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NIH funding notice PAR-19-253

Focused Technology Research and Development (R01 - Clinical Trial Not Allowed)

Closed on March 21, 2022.

Posted
April 12, 2019
Close date
March 21, 2022
Activity codes
R01
Institutes taking part
NIGMS, NCCIH

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

  1. Reissues: PAR-17-045 Focused Technology Research and Development (R01)

Replaced by PAR-22-127.

Who won it before

227 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $87,332,903 in first-year total cost, median $357,000.

Most frequent study sections

  1. Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]49
  2. Cellular and Molecular Technologies Study Section[CMT]32
  3. Instrumentation and Systems Development Study Section[ISD]32
  4. Macromolecular Structure and Function D Study Section[MSFD]14
  5. Genomics, Computational Biology and Technology Study Section[GCAT]12

Most frequent institutions

  1. STANFORD UNIVERSITY7
  2. UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB7
  3. CORNELL UNIVERSITY6
  4. JOHNS HOPKINS UNIVERSITY6
  5. UNIVERSITY OF CALIFORNIA, SAN DIEGO6
Competing awards under PAR-19-253 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2023Development of approaches to apply CRISPR/Cas9-mediated gene conversion to model complex genetic traits in mice1R01GM148640-01COOPER, KIMBERLY LYNNUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$521,400GCAT
2023Cell membrane-targeting proteoglycan chimeras as selective growth factor signaling actuators1R01GM145913-01A1GODULA, KAMILUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$497,062SBCA
2023Development of Analytical Tools for Concentration and Real-Time Control of Dissolved Gases and Their Regulation of Tissue Function1R01GM148741-01KRAMLICH, JOHN C.SWEET, IAN RUNIVERSITY OF WASHINGTON, WA$486,047ISD
2023Femto-seq: Targeted photo-biotinylation, pulldown and sequencing of locus and region-specific DNA from femtoliter volumes within individual cells1R01GM145934-01A1ZIPFEL, WARREN RCORNELL UNIVERSITY, NY$421,283CMT
2023Three-dimensional fluorescence imaging flow cytometry at up to million frames per second1R01GM148906-01BEN-YAKAR, ADELAUNIVERSITY OF TEXAS AT AUSTIN, TX$415,512CMT
2023Quantitative Characterization of Glycopeptide Isomers2R01GM130091-05MECHREF, YEHIATEXAS TECH UNIVERSITY, TX$342,210ZRG1
2023Optical platform for functional longitudinal imaging of metabolite uptake in vivo1R01EB034607-01A1GOUN, ELENAUNIVERSITY OF MISSOURI-COLUMBIA, MO$341,955SBCA
2023Genome engineering in the nematode C. elegans1R01GM146005-01A1JORGENSEN, ERIK MUNIVERSITY OF UTAH, UT$316,811GCAT
2023Multivalent protein-DNA nanostructures as synthetic blocking antibodies1R01GM145916-01A1STEPHANOPOULOS, NICHOLASSULC, PETRARIZONA STATE UNIVERSITY-TEMPE CAMPUS, AZ$296,022NANO
2022High throughput sample delivery method for time resolved studies of enzyme reactions with X-ray and complementary techniques2R01GM126289-05A1KERN, JAN FUNIVERSITY OF CALIF-LAWRENC BERKELEY LAB, CA$608,543MSFA
2022Spatial proteomics using highly parallel fluorescence hyperspectral and lifetime imaging1R01GM147741-01GRATTON, ENRICOKESSENBROCK, KAIUNIVERSITY OF CALIFORNIA-IRVINE, CA$555,891EBIT
2022Assay for Detection of Homologous DNA Interactions1R01GM141698-01A1BOERNER, VALENTINTANAKA, HISASHICLEVELAND STATE UNIVERSITY, OH$494,647MGB
2022Adaptive Tracking and Quantum Imaging for Protein-Protein Interactions1R01GM140284-01A1BECERRA CHAVEZ, FRANCISCO ELOHIMLIDKE, KEITH AUNIVERSITY OF NEW MEXICO, NM$474,799ISD
2022Harnessing the gut microbiome to detect and quantify glycans1R01GM147178-01TOWNSEND, GUY EDMUNDPENNSYLVANIA STATE UNIV HERSHEY MED CTR, PA$452,982EBIT
2022Harmonic Acoustics for Neighboring cell Dynamic studies(HANDs)1R01GM145960-01LEE, LUKE P.BRIGHAM AND WOMEN'S HOSPITAL, MA$447,396CMT
2022Next Generation Quantitative Acoustic Microscopy for Biomedical Application1R01GM143388-01A1MAMOU, JONATHANWEILL MEDICAL COLL OF CORNELL UNIV, NY$446,025ITD
2022Development of high-dose time-resolved X-ray footprinting technologies to enable detailed structural and kinetics information to be obtained for challenging biological problems2R01GM126218-05A1RALSTON, CORIE YUNIVERSITY OF CALIF-LAWRENC BERKELEY LAB, CA$425,897MSFB
2022Development of potent and predictable Cas9 gene activation tools through high-throughput screening1R01GM143249-01A1SHERWOOD, RICHARD IBRIGHAM AND WOMEN'S HOSPITAL, MA$413,490GCAT
