITA, KHALID S.EMORY UNIVERSITY, GA$331,733CMT
2019Increasing the Selectivity of Hybrid Mass Spectrometry using Multidimensional Ion Mobility Spectrometry1R01GM130708-01BUSH, MATTHEW FRANCISUNIVERSITY OF WASHINGTON, WA$331,496EBIT
2019Advanced recombinase-based gene expression technology in mammalian cells1R01GM129011-01WONG, WILSONBOSTON UNIVERSITY (CHARLES RIVER CAMPUS), MA$330,000CMT
2019Volumetric time-lapse imaging of biophysical cell-extracellular matrix interactions for systems mechanobiology research1R01GM132823-01ADIE, STEVEN GRAHAMCORNELL UNIVERSITY, NY$323,832CMT
2019Nanomechanical imaging of protein dynamics via programmable DNA interactions1R01GM130948-01A1SAHIN, OZGURCOLUMBIA UNIV NEW YORK MORNINGSIDE, NY$319,970ISD
2019Tools for parameterizing and visualizing electrophysiological rhythmic and arrhythmic features1R01GM134363-01VOYTEK, BRADLEY T.UNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$315,000BDMA
2019Ultrahigh-resolution and single-molecule stimulated Raman scattering (SRS) microscopy1R01GM132860-01MIN, WEICOLUMBIA UNIV NEW YORK MORNINGSIDE, NY$314,314EBIT
2019Quantitative Characterization of Glycopeptide Isomers1R01GM130091-01A1MECHREF, YEHIATEXAS TECH UNIVERSITY, TX$313,024EBIT
2019Cross-path reactive chromatography/mass spectrometry as a versatile platform for characterization of primary and higher order structure of complex heterogeneous proteins1R01GM132673-01KALTASHOV, IGOR AUNIVERSITY OF MASSACHUSETTS AMHERST, MA$310,439EBIT
2019Chemical Biology Approach for Validating and Manipulating Cellular RNA-Protein Interactions1R01GM135252-01GARNER, AMANDAUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$308,100CMT
2019Riboglow: a robust multi-color riboswitch-based platform for imaging RNA in living cells1R01GM133184-01BATEY, ROBERT TPALMER, AMY EUNIVERSITY OF COLORADO, CO$308,000CMT
2019Designing Novel Protein Assemblies as Rigid Symmetric Scaffolds for Cryo-EM Imaging1R01GM129854-01A1YEATES, TODD OUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$304,620MSFD
2019Sparse NMR Labeling Approach to Glycoprotein Structure and Function1R01GM134335-01PRESTEGARD, JAMES H.UNIVERSITY OF GEORGIA, GA$302,000MSFB
2019Hyperpolarization Assisted and Structure Based Screening of Protein-Ligand Interactions in Live Cells1R01GM132655-01HILTY, CHRISTIAN B.TEXAS A&M UNIVERSITY, TX$301,760EBIT
2019Analysis tools for quantifying protein conformational landscapes using DEER spectroscopy1R01GM125753-01A1STOLL, STEFANUNIVERSITY OF WASHINGTON, WA$301,427MSFD
2019Theoretical Models of Single Molecule Dynamics from Minimal Photon Numbers1R01GM134426-01PRESSE, STEVEARIZONA STATE UNIVERSITY-TEMPE CAMPUS, AZ$285,991BDMA
2019Macrocyclic Peptide Modulators of Protein Function1R01GM134076-01FASAN, RUDIUNIVERSITY OF ROCHESTER, NY$284,101SBCB
2019Extreme High Throughput Screening Via Massively Parallel Droplet Dispenser Arrays1R01GM134418-01HUI, ELLIOT EUNIVERSITY OF CALIFORNIA-IRVINE, CA$239,605ISD
2019High-resolution spectroscopic imaging with infrared nonlinear optical (IR-NLO) microscopy1R01GM132506-01POTMA, ERIC OLAFUNIVERSITY OF CALIFORNIA-IRVINE, CA$157,893ZRG1
2019Expanding the HIDE nanoscopy toolbox: More organelles, colors, and modalities1R01GM131372-01SCHEPARTZ, ALANNAYALE UNIVERSITY, CT$37,020ZRG1
2018Development of an ultra-sensitive, laser-based, carbon-14 spectrometer for molecular speciation of liquid-chromatography analytes and small, biological samples1R01GM127573-01MCCARTT, ALAN DANIELUNIVERSITY OF CALIF-LAWRNC LVRMR NAT LAB, CA$753,462ISD
