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NIH funding notice PAR-19-071

Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R21 Clinical Trial Not Allowed)

Closed on November 12, 2021.

Posted
November 16, 2018
Close date
November 12, 2021
Activity codes
Not stated on the notice page
Institutes taking part
Not stated on the notice page

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

Its page was not saved, so the notices it replaced are not known.

Who won it before

147 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $52,864,503 in first-year total cost, median $417,853.

Most frequent study sections

  1. Special Emphasis Panel[ZRG1 BDCN-A (55)]18
  2. Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]11
  3. Clinical Neuroscience and Neurodegeneration Study Section[CNN]10
  4. Special Emphasis Panel[ZRG1 MDCN-P (56)]10
  5. Cellular and Molecular Biology of Glia Study Section[CMBG]7

Most frequent institutions

  1. MASSACHUSETTS GENERAL HOSPITAL7
  2. COLUMBIA UNIVERSITY HEALTH SCIENCES6
  3. UNIVERSITY OF CALIFORNIA, SAN DIEGO6
  4. UNIVERSITY OF WISCONSIN-MADISON6
  5. UNIVERSITY OF CALIFORNIA-IRVINE5
Competing awards under PAR-19-071 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2022Alternative folding of soluble proteins induced by Aβ42 and Tau in aged cells1R21AG077556-01ZHOU, CHUANKAIBUCK INSTITUTE FOR RESEARCH ON AGING, CA$533,500CMAD
2022Reducing cognitive decline in patients with mild cognitive impairment and Alzheimer's Disease and related dementias by developing and testing clinician and caregiver deprescribing tools1R21AG075928-01LAUFFENBURGER, JULIE CHRISTINEBRIGHAM AND WOMEN'S HOSPITAL, MA$510,979ODHS
2022Mapping tauopathy-induced changes in subcellular proteostasis with compartment-targeted sensors1R21AG079267-01DEMONTIS, FABIOST. JUDE CHILDREN'S RESEARCH HOSPITAL, TN$500,500CMAD
2022Identifying risk factors of Alzheimer's disease and related dementias in older Chinese immigrants1R21AG077649-01LI, CLARAICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$495,123APDA
2022Functional and Transcriptional Profiling of Monocytes in Alzheimer's Disease1R21AG072486-01A1WEINER, HOWARD LBRIGHAM AND WOMEN'S HOSPITAL, MA$492,250ZRG1
2022Endothelial Pannexin1 in Alzheimer’s Disease1R21AG075796-01A1GOOD, MIRANDA ETUFTS MEDICAL CENTER, MA$489,500BINP
2022Multimodal imaging measures to assess synaptic dysfunction in Alzheimer's disease1R21AG077498-01RANASINGHE, KAMALINI GAYATHREEUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$483,995ZRG1
2022Home Based Primary Care for Persons Living with Dementia: Nurse Practitioner Teams and Outcomes1R21AG077384-01OSAKWE, ZAINAB TOTEHPOGHOSYAN, LUSINECOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$476,847ZRG1
2022Selective neurovascular regulation by a vascular dementia-related noncoding RNA Snord1181R21AG070681-01A1CHEN, JIANFUUNIVERSITY OF SOUTHERN CALIFORNIA, CA$467,471ZRG1
2022Digital Spatial Profiling of Hippocampal Subregions in Alzheimer’s Disease, Primary Age-Related Tauopathy, and Chronic Traumatic Encephalopathy1R21AG078505-01RICHARDSON, TIMOTHY ERICWALKER, JAMIEICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$464,750CNN
2022Shedding light on functional heterogeneity of dementia-related alpha-synuclein strains1R21AG077631-01LIANG, YAJIEUNIVERSITY OF MARYLAND BALTIMORE, MD$463,124CMND