2022New techniques for detecting and handling nanocrystals for cutting edge structural biology methods1R01GM141273-01A1BOWMAN, SARAH ELIZABETH JOHNSONLYNCH, MIRANDAHAUPTMAN-WOODWARD MEDICAL RESEARCH INST, NY$407,732MSFC
2022High throughput platform to engineer light-controlled inhibitors against guanine exchange factors of the Dbl family1R01GM144632-01AZOITEI, MIHAI LUCHIANDUKE UNIVERSITY, NC$398,541ZRG1
2022Analysis Tools for Fiber Diffraction of Muscle1R01GM144555-01IRVING, THOMAS CILLINOIS INSTITUTE OF TECHNOLOGY, IL$395,635MSFD
2022Development of a technology to certify engineered DNA molecules1R01GM147816-01PECCOUD, JEAN MCOLORADO STATE UNIVERSITY, CO$388,013BDMA
2022Photo-hyperpolarized 13C MRI1R01GM143626-01A1AJOY, ASHOKSHENDEROVA, OLGA AADAMAS NANOTECHNOLOGIES, INC., NC$385,632IPCA
2022Four-dimensional Adhesion Frequency Assay for Full Profiling of Receptor-ligand Interactions on Cells1R01GM146962-01ZHENG, YUEBINGUNIVERSITY OF TEXAS AT AUSTIN, TX$379,952ISD
2022Maintenance and development of DelPhi and associated resources2R01GM093937-10A1ALEXOV, EMIL GEORGIEVCLEMSON UNIVERSITY, SC$375,603MSFD
2022Development of Single Cell Printing-Liquid Vortex Capture-Mass Spectrometry for the Metabolic Profiling of Single Cells1R01GM144421-01CAHILL, JOHN FUT-BATTELLE, LLC-OAK RIDGE NATIONAL LAB, TN$374,543EBIT
2022Acoustic platform for separation, isolation, and enrichment in biomedical research1R01GM141344-01A1MEACHAM, JOHN MARKWASHINGTON UNIVERSITY, MO$369,375ISD
2022Photoactivatable Fluorophores for High-Throughput Multiplexed Tracking of Single-Molecules in Live Cells1R01GM143397-01A1RAYMO, FRANCISCO MUNIVERSITY OF MIAMI CORAL GABLES, FL$367,684SBCA
2022Cell Penetration Profiling for Biotherapeutics2R01GM127585-05KRITZER, JOSHUA ATUFTS UNIVERSITY MEDFORD, MA$360,446SBCB
2022FRET detection and in situ quantification of efferocytosis using designed enzymatic activity1R01GM148812-01DIDENKO, VLADIMIR VBAYLOR COLLEGE OF MEDICINE, TX$354,200EBIT
2022Engineering Smart Antibody-like Protein Scaffolds with precision switches1R01GM144986-01A1ZHOU, YUBINTEXAS A&M UNIVERSITY HEALTH SCIENCE CTR, TX$346,346CMT
2022Single-component optogenetic tools to bidirectionally control RhoA in mechanotransduction1R01GM143400-01A1BOERCKEL, JOEL DCHOW, BRIAN YUNIVERSITY OF PENNSYLVANIA, PA$345,083CMT
2022Viral vector technology for cell type specific gene delivery1R01GM141152-01A1LEBEAU, AARON MATTHEWSCHMIDT, DANIELUNIVERSITY OF MINNESOTA, MN$342,667GDD
2022Programmable Microvesicles for Intracellular Macromolecule Delivery1R01GM144749-01LIU, XUEDONGUNIVERSITY OF COLORADO, CO$342,660NANO
2022Development of a Novel Technology for Preparative Fractionation and Characterization of Lipoprotein Particles1R01GM147545-01ZIVKOVIC, ANGELA MUNIVERSITY OF CALIFORNIA AT DAVIS, CA$333,340EBIT
2022Molecular profiling of global tissue dynamics at sub cellular resolution1R01GM138790-01A1MILLER, MILES AMASSACHUSETTS GENERAL HOSPITAL, MA$332,892CMT
2022Multiplexed proteomics-based kinase assay development1R01GM146386-01PARKER, LAURIE L.UNIVERSITY OF MINNESOTA, MN$327,590EBIT
2022Online Affinity Micro Free Flow Electrophoresis Assays for Continuous Monitoring of Biochemical Messengers1R01GM145956-01BOWSER, MICHAEL TUNIVERSITY OF MINNESOTA, MN$323,824EBIT
2022"Developing A Comprehensive Toolkit for Chemical Inducible Epigenome Remodeling"1R01GM143256-01A1LIANG, FU-SENCASE WESTERN RESERVE UNIVERSITY, OH$322,000CMT
2022Optogenomic mapping of chromatin accessibility in live cells1R01GM149076-01WANG, XIAOZHONG ALECNORTHWESTERN UNIVERSITY, IL$320,000GCAT
2022High-Resolution Mapping of Bacterial Transcriptional Responses in Human-Associated Microbiota1R01GM147731-01BRITO, ILANA LAURENCORNELL UNIVERSITY, NY$319,906GCAT
2022Tools to determine and analyze the structures of molecular machines in motion1R01GM144542-01DAVIS, JOSEPH HARRYMASSACHUSETTS INSTITUTE OF TECHNOLOGY, MA$319,795MSFC
2022HPF-X: High-pressure freezing with buffer exchange1R01GM146791-01PRIGOZHIN, MAXIMHARVARD UNIVERSITY, MA$318,939ISD
2022A new class of biosensors for detecting signaling dynamics without live-cell microscopy1R01GM144362-01TOETTCHER, JARED EPRINCETON UNIVERSITY, NJ$318,605CMT
2022Mapping the Interactions and Dynamics that Organize Bacteria Cells1R01GM144731-01BITEEN, JULIEUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$317,315EBIT
2022Chemoenzymatic construction of synthetic human milk oligosaccharide (HMO) glycome1R01GM148568-01CHEN, XIUNIVERSITY OF CALIFORNIA AT DAVIS, CA$316,030SBCA
