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NIH funding notice PAR-21-167

Development of Animal Models and Related Biological Materials for Research (R21 Clinical Trial Not Allowed)

Closed on November 14, 2024.

Posted
March 17, 2021
Close date
November 14, 2024
Activity codes
R21
Institutes taking part
ORIP

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

  1. Reissues: PAR-19-369 Development of Animal Models and Related Biological Materials for Research (R21 Clinical Trial Not Allowed)
  2. 2 steps back: PA-16-141 Development of Animal Models and Related Biological Materials for Research (R21)
  3. 3 steps back: PA-13-145 Development of Animal Models and Related Biological Materials for Research (R21)
  4. 4 steps back: PA-10-138 Development of Animal Models and Related Biological Materials For Research (R21)
  5. 5 steps back: PA-07-336 Development of Animal Models and Related Biological Materials For Research (R21)

Replaced by PAR-25-273.

Who won it before

135 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $30,362,311 in first-year total cost, median $228,000.

Most frequent study sections

  1. Therapeutic Approaches to Genetic Diseases Study Section[TAG]18
  2. Development - 2 Study Section[DEV2]15
  3. Development - 1 Study Section[DEV1]7
  4. Genomics, Computational Biology and Technology Study Section[GCAT]5
  5. Molecular Neurogenetics Study Section[MNG]5

Most frequent institutions

  1. JACKSON LABORATORY6
  2. BAYLOR COLLEGE OF MEDICINE5
  3. STANFORD UNIVERSITY5
  4. UNIVERSITY OF MICHIGAN AT ANN ARBOR5
  5. CINCINNATI CHILDRENS HOSP MED CTR4
Competing awards under PAR-21-167 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2025Developing mouse models for functional studies of locus-specific DNA methylation1R21OD038402-01SHEN, LANLANBAYLOR COLLEGE OF MEDICINE, TX$395,450MG
2025The Mouse Model System for Targeted Trimming of Disease Susceptibility Loci1R21OD038406-01PETUKHOVA, GALINAHENRY M. JACKSON FDN FOR THE ADV MIL/MED, MD$261,017MG
2025Development of a Rat Model to Investigate the Physiology of Telomerase Reverse Transcriptase alternative splicing isoforms1R21OD037663-01A1BEYER, ANDREAS MLUDLOW, ANDREW TODDUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$259,423CMAD
2025Characterizing a novel mouse model linking sphingolipid metabolism to multi-organ fibrosis1R21OD037868-01SABA, JULIE DUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$246,000DBDT
2025MOLECULAR AND GENETIC CHARACTERIZATION OF EMS-INDUCED LETHAL MUTATIONS IN DROSOPHILA ENRICHED FOR ORTHOLOGS OF HUMAN DISEASE-CAUSING GENES1R21OD038417-01YAMAMOTO, SHINYABAYLOR COLLEGE OF MEDICINE, TX$240,750GCAT
2025A Novel Mouse Model for the Detection of Genome Editing1R21OD037647-01A1WALKEY, CHRISTOPHER JOHNBAYLOR COLLEGE OF MEDICINE, TX$240,039TAG
2025Generation and characterization of PET-reporter pigs for noninvasive imaging and cell therapy research1R21OD037856-01TELUGU, BHANU PRAKASHUNIVERSITY OF MISSOURI-COLUMBIA, MO$234,750TAG
2025Development of Transgenic Mouse Model Resources for Red Fluorescence-Based Genetically Encoded Indicator Studies1R21OD037867-01A1BAGHER, POONEHGURUMURTHY, CHANNABASAVAIAHUNIVERSITY OF NEBRASKA MEDICAL CENTER, NE$230,250ZRG1