2022Leveraging simultaneous BOLD-fMRI and wide-field Ca2+ imaging to reveal measures of neurovascular health that cross scales and species which have AD symptom and treatment response prognostic utility1R21AG075778-01LAKE, EVELYN MRYALE UNIVERSITY, CT$460,625CDIN
2022Generation and trans-neuronal seeding of phosphorylated T217-Tau in aging macaque cortical circuits1R21AG079145-01DATTA, DIBYADEEPYALE UNIVERSITY, CT$460,625CDIN
2022Integrative analysis of proteomics and transcriptomics to delineate vesicular transport related protein abnormalities related to Alzheimer's, Lewy body and mixed Pathologies1R21AG074287-01A1BEBEK, GURKANPILLAI, JAGAN AYYAPPANCLEVELAND CLINIC LERNER COM-CWRU, OH$455,583ZRG1
2022Neurovascular functions of a small RNA Snord118-mediated ribosome biogenesis1R21AG075665-01CHEN, JIANFUUNIVERSITY OF SOUTHERN CALIFORNIA, CA$453,750BINP
2022Dynamic immune cell landscape in late-onset Alzheimer's disease: role of ApoE-mediated microglial lipid metabolism1R21AG070971-01A1YU, I-CHEN IVORINEINDIANA UNIVERSITY INDIANAPOLIS, IN$451,042CMBG
2022MRI assessment of cerebral oxygen extraction fraction (OEF) in the medial temporal lobe as a biomarker in Alzheimer's disease1R21AG079098-01LU, HANZHANGJOHNS HOPKINS UNIVERSITY, MD$450,313EITN
2022Validating pig models for Alzheimer's disease1R21AG079292-01ALLEN, TIMOTHY ALEXANDERJAROME, TIMOTHY JOSEPHLEE, KIHOUNIVERSITY OF MISSOURI-COLUMBIA, MO$446,615CDIN
2022Development and evaluation of cell therapy strategies for Alzheimer's disease.1R21AG075807-01A1KASTANENKA, KSENIA V.MASSACHUSETTS GENERAL HOSPITAL, MA$445,680ZRG1
2022Identifying shared and distinct cell type vulnerability across neurological diseases.1R21AG075754-01AL DALAHMAH, OSAMAGOLDMAN, JAMESMENON, VILASCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$445,500MNG
2022Human Astrocyte-Based Nanovesicles to Target Neuroinflammation in Alzheimer's Disease1R21AG075189-01KRENCIK, ROBERT CONRADTARABALLI, FRANCESCAMETHODIST HOSPITAL RESEARCH INSTITUTE, TX$444,125BNVT
2022Genetic risk for trajectories of cognitive decline and progression to dementia among Mexican Americans and non-Hispanic whites1R21AG075791-01A1JIAN, XUEQIUUNIVERSITY OF TEXAS HLTH SCIENCE CENTER, TX$439,550ZRG1
2022Common CD36-dependent gut-brain neuroimmune pathway regulates disruption of intestinal motility in Alzheimer's Disease1R21AG077521-01BECKER, LARENSHAMLOO, MEHRDADSTANFORD UNIVERSITY, CA$437,265ZRG1
2022Protein homeostasis in a frontotemporal dementia iPSC model1R21AG075814-01A1CHU, CHARLEEN TUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$434,890CMND
2022Microbial dysbiosis as a driver of neuroinflammation and pathology in Alzheimer's disease1R21AG075836-01LUKENS, JOHN RUNIVERSITY OF VIRGINIA, VA$434,655ZRG1
2022Arachnoid Granulation Senescence in Aging, CAA and Alzheimer's Disease1R21AG079221-01MEHTA, RUPAL I.RUSH UNIVERSITY MEDICAL CENTER, IL$434,500ZRG1
2022Synthetically-evolved and engineered Nanobodies selective for Cb isoforms of PKA1R21AG079330-01CHANG, GEOFFREY ATAYLOR, SUSAN S.UNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$434,500EBIT
2022Optimization of imaging mass cytometry, a single-cell spatial proteomics technology, for the study of Alzheimer disease1R21AG077643-01XU, JINBINZHAO, GUOYANWASHINGTON UNIVERSITY, MO$433,125EBIT
2022Evaluation of Monoamine Oxidase-A as a New Biomarker for Alzheimer's Disease1R21AG079189-01MUKHERJEE, JOGESHWARUNIVERSITY OF CALIFORNIA-IRVINE, CA$431,750CNN
2022Establishing Genotype-to-Phenotype Relationships Between Alzheimer’s Related BIN1 Variants1R21AG079279-01BRAFMAN, DAVID AARIZONA STATE UNIVERSITY-TEMPE CAMPUS, AZ$431,750ZRG1
