The notices it replaced
- Reissues: PA-16-141 Development of Animal Models and Related Biological Materials for Research (R21)
- 2 steps back: PA-13-145 Development of Animal Models and Related Biological Materials for Research (R21)
- 3 steps back: PA-10-138 Development of Animal Models and Related Biological Materials For Research (R21)
- 4 steps back: PA-07-336 Development of Animal Models and Related Biological Materials For Research (R21)
Replaced by PAR-21-167.
Who won it before
87 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $19,073,753 in first-year total cost, median $222,750.
Most frequent study sections
- Development - 2 Study Section[DEV2]11
- Therapeutic Approaches to Genetic Diseases Study Section[TAG]9
- Molecular Neurogenetics Study Section[MNG]5
- Arthritis, Connective Tissue and Skin Study Section[ACTS]4
- Genetics of Health and Disease Study Section[GHD]4
Most frequent institutions
- JACKSON LABORATORY4
- STANFORD UNIVERSITY4
- UNIVERSITY OF MICHIGAN AT ANN ARBOR4
- MEDICAL COLLEGE OF WISCONSIN3
- OHIO STATE UNIVERSITY3
| FY | Project | PIs | Institution | First-year cost | Study section |
|---|---|---|---|---|---|
| 2022 | Direct generation of complex genetically-modified mouse models via embryonic stem cells1R21OD031973-01 | WEN, DUANCHENG | WEILL MEDICAL COLL OF CORNELL UNIV, NY | $254,250 | DEV1 |
| 2022 | Genetic and genomic tools for C. briggsae research1R21OD030067-01A1 | ANDERSEN, ERIK CHRISTIANCHAMBERLIN, HELEN M | OHIO STATE UNIVERSITY, OH | $242,593 | GVE |
| 2022 | A novel mouse model to distinguish the specific physiological significance of RNAi and biophysical mechanisms of microRNA1R21OD031965-01 | FU, JIDONG | OHIO STATE UNIVERSITY, OH | $236,250 | MPPA |
| 2022 | mtDNA depleter mouse for decoding mitochondrial regulation of diverse organs1R21OD031970-01 | SINGH, KESHAV K | UNIVERSITY OF ALABAMA AT BIRMINGHAM, AL | $222,750 | TAG |
| 2022 | Developing a new chordate model for stem cell biology and regeneration1R21OD030520-01A1 | DE TOMASO, ANTHONY W | UNIVERSITY OF CALIFORNIA SANTA BARBARA, CA | $183,927 | DEV2 |
| 2021 | Generating mtDNA mutant mice to model human mitochondrial diseases1R21OD030076-01 | FAN, WEIWEI | SALK INSTITUTE FOR BIOLOGICAL STUDIES, CA | $285,000 | TAG |
| 2021 | Building transgenic tools in Acomys cahirinus, an emerging model for mammalian regenerative biology and healthy aging1R21OD030107-01 | MILLEN, KATHLEEN JOYCE | SEATTLE CHILDREN'S HOSPITAL, WA | $282,750 | DEV2 |
| 2021 | Collagen XVII unmasking in Parkinson's disease and scratching1R21OD030057-01A1 | AMBER, KYLE T. | RUSH UNIVERSITY MEDICAL CENTER, IL | $249,750 | ACTS |
| 2021 | Establish a novel mouse model tracking multiple extracellular vesicles1R21OD031906-01 | NAKAMURA, TAKAHISA | CINCINNATI CHILDRENS HOSP MED CTR, OH | $238,500 | BMDM |
| 2021 | Frequent concatemeric insertions during AAV6/Cas9-mediated genome editing: Detection and Prevention1R21OD030529-01 | MAJETI, RAVINDRANAKAUCHI, HIROMITSU | STANFORD UNIVERSITY, CA | $236,936 | TAG |