2022Capillary-channeled polymers fibers and films - A platform technology for exosome isolation and analytics1R01GM141347-01A1BRUCE, TERRI LANE FOSTERMARCUS, RICHARD KENNETHCLEMSON UNIVERSITY, SC$308,253ISD
2022Deep learning methods for automated and accurate reconstruction of protein structures from cryo-EM image data1R01GM146340-01CHENG, JIANLINUNIVERSITY OF MISSOURI-COLUMBIA, MO$305,657BDMA
2022Microfluidics to explore ultrafast cell deformations to deliver large cargo via convective transport1R01GM144727-01A1SULCHEK, TODDGEORGIA INSTITUTE OF TECHNOLOGY, GA$300,999CMT
2022Increasing the Coverage, Sensitivity and Specificity of Rapid Lipidomic Measurements1R01GM141277-01A1BAKER, ERIN SUNIV OF NORTH CAROLINA CHAPEL HILL, NC$300,467EBIT
2022Improving Fragment Based Drug Discovery and the Development of Tools for Chemical Biology through Nanoscale Encapsulation and NMR Spectroscopy1R01GM145751-01WAND, A. JOSHUATEXAS A&M AGRILIFE RESEARCH, TX$298,659MSFA
2022Next generation implicit solvation for atomistic modeling1R01GM144596-01ONUFRIEV, ALEXEY VLADVIRGINIA POLYTECHNIC INST AND ST UNIV, VA$294,013MSFD
2022Acoustic microvortices instrumentation for dosage controlled, high efficiency cell engineering1R01GM145987-01LEE, ABRAHAM PUNIVERSITY OF CALIFORNIA-IRVINE, CA$280,482ISD
2022Optical imaging of size, charge, mobility and binding of single proteins1R01GM140193-01A1WANG, SHAOPENGARIZONA STATE UNIVERSITY-TEMPE CAMPUS, AZ$275,738ISD
2022Chemical Tools for the Investigation and Manipulation of Protein Glycosylation2R01GM125939-05PRATT, MATTHEW ROBERTUNIVERSITY OF SOUTHERN CALIFORNIA, CA$272,250ZRG1
2022Development of a multifunctional, acoustofluidic 3D bioprinter with single-cell resolution1R01GM144417-01TIAN, ZHENHUAMISSISSIPPI STATE UNIVERSITY, MS$1ISD
2021Development of Laser-Based Phase Contrast for Biological Electron Microscopy2R01GM126011-05MUELLER, HOLGERUNIVERSITY OF CALIF-LAWRENC BERKELEY LAB, CA$888,277CMT
2021Automated, optimized, intelligent data collection for cryo-EM1R01GM143805-01LANDER, GABRIEL CSTAGG, SCOTT MSCRIPPS RESEARCH INSTITUTE, THE, CA$655,046BDMA
2021Extending the temporal and spatial capabilities of single-molecule methods1R01GM143554-01CHU, STEVENSTANFORD UNIVERSITY, CA$578,550ISD
2021Instrument development for vibrational circular dichroism imaging1R01GM142172-01BHARGAVA, ROHITUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$554,196ISD
2021Development of Technologies for Efficient In Vivo Prime Editing1R01GM141296-01PEREZ-PINERA, PABLOSONG, JUN SUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$535,871TAG
2021MusIC: A multi-scale technology for integrating dynamic cellular function and molecular profiles1R01GM143243-01VARADARAJAN, NAVINUNIVERSITY OF HOUSTON, TX$523,272CMT
2021Novel Carbohydrate-binding Antibodies to Human Glycans Using the Lamprey System1R01GM140201-01A1CUMMINGS, RICHARD DBETH ISRAEL DEACONESS MEDICAL CENTER, MA$504,033EBIT
2021Development of high-throughput, high-sensitivity EPR sample handling capabilities for biomedical research1R01GM140385-01KLUG, CANDICE SLERCH, MICHAEL TAYLORMEDICAL COLLEGE OF WISCONSIN, WI$483,900ISD
2021Rapid, Robust, and Routine: Multiplexed Microscopy for Spatially Resolved Whole-Transcriptomic Single-Cell Profiling and the Construction of Cell Atlases of all Tissues and in all Organisms1R01GM143277-01MOFFITT, JEFFREYBOSTON CHILDREN'S HOSPITAL, MA$429,240CMT
2021OpenMM: Scalable biomolecular modeling, simulation, and machine learning1R01GM140090-01MARKLAND, THOMAS EDWARDSTANFORD UNIVERSITY, CA$426,294MSFD
2021Diamond Rotors1R01GM139055-01A1GERSHENFELD, NEILMASSACHUSETTS INSTITUTE OF TECHNOLOGY, MA$419,786ISD
2021A Continuous Flow-Based Approach to Automated Microbial Oligosaccharide Synthesis.1R01GM138784-01A1BENNETT, CLAY SAMUELPOHL, NICOLA L. B.TUFTS UNIVERSITY MEDFORD, MA$414,747SBCA
2021Development of a digital acoustofluidic system for automating liquid handling in biomedical research1R01GM141055-01HUANG, TONY JUNDUKE UNIVERSITY, NC$412,551ISD
2021A system for long-term high-resolution 3D tracking of movement kinematics in freely behaving animals1R01GM136972-01A1OLVECZKY, BENCE PHARVARD UNIVERSITY, MA$411,071BNVT
2021Development of a cavitation enhancement technology to access archived tissues for epigenetic-based biomedical research1R01GM138912-01A1DAVIS, IAN JPATTENDEN, SAMANTHA GAILUNIV OF NORTH CAROLINA CHAPEL HILL, NC$401,503EBIT
2021Recombineering-based no-cleavage gene-editing toolkit for large-scale genome engineering and functional screening1R01GM141627-01CONG, LESTANFORD UNIVERSITY, CA$391,444GCAT