2025Defining the ciliary proteomes in vivo1R21OD038399-01YODER, BRADLEY K.UNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$222,750CSF1
2025A modular system for murine CRISPR genome and epigenome editing1R21OD037909-01A1PU, WILLIAM TSWENCHINGBOSTON CHILDREN'S HOSPITAL, MA$222,500GCAT
2025Developing robust genome editing tools for generating floxed alleles and editing amino acid change in zebrafish1R21OD037634-01A1KANG, JUNSUUNIVERSITY OF WISCONSIN-MADISON, WI$194,375DEV2
2025Development of Mouse Models to Study the Role of Mechanotransduction in Disease Pathogenesis1R21OD037863-01A1RADICE, GLENN LAWRENCERHODE ISLAND HOSPITAL, RI$95,196ZRG1
2024Establishing Acomys as a genetic platform for regeneration research1R21OD036471-01MILLEN, KATHLEEN JOYCESEATTLE CHILDREN'S HOSPITAL, WA$293,550DEV2
2024Rapid Development of Mouse Resource Strains through the Application of Prime Editors1R21OD037653-01BERGSTROM, DAVID ERICJACKSON LABORATORY, ME$265,500GCAT
2024Rapid Generation of Transgenic Rhesus Macaques using a Safe-harbor Genomic Docking Site1R21OD037648-01BIMBER, BENJAMINBURWITZ, BENJAMIN JOREGON HEALTH & SCIENCE UNIVERSITY, OR$263,250TAG
2024Identifying non-human primate models for specific human microbiome traits1R21OD033659-01A1AMATO, KATHERINE RYANNORTHWESTERN UNIVERSITY, IL$246,020DHMI
2024Genetically enabling Hydra oligactis for comparative studies in development, regeneration and aging.1R21OD037741-01JULIANO, CELINAUNIVERSITY OF CALIFORNIA AT DAVIS, CA$241,500ZRG1
2024A validated mouse model of brown fat targeting1R21OD034470-01A1SANCHEZ-GURMACHES, JUANCINCINNATI CHILDRENS HOSP MED CTR, OH$240,750BMDM
2024Identifying the radioprotective potential of radiation-resistant fungi using Drosophila1R21OD034471-01A1COX, RACHEL TAFELHENRY M. JACKSON FDN FOR THE ADV MIL/MED, MD$239,363RTB
2024Novel Knock-in mtDNA Mouse Model to Study Mitochondrial Dysfunction1R21OD037651-01COPPOTELLI, GIUSEPPEROSS, JAIME MARIEUNIVERSITY OF RHODE ISLAND, RI$236,250CMAD
2024The Unilateral Mosaic (UMos): Novel tools to compartmentalize pathology and trace cellular interactions in mouse models of human disease1R21OD037879-01GLUDISH, DAVID WCORNELL UNIVERSITY, NY$235,500CMT
2024Multicolor mouse models to resolve hematopoietic stem and progenitor cells in vivo1R21OD037861-01TAMPLIN, OWEN JAMESUNIVERSITY OF WISCONSIN-MADISON, WI$217,533BBHV
2024Conditional Animal Models of mtDNA Disease1R21OD036173-01EKKER, STEPHEN CARLUNIVERSITY OF TEXAS AT AUSTIN, TX$198,750TAG
2024Deciphering mechanobiology in human diseases by developing a TMEM63B channelopathy mouse model1R21OD037849-01YANG, HUANGHEDUKE UNIVERSITY, NC$193,101CSF1
2024Targeted ingression of SNPs into the zebrafish genome1R21OD036481-01A1ESSNER, JEFFREY JIOWA STATE UNIVERSITY, IA$181,754MG
2023Novel humanized mouse model of mucosal immunity1R21OD032454-01A1PALUCKA, ANNA KAROLINAJACKSON LABORATORY, ME$291,555CMIB
2023Novel hematopoietic humanized mouse model to study CAR-T therapy-associated cytokine release syndrome1R21OD034476-01FAN, YONGALLEGHENY-SINGER RESEARCH INSTITUTE, PA$249,570CIC
2023Development of foundational building blocks for stable genetic modification of sea urchin embryos1R21OD034075-01HAMDOUN, AMRO MUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$237,000DEV1