| 2021 | Generate Zebrafish Conditional Knockout Model for Ciliopathy Research1R21OD030065-01A1 | PARANT, JOHN M | UNIVERSITY OF ALABAMA AT BIRMINGHAM, AL | $222,750 | TAG |
| 2021 | Advanced Image Analysis Tools for Super-Resolved MRI in Small Animals1R21OD030163-01A1 | PHAM, DZUNG L | HENRY M. JACKSON FDN FOR THE ADV MIL/MED, MD | $218,013 | ITD |
| 2021 | Understanding SHRF, an RNA exosome-linked disease with multi-organ involvement1R21OD030077-01 | LU, BINGWEI | STANFORD UNIVERSITY, CA | $197,032 | MGB |
| 2021 | Pathogenesis of HIV and HBV Co-Infection in a Humanized Mouse Model1R21OD030204-01A1 | AMBROSE, ZANDREAGUO, HAITAO | UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA | $195,625 | HCAC |
| 2021 | Host genetic variation affecting the microbiome in rhesus macaques1R21OD030072-01A1 | VALLENDER, ERIC J. | UNIVERSITY OF MISSISSIPPI MED CTR, MS | $193,750 | GVE |
| 2020 | The Burmese Python as a Model System for the Study of Metabolism and Organ Regeneration1R21OD029996-01 | SAEIDI, NIMASTYLOPOULOS, NICHOLAS | BOSTON CHILDREN'S HOSPITAL, MA | $279,368 | IPOD |
| 2020 | Mouse models for decoding microRNA regulation in diverse tissues and cell types1R21OD029999-01 | MACRAE, IAN JOHN | SCRIPPS RESEARCH INSTITUTE, THE, CA | $266,250 | MGB |
| 2020 | Anastasis biosensor for tracking reversal of apoptosis in vivo1R21OD028764-01 · under PA-16-141 | TANG, HO LAM | JOHNS HOPKINS UNIVERSITY, MD | $237,338 | CMT |
| 2020 | Bellymount: A platform for ultra-long term imaging of abdominal organs in live adult Drosophila1R21OD028273-01 · under PA-16-141 | O'BRIEN, LUCY ERIN | STANFORD UNIVERSITY, CA | $236,550 | DEV2 |
| 2020 | A comprehensive toolkit to visualize endogenously tagged fluorescent basement membrane components in a living animal1R21OD028766-01 · under PA-16-141 | SHERWOOD, DAVID R | DUKE UNIVERSITY, NC | $233,968 | ZRG1 |
| 2020 | Developing zebra finch transgenic lines with functional receptors for VSV-G-pseudotyped lentiviruses1R21OD028774-01 · under PA-16-141 | MELLO, CLAUDIO V | OREGON HEALTH & SCIENCE UNIVERSITY, OR | $231,000 | MNG |
| 2020 | Development of an exosome and cargo tracking mouse1R21OD028749-01 · under PA-16-141 | ZEMPLENI, JANOS | UNIVERSITY OF NEBRASKA LINCOLN, NE | $222,750 | ICI |
| 2020 | Optimization of homology-directed repair in zebrafish1R21OD030004-01 | LAWSON, NATHAN D | UNIV OF MASSACHUSETTS MED SCH WORCESTER, MA | $209,375 | DEV2 |
| 2020 | Selectable non-mosaic embryo editing1R21OD030009-01 | NAKAUCHI, HIROMITSU | STANFORD UNIVERSITY, CA | $202,122 | TAG |
| 2020 | Derivation of chimera competent pig embryonic stem cells under a novel condition1R21OD028763-01 · under PA-16-141 | WU, JUN | UT SOUTHWESTERN MEDICAL CENTER, TX | $163,416 | DEV2 |
| 2019 | Development and Validation of a Novel Cas13a and Nanoparticle Guide-RNA Delivery System that Allows Precise Ablation of Host Macrophage Populations in a Humanized Mouse Model1R21OD027052-01 · under PA-16-141 | WILES, MICHAEL VAN | JACKSON LABORATORY, ME | $269,900 | TAG |