2021Differential Scanning Fluorimetry (DSF) Methods for Studying Protein Stability1R01GM141299-01GESTWICKI, JASON EUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$390,539MSFA
2021Developing optogenetic and chemogenetic approaches to control RNA metabolism in live cells1R01GM136897-01A1WU, BINJOHNS HOPKINS UNIVERSITY, MD$387,065MGA
2021Three-Dimensional (3D) Acoustofluidic Scanning Nanoscope with Super Resolution and Large Field of View1R01GM143439-01ZHAO, CHENGLONGUNIVERSITY OF DAYTON, OH$381,237ISD
2021Multiplex labeling chemistry methods for protein footprinting1R01GM141078-01KISELAR, JANNACASE WESTERN RESERVE UNIVERSITY, OH$378,804MSFB
2021New Technologies for detecting extracellular fluxes1R01GM138697-01A1KOBERTZ, WILLIAM RUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$371,705BPNS
2021Developing novel algorithms for spatial molecular profiling technologies1R01GM141519-01XIAO, GUANGHUAUT SOUTHWESTERN MEDICAL CENTER, TX$370,939MABS
2021Quantitative Analysis of Labile Metabolites in Biological Samples1R01GM138465-01A1GOWDA, G. A. NAGANARAFTERY, DANIELUNIVERSITY OF WASHINGTON, WA$370,650EBIT
2021Harnessing multiplexed Cas9 genome editing for sequential genetic manipulations and recording activities in cell lineages1R01GM139894-01MERRILL, BRADLEY JUNIVERSITY OF ILLINOIS AT CHICAGO, IL$327,013CMT
2021A Computational Platform for In-Situ Structure Determination at Near-Atomic Resolution using Cryo-Electron Tomography1R01GM141223-01BARTESAGHI, ALBERTODUKE UNIVERSITY, NC$318,913MSFD
2021Optical control of endogenous G protein Coupled Receptor and G Protein Signaling.1R01GM140191-01KARUNARATHNE, WELIVITIYA KANKANAMLAGE AJITHUNIVERSITY OF TOLEDO, OH$316,050CMT
2021Easily Used Kits to Evolve Reagents that Covalently Tag and Inactivate Proteins1R01GM141391-01A1BENNER, STEVEN AFOUNDATION FOR APPLIED MOLECULAR EVOLUTN, FL$313,900EBIT
2021Simulation of Multi-Protein systems1R01GM140098-01KOZAKOV, DMYTROSTATE UNIVERSITY NEW YORK STONY BROOK, NY$310,763MSFD
2021Repurposing Endonuclease V for the detection and engineering of adenosine-to-inosine editing1R01GM140657-01HEEMSTRA, JENNIFER MARGARETEMORY UNIVERSITY, GA$310,045EBIT
2021Chemoenzymatic synthesis of bacterial nonulosonic acids and glycans1R01GM141324-01CHEN, XIUNIVERSITY OF CALIFORNIA AT DAVIS, CA$309,114SBCA
2021Development of spectroscopic Single-Molecule Localization Microscopy1R01GM140478-01SUN, CHENGZHANG, HAO FNORTHWESTERN UNIVERSITY, IL$306,142ISD
2021Ex vivo single molecule tools to analyze membrane receptor dynamics1R01GM138837-01A1RICHARDS, CHRISTOPHER IUNIVERSITY OF KENTUCKY, KY$299,122EBIT
2021Single molecule localization microscopy via angstrom-scale three-dimensional imaging of electron spin labels1R01GM143556-01MAROHN, JOHN ACORNELL UNIVERSITY, NY$294,973EBIT
2021Tractable Tandem Ion Mobility Technology using Structures for Lossless Ion Manipulations and Photodissociation1R01GM140129-01CLOWERS, BRIANWASHINGTON STATE UNIVERSITY, WA$285,876EBIT
2021A low-input microfluidic ChIRP-seq technology for studying endogenous lncRNA binding1R01GM141096-01LU, CHANGVIRGINIA POLYTECHNIC INST AND ST UNIV, VA$278,523ISD
2021Novel transgenesis and expression technology for nematodes1R01GM141688-01NONET, MICHAEL LWASHINGTON UNIVERSITY, MO$269,875GCAT
2021Genetic code expansion for the construction of beyond rule-of-5 compliant macrocyclic peptide libraries1R01GM143396-01HARTMAN, MATTHEW CVIRGINIA COMMONWEALTH UNIVERSITY, VA$248,870SBCB
2021Cooling-Triggered Release Of Anesthetics From Thermoresponsive Gels For On Demand Pain Relief1R01GM141604-01A1BELLAN, LEON MARCELVANDERBILT UNIVERSITY, TN$229,788BMBI
2020Open data-driven infrastructure for building biomolecular force fields for predictive biophysics and drug design1R01GM132386-01A1 · under PAR-17-045SHIRTS, MICHAEL RUNIVERSITY OF COLORADO, CO$675,565MSFD
2020The Expedit-Isotopomeric CrossLinking Mass Spectrometry (Expedit-ICLMS) technology for mapping global and dynamic protein-protein interaction networks1R01GM136974-01RANISH, JEFFREY AINSTITUTE FOR SYSTEMS BIOLOGY, WA$542,967EBIT
2020Visualizing Live Cell Physiology with High Resolution Using Phase-Contrast STEM1R01GM138870-01TIMP, GREGORY LOUISUNIVERSITY OF NOTRE DAME, IN$540,747ISD
2020SPOTs: Optical Technologies for Instantly Quantifying Multicellular Response Profiles1R01GM127985-01A1CHIOU, PEI-YUTEITELL, MICHAEL AUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$530,374ISD
2020A nanophotonic approach to building DNA using enzymatic synthesis1R01GM138716-01DAVIS, RONALD WAYNESTANFORD UNIVERSITY, CA$530,297NANO