2022PET imaging for neuroimmune function in Alzheimer's disease1R21AG078058-01LIANG, STEVEN HEMORY UNIVERSITY, GA$430,375EITN
2022Development of the ADRD Systematic Hospital Inclusion Family Toolkit: A-SHIFT1R21AG077439-01FIELDS, BETHWERNER, NICOLE ETRUSTEES OF INDIANA UNIVERSITY, IN$428,925ZRG1
2022Characterizing the Effect of Altered CSF and Blood Flow Dynamics on Alzheimer’s Disease Proteinopathy, Brain Health, and Cognition1R21AG077337-01RIVERA RIVERA, LEONARDO AUNIVERSITY OF WISCONSIN-MADISON, WI$427,625CNN
2022Development and characterization of EEG signature of cognitive fluctuations in Lewy body dementia1R21AG077469-01BARRETT, MATTHEW JAMESMUKHOPADHYAY, NITAI D.VIRGINIA COMMONWEALTH UNIVERSITY, VA$426,938ZRG1
2022Protein Stability Profiling for the Characterization of Alzheimer's Disease1R21AG074317-01A1FITZGERALD, MICHAEL CDUKE UNIVERSITY, NC$423,898ZRG1
2022Oxidative stress-induced vascular pathology and dysfunction in Alzheimer’s disease1R21AG074146-01A1SOMPOL, PRADOLDEJUNIVERSITY OF KENTUCKY, KY$420,750ZRG1
2022Roles of neuroestradiol in comorbid hyperexcitability and seizure susceptibility in Alzheimer Disease1R21AG077694-01CHRISTIAN-HINMAN, CATHERINE AUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$417,878ZRG1
2022Predicting glymphatic function via PET/MR imaging biomarkers and Nose to Brain contrast delivery1R21AG075795-01ZINN, KURT RMICHIGAN STATE UNIVERSITY, MI$417,853EITN
2022Investigating the cause of cerebral blood flow reductions in a mouse model of frontotemporal dementia1R21AG075798-01A1BRACKO, OLIVERUNIVERSITY OF MIAMI CORAL GABLES, FL$410,845BINP
2022Identification of endophenotypes associated with Alzheimer’s disease progression in Hispanic population1R21AG077501-01ALMEIDA, MARCIOUNIVERSITY OF TEXAS RIO GRANDE VALLEY, TX$404,953ZRG1
2022Proteomic aging clock and brain structure, cognitive decline and the risk of Alzheimers Disease and related dementias1R21AG079242-01PRIZMENT, ANNASEDAGHAT, SANAZUNIVERSITY OF MINNESOTA, MN$400,146ZRG1
2022Digital biomarkers for Alzheimer's Disease with compact dual-mode brain sensing1R21AG079309-01LIU, HANLIUNIVERSITY OF TEXAS ARLINGTON, TX$388,494ZRG1
2022Post-mortem MRI for improving the diagnosis of Alzheimer’s mimics in the oldest old1R21AG075870-01SAJJADI, SEYED AHMADUNIVERSITY OF CALIFORNIA-IRVINE, CA$251,801CNN
2022Recruiting multiethnic populations to preclinical Alzheimers disease trials1R21AG074371-01A1GRILL, JOSHUAUNIVERSITY OF CALIFORNIA-IRVINE, CA$250,219HHD
2022Blood DNA Methylation Biomarkers of Alzheimer’s Disease and Postoperative Neurocognitive Disorder1R21AG077633-01ALISCH, REID SPENCERHOGAN, KIRK JUNIVERSITY OF WISCONSIN-MADISON, WI$249,590ZRG1
2022CCN1-induced Senescence in the Cerebral Vasculature1R21AG075750-01MORUNO MANCHON, JOSE FELIXUNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TX$234,000BINP
2022Bioengineering a cortical microtissue model to study human microglia in Alzheimer's disease1R21AG077697-01BORTON, DAVID ALLENSONHUANG, YU-WEN ALVINBROWN UNIVERSITY, RI$226,793CMBG
2022Feasibility of Linking the Occupational Exposome to Alzheimer's Disease Neuropathology1R21AG079277-01POWELL, WILLIAM RYANUNIVERSITY OF WISCONSIN-MADISON, WI$226,590ZRG1
2022Multimorbidity Trajectories, Psychosocial Resilience and Stress, and Risk of Dementia and Poor Cognitive Functioning1R21AG079233-01WHILBY, KELLEE WHITEUNIV OF MARYLAND, COLLEGE PARK, MD$226,081SSPB