| 2019 | Germ cell preservation of immunodeficient pigs utilizing embryo complementation approach1R21OD027062-01 · under PA-16-141 | LEE, KIHO | VIRGINIA POLYTECHNIC INST AND ST UNIV, VA | $241,500 | CMIR |
| 2019 | In situ imaging of collagen degradation activity in multiple myeloma and lung fibrosis mouse model1R21OD026618-01A1 · under PA-16-141 | YOON, DONGHOONYU, MICHAEL S | UNIVERSITY OF UTAH, UT | $240,000 | IPCA |
| 2019 | Tandem Genetically Encoded Voltage and Calcium Indicator Mice for Optical Physiology of Excitable Cells1R21OD025345-01A1 · under PA-16-141 | THOMPSON, CHRISTOPHER H | NORTHWESTERN UNIVERSITY AT CHICAGO, IL | $237,000 | NTRC |
| 2019 | A Single cell expression atlas of muscle and dermis during regeneration after wounding in Acomys cahirinus - an adult mammal model for de novo muscle regeneration1R21OD028209-01 · under PA-16-141 | BARBAZUK, WILLIAM B | UNIVERSITY OF FLORIDA, FL | $224,424 | ACTS |
| 2019 | Development of an in vitro mouse genetic reference platform to improve preclinical drug safety assessment1R21OD028216-01 · under PA-16-141 | MOSEDALE, MERRIE | UNIV OF NORTH CAROLINA CHAPEL HILL, NC | $223,571 | XNDA |
| 2019 | Hepatocyte-targeted somatic-cell genetic complementation in mice1R21OD026444-01A1 · under PA-16-141 | SCHMIDT, EDWARD E | MONTANA STATE UNIVERSITY - BOZEMAN, MT | $216,000 | HBPP |
| 2019 | Enhancing CRISPR-Cas for disease modeling in Xenopus1R21OD023810-01A1 · under PA-16-141 | HORB, MARKO E | MARINE BIOLOGICAL LABORATORY, MA | $207,500 | DEV1 |
| 2019 | Rapid production and dissemination of intersectional genetic alleles for the study of nervous system circuit development and function in the mouse.1R21OD025327-01A1 · under PA-16-141 | RAY, RUSSELL S | BAYLOR COLLEGE OF MEDICINE, TX | $198,125 | MNG |
| 2019 | Rapid Fluorescent Tagging of Endogenous Proteins in Mouse Models1R21OD027053-01 · under PA-16-141 | HE, LIN | UNIVERSITY OF CALIFORNIA BERKELEY, CA | $196,250 | TAG |
| 2019 | Genetic Modification to Harness the Regenerative Power of the African Spiny Mouse1R21OD028211-01 · under PA-16-141 | TERADA, NAOHIRO | UNIVERSITY OF FLORIDA, FL | $190,625 | ACTS |
| 2019 | Image-guided robot for high-throughput microinjection of Drosophila embryos1R21OD028214-01 · under PA-16-141 | GOHL, DARYLKODANDARAMAIAH, SUHASA B | UNIVERSITY OF MINNESOTA, MN | $184,118 | ISD |
| 2018 | Rapid In Vivo Modeling of Developmental Disorders1R21OD024941-01 · under PA-16-141 | MURRAY, STEPHEN A | JACKSON LABORATORY, ME | $262,500 | GHD |
| 2018 | Improved Mouse Modeling of 25 to 300-Kilobase-Scale Human Genomic Structural Variation by CRISPR/Cas9-Stimulated Homologous Recombination of BacterialArtificial Chromosome Vectors (CRISPR/BAC/HR)1R21OD023803-01A1 · under PA-16-141 | BERGSTROM, DAVID ERIC | JACKSON LABORATORY, ME | $254,375 | GHD |
| 2018 | Sry transgenic rats for investigation of XX vs. XY differences in phenotypes1R21OD026560-01 · under PA-16-141 | ARNOLD, ARTHUR PDWINELL, MELINDA RGEURTS, ARON M | UNIVERSITY OF CALIFORNIA LOS ANGELES, CA | $246,045 | CMIR |