2020Multiplexed Charge Detection Mass Spectrometer for Extended Mass and Collisional Cross Section Measurements1R01GM139338-01WILLIAMS, EVAN RUNIVERSITY OF CALIFORNIA BERKELEY, CA$517,350ZRG1
2020Engineered probes for sialoglycan detection1R01GM137458-01A1IVERSON, T MVANDERBILT UNIVERSITY, TN$493,284EBIT
2020Integrated Acoustofluidic Plasmonic Molecular Diagnostic System for Detecting MicroRNA Biomarkers1R01GM135486-01 · under PAR-17-045VO-DINH, TUANDUKE UNIVERSITY, NC$476,407ZRG1
2020A Machine Learning Platform for Adaptive Chemical Screening1R01GM135631-01A1GITTER, ANTHONY JAMESMORGRIDGE INSTITUTE FOR RESEARCH, INC., WI$475,021BDMA
2020Computational tools to aid the design of glycomimetic agents1R01GM135473-01A1WOODS, ROBERT JUNIVERSITY OF GEORGIA, GA$433,844MSFD
2020Molecular toolkit for high content resolution of glycomes by expansionmicroscopy1R01GM137314-01ALABI, CHRISTOPHER AKINLEYEDELISA, MATTHEW PPASZEK, MATTHEW JCORNELL UNIVERSITY, NY$410,000EBIT
2020BeamMap: Ultra-High Resolution Topological and Chemical Imaging with Synergistic Liquid and Electron Beams1R01GM138802-01FEDOROV, ANDREI GGEORGIA INSTITUTE OF TECHNOLOGY, GA$406,801ISD
2020Towards Accurate Protein Structure Predictions with SAXS Technology (TAPESTRY)1R01GM137021-01TSUTAKAWA, SUSAN EMIKOUNIVERSITY OF CALIF-LAWRENC BERKELEY LAB, CA$404,480MSFD
2020Establishing the feasibility of editing the human gut microbiome1R01AT011117-01A1TURNBAUGH, PETER JAMESUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$403,750GCAT
2020Exploring the limits of luciferase multiplexing to assay multiple cellular signaling pathways at once1R01GM138781-01VENKEN, KOEN JOZEF THEOBAYLOR COLLEGE OF MEDICINE, TX$400,000EBIT
2020Small Molecule Tools for Modulating Membrane Rafts1R01GM138493-01KENWORTHY, ANNE KSANDERS, CHARLES RUNIVERSITY OF VIRGINIA, VA$397,145BBM
2020Advancing Multi-Color EM via Direct Detector-enabled 4D-STEM1R01GM138780-01ELLISMAN, MARK HUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$365,079CMT
2020Development of plasmon-enhanced biosensing for multiplexed profiling of extracellular vesicles1R01GM138778-01IM, HYUNGSOONMASSACHUSETTS GENERAL HOSPITAL, MA$357,000NANO
2020Strategies for Expedited Synthesis of Sulfated Aminoglycans1R01GM136968-01NGUYEN, HIEN MWAYNE STATE UNIVERSITY, MI$343,035SBCA
2020Novel machine learning approaches for improving structural discrimination in cryo-electron tomography1R01GM134020-01A1XU, MINCARNEGIE-MELLON UNIVERSITY, PA$342,970MSFD
2020Expanding the fluorescent toolkit with non-canonical amino acids1R01GM136996-01MILLS, JEREMYARIZONA STATE UNIVERSITY-TEMPE CAMPUS, AZ$342,625MSFD
2020Single cell tagging of localized RNA from whole populations1R01GM140013-01STORMO, GARY DWHITE, MICHAEL AARONWASHINGTON UNIVERSITY, MO$338,625GCAT
2020Oligonucleotide-directed in situ proximity biotinylation: a unified method for mapping RNA-interacting proteomes, transcriptomes and genomic loci within intact cells.1R01GM138799-01SHECHNER, DAVID MICHAELUNIVERSITY OF WASHINGTON, WA$338,242CMT
2020Next Generation Glycan Microarray using DNA-coded glycans and Next Generation Sequencing (NGS)1R01GM137011-01A1SONG, XUEZHENGEMORY UNIVERSITY, GA$335,400EBIT
2020Fully automated and ultra-high-throughput platform for in-depth single-cell proteomics1R01GM138931-01KELLY, RYAN TBRIGHAM YOUNG UNIVERSITY, UT$330,525EBIT
2020ActuAtor, a molecular tool for generating force in living cells1R01GM136858-01INOUE, TAKANARIJOHNS HOPKINS UNIVERSITY, MD$327,500CMT
2020Intrinsic-contrast super-resolution imaging of DNA at 2-nm resolution1R01GM139151-01ZHANG, HAO FNORTHWESTERN UNIVERSITY, IL$312,050ZRG1
2020Systems for Dramatically Improved Synthetic RNA1R01GM134042-01A1MARTIN, CRAIG TUNIVERSITY OF MASSACHUSETTS AMHERST, MA$307,420MSFB
2020High-precision pooled screening for quantitative molecular phenotypes1R01GM135233-01A1INGOLIA, NICHOLAS TUNIVERSITY OF CALIFORNIA BERKELEY, CA$305,313GCAT
2020Imaging mass spectrometry at isomeric chemical resolution using gas phase ion/ion reactions1R01GM138660-01PRENTICE, BOONE M.UNIVERSITY OF FLORIDA, FL$304,811EBIT
2020Multi-tiered containment system for engineered microbes1R01GM135483-01 · under PAR-17-045VAN PIJKEREN, JAN-PETERUNIVERSITY OF WISCONSIN-MADISON, WI$304,720PCMB
2020Non-Invasive Single-Cell Morphometry and Tracking in Living Bacterial Biofilms1R01GM139002-01GAHLMANN, ANDREASUNIVERSITY OF VIRGINIA, VA$302,927CMT
2020A nucleic acid nanostructure built through on-electrode ligation for electrochemical detection of proteins, peptides, and small molecules1R01GM138828-01EASLEY, CHRISTOPHER JAUBURN UNIVERSITY AT AUBURN, AL$293,281ISD