2022Phase separation of nuclear tau and its role in gene regulation1R21AG079239-01DEBELOUCHINA, GALIAUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$224,864MSFC
2022Engaging care partners in fall risk management for community-dwelling older adults living with dementia1R21AG079316-01ZHOU, YUANJINUNIVERSITY OF TEXAS AT AUSTIN, TX$209,540CIHB
2022Mapping protein interactome of TREM2 and its variants to probe the etiology of Alzheimer's Disease1R21AG075875-01GAO, JIEOHIO STATE UNIVERSITY, OH$196,875ZRG1
2021New assay method for pinpointing structural features in amyloid oligomer formation1R21AG072478-01RALSTON, CORIE YUNIVERSITY OF CALIF-LAWRENC BERKELEY LAB, CA$558,671MSFB
2021Defining Molecular Signatures Underlying Lysosomal Dysfunction in Alzheimer’s Disease1R21AG072511-01WEISSMAN, JONATHAN S.WHITEHEAD INSTITUTE FOR BIOMEDICAL RES, MA$536,250CMND
2021Targeting conserved diet-responsive transcriptional networks in neurons to slow neurodegeneration in Alzheimer's disease1R21AG072663-01KAPAHI, PANKAJBUCK INSTITUTE FOR RESEARCH ON AGING, CA$533,500NOMD
2021Identifying Risk Factors For Late-Life Dementia Based On Job Characteristics During The Working Life1R21AG072609-01HUDOMIET, PETERRAND CORPORATION, CA$528,653SSPA
2021Nuclear transport as a molecular and cellular vulnerability in AD1R21AG072516-01MITCHISON, TIMOTHY JSONG, YUYUHARVARD MEDICAL SCHOOL, MA$480,625SYN
2021Microvascular Network Degeneration in a Novel Mouse Model of Alzheimer's Disease and Cerebral Amyloid Angiopathy1R21AG070859-01SCHRAG, MATTHEWVANDERBILT UNIVERSITY MEDICAL CENTER, TN$466,590CNN
2021Development and validation of a law-cost cerebral oximeter for detection of cognitive impairment and Alzheimer's disease1R21AG072481-01FRANCESCHINI, MARIA ANGELASALAT, DAVID HMASSACHUSETTS GENERAL HOSPITAL, MA$462,000ZRG1
2021Muli-scale Structural Imaging of Alzheimer's Disease Neuropathology and Neurodegeneration1R21AG072431-01DICKERSON, BRADFORD CSALAT, DAVID HMASSACHUSETTS GENERAL HOSPITAL, MA$461,108CNN
2021Development of Retinal Biomarkers in Autosomal Dominant Alzheimer's Disease: A pilot study1R21AG074153-01ALBER, JESSICAUNIVERSITY OF RHODE ISLAND, RI$458,896CNN
2021Glial lactate and sleep-wake disturbances of Alzheimer's disease1R21AG070927-01HAYDON, PHILIP GTUFTS UNIVERSITY BOSTON, MA$453,750CDIN
2021Phosphorylated tau protein detection in olfactory neurons at a single-cell resolution: needle-free biopsy for Alzheimer's disease pathophysiology study1R21AG070754-01ISHIZUKA, KOKOJOHNS HOPKINS UNIVERSITY, MD$450,313ZRG1
2021A multidimensional approach to studying the impact of caregiving on health among dementia caregivers1R21AG072395-01CHO, JINMYOUNGBAYLOR RESEARCH INSTITUTE, TX$445,288CMPC
2021Factors Associated with Healthcare Utilization Among Community-Dwelling Adults with Clinical Features of Dementia with Lewy Bodies1R21AG074368-01WYMAN-CHICK, KATHRYN AHEALTHPARTNERS INSTITUTE, MN$440,890ODHS
2021CareBand: A Collaborative Pilot Study to Optimize a Life-Space Performance Metric for Monitoring and Early Detection of Alzheimer's Disease and Related Dementias in Rural and Indigenous Communities1R21AG072566-01WARRY, WAYNE RICHARDUNIVERSITY OF MINNESOTA, MN$438,699ZRG1
2021Stricker Learning Span: A Computer Adaptive Word List Memory Test Optimized for Remote Assessment1R21AG073967-01STRICKER, NIKKI HMAYO CLINIC ROCHESTER, MN$437,250APDA
2021Magnetic susceptibility and volume of microvascular lesions as proof-of concept biomarkers for mixed dementia1R21AG069477-01A1CHENG, YU-CHUNG NORMANCOUNTS, SCOTT EWAYNE STATE UNIVERSITY, MI$437,221EITA