| 2018 | Generation and characterization of a novel cell subpopulation ablation model1R21OD024931-01A1 · under PA-16-141 | QIN, XUEBIN | TEMPLE UNIV OF THE COMMONWEALTH, PA | $237,750 | HAI |
| 2018 | Engraftment of human hematopoietic stem cells to immunodeficient rabbits1R21OD024789-01A1 · under PA-16-141 | BILITY, MOSES TURKLEXU, JIE | UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI | $207,999 | TTT |
| 2018 | Establish a zebrafish genetic mosaic system for disease modeling and developmental biology1R21OD026524-01 · under PA-16-141 | ZONG, HUI | UNIVERSITY OF VIRGINIA, VA | $201,875 | NCF |
| 2018 | A New Method for Mosaic Analysis of Clonal Mutations in Mice1R21OD023822-01A1 · under PA-16-141 | ZHUANG, YUAN | DUKE UNIVERSITY, NC | $199,479 | CMIA |
| 2018 | Animal Models for SCN2A Neurodevelopmental Disorders1R21OD025330-01 · under PA-16-141 | KEARNEY, JENNIFER A | NORTHWESTERN UNIVERSITY AT CHICAGO, IL | $197,500 | NDPR |
| 2018 | Characterization of split-GAL4 driver expression in the Drosophila intestine at the Bloomington Drosophila Stock Center1R21OD026525-01 · under PA-16-141 | COOK, KEVIN RSOKOL, NICHOLAS | TRUSTEES OF INDIANA UNIVERSITY, IN | $196,875 | DEV2 |
| 2018 | Using cortico-striatal evolutionary innovations for modeling Huntington's disease1R21OD025320-01 · under PA-16-141 | MEHLER, MARK F | ALBERT EINSTEIN COLLEGE OF MEDICINE, INC, NY | $105,902 | MNG |
| 2018 | Generation of novel Fn1-fluorescent fusion proteins in vivo for the investigation of cell-ECM dynamics in real time1R21OD025323-01 · under PA-16-141 | ASTROF, SOPHIE | THOMAS JEFFERSON UNIVERSITY, PA | $45,845 | ICI |
| 2017 | New transgenic tools for mammalian fibrosis and regenerative repair research1R21OD023838-01 · under PA-16-141 | MILLEN, KATHLEEN JOYCENELSON, BRANDEN R | SEATTLE CHILDREN'S HOSPITAL, WA | $274,883 | ACTS |
| 2017 | Identifying the genetic changes which induce tissue and organ regeneration in a novel mammalian model system.1R21OD023210-01 · under PA-13-145 | MADEN, MALCOLM | UNIVERSITY OF FLORIDA, FL | $253,531 | GCAT |
| 2017 | Optimization of Targeted Nuclease Mediated HDR Events in Inbred Mouse Zygotes1R21OD023800-01 · under PA-16-141 | WILES, MICHAEL VAN | JACKSON LABORATORY, ME | $249,375 | TAG |
| 2017 | Proximity- and complementation-based analysis of signaling complexes1R21OD023204-01 · under PA-13-145 | SOKOL, SERGEI | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY | $201,281 | ICI |
| 2017 | Resource for marking clones on the fly 4th chromosome1R21OD024794-01 · under PA-16-141 | NEWFELD, STUART J | ARIZONA STATE UNIVERSITY-TEMPE CAMPUS, AZ | $196,805 | DEV2 |
| 2017 | A light-inducible protein trapping system for studying cellular dynamics in Drosophila1R21OD023824-01A1 · under PA-16-141 | HAN, CHUN | CORNELL UNIVERSITY, NY | $187,338 | MNG |
| 2017 | Development of conditional and inducible gene targeting tools in rabbits1R21OD023194-01A1 · under PA-16-141 | XU, JIE | UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI | $184,063 | TAG |