2020Nucleic Acid-Based Anti-CRISPR Inhibitors of Cas91R01GM135646-01 · under PAR-17-045GAGNON, KEITH THOMASSOUTHERN ILLINOIS UNIVERSITY CARBONDALE, IL$281,595SBCA
2019High-Throughput Platform for Thermodynamic Characterization of Biomolecular Interactions1R01GM132324-01A1 · under PAR-17-045RECHT, MICHAELPALO ALTO RESEARCH CENTER, CA$869,597EBIT
2019A Biophotonics Platform for Mechanotransduction and Metabolic Microscopy1R01GM129426-01A1 · under PAR-17-045VENUGOPALAN, VASANUNIVERSITY OF CALIFORNIA-IRVINE, CA$709,000ISD
2019Ultra-High Resolution Gas Phase Separation and Analysis Platform for Metabolomics1R01GM130709-01 · under PAR-17-045IBRAHIM, YEHIABATTELLE PACIFIC NORTHWEST LABORATORIES, WA$609,886EBIT
2019Development of Single Molecule Chromatin Interaction Assays (smChIA) in Single Nuclei1R01GM127531-01A1 · under PAR-17-045WEI, CHIA-LINJACKSON LABORATORY, ME$608,297EBIT
2019Tools to probe the biophysical properties of cells1R01GM132447-01 · under PAR-17-045HOLT, LIAM JNEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$575,450CMT
2019Molecular Diagnostics using a Nanopore to Analyze Secretions from Single Cells1R01GM127537-01A1 · under PAR-17-045LI, JUNTIMP, GREGORY LOUISUNIVERSITY OF NOTRE DAME, IN$533,474NANO
2019Development of Multidimensional, Linear and Differential Ion Mobility MS Separations for Middle-Down Proteoforms1R01GM134247-01 · under PAR-17-045FERNANDEZ-LIMA, FRANCISCOFLORIDA INTERNATIONAL UNIVERSITY, FL$523,560ZRG1
2019Next Generation Elemental Mass Spectrometry of Non-Metals1R01GM132112-01A1 · under PAR-17-045JORABCHI, KAVEHGEORGETOWN UNIVERSITY, DC$478,211EBIT
2019Robust microdroplet-based mechanical probes for wide-ranging mechanobiology applications1R01GM135380-01 · under PAR-17-045CAMPAS, OTGERSLETTEN, ELLEN MAYZINK, JEFFREY IUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$468,508CMT
2019Universal Metabolite Tagging1R01GM134081-01 · under PAR-17-045ARNATT, CHRISTOPHER KBYTHELL, BENJAMIN J.EDWARDS, JAMES LPATTI, GARY JSAINT LOUIS UNIVERSITY, MO$465,781EBIT
2019High-Throughput De Novo Glycan Sequencing1R01GM132675-01 · under PAR-17-045HONG, PENGYULIN, CHENGBOSTON UNIVERSITY MEDICAL CAMPUS, MA$462,286EBIT
2019Multiplexed Imaging in the Near Infrared with Indium Phosphide Quantum Shells1R01GM129437-01A1 · under PAR-17-045DENNIS, ALLISON MARIEBOSTON UNIVERSITY (CHARLES RIVER CAMPUS), MA$462,000NANO
2019High accuracy optical growth assay of 3D cellular systems1R01GM129709-01A1 · under PAR-17-045POPESCU, GABRIELUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$443,191CMT
2019Enabling exosome biomarker development via digitized single vesicle analysis1R01GM130923-01 · under PAR-17-045DEVOE, DON LWHITE, IAN MUNIV OF MARYLAND, COLLEGE PARK, MD$428,266ISD
2019Methods for determination of glycoprotein glycosylation similarities among disease states1R01GM133963-01 · under PAR-17-045ZAIA, JOSEPHBOSTON UNIVERSITY MEDICAL CAMPUS, MA$420,750BDMA
2019New biosensor tools for Diaphanous related formin mDia 1 and 2, useful for multiplex imaging1R01GM132098-01 · under PAR-17-045HODGSON, LOUISALBERT EINSTEIN COLLEGE OF MEDICINE, NY$407,639CMT
2019Development of 3D interferometric super-resolution methods for imaging dynamic, multi-component molecular systems, in single cells and in multi-cellular environments1R01GM135545-01 · under PAR-17-045PERTSINIDIS, ALEXANDROSSLOAN-KETTERING INST CAN RESEARCH, NY$399,719ISD
2019Ultra-Sensitive Multiplexed Quantification of Proteins Secreted from Single-Cells - Resubmission 011R01GM127527-01A1 · under PAR-17-045TAY, SAVASUNIVERSITY OF CHICAGO, IL$395,280EBIT
2019Develop General Methods for the Synthesis of Proteins with Posttranslational Lysine Modifications1R01GM127575-01A1 · under PAR-17-045LIU, WENSHE RAYTEXAS A&M UNIVERSITY, TX$394,016SBCB
2019Native Cell Membrane Nanoparticles System1R01GM132329-01 · under PAR-17-045GUO, YOUZHONGVIRGINIA COMMONWEALTH UNIVERSITY, VA$382,600BBM
2019High-resolution molecular recognition of ligands using solution X-ray scattering1R01GM133998-01 · under PAR-17-045GRANT, THOMAS D.STATE UNIVERSITY OF NEW YORK AT BUFFALO, NY$376,637MSFD
2019Lagrangian computational modeling for biomedical data science1R01GM130825-01 · under PAR-17-045ROHDE, GUSTAVO KUNDEUNIVERSITY OF VIRGINIA, VA$375,602BDMA
2019Development of an improved core technology for efficient genetic code expansion in biomedical research1R01GM131168-01 · under PAR-17-045MEHL, RYAN AOREGON STATE UNIVERSITY, OR$370,856MSFB