2023Danionella cerebrum as a transparent vertebrate adult model for studying immune-related biological processes and diseases1R21OD033664-01A1LAM, PUI YINGMEDICAL COLLEGE OF WISCONSIN, WI$234,000DEV1
2023Establishment of xenopus stem cell lines1R21OD033669-01A1GOUIGNARD, NADEGEUNIVERSITY OF WISCONSIN MILWAUKEE, WI$231,000DEV1
2023Dissecting out differential molecular phenotypes across Lysine(K) AcetylTransferase mutations in mouse development1R21OD035421-01ARBOLEDA, VALERIE AUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$230,494TAG
2023CRISPR-Cas13d: Transgenic zebrafish lines toknockdown mRNA1R21OD034161-01BAZZINI, ARIELSTOWERS INSTITUTE FOR MEDICAL RESEARCH, MO$206,250GCAT
2023Illuminating gene therapy1R21OD034078-01MCMANUS, MICHAEL TUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$201,875TAG
2023A suite of conditional mouse models for secretome labeling1R21OD034455-01LONG, JONATHAN ZSTANFORD UNIVERSITY, CA$198,226EBIT
2023Increasing the efficiency and range of prime editing for disease modeling in zebrafish1R21OD033668-01A1SOLNICAKREZEL, LILIANNAWASHINGTON UNIVERSITY, MO$195,417TAG
2023A Novel Large Animal Model for Studying the Developmental Potential and Function of LGR5 Stem Cells in Vivo and in Vitro1R21OD034080-01PIEDRAHITA, JORGE ANORTH CAROLINA STATE UNIVERSITY RALEIGH, NC$190,000RIBT
2023Creation of Knockout Laboratory Opossums1R21OD034473-01VANDEBERG, JOHN LUNIVERSITY OF TEXAS RIO GRANDE VALLEY, TX$185,000DBD
2022Systematic functional study of 21st chromosome ortholog overexpression in C. elegans1R21OD032463-01PIERCE, JONATHAN THOMASUNIVERSITY OF TEXAS AT AUSTIN, TX$422,421TAG
2022A new mouse model to study GBA1 mutation-associated diseases with multiple organs involvement1R21OD033660-01LIU, CHUANJUSUN, YINGCINCINNATI CHILDRENS HOSP MED CTR, OH$258,500TAG
2022Direct generation of complex genetically-modified mouse models via embryonic stem cells1R21OD031973-01 · under PAR-19-369WEN, DUANCHENGWEILL MEDICAL COLL OF CORNELL UNIV, NY$254,250DEV1
2022Development and validation of genetic cell ablation systems in axolotl1R21OD031971-01A1MURAWALA, PRAYAGMOUNT DESERT ISLAND BIOLOGICAL LAB, ME$249,000DEV1
2022Genetic and genomic tools for C. briggsae research1R21OD030067-01A1 · under PAR-19-369ANDERSEN, ERIK CHRISTIANCHAMBERLIN, HELEN MOHIO STATE UNIVERSITY, OH$242,593GVE
2022A CRISPR-based modular transgenic system to advance in vivo investigations of angiogenesis and fibrosis1R21OD032144-01WOLF, MATTHEW JUNIVERSITY OF VIRGINIA, VA$242,250MPPA
2022Development of a mouse model of brown fat dystrophia1R21OD031907-01A1SANCHEZ-GURMACHES, JUANCINCINNATI CHILDRENS HOSP MED CTR, OH$238,500BMDM
2022A novel mouse model to distinguish the specific physiological significance of RNAi and biophysical mechanisms of microRNA1R21OD031965-01 · under PAR-19-369FU, JIDONGOHIO STATE UNIVERSITY, OH$236,250MPPA
2022Illuminating apical extracellular matrix structure and biogenesis1R21OD033663-01CHISHOLM, ANDREW DWARD, JORDAN DAVIDUNIVERSITY OF CALIFORNIA SANTA CRUZ, CA$234,000ZRG1
2022A Comprehensive Endogenous Basement Membrane Toolkit to Elucidate how Basement Membranes Stretch on Mechanically Active Tissues and Decline during Aging1R21OD032430-01SHERWOOD, DAVID RDUKE UNIVERSITY, NC$233,871ICI