| 2017 | Development of Mas Receptor Knockout Rat Resource1R21OD024781-01 · under PA-16-141 | LOMBARD, JULIAN H | MEDICAL COLLEGE OF WISCONSIN, WI | $182,875 | HM |
| 2016 | Developing techniques to generate the first transgenic opossums1R21OD022988-01 · under PA-13-145 | SEARS, KAREN E | UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL | $237,900 | DEV1 |
| 2016 | RESOLVING COMPLEX SYSTEMIC ENDOGENOUS EXPRESSION PATTERNS INTO SUBCELLULAR HIGH-RESOLUTION LOCALIZATION1R21OD022981-01 · under PA-13-145 | VENKEN, KOEN JOZEF THEO | BAYLOR COLLEGE OF MEDICINE, TX | $237,750 | MGA |
| 2016 | Development of mouse models for autoinflammatory rare diseases1R21OD019928-01A1 · under PA-13-145 | KIM, DO-HYUNG | UNIVERSITY OF MINNESOTA, MN | $228,000 | HAI |
| 2016 | Investigating the Effects of Reducing Nonsense-Mediated mRNA Decay Efficiency1R21OD019922-01A1 · under PA-13-145 | KEELING, KIM MARIE | UNIVERSITY OF ALABAMA AT BIRMINGHAM, AL | $220,500 | MGA |
| 2016 | Novel Mouse Resources for Diabetic Nephropathy1R21OD021437-01 · under PA-13-145 | KOBAYASHI, AKIO | UNIVERSITY OF WASHINGTON, WA | $217,500 | KMBD |
| 2016 | T cell-tissue interaction models1R21OD020185-01A1 · under PA-13-145 | BROWN, BRIAN D | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY | $211,875 | CMIB |
| 2016 | A novel rabbit model of cystic fibrosis1R21OD020187-01A1 · under PA-13-145 | XU, JIE | UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI | $193,750 | LCMI |
| 2015 | Identification of autophagy mediators through screening transgenic animal library1R21OD018265-01A1 · under PA-13-145 | LEE, JUN HEE | UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI | $266,040 | CSRS |
| 2015 | Characterization of a Temporally Controlled Dominant-Negative RB1 Mouse Model1R21OD019745-01A1 · under PA-13-145 | ROCHA-SANCHEZ, SONIA M | CREIGHTON UNIVERSITY, NE | $226,960 | AUD |
| 2015 | Targeting non-HIF-mediated regulators of hypoxic responses1R21OD019932-01 · under PA-13-145 | BAKER, KEITH D | VIRGINIA COMMONWEALTH UNIVERSITY, VA | $219,030 | CSRS |
| 2015 | Dissecting Distinct and Redundant Roles of ThPOK and LRF, Key Regulators of Hematopoiesis1R21OD017958-01A1 · under PA-13-145 | KAPPES, DIETMAR J | RESEARCH INST OF FOX CHASE CAN CTR, PA | $218,663 | ZRG1 |
| 2015 | Exome screening and directed breeding of rhesus for human genetic disease models1R21OD019930-01A1 · under PA-13-145 | JOHNSON, R. PAULNORGREN, ROBERT B. | UNIVERSITY OF NEBRASKA MEDICAL CENTER, NE | $216,028 | GHD |
| 2015 | CRISPR/Cas9 guided production of genetically engineered pigs lacking CD8+ T-cells1R21OD019934-01A1 · under PA-13-145 | LEE, KIHOYUAN, LIJUAN | VIRGINIA POLYTECHNIC INST AND ST UNIV, VA | $197,225 | CMIA |
| 2015 | Development of mouse strains with human-like telomerase regulation1R21OD021432-01 · under PA-13-145 | ZHU, JIYUE | WASHINGTON STATE UNIVERSITY, WA | $184,975 | CMAD |
| 2015 | Novel Transgenic Mouse Models for L1 Retrotransposons in Development and Disease1R21OD017965-01A1 · under PA-13-145 | AN, WENFENG | SOUTH DAKOTA STATE UNIVERSITY, SD | $178,850 | CMIR |