2019Synthetic adenovirus libraries for vector optimization1R01GM135485-01 · under PAR-17-045BUNZ, FREDJOHNS HOPKINS UNIVERSITY, MD$368,438GDD
2019Calibration nanotemplates as universal standards for determining protein copy number in super-resolution microscopy1R01GM133842-01A1 · under PAR-17-045LAKADAMYALI, MELIKEUNIVERSITY OF PENNSYLVANIA, PA$364,500CMT
2019Toolkit for Fast, Multipurpose and Inducible Bioorthogonal Chemistry1R01GM132460-01 · under PAR-17-045FOX, JOSEPH MUNIVERSITY OF DELAWARE, DE$358,800SBCA
2019A high-throughput, comprehensive, and quantitative approach for measuring nucleosome-protein binding1R01GM132199-01A1 · under PAR-17-045BUCK, MICHAEL JOSEPHSTATE UNIVERSITY OF NEW YORK AT BUFFALO, NY$352,755GCAT
2019Building Bridges to New Fluorophores1R01GM135474-01 · under PAR-17-045MILLER, STEPHEN C.UNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$351,520SBCA
2019Development of Photoreversible 4D Cell Culture Technologies1R01GM132677-01A1 · under PAR-17-045KALOW, JULIA ANNNORTHWESTERN UNIVERSITY, IL$347,754BMBI
2019Mesoscale spatial kinetic modeling of cell systems1R01GM132859-01A1 · under PAR-17-045LOEW, LESLIE MUNIVERSITY OF CONNECTICUT SCH OF MED/DNT, CT$344,400MABS
2019A universal multiplexing approach to unlock the hidden proteome1R01GM133981-01 · under PAR-17-045SWANEY, DANIELLE LUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$341,727EBIT
2019Advanced Molecular Probes and Cell Engineering Tools for Accurate Single-Molecule Analysis of Signaling in Individual Cells1R01GM131272-01 · under PAR-17-045SMITH, ANDREW MICHAELUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$338,776CMT
2019MEMS Acoustic Tweezers for Micromanipulation of Living Cells1R01GM134352-01 · under PAR-17-045KIM, EUN SOKUNIVERSITY OF SOUTHERN CALIFORNIA, CA$337,970ISD
2019Strategies for N to C solid-phase peptide synthesis1R01GM129475-01A1 · under PAR-17-045STOCKDILL, JENNIFER LYNNWAYNE STATE UNIVERSITY, MI$336,966SBCB
2019Precise regulation of native transcription factor at the single-cell level1R01GM132438-01A1 · under PAR-17-045ZHANG, KAIUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$336,767CMT
2019A Nanomechanical Toolkit to Guide Membrane Structure and Dynamics1R01GM132114-01 · under PAR-17-045LIN, CHENXIANGYALE UNIVERSITY, CT$335,000NANO
2019Molecular imaging technologies for mechanobiology1R01GM131099-01 · under PAR-17-045MATTHEYSES, ALEXA LYNNSALAITA, KHALID S.EMORY UNIVERSITY, GA$331,733CMT
2019Increasing the Selectivity of Hybrid Mass Spectrometry using Multidimensional Ion Mobility Spectrometry1R01GM130708-01 · under PAR-17-045BUSH, MATTHEW FRANCISUNIVERSITY OF WASHINGTON, WA$331,496EBIT
2019Advanced recombinase-based gene expression technology in mammalian cells1R01GM129011-01 · under PAR-17-045WONG, WILSONBOSTON UNIVERSITY (CHARLES RIVER CAMPUS), MA$330,000CMT
2019Volumetric time-lapse imaging of biophysical cell-extracellular matrix interactions for systems mechanobiology research1R01GM132823-01 · under PAR-17-045ADIE, STEVEN GRAHAMCORNELL UNIVERSITY, NY$323,832CMT
2019Nanomechanical imaging of protein dynamics via programmable DNA interactions1R01GM130948-01A1 · under PAR-17-045SAHIN, OZGURCOLUMBIA UNIV NEW YORK MORNINGSIDE, NY$319,970ISD
2019Tools for parameterizing and visualizing electrophysiological rhythmic and arrhythmic features1R01GM134363-01 · under PAR-17-045VOYTEK, BRADLEY T.UNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$315,000BDMA
2019Ultrahigh-resolution and single-molecule stimulated Raman scattering (SRS) microscopy1R01GM132860-01 · under PAR-17-045MIN, WEICOLUMBIA UNIV NEW YORK MORNINGSIDE, NY$314,314EBIT
2019Quantitative Characterization of Glycopeptide Isomers1R01GM130091-01A1 · under PAR-17-045MECHREF, YEHIATEXAS TECH UNIVERSITY, TX$313,024EBIT
2019Cross-path reactive chromatography/mass spectrometry as a versatile platform for characterization of primary and higher order structure of complex heterogeneous proteins1R01GM132673-01 · under PAR-17-045KALTASHOV, IGOR AUNIVERSITY OF MASSACHUSETTS AMHERST, MA$310,439EBIT
2019Chemical Biology Approach for Validating and Manipulating Cellular RNA-Protein Interactions1R01GM135252-01 · under PAR-17-045GARNER, AMANDAUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$308,100CMT
2019Riboglow: a robust multi-color riboswitch-based platform for imaging RNA in living cells1R01GM133184-01 · under PAR-17-045BATEY, ROBERT TPALMER, AMY EUNIVERSITY OF COLORADO, CO$308,000CMT