2022Enhancement of Human Immune System Development in Mouse Models1R21OD034048-01GORANTLA, SANTHIGURUMURTHY, CHANNABASAVAIAHPOLUEKTOVA, LARISA YUNIVERSITY OF NEBRASKA MEDICAL CENTER, NE$230,250HIVD
2022Development of genome-modified Xiphophorus1R21OD031910-01A1SCHARTL, MANFREDTEXAS STATE UNIVERSITY, TX$223,927DEV2
2022mtDNA depleter mouse for decoding mitochondrial regulation of diverse organs1R21OD031970-01 · under PAR-19-369SINGH, KESHAV KUNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$222,750TAG
2022Establishment of Somatic Cell Nuclear Transfer as a Universal Platform for Cloning Marmosets1R21OD033666-01PARK, JUNG EUNUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$220,800DEV2
2022Deciphering the Pathogenesis of EHEC Infection and the Effects of Bacteria-Based Therapies Using Comparative Gut-on-a-Chip1R21OD031903-01A1AMBROSINI, YOKO MIYAMOTOWASHINGTON STATE UNIVERSITY, WA$189,331CMT
2022Developing a new chordate model for stem cell biology and regeneration1R21OD030520-01A1 · under PAR-19-369DE TOMASO, ANTHONY WUNIVERSITY OF CALIFORNIA SANTA BARBARA, CA$183,927DEV2
2021Generating mtDNA mutant mice to model human mitochondrial diseases1R21OD030076-01 · under PAR-19-369FAN, WEIWEISALK INSTITUTE FOR BIOLOGICAL STUDIES, CA$285,000TAG
2021Building transgenic tools in Acomys cahirinus, an emerging model for mammalian regenerative biology and healthy aging1R21OD030107-01 · under PAR-19-369MILLEN, KATHLEEN JOYCESEATTLE CHILDREN'S HOSPITAL, WA$282,750DEV2
2021Collagen XVII unmasking in Parkinson's disease and scratching1R21OD030057-01A1 · under PAR-19-369AMBER, KYLE T.RUSH UNIVERSITY MEDICAL CENTER, IL$249,750ACTS
2021Establish a novel mouse model tracking multiple extracellular vesicles1R21OD031906-01 · under PAR-19-369NAKAMURA, TAKAHISACINCINNATI CHILDRENS HOSP MED CTR, OH$238,500BMDM
2021Frequent concatemeric insertions during AAV6/Cas9-mediated genome editing: Detection and Prevention1R21OD030529-01 · under PAR-19-369MAJETI, RAVINDRANAKAUCHI, HIROMITSUSTANFORD UNIVERSITY, CA$236,936TAG
2021Generate Zebrafish Conditional Knockout Model for Ciliopathy Research1R21OD030065-01A1 · under PAR-19-369PARANT, JOHN MUNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$222,750TAG
2021Advanced Image Analysis Tools for Super-Resolved MRI in Small Animals1R21OD030163-01A1 · under PAR-19-369PHAM, DZUNG LHENRY M. JACKSON FDN FOR THE ADV MIL/MED, MD$218,013ITD
2021Understanding SHRF, an RNA exosome-linked disease with multi-organ involvement1R21OD030077-01 · under PAR-19-369LU, BINGWEISTANFORD UNIVERSITY, CA$197,032MGB
2021Pathogenesis of HIV and HBV Co-Infection in a Humanized Mouse Model1R21OD030204-01A1 · under PAR-19-369AMBROSE, ZANDREAGUO, HAITAOUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$195,625HCAC
2021Host genetic variation affecting the microbiome in rhesus macaques1R21OD030072-01A1 · under PAR-19-369VALLENDER, ERIC J.UNIVERSITY OF MISSISSIPPI MED CTR, MS$193,750GVE
2020The Burmese Python as a Model System for the Study of Metabolism and Organ Regeneration1R21OD029996-01 · under PAR-19-369SAEIDI, NIMASTYLOPOULOS, NICHOLASBOSTON CHILDREN'S HOSPITAL, MA$279,368IPOD