2018Visualizing and manipulating chromatin dynamics in living cells1R01GM127538-01LIONNET, TIMOTHEENEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$632,762ZRG1
2018Development of a Structurally Interacting RNA (sxRNA) technology1R01GM125870-01TENENBAUM, SCOTT ASUNY POLYTECHNIC INSTITUTE, NY$567,247MGB
2018Molecular Structure Determination by Mass Spectrometry and Computational Modeling1R01GM127267-01SHARP, JOSHUA SUNIVERSITY OF MISSISSIPPI, MS$564,706EBIT
2018Noninvasive deep-tissue single-cell imaging and nanoprobe development1R01GM128089-01A1CHU, STEVENRAO, JIANGHONGSTANFORD UNIVERSITY, CA$549,537BMIT
2018Development of Cryo-EM/TEM Technologies for Small Protein and RNA Systems1R01GM125907-01HAFENSTEIN, SUSANLINDNER, SCOTT EPENNSYLVANIA STATE UNIVERSITY, THE, PA$546,434ZRG1
2018Resonator Approach to Pulsed Dynamic Nuclear Polarization of Membrane Proteins1R01GM130821-01NEVZOROV, ALEXANDER A.SMIRNOV, ALEX I.NORTH CAROLINA STATE UNIVERSITY RALEIGH, NC$524,862EBIT
2018An integrated pipeline for next-generation protein interactomics1R01GM126170-01LACAVA, JOHNROCKEFELLER UNIVERSITY, NY$520,227EBIT
2018Technologies to predict and probe glycosyl transfer1R01GM127578-01GRAY, JEFFREY JJOHNS HOPKINS UNIVERSITY, MD$482,519MSFB
2018Highly Sensitive Chemical Microscopy by Probing the Thermal Effect of Infrared Light1R01GM126049-01CHENG, JI-XINBOSTON UNIVERSITY (CHARLES RIVER CAMPUS), MA$466,899ZRG1
2018Nanopore Direct Single-Molecule Protein Sequencing1R01GM126013-01A1HUANG, XIAOHUAUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$442,757ISD
2018Hybrid structural mass spectrometry for rapid site-specific glycan structural elucidation1R01GM127579-01GUTTMAN, MIKLOSUNIVERSITY OF WASHINGTON, WA$439,210EBIT
2018Development of a Laser-Assisted NMR Technology for the Atomic-Resolution Analysis of Medically Relevant Biomolecules in Solution at Submicromolar Concentration1R01GM125995-01CAVAGNERO, SILVIAUNIVERSITY OF WISCONSIN-MADISON, WI$434,630EBIT
2018A nanofluidic platform for tunable drug delivery1R01GM127558-01GRATTONI, ALESSANDROLIU, XUEWUMETHODIST HOSPITAL RESEARCH INSTITUTE, TX$425,438ISD
2018Red and Far-Red Fluorescent Biosensors for Compartmentalized Redox Signaling1R01GM129291-01AI, HUIWANGUNIVERSITY OF VIRGINIA, VA$378,351CMT
2018Fractionating Organelle Subpopulations by Size and Type1R01GM127562-01ROS, ALEXANDRAARIZONA STATE UNIVERSITY-TEMPE CAMPUS, AZ$367,119ISD
2018Technology Development for High-Throughput Biomolecular CryoSAXS1R01GM127528-01THORNE, ROBERT E.CORNELL UNIVERSITY, NY$366,609MSFB
2018A Functional genomics platform with integrated library cloning and molecular display1R01GM127353-01LARMAN, HARRY BENJAMINPAREKKADAN, BIJUJOHNS HOPKINS UNIVERSITY, MD$364,338GCAT
2018Development of high-dose time-resolved x-ray footprinting technologies to enable the next level of structural analysis for challenging biological problems1R01GM126218-01RALSTON, CORIE YUNIVERSITY OF CALIF-LAWRENC BERKELEY LAB, CA$362,948MSFC
2018Coupled Emission Microscopy for the Biosciences1R01GM125976-01LAKOWICZ, JOSEPH R.UNIVERSITY OF MARYLAND BALTIMORE, MD$362,805ZRG1
2018Principal subspace analysis of cryo-EM heterogeneity1R01GM125769-01TAGARE, HEMANT DYALE UNIVERSITY, CT$344,178MSFC
2018Utilizing Endocytic Dynamics to Obtain Comprehensive Spatiotemporal Tension Maps of Live Tissues1R01GM127526-01KURAL, COMERTOHIO STATE UNIVERSITY, OH$343,861ZRG1