2019Designing Novel Protein Assemblies as Rigid Symmetric Scaffolds for Cryo-EM Imaging1R01GM129854-01A1 · under PAR-17-045YEATES, TODD OUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$304,620MSFD
2019Sparse NMR Labeling Approach to Glycoprotein Structure and Function1R01GM134335-01 · under PAR-17-045PRESTEGARD, JAMES H.UNIVERSITY OF GEORGIA, GA$302,000MSFB
2019Hyperpolarization Assisted and Structure Based Screening of Protein-Ligand Interactions in Live Cells1R01GM132655-01 · under PAR-17-045HILTY, CHRISTIAN B.TEXAS A&M UNIVERSITY, TX$301,760EBIT
2019Analysis tools for quantifying protein conformational landscapes using DEER spectroscopy1R01GM125753-01A1 · under PAR-17-045STOLL, STEFANUNIVERSITY OF WASHINGTON, WA$301,427MSFD
2019Theoretical Models of Single Molecule Dynamics from Minimal Photon Numbers1R01GM134426-01 · under PAR-17-045PRESSE, STEVEARIZONA STATE UNIVERSITY-TEMPE CAMPUS, AZ$285,991BDMA
2019Macrocyclic Peptide Modulators of Protein Function1R01GM134076-01 · under PAR-17-045FASAN, RUDIUNIVERSITY OF ROCHESTER, NY$284,101SBCB
2019Extreme High Throughput Screening Via Massively Parallel Droplet Dispenser Arrays1R01GM134418-01 · under PAR-17-045HUI, ELLIOT EUNIVERSITY OF CALIFORNIA-IRVINE, CA$239,605ISD
2019High-resolution spectroscopic imaging with infrared nonlinear optical (IR-NLO) microscopy1R01GM132506-01 · under PAR-17-045POTMA, ERIC OLAFUNIVERSITY OF CALIFORNIA-IRVINE, CA$157,893ZRG1
2019Expanding the HIDE nanoscopy toolbox: More organelles, colors, and modalities1R01GM131372-01 · under PAR-17-045SCHEPARTZ, ALANNAYALE UNIVERSITY, CT$37,020ZRG1
2018Development of an ultra-sensitive, laser-based, carbon-14 spectrometer for molecular speciation of liquid-chromatography analytes and small, biological samples1R01GM127573-01 · under PAR-17-045MCCARTT, ALAN DANIELUNIVERSITY OF CALIF-LAWRNC LVRMR NAT LAB, CA$753,462ISD
2018Visualizing and manipulating chromatin dynamics in living cells1R01GM127538-01 · under PAR-17-045LIONNET, TIMOTHEENEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$632,762ZRG1
2018Development of a Structurally Interacting RNA (sxRNA) technology1R01GM125870-01 · under PAR-17-045TENENBAUM, SCOTT ASUNY POLYTECHNIC INSTITUTE, NY$567,247MGB
2018Molecular Structure Determination by Mass Spectrometry and Computational Modeling1R01GM127267-01 · under PAR-17-045SHARP, JOSHUA SUNIVERSITY OF MISSISSIPPI, MS$564,706EBIT
2018Noninvasive deep-tissue single-cell imaging and nanoprobe development1R01GM128089-01A1 · under PAR-17-045CHU, STEVENRAO, JIANGHONGSTANFORD UNIVERSITY, CA$549,537BMIT
2018Development of Cryo-EM/TEM Technologies for Small Protein and RNA Systems1R01GM125907-01 · under PAR-17-045HAFENSTEIN, SUSANLINDNER, SCOTT EPENNSYLVANIA STATE UNIVERSITY, THE, PA$546,434ZRG1
2018Resonator Approach to Pulsed Dynamic Nuclear Polarization of Membrane Proteins1R01GM130821-01 · under PAR-17-045NEVZOROV, ALEXANDER A.SMIRNOV, ALEX I.NORTH CAROLINA STATE UNIVERSITY RALEIGH, NC$524,862EBIT
2018An integrated pipeline for next-generation protein interactomics1R01GM126170-01 · under PAR-17-045LACAVA, JOHNROCKEFELLER UNIVERSITY, NY$520,227EBIT
2018Technologies to predict and probe glycosyl transfer1R01GM127578-01 · under PAR-17-045GRAY, JEFFREY JJOHNS HOPKINS UNIVERSITY, MD$482,519MSFB
2018Highly Sensitive Chemical Microscopy by Probing the Thermal Effect of Infrared Light1R01GM126049-01 · under PAR-17-045CHENG, JI-XINBOSTON UNIVERSITY (CHARLES RIVER CAMPUS), MA$466,899ZRG1
2018Nanopore Direct Single-Molecule Protein Sequencing1R01GM126013-01A1 · under PAR-17-045HUANG, XIAOHUAUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$442,757ISD
2018Hybrid structural mass spectrometry for rapid site-specific glycan structural elucidation1R01GM127579-01 · under PAR-17-045GUTTMAN, MIKLOSUNIVERSITY OF WASHINGTON, WA$439,210EBIT
2018Development of a Laser-Assisted NMR Technology for the Atomic-Resolution Analysis of Medically Relevant Biomolecules in Solution at Submicromolar Concentration1R01GM125995-01 · under PAR-17-045CAVAGNERO, SILVIAUNIVERSITY OF WISCONSIN-MADISON, WI$434,630EBIT
2018A nanofluidic platform for tunable drug delivery1R01GM127558-01 · under PAR-17-045GRATTONI, ALESSANDROLIU, XUEWUMETHODIST HOSPITAL RESEARCH INSTITUTE, TX$425,438ISD
2018Red and Far-Red Fluorescent Biosensors for Compartmentalized Redox Signaling1R01GM129291-01 · under PAR-17-045AI, HUIWANGUNIVERSITY OF VIRGINIA, VA$378,351CMT
2018Fractionating Organelle Subpopulations by Size and Type1R01GM127562-01 · under PAR-17-045ROS, ALEXANDRAARIZONA STATE UNIVERSITY-TEMPE CAMPUS, AZ$367,119ISD

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