2021ABCA7 dysfunction in Alzheimer's disease pathogenesis1R21AG069180-01A1ALAM, AMERUNIVERSITY OF MINNESOTA, MN$435,750BPNS
2021The Role of Chromogranin A in Tauopathy1R21AG072487-01CHEN, XUGHOSH, GOURISANKARMAHATA, SUSHIL KUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$434,375ZRG1
2021Enhancing microglia-dependent plaque clearance in the Alzheimer disease brain by targeting Ifi27l2a expression1R21AG072488-01KIM, GAB SEOKUNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TX$428,984ZRG1
2021Investigating CD33 function on microglia during Alzheimer’s disease using CRISPR nanoparticles1R21AG072423-01HOPP, SARAH CHRISTINEUNIVERSITY OF TEXAS HLTH SCIENCE CENTER, TX$425,625CMBG
2021Empathy, Support Exchanges, and Well-Being in Older Couples Coping With Early Stage Alzheimer’s Disease1R21AG069045-01A1HUO, MENGUNIVERSITY OF CALIFORNIA AT DAVIS, CA$424,269SPIP
2021Gene Profile Analysis of Associations between Alzheimer’s Disease and Circadian Rhythmic Patterns of Human Brain Regions Using Machine Learning1R21AG070909-01CHENG, QIANGUNIVERSITY OF KENTUCKY, KY$420,750ZRG1
2021Disease Mechanisms at the Intersection of Glaucoma and Alzheimer's Disease1R21AG074395-01MCLELLAN, GILLIAN JANEUNIVERSITY OF WISCONSIN-MADISON, WI$414,306ZRG1
2021Exploring the Use of Deep Learning Neural Networks to Improve Dementia Detection: Automating Coding of the Clock-Drawing Test1R21AG073971-01HU, MENGYAOUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$406,555NAME
2021Uncovering BIN1 functions in myelin-producing oligodendrocytes1R21AG072479-01LI, JIANRONGTEXAS A&M UNIVERSITY, TX$402,526CMBG
2021Study of Comorbid Seizures in Alzheimer's Disease1R21AG071278-01TSAI, NIEN-PEIUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$401,252NTRC
2021Smartphone Pupillometer for At-Home Screening for Risk of Alzheimer’s Disease1R21AG072534-01WANG, EDWARD JAYUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$392,099ZRG1
2021Leukocyte Telomere Length, Mitochondrial DNA Copy Number, Plasma Proteomics, and Alzheimer's Disease-related Dementia1R21AG072530-01TANG, WEIHONGUNIVERSITY OF MINNESOTA, MN$385,204BGES
2021MALDI imaging of glial scar-forming glycans in Alzheimers disease1R21AG074152-01ALONGE, KIMBERLY MICHELEUNIVERSITY OF WASHINGTON, WA$264,750ZRG1
2021Engineering Human Brain Neurovascular Niche for Modeling Brain Diseases1R21AG074373-01YOUNG, JESSICA ELAINEZHENG, YINGUNIVERSITY OF WASHINGTON, WA$264,750ZRG1
2021Elevated locus coeruleus metabolism as mechanism driving Alzheimer's disease pathology1R21AG074220-01JACOBS, HEIDI IRMAMASSACHUSETTS GENERAL HOSPITAL, MA$260,146ZRG1
2021Alterations in Ventral Hippocampal CA1 Processing as a Mechanism for Anxiety in Alzheimer’s Disease1R21AG070880-01MASURKAR, ARJUN VIJAYNEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$254,250ZRG1
2021Novel Spectral Biomarkers for Alzheimer's Disease1R21AG070972-01MCMURRAY, CYNTHIA THERESEUNIVERSITY OF CALIF-LAWRENC BERKELEY LAB, CA$252,345ZRG1
2021Validation of a Virtual Reality Floor Maze Test to Detect Early Signs of Cognitive Impairment1R21AG072469-01MARTELLI, DARIOUNIVERSITY OF ALABAMA IN TUSCALOOSA, AL$248,407CP
2021PET Imaging for neuroinflammation in Alzheimer's disease1R21AG074218-01LIANG, STEVEN HMASSACHUSETTS GENERAL HOSPITAL, MA$246,560CNN
2021Combining information from multiple circadian activity rhythm metrics to optimally detect mild cognitive impairment using a consumer wearable1R21AG074094-01SMAGULA, STEPHEN FUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$245,140APDA
