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NIH funding notice PAR-21-343

Opportunities for Collaborative Research at the NIH Clinical Center (U01 Clinical Trial Optional)

Closed on April 18, 2024.

Posted
November 19, 2021
Close date
April 18, 2024
Activity codes
U01
Institutes taking part
NICHD, NEI, NHLBI, NHGRI, NIAAA, NIAID, NIAMS, NIDCD, NIDCR, NIMH, NINDS, NCCIH, NCI, ORWH

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

  1. Reissues: PAR-18-951 Opportunities for Collaborative Research at the NIH Clinical Center (U01 Clinical Trial Optional)
  2. 2 steps back: PAR-18-646 Opportunities for Collaborative Research at the NIH Clinical Center (U01 - Clinical Trial Optional)
  3. 3 steps back: PAR-15-287 Opportunities for Collaborative Research at the NIH Clinical Center (U01)
  4. 4 steps back: PAR-13-358 Opportunities for Collaborative Research at the NIH Clinical Center (U01)
  5. 5 steps back: PAR-13-029 Opportunities for Collaborative Research at the NIH Clinical Center (U01)

Replaced by PAR-26-116.

Who won it before

63 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $32,815,320 in first-year total cost, median $524,790.

Most frequent study sections

  1. Special Emphasis Panel[ZRG1 BDCN-L (60)]7
  2. Special Emphasis Panel[ZCA1 SRB-K (O2)]6
  3. Special Emphasis Panel[ZHL1 CSR-S (O1)]6
  4. Special Emphasis Panel[ZCA1 RTRB-4 (O1)]4
  5. Special Emphasis Panel[ZCA1 TCRB-O (O1)]4