2018Engineering platforms for editing RNA with single base resolution1R01GM127497-01PEREZ-PINERA, PABLOUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$321,097TAG
2018Probing the Transcriptome with Multifunctional Acylation Chemistry1R01GM127295-01KOOL, ERIC T.STANFORD UNIVERSITY, CA$316,518SBCB
2018xMD-miRNA-Seq estimates cell-specific miRNA expression1R01GM130564-01HALUSHKA, MARC KJOHNS HOPKINS UNIVERSITY, MD$311,125EBIT
2018Cardiotoxicity Assays on an Integrated Platform of a Heart-on-a-Chip and an Optical Immunosensor1R01GM126571-01KHADEMHOSSEINI, ALIYE, JING YONGUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$310,273ISD
2018Development of Single-Cell Multiplex in Situ Tagging Microtechnology for Comprehensive Profiling of Functionally Diverse Subpopulations and Their Signaling Pathways1R01GM128984-01WANG, JUNSTATE UNIVERSITY OF NEW YORK AT ALBANY, NY$310,135CMT
2018Development of an In Vivo Footprinting Method Coupled with Mass Spectrometry in C. elegans1R01GM127595-01JONES, LISA MUNIVERSITY OF MARYLAND BALTIMORE, MD$309,000EBIT
2018Real Time (RT) In-cell NMR technology to study protein interactions in live cells2R01GM085006-06A1SHEKHTMAN, ALEXANDERSTATE UNIVERSITY OF NEW YORK AT ALBANY, NY$308,012EBIT
2018Development of a novel pulse-chase in-cell footprinting method for protein folding analysis1R01GM128985-01JONES, LISA MUNIVERSITY OF MARYLAND BALTIMORE, MD$304,905EBIT
2018Expanding the genetic code with phosphotyrosine and phosphothreonine1R01GM125951-01ISAACS, FARREN J.RINEHART, JESSEYALE UNIVERSITY, CT$304,820MGA
2018Remote-Control Mechano-Genetics and Epigenetics for Live Cell Manipulation1R01GM126016-01WANG, YINGXIAOUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$302,898ZRG1
2018A novel strategy to capture post-translational modification-triggered protein-protein interactions1R01GM126220-01A1CHATTERJEE, ABHISHEKBOSTON COLLEGE, MA$297,350EBIT
2018A Technique for Measuring Transcription Factor Activity1R01GM125871-01A1DOWELL-DEEN, ROBIN DEANNEUNIVERSITY OF COLORADO, CO$286,702MGB
2018ENANTIOSELECTIVE TRIPLET SENSITIZATION REACTIONS1R01GM127545-01YOON, TEHSHIK PUNIVERSITY OF WISCONSIN-MADISON, WI$281,033SBCB
2018Cyclopropenones to assemble, analyze, and activate biomolecules1R01GM126226-01PRESCHER, JENNIFERUNIVERSITY OF CALIFORNIA-IRVINE, CA$276,150SBCA
2018Brillouin Microscope for Biomedical Research1R01GM127696-01YAKOVLEV, VLADISLAV V.TEXAS ENGINEERING EXPERIMENT STATION, TX$273,968ZRG1
2018Cell Penetration Profiling for Biotherapeutics1R01GM127585-01KRITZER, JOSHUA ATUFTS UNIVERSITY MEDFORD, MA$261,561SBCB
2017High throughput sample delivery method for time resolved studies of enzyme reactions with X-ray and complementary techniques1R01GM126289-01KERN, JAN FUNIVERSITY OF CALIF-LAWRENC BERKELEY LAB, CA$548,914MSFC
2017Development of Laser-Based Phase Contrast for Biological Electron Microscopy1R01GM126011-01MUELLER, HOLGERUNIVERSITY OF CALIF-LAWRENC BERKELEY LAB, CA$446,541ZRG1
2017Chemical Tools for the Investigation and Manipulation of Protein Glycosylation1R01GM125939-01PRATT, MATTHEW ROBERTUNIVERSITY OF SOUTHERN CALIFORNIA, CA$327,857SBCA
2017Secrete, Capture, Sort, Sequence: NGS Decoded Molecular Recognition Pairs1R01GM126657-01BRUCHEZ, MARCEL PCARNEGIE-MELLON UNIVERSITY, PA$316,200EBIT
2017Developing nanoscale electrophysiology sensors for robust intracellular recording1R01GM125737-01CUI, BIANXIAOSTANFORD UNIVERSITY, CA$310,965EBIT

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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