2020Mouse models for decoding microRNA regulation in diverse tissues and cell types1R21OD029999-01 · under PAR-19-369MACRAE, IAN JOHNSCRIPPS RESEARCH INSTITUTE, THE, CA$266,250MGB
2020Anastasis biosensor for tracking reversal of apoptosis in vivo1R21OD028764-01 · under PA-16-141TANG, HO LAMJOHNS HOPKINS UNIVERSITY, MD$237,338CMT
2020Bellymount: A platform for ultra-long term imaging of abdominal organs in live adult Drosophila1R21OD028273-01 · under PA-16-141O'BRIEN, LUCY ERINSTANFORD UNIVERSITY, CA$236,550DEV2
2020A comprehensive toolkit to visualize endogenously tagged fluorescent basement membrane components in a living animal1R21OD028766-01 · under PA-16-141SHERWOOD, DAVID RDUKE UNIVERSITY, NC$233,968ZRG1
2020Developing zebra finch transgenic lines with functional receptors for VSV-G-pseudotyped lentiviruses1R21OD028774-01 · under PA-16-141MELLO, CLAUDIO VOREGON HEALTH & SCIENCE UNIVERSITY, OR$231,000MNG
2020Development of an exosome and cargo tracking mouse1R21OD028749-01 · under PA-16-141ZEMPLENI, JANOSUNIVERSITY OF NEBRASKA LINCOLN, NE$222,750ICI
2020Optimization of homology-directed repair in zebrafish1R21OD030004-01 · under PAR-19-369LAWSON, NATHAN DUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$209,375DEV2
2020Selectable non-mosaic embryo editing1R21OD030009-01 · under PAR-19-369NAKAUCHI, HIROMITSUSTANFORD UNIVERSITY, CA$202,122TAG
2020Derivation of chimera competent pig embryonic stem cells under a novel condition1R21OD028763-01 · under PA-16-141WU, JUNUT SOUTHWESTERN MEDICAL CENTER, TX$163,416DEV2
2019Development and Validation of a Novel Cas13a and Nanoparticle Guide-RNA Delivery System that Allows Precise Ablation of Host Macrophage Populations in a Humanized Mouse Model1R21OD027052-01 · under PA-16-141WILES, MICHAEL VANJACKSON LABORATORY, ME$269,900TAG
2019Germ cell preservation of immunodeficient pigs utilizing embryo complementation approach1R21OD027062-01 · under PA-16-141LEE, KIHOVIRGINIA POLYTECHNIC INST AND ST UNIV, VA$241,500CMIR
2019In situ imaging of collagen degradation activity in multiple myeloma and lung fibrosis mouse model1R21OD026618-01A1 · under PA-16-141YOON, DONGHOONYU, MICHAEL SUNIVERSITY OF UTAH, UT$240,000IPCA
2019Tandem Genetically Encoded Voltage and Calcium Indicator Mice for Optical Physiology of Excitable Cells1R21OD025345-01A1 · under PA-16-141THOMPSON, CHRISTOPHER HNORTHWESTERN UNIVERSITY AT CHICAGO, IL$237,000NTRC
2019A Single cell expression atlas of muscle and dermis during regeneration after wounding in Acomys cahirinus - an adult mammal model for de novo muscle regeneration1R21OD028209-01 · under PA-16-141BARBAZUK, WILLIAM BUNIVERSITY OF FLORIDA, FL$224,424ACTS
2019Development of an in vitro mouse genetic reference platform to improve preclinical drug safety assessment1R21OD028216-01 · under PA-16-141MOSEDALE, MERRIEUNIV OF NORTH CAROLINA CHAPEL HILL, NC$223,571XNDA
2019Hepatocyte-targeted somatic-cell genetic complementation in mice1R21OD026444-01A1 · under PA-16-141SCHMIDT, EDWARD EMONTANA STATE UNIVERSITY - BOZEMAN, MT$216,000HBPP
2019Enhancing CRISPR-Cas for disease modeling in Xenopus1R21OD023810-01A1 · under PA-16-141HORB, MARKO EMARINE BIOLOGICAL LABORATORY, MA$207,500DEV1
2019Rapid production and dissemination of intersectional genetic alleles for the study of nervous system circuit development and function in the mouse.1R21OD025327-01A1 · under PA-16-141RAY, RUSSELL SBAYLOR COLLEGE OF MEDICINE, TX$198,125MNG