| 2014 | CHD5 dosage in epigenetic control of Cancer, Infertility, and Autism1R21OD018332-01 · under PA-13-145 | MILLS, ALEA A. | COLD SPRING HARBOR LABORATORY, NY | $283,500 | GHD |
| 2014 | Non-Human Primate Model for Systems Biology Studies of Stress Response1R21OD017959-01 · under PA-10-138 | JASINSKA, ANNA JOANNA | UNIVERSITY OF CALIFORNIA LOS ANGELES, CA | $269,500 | BRLE |
| 2014 | Light-inducible Cre Transgenic Mouse Models1R21OD019764-01 · under PA-13-145 | BEHRINGER, RICHARD R | UNIVERSITY OF TX MD ANDERSON CAN CTR, TX | $240,000 | DEV2 |
| 2014 | Experimental Strategies for Light-Induced Elimination of Protein Function in vivo1R21OD017964-01 · under PA-10-138 | STEIN, DAVID S. | UNIVERSITY OF TEXAS AT AUSTIN, TX | $231,750 | DEV2 |
| 2014 | Development of humanized TLR4 SNP mouse models1R21OD017233-01A1 · under PA-13-145 | HAJJAR, ADELINE M | UNIVERSITY OF WASHINGTON, WA | $231,750 | IHD |
| 2014 | Developing models for identification of therapeutic cell populations1R21OD017244-01A1 · under PA-13-145 | ZIOUZENKOVA, OULIANA ZIOUZENKOVA | OHIO STATE UNIVERSITY, OH | $230,250 | ZRG1 |
| 2014 | Model for evaluation of FCGR variants in disease and response to therapeutics1R21OD012234-01A1 · under PA-10-138 | KOLLER, BEVERLY H | UNIV OF NORTH CAROLINA CHAPEL HILL, NC | $228,000 | CII |
| 2014 | Assembly of disease-relevant pathways in the mouse1R21OD016565-01A1 · under PA-10-138 | KOLLER, BEVERLY H | UNIV OF NORTH CAROLINA CHAPEL HILL, NC | $228,000 | MNG |
| 2014 | Seq-ing the etiology of birth defects in a new frog model, Lepidobatrachus laevis1R21OD017963-01A1 · under PA-13-145 | NASCONE-YODER, NANETTE M | NORTH CAROLINA STATE UNIVERSITY RALEIGH, NC | $227,250 | DEV2 |
| 2014 | Generation of a Transgenic Mouse Model to Study Human TLR9 Role in Disease1R21OD018317-01 · under PA-13-145 | GUIDUCCI, CRISTIANA | DYNAVAX TECHNOLOGIES CORPORATION, CA | $227,161 | III |
| 2014 | Gene targeting in zebrafish: building models to assay disease genes1R21OD018323-01 · under PA-13-145 | GRUNWALD, DAVID J. | UNIVERSITY OF UTAH, UT | $223,500 | DEV2 |
| 2014 | Humanized mice to study mast cell function1R21OD017843-01A1 · under PA-10-138 | ALI, HYDAR | UNIVERSITY OF PENNSYLVANIA, PA | $200,000 | LCMI |
| 2014 | Development of RhoA Optical Sensor Mice for Novel Vascular Smooth Muscle Studies1R21OD018315-01 · under PA-13-145 | RIZZO, MEGAN AWIER, WITHROW GIL | UNIVERSITY OF MARYLAND BALTIMORE, MD | $191,875 | MEDI |
| 2014 | Oxidant Stress in the Nrf2 Knockout Rat1R21OD018309-01 · under PA-13-145 | LOMBARD, JULIAN H | MEDICAL COLLEGE OF WISCONSIN, WI | $191,250 | HM |
| 2014 | Differentiation of mitochondrial vs. nuclear function of telomerase1R21OD018306-01 · under PA-13-145 | BEYER, ANDREAS M | MEDICAL COLLEGE OF WISCONSIN, WI | $191,250 | VCMB |
| 2014 | Mechanisms of PGRMC2 action in female reproduction1R21OD016564-01A1 · under PA-13-145 | PRU, JAMES K | WASHINGTON STATE UNIVERSITY, WA | $166,349 | ICER |
Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.