2021Immunoprofiling postoperative delirium during aging and neurodegeneration1R21AG074232-01GELBARD, HARRIS ATERRANDO, NICCOLOUNIVERSITY OF ROCHESTER, NY$239,843CDIN
2021Infectious Influence: Using fate mapping to determine the impact of viral infection sites on Alzheimer's disease initiation1R21AG074324-01MOSEMAN, E. ASHLEYDUKE UNIVERSITY, NC$237,829ZRG1
2021Identification of intrinsic and extrinsic regulators of TDP43 splicing function1R21AG070619-01ROHATGI, RAJATSTANFORD UNIVERSITY, CA$236,288MNG
2021Characterization of Orexin/Hypocretin Kinetics in Alzheimer's Disease1R21AG074151-01LUCEY, BRENDAN PATRICKWASHINGTON UNIVERSITY, MO$236,250CNN
2021Interplay between amyloid precursor protein metabolism and ER-mitochondria contact1R21AG074414-01LU, BINGWEISTANFORD UNIVERSITY, CA$236,100MBPP
2021The role of NMDA receptor subunit GluN3A in age and Alzheimer's disease-related dementia1R21AG067473-01A1YU, SHAN P.EMORY UNIVERSITY, GA$234,750NOMD
2021Cost effective Electroencephalography sensor for monitoring sleep disruption in early stages of Alzheimer's disease1R21AG072517-01WU, JIAN-YOUNGGEORGETOWN UNIVERSITY, DC$234,000ZRG1
2021Synergistic effect of APOE genotype and obesity in CNS inflammation and risk of Alzheimer's disease1R21AG074139-01REBECK, G WILLIAMGEORGETOWN UNIVERSITY, DC$234,000CDIN
2021Drug Discovery for Alzheimer’s Disease Enabled by Multi-Omics and Artificial Intelligence1R21AG074234-01MEYER, JESSEMEDICAL COLLEGE OF WISCONSIN, WI$234,000MNG
2021Sexual Dimorphism in Cerebral Amyloid Angiopathy and Vascular Dementia: Investigating the Role of Fibrinolytic System1R21AG070860-01A1MANWANI, BHARTIUNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TX$234,000CDIN
2021Deciphering the non-canonical function of the histone methyltransferase G9a in the etiology of AD1R21AG071229-01CHEN, XIANUNIV OF NORTH CAROLINA CHAPEL HILL, NC$233,250MNG
2021Altered Diversity of Astrocyte sub-types and Signaling Capabilities in Alzheimer's Disease1R21AG074293-01ASRICAN, BRENTUNIV OF NORTH CAROLINA CHAPEL HILL, NC$233,250CMBG
2021Validation of the DCTclock drawing task as a cognitive screening tool for prodromal Alzheimers disease in the Framingham Heart Study1R21AG072588-01THOMPSON, LOUISABROWN UNIVERSITY, RI$231,533CP
2021Development of in vivo quantitative stable isotope probing to quantify microbiome dynamics in Alzheimers Disease1R21AG074203-01COPE, EMILY KNORTHERN ARIZONA UNIVERSITY, AZ$228,000CDIN
2021Understanding the relationship between female reproductive span and dementia risk1R21AG074212-01PANIZZON, MATTHEW SUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$226,840NAME
2021Linked Lives, Linked Health: Health Trajectories of Persons with Cognitive Impairment and Their Caregivers' Health1R21AG074238-01ZANG, EMMAYALE UNIVERSITY, CT$223,942SSPA
2021How Distinct are the two Chiral Sulfur Epimers of Amyloid Beta Met35 Sulfoxide in their Aggregation, Toxicity and Reactivity with Methionine Sulfoxide Reductases A and B?1R21AG070888-01RASKATOV, JEVGENIJUNIVERSITY OF CALIFORNIA SANTA CRUZ, CA$222,329MSFA
2021The Effect of De-Prescribing Antipsychotics on Health and Quality of Life for People with Dementia1R21AG070942-01SACARNY, ADAM JONCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$217,583HSOD
2021Investigating the Effects of APOE Genotype on AD Pathology in a Novel AD Mouse Model1R21AG074308-01GUO, JIANURIEL, TALCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$202,500CDIN