2019Rapid Fluorescent Tagging of Endogenous Proteins in Mouse Models1R21OD027053-01 · under PA-16-141HE, LINUNIVERSITY OF CALIFORNIA BERKELEY, CA$196,250TAG
2019Genetic Modification to Harness the Regenerative Power of the African Spiny Mouse1R21OD028211-01 · under PA-16-141TERADA, NAOHIROUNIVERSITY OF FLORIDA, FL$190,625ACTS
2019Image-guided robot for high-throughput microinjection of Drosophila embryos1R21OD028214-01 · under PA-16-141GOHL, DARYLKODANDARAMAIAH, SUHASA BUNIVERSITY OF MINNESOTA, MN$184,118ISD
2018Rapid In Vivo Modeling of Developmental Disorders1R21OD024941-01 · under PA-16-141MURRAY, STEPHEN AJACKSON LABORATORY, ME$262,500GHD
2018Improved Mouse Modeling of 25 to 300-Kilobase-Scale Human Genomic Structural Variation by CRISPR/Cas9-Stimulated Homologous Recombination of BacterialArtificial Chromosome Vectors (CRISPR/BAC/HR)1R21OD023803-01A1 · under PA-16-141BERGSTROM, DAVID ERICJACKSON LABORATORY, ME$254,375GHD
2018Sry transgenic rats for investigation of XX vs. XY differences in phenotypes1R21OD026560-01 · under PA-16-141ARNOLD, ARTHUR PDWINELL, MELINDA RGEURTS, ARON MUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$246,045CMIR
2018Generation and characterization of a novel cell subpopulation ablation model1R21OD024931-01A1 · under PA-16-141QIN, XUEBINTEMPLE UNIV OF THE COMMONWEALTH, PA$237,750HAI
2018Engraftment of human hematopoietic stem cells to immunodeficient rabbits1R21OD024789-01A1 · under PA-16-141BILITY, MOSES TURKLEXU, JIEUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$207,999TTT
2018Establish a zebrafish genetic mosaic system for disease modeling and developmental biology1R21OD026524-01 · under PA-16-141ZONG, HUIUNIVERSITY OF VIRGINIA, VA$201,875NCF
2018A New Method for Mosaic Analysis of Clonal Mutations in Mice1R21OD023822-01A1 · under PA-16-141ZHUANG, YUANDUKE UNIVERSITY, NC$199,479CMIA
2018Animal Models for SCN2A Neurodevelopmental Disorders1R21OD025330-01 · under PA-16-141KEARNEY, JENNIFER ANORTHWESTERN UNIVERSITY AT CHICAGO, IL$197,500NDPR
2018Characterization of split-GAL4 driver expression in the Drosophila intestine at the Bloomington Drosophila Stock Center1R21OD026525-01 · under PA-16-141COOK, KEVIN RSOKOL, NICHOLASTRUSTEES OF INDIANA UNIVERSITY, IN$196,875DEV2
2018Using cortico-striatal evolutionary innovations for modeling Huntington's disease1R21OD025320-01 · under PA-16-141MEHLER, MARK FALBERT EINSTEIN COLLEGE OF MEDICINE, INC, NY$105,902MNG
2018Generation of novel Fn1-fluorescent fusion proteins in vivo for the investigation of cell-ECM dynamics in real time1R21OD025323-01 · under PA-16-141ASTROF, SOPHIETHOMAS JEFFERSON UNIVERSITY, PA$45,845ICI
2017New transgenic tools for mammalian fibrosis and regenerative repair research1R21OD023838-01 · under PA-16-141MILLEN, KATHLEEN JOYCENELSON, BRANDEN RSEATTLE CHILDREN'S HOSPITAL, WA$274,883ACTS
2017Identifying the genetic changes which induce tissue and organ regeneration in a novel mammalian model system.1R21OD023210-01 · under PA-13-145MADEN, MALCOLMUNIVERSITY OF FLORIDA, FL$253,531GCAT
2017Optimization of Targeted Nuclease Mediated HDR Events in Inbred Mouse Zygotes1R21OD023800-01 · under PA-16-141WILES, MICHAEL VANJACKSON LABORATORY, ME$249,375TAG
