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NIH funding notice PAR-18-174

Alzheimer's Drug-Development Program (U01 Clinical Trial Optional)

Closed on June 7, 2018.

Posted
November 8, 2017
Close date
June 7, 2018
Activity codes
U01
Institutes taking part
NIA

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

  1. Reissues: PAR-15-174 Alzheimer's Drug-Development Program (U01)
  2. 2 steps back: PAR-12-015 Alzheimer's Disease Drug Development Program (U01)
  3. 3 steps back: PA-10-205 Alzheimers Disease Drug Development Program (U01)
  4. 4 steps back: PAR-08-266 Alzheimers Disease Drug Development Program (U01)
  5. 5 steps back: PAR-05-148

Replaced by PAR-18-820.

Who won it before

12 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $12,371,301 in first-year total cost, median $1,032,315.

Most frequent study sections

  1. Special Emphasis Panel[ZAG1 ZIJ-6 (M1)]3
  2. Special Emphasis Panel[ZAG1 ZIJ-6 (O2)]3
  3. Special Emphasis Panel[ZAG1 ZIJ-6 (J1)]2
  4. Special Emphasis Panel[ZAG1 ZIJ-6 (J4)]2
  5. Special Emphasis Panel[ZAG1 ZIJ-6 (J3)]1

Most frequent institutions

  1. INSTITUTE FOR MOLECULAR MEDICINE2
  2. UNIVERSITY OF CALIFORNIA, SAN DIEGO2
  3. ACUMEN PHARMACEUTICALS, INC.1
  4. EMORY UNIVERSITY1
  5. OHIO STATE UNIVERSITY1
Competing awards under PAR-18-174 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2019IND-enabling Preclinical Studies on Anti-Tau AD Vaccine for Phase 1 Trial1U01AG060965-01AGADJANYAN, MICHAEL GINSTITUTE FOR MOLECULAR MEDICINE, CA$1,116,260ZAG1
2019Optimization of microtubule-stabilizing triazolopyrimidines as therapeutics for Alzheimer's disease and related tauopathies1U01AG061173-01BALLATORE, CARLOBRUNDEN, KURT R.UNIVERSITY OF PENNSYLVANIA, PA$948,369ZAG1
2018Silent Allosteric Modulation of mGluR5 for Safe and Effective Therapy of Alzheimer's Disease1U01AG058608-01A1 · under PAR-15-174STRITTMATTER, STEPHEN MYALE UNIVERSITY, CT$1,646,216ZAG1
2018Neural Stem Cell Transplantation: A Novel Cellular Therapy for Alzheimer's Disease1U01AG057562-01A1 · under PAR-15-174FELDMAN, EVA LUCILLEMURPHY, GEOFFREY GUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$687,010ZAG1
2017Development of small molecule activators of glutamate transporter EAAT2 for treatment of Alzheimer's disease1U01AG054444-01A1 · under PAR-15-174LIN, CHIEN-LIANG GLENNOHIO STATE UNIVERSITY, OH$772,430ZAG1
2017Amyloid-Beta Oligomer Selective Immunotherapy for Prodromal or Mild Alzheimer Disease1U01AG053247-01A1 · under PAR-15-174GOURE, WILLIAMACUMEN PHARMACEUTICALS, INC., VA$444,503ZAG1
2016Optimization and preclinical development of soluble gamma-secretase modulators for AD1U01AG048986-01A1 · under PAR-12-015WAGNER, STEVEN LEEUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$1,514,460ZAG1
2016Development of EP2 receptor antagonists for suppression of Alzheimer's neuropathology1U01AG052460-01A1 · under PAR-15-174GANESH, THOTAEMORY UNIVERSITY, GA$758,149ZAG1
2015Preclinical Development of a Selective Suppressor of Neuroinflammation for MCI/AD1U01AG050636-01 · under PAR-12-015VAN ELDIK, LINDA JWATTERSON, DANIEL MARTINUNIVERSITY OF KENTUCKY, KY$1,416,252ZAG1
2015Pre-clinical study to fulfill FDA requirements for the completion of AV-1959 IND1U01AG048310-01A1 · under PAR-12-015AGADJANYAN, MICHAEL GINSTITUTE FOR MOLECULAR MEDICINE, CA$1,152,198ZAG1
2014A Translational Program of BDNF Gene Delivery in Alzheimer's Disease1U01AG043416-01A1 · under PAR-12-015TUSZYNSKI, MARK H.UNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$1,194,177ZAG1
2014Allopregnanolone a Regenerative Therapy for Alzheimer's: FDA-Required Toxicolog1U01AG047222-01 · under PAR-12-015BRINTON, ROBERTA EILEENUNIVERSITY OF SOUTHERN CALIFORNIA, CA$721,277ZAG1

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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