2021Multiclass classification under prioritized error control and specific error costs with applications to dementia classification1R21AG074205-01FENG, YANGNEW YORK UNIVERSITY, NY$199,405BMRD
2021The Role of COVID-19 Endothelial Cell Dysfunction and Hypercoagulability in the Development of Post-ICU Cognitive Impairment and Dementia1R21AG074179-01WANG, SOPHIAINDIANA UNIVERSITY INDIANAPOLIS, IN$198,125ZRG1
2021Preventing Alzheimer's Disease with Designer Lipids1R21AG074331-01SCOTT, ALISON JUNIVERSITY OF MARYLAND BALTIMORE, MD$193,125ZRG1
2021Social spatial navigation assessment for early-stage Alzheimer's disease1R21AG070877-01ARZY, SHAHARMARSHALL, GAD ASHERSPIERS, HUGOBRIGHAM AND WOMEN'S HOSPITAL, MA$190,054APDA
2021Neuroimage-driven biophysical inverse problems for atrophy and tau propagation1R21AG074276-01BIROS, GEORGEUNIVERSITY OF TEXAS AT AUSTIN, TX$183,464ZRG1
2021Helping the helpers: User-centered technology to aid caregiver management of medications for people with ADRD1R21AG072418-01HOLDEN, RICHARD JWERNER, NICOLE EUNIVERSITY OF WISCONSIN-MADISON, WI$148,650CMPC
2021Development of an Intervention for Long-Distance Caregivers1R21AG069019-01A1CIMAROLLI, VERENALEADINGAGE, INC., DC$141,024SPIP
2021Targeting Whole-body Fatty Acid Metabolism in Alzheimer’s Disease, with Special Interest in Lauric acid1R21AG072561-01GU, HAIWEIJENTARRA, GARILYN MARIEARIZONA STATE UNIVERSITY-TEMPE CAMPUS, AZ$1ZRG1
2020Evolving CRISPR-based platforms for the discovery of Alzheimer relevant neurodegenerative pathways1R21AG069183-01MUCKE, LENNARTJ. DAVID GLADSTONE INSTITUTES, CA$519,750ZRG1
2020Determining neuroprotective autophagy functions using different types of human neurons1R21AG067570-01YANG, NANYUE, ZHENYUICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$466,125CMND
2020Exploring the Relationship Between Tau Deposition and Neurovascular Health in Alzheimer's Disease1R21AG067562-01HUANG, SUSIE YIYEN, YI-FENMASSACHUSETTS GENERAL HOSPITAL, MA$462,000ZRG1
2020Correction of Partial Volume Effects in PET for Alzheimer's Disease Using Unsupervised Deep Learning1R21AG067422-01GONG, KUANGMASSACHUSETTS GENERAL HOSPITAL, MA$452,956EITA
2020Brain microbial proteome in normal aging and Alzheimer's disease1R21AG067400-01VEGA, IRVING EMICHIGAN STATE UNIVERSITY, MI$444,134ZRG1
2020A Novel Animal Model of Late Onset Alzheimer's Disease1R21AG067340-01GOTTSCHALK, WILLIAM KIRBYDUKE UNIVERSITY, NC$442,750CDIN
2020Hyper phosphorylation and the plexin CRMP scaffold in Alzheimers Disease1R21AG069268-01BUCK, MATTHIASCASE WESTERN RESERVE UNIVERSITY, OH$442,750BPNS
2020tRNA-derived RNA Fragments, A New Regulator for Alzheimer's Disease1R21AG069226-01BAO, XIAOYONGUNIVERSITY OF TEXAS MED BR GALVESTON, TX$434,500ZRG1
2020Characterization of Neurofilament Light Chain in Alzheimer's Disease and Other Neurodegenerative Disorders1R21AG067559-01BATEMAN, RANDALL JWASHINGTON UNIVERSITY, MO$432,938ZRG1
2020NF-κB as a driver of neurotoxic astrocytes in Alzheimers disease1R21AG069081-01LAFERLA, FRANK MUNIVERSITY OF CALIFORNIA-IRVINE, CA$431,750CMBG
2020Regulation of microglia by tissue stiffness and Piezo1 in Alzheimer's disease1R21AG069067-01LIU, WENDYUNIVERSITY OF CALIFORNIA-IRVINE, CA$431,750CMBG
2020Personalized predictions of biomarker progression in Alzheimer's disease1R21AG067442-01WEICKENMEIER, JOHANNESTHE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY, NJ$424,050CNN