2017Proximity- and complementation-based analysis of signaling complexes1R21OD023204-01 · under PA-13-145SOKOL, SERGEIICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$201,281ICI
2017Resource for marking clones on the fly 4th chromosome1R21OD024794-01 · under PA-16-141NEWFELD, STUART JARIZONA STATE UNIVERSITY-TEMPE CAMPUS, AZ$196,805DEV2
2017A light-inducible protein trapping system for studying cellular dynamics in Drosophila1R21OD023824-01A1 · under PA-16-141HAN, CHUNCORNELL UNIVERSITY, NY$187,338MNG
2017Development of conditional and inducible gene targeting tools in rabbits1R21OD023194-01A1 · under PA-16-141XU, JIEUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$184,063TAG
2017Development of Mas Receptor Knockout Rat Resource1R21OD024781-01 · under PA-16-141LOMBARD, JULIAN HMEDICAL COLLEGE OF WISCONSIN, WI$182,875HM
2016Developing techniques to generate the first transgenic opossums1R21OD022988-01 · under PA-13-145SEARS, KAREN EUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$237,900DEV1
2016RESOLVING COMPLEX SYSTEMIC ENDOGENOUS EXPRESSION PATTERNS INTO SUBCELLULAR HIGH-RESOLUTION LOCALIZATION1R21OD022981-01 · under PA-13-145VENKEN, KOEN JOZEF THEOBAYLOR COLLEGE OF MEDICINE, TX$237,750MGA
2016Development of mouse models for autoinflammatory rare diseases1R21OD019928-01A1 · under PA-13-145KIM, DO-HYUNGUNIVERSITY OF MINNESOTA, MN$228,000HAI
2016Investigating the Effects of Reducing Nonsense-Mediated mRNA Decay Efficiency1R21OD019922-01A1 · under PA-13-145KEELING, KIM MARIEUNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$220,500MGA
2016Novel Mouse Resources for Diabetic Nephropathy1R21OD021437-01 · under PA-13-145KOBAYASHI, AKIOUNIVERSITY OF WASHINGTON, WA$217,500KMBD
2016T cell-tissue interaction models1R21OD020185-01A1 · under PA-13-145BROWN, BRIAN DICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$211,875CMIB
2016A novel rabbit model of cystic fibrosis1R21OD020187-01A1 · under PA-13-145XU, JIEUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$193,750LCMI
2015Identification of autophagy mediators through screening transgenic animal library1R21OD018265-01A1 · under PA-13-145LEE, JUN HEEUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$266,040CSRS
2015Characterization of a Temporally Controlled Dominant-Negative RB1 Mouse Model1R21OD019745-01A1 · under PA-13-145ROCHA-SANCHEZ, SONIA MCREIGHTON UNIVERSITY, NE$226,960AUD
2015Targeting non-HIF-mediated regulators of hypoxic responses1R21OD019932-01 · under PA-13-145BAKER, KEITH DVIRGINIA COMMONWEALTH UNIVERSITY, VA$219,030CSRS
2015Dissecting Distinct and Redundant Roles of ThPOK and LRF, Key Regulators of Hematopoiesis1R21OD017958-01A1 · under PA-13-145KAPPES, DIETMAR JRESEARCH INST OF FOX CHASE CAN CTR, PA$218,663ZRG1
2015Exome screening and directed breeding of rhesus for human genetic disease models1R21OD019930-01A1 · under PA-13-145JOHNSON, R. PAULNORGREN, ROBERT B.UNIVERSITY OF NEBRASKA MEDICAL CENTER, NE$216,028GHD
2015CRISPR/Cas9 guided production of genetically engineered pigs lacking CD8+ T-cells1R21OD019934-01A1 · under PA-13-145LEE, KIHOYUAN, LIJUANVIRGINIA POLYTECHNIC INST AND ST UNIV, VA$197,225CMIA
2015Development of mouse strains with human-like telomerase regulation1R21OD021432-01 · under PA-13-145ZHU, JIYUEWASHINGTON STATE UNIVERSITY, WA$184,975CMAD
2015Novel Transgenic Mouse Models for L1 Retrotransposons in Development and Disease1R21OD017965-01A1 · under PA-13-145AN, WENFENGSOUTH DAKOTA STATE UNIVERSITY, SD$178,850CMIR
2014CHD5 dosage in epigenetic control of Cancer, Infertility, and Autism1R21OD018332-01 · under PA-13-145MILLS, ALEA A.COLD SPRING HARBOR LABORATORY, NY$283,500GHD
2014Non-Human Primate Model for Systems Biology Studies of Stress Response1R21OD017959-01 · under PA-10-138JASINSKA, ANNA JOANNAUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$269,500BRLE
2014Light-inducible Cre Transgenic Mouse Models1R21OD019764-01 · under PA-13-145BEHRINGER, RICHARD RUNIVERSITY OF TX MD ANDERSON CAN CTR, TX$240,000DEV2
2014Experimental Strategies for Light-Induced Elimination of Protein Function in vivo1R21OD017964-01 · under PA-10-138STEIN, DAVID S.UNIVERSITY OF TEXAS AT AUSTIN, TX$231,750DEV2
2014Development of humanized TLR4 SNP mouse models1R21OD017233-01A1 · under PA-13-145HAJJAR, ADELINE MUNIVERSITY OF WASHINGTON, WA$231,750IHD
2014Developing models for identification of therapeutic cell populations1R21OD017244-01A1 · under PA-13-145ZIOUZENKOVA, OULIANA ZIOUZENKOVAOHIO STATE UNIVERSITY, OH$230,250ZRG1
2014Model for evaluation of FCGR variants in disease and response to therapeutics1R21OD012234-01A1 · under PA-10-138KOLLER, BEVERLY HUNIV OF NORTH CAROLINA CHAPEL HILL, NC$228,000CII
2014Assembly of disease-relevant pathways in the mouse1R21OD016565-01A1 · under PA-10-138KOLLER, BEVERLY HUNIV OF NORTH CAROLINA CHAPEL HILL, NC$228,000MNG
2014Seq-ing the etiology of birth defects in a new frog model, Lepidobatrachus laevis1R21OD017963-01A1 · under PA-13-145NASCONE-YODER, NANETTE MNORTH CAROLINA STATE UNIVERSITY RALEIGH, NC$227,250DEV2
2014Generation of a Transgenic Mouse Model to Study Human TLR9 Role in Disease1R21OD018317-01 · under PA-13-145GUIDUCCI, CRISTIANADYNAVAX TECHNOLOGIES CORPORATION, CA$227,161III
2014Gene targeting in zebrafish: building models to assay disease genes1R21OD018323-01 · under PA-13-145GRUNWALD, DAVID J.UNIVERSITY OF UTAH, UT$223,500DEV2
2014Humanized mice to study mast cell function1R21OD017843-01A1 · under PA-10-138ALI, HYDARUNIVERSITY OF PENNSYLVANIA, PA$200,000LCMI
2014Development of RhoA Optical Sensor Mice for Novel Vascular Smooth Muscle Studies1R21OD018315-01 · under PA-13-145RIZZO, MEGAN AWIER, WITHROW GILUNIVERSITY OF MARYLAND BALTIMORE, MD$191,875MEDI
2014Oxidant Stress in the Nrf2 Knockout Rat1R21OD018309-01 · under PA-13-145LOMBARD, JULIAN HMEDICAL COLLEGE OF WISCONSIN, WI$191,250HM
2014Differentiation of mitochondrial vs. nuclear function of telomerase1R21OD018306-01 · under PA-13-145BEYER, ANDREAS MMEDICAL COLLEGE OF WISCONSIN, WI$191,250VCMB
2014Mechanisms of PGRMC2 action in female reproduction1R21OD016564-01A1 · under PA-13-145PRU, JAMES KWASHINGTON STATE UNIVERSITY, WA$166,349ICER

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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PAR-21-167: Development of Animal Models and Related Biological Materials for Research (R21 Clinical Trial Not Allowed) | ScienceDex | ConductScience