2020Involvement of an ER to lysosome signaling axis in the onset of neurodegeneration in models of AD1R21AG067414-01VENKATACHALAM, KARTIKUNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TX$421,329SYN
2020Understanding the influence of FTDP-17 mutation on human tau circular RNA formation and function to develop treatment options1R21AG067438-01STAMM, STEFANUNIVERSITY OF KENTUCKY, KY$420,750CMND
2020Branched-chain amino acids as a novel biomarker and treatment for Alzheimer's disease1R21AG069140-01HEGDE, VIJAY KARKALSHIN, ANDREW CHANGHUNTEXAS TECH UNIVERSITY, TX$415,355ZRG1
2020Structural transformations of dementia-related proteins: droplets, gels and amyloids1R21AG069064-01DEBELOUCHINA, GALIAUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$413,431MSFB
2020Genetic analysis of mitochondria-dependent cellular toxicity of alpha-synuclein1R21AG067446-01ZHONG, QUANWRIGHT STATE UNIVERSITY, OH$412,500CMAD
2020Ceramide Signaling in AD Pathogenesis1R21AG067443-01BHAT, NARAYAN RMEDICAL UNIVERSITY OF SOUTH CAROLINA, SC$411,125ZRG1
2020Development of in vitro disease-relevant strains of tau1R21AG069112-01GAMBLIN, TRUMAN CUNIVERSITY OF TEXAS SAN ANTONIO, TX$404,500BPNS
2020Identifying Metabolomic Risk Factors in Plasma and Cerebrospinal Fluid for Alzheimer's Disease1R21AG067092-01LU, QIONGSHIUNIVERSITY OF WISCONSIN-MADISON, WI$374,959ZRG1
2020Pregnancy complications and the development of Alzheimer's disease and related dementias in women in the Adult Changes in Thought study1R21AG069111-01MILLER, ELIZA CCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$316,973ZRG1
2020Role of Senescent T cells in Alzheimer's Disease1R21AG067441-01PENG, GUANGYONGSAINT LOUIS UNIVERSITY, MO$285,918ZRG1
2020Validation of The Environmental Audit Scoring Evaluation (EASE) Tool1R21AG067010-01KAUP, MIGETTEKANSAS STATE UNIVERSITY, KS$246,388CIHB
2020Modulation of TGF-beta signaling by omega-6 polyunsaturated fatty acids for treating Alzheimer's disease1R21AG069100-01MA, QIULANUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$234,000ZRG1
2020The Effects of Cognitive Map Building on the Development of Alzheimer's Disease1R21AG069267-01KENNEDY, KRISTEN M.YUAN, MAYUNIVERSITY OF TEXAS DALLAS, TX$229,500NAME
2020Cellular Mechanism underlying emotional problems of Alzheimer's disease1R21AG067445-01LIU, MENGMEDICAL UNIVERSITY OF SOUTH CAROLINA, SC$224,250ZRG1
2020Functional assessment of 1,500 human genes against coexistent Abeta and tau pathology in vivo1R21AG069050-01RINCON-LIMAS, DIEGO EUNIVERSITY OF FLORIDA, FL$221,586CMND
2020Refining a Driving Cessation Management Intervention for Person with Dementia and their Family Caregivers: CarFreeMe1R21AG067537-01GAUGLER, JOSEPH E.UNIVERSITY OF MINNESOTA, MN$195,033APDA
2019The molecular mechanism of PICALM-dependent endosomal trafficking1R21AG066090-01ZHAO, ZHENUNIVERSITY OF SOUTHERN CALIFORNIA, CA$247,500ZRG1
2019Decoding Early Signs of Alzheimer's Disease in The Lateral Entorhinal Cortex Using Machine Learning1R21AG066168-01HUSSAINI, S. ABIDCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$243,000CDIN
2019Sex hormones, inflammation, and cognitive decline in older men and women1R21AG066140-01KNIGHT, ERIK LPENNSYLVANIA STATE UNIVERSITY, THE, PA$239,790ZRG1
2019Gene co-expression underlying the connectomic alterations in Alzheimer's disease1R21AG066135-01YAN, JINGWENINDIANA UNIVERSITY INDIANAPOLIS, IN$194,366MNG

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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