Most frequent institutions

  1. BRIGHAM AND WOMEN'S HOSPITAL5
  2. CHILDREN'S RESEARCH INSTITUTE3
  3. JOHNS HOPKINS UNIVERSITY3
  4. MASSACHUSETTS GENERAL HOSPITAL3
  5. UNIVERSITY OF CALIFORNIA, SAN FRANCISCO3
Competing awards under PAR-21-343 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2025Proton and hyperpolarized xenon pulmonary MRI at 0.55T1U01HL178354-01CAMPBELL, ADRIENNEMEYER, CRAIG HMUGLER, JOHN PUNIVERSITY OF VIRGINIA, VA$659,644ZHL1
2025Targeting mutant-MYOD1 driven rhabdomyosarcoma1U01CA298763-01STANTON, BENJAMINRESEARCH INST NATIONWIDE CHILDREN'S HOSP, OH$481,052ZCA1
2025Cell-Cell Signaling Driving HPV-Induced Respiratory Disease and Vaccine Response1U01CA298630-01WELLS, SUSANNE IWIKENHEISER-BROKAMP, KATHRYN ANNCINCINNATI CHILDRENS HOSP MED CTR, OH$95,392ZCA1
2024Developing a Translation Pipeline for VHL Mutant Malignancies2U01CA236489-05A1MCDERMOTT, DAVIDBETH ISRAEL DEACONESS MEDICAL CENTER, MA$669,180ZCA1
2024E7 TCR-T cell therapy for HPV-associated cancers1U01CA287904-01CAO, JIANGULLEY, JAMES L.HINRICHS, CHRISTIANRUTGERS BIOMEDICAL AND HEALTH SCIENCES, NJ$642,086ZCA1
2024National Succinate Dehydrogenase-deficient GIST Translational Research and Clinical Trial Consortium1U01CA278470-01A1GLOD, JOHN WALTERSICKLICK, JASON KEITHUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$549,618ZCA1
2024Microbial, immune, metabolic perturbations by antibiotics (MIME study)2U01AI122285-07A1BLASER, MARTIN JHOLLAND, STEVEN MRUTGERS BIOMEDICAL AND HEALTH SCIENCES, NJ$458,038ZCA1
2024Use of Tiered Genetic Sequencing and Specialty Referral for Identifying and Managing Rare Genetic Causes of Chronic Suppurative Respiratory Disease1U01HL172658-01FREEMAN, ALEXANDRAOLIVIER, KENNETH N.SHAPIRO, ADAMUNIV OF NORTH CAROLINA CHAPEL HILL, NC$423,120ZHL1
2023Polygenic risk stratification combined with mpMRI to identify clinically relevant prostate cancer1U01CA268810-01A1KIBEL, ADAM SBRIGHAM AND WOMEN'S HOSPITAL, MA$540,039ZCA1
2023Volumetric Real-Time MRI at 0.55 Tesla1U01HL167613-01CAMPBELL, ADRIENNENAYAK, KRISHNA SUNIVERSITY OF SOUTHERN CALIFORNIA, CA$525,550ZHL1
2023Delineation of the natural history of Ollier disease and Muffucci syndrome and investigation of their genetic bases1U01HD107957-01A1MARINI, JOAN CSOBREIRA, NARAJOHNS HOPKINS UNIVERSITY, MD$510,889CHHD
2023Preclinical-clinical trials collaboration to effectively advance new combination therapies for atypical neurofibroma in neurofibromatosis type 11U01CA278474-01CLAPP, DAVID WINDIANA UNIVERSITY INDIANAPOLIS, IN$495,641ZCA1
2023Hybrid Intelligence for Trustable Diagnosis And Patient Management of Prostate Cancer (HIT-PIRADS)1U01CA268808-01A1BAGCI, ULASNORTHWESTERN UNIVERSITY AT CHICAGO, IL$376,880ZCA1
2022The molecular and cellular mechanisms of the STAT3 mutation-mediated pulmonary disorder in Autosomal Dominant Hyper IgE Syndrome (AD-HIES)1U01HL156655-01A1 · under PAR-18-951BOUCHER, RICHARD CHARLESCHEN, GANGUNIV OF NORTH CAROLINA CHAPEL HILL, NC$748,549ZHL1
2022The role of inflammation in driving leukemogenesis in germline predisposition syndromes1U01CA257666-01A1 · under PAR-18-951AGARWAL, ANUPRIYABRESNICK, EMERY HGODLEY, LUCY ANNSPECK, NANCYUNIVERSITY OF CHICAGO, IL$707,850ZCA1
2022ATTRACT: Assessment of Temporomandibular JoinT MoRphology, Mechanics, And Mechanobiology in Class II and III Target and Surgical Phenotypes1U01DE031512-01 · under PAR-18-951LEE, JANICE SYAO, HAICLEMSON UNIVERSITY, SC$620,600ZRG1
2022Microfluidic isolation and molecular analysis of circulating tumor cells for the study of neuroendocrine transdifferentiation in prostate cancer1U01CA268933-01 · under PAR-18-951MADAN, RAVI AMRITTONER, MEHMETMASSACHUSETTS GENERAL HOSPITAL, MA$611,138ZCA1
2022Preclinical-Clinical Trials Collaboration to effectively advance new combination therapies for malignant peripheral nerve sheath tumors1U01CA268814-01 · under PAR-18-951CICHOWSKI, KAREN MBRIGHAM AND WOMEN'S HOSPITAL, MA$480,710ZCA1
2022A phase II multi-center trial evaluating dual targeting of the PI3K/AKT and NOS pathways for treating metaplastic breast cancer (MpBC)1U01CA268813-01 · under PAR-18-951CHANG, JENNY C-NLIPKOWITZ, STANLEYMERIC-BERNSTAM, FUNDAWONG, STEPHEN TCMETHODIST HOSPITAL RESEARCH INSTITUTE, TX$448,905ZCA1
2022Therapy with fecal microbiota transplantation and immune checkpoint blockade for solid tumors1U01CA268806-01 · under PAR-18-951TRINCHIERI, GIORGIOZAROUR, HASSANE MUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$236,768ZCA1
2021Microphthalmia, Anophthalmia, and Coloboma Genetic Epidemiology in Children (MAGIC) Study1U01EY032403-01 · under PAR-18-951BROOKS, BRIAN PATRICKLUPO, PHILIPBAYLOR COLLEGE OF MEDICINE, TX$769,911ZRG1
2021Endometrial Basis for Infertility in Women with Recurrent Implantation Failure and Pregnancy Loss1U01HD104482-01 · under PAR-18-951DECHERNEY, ALAN H.SPENCER, THOMAS EUNIVERSITY OF MISSOURI-COLUMBIA, MO$696,508ZRG1
2021Clinical and genetic risk factors associated with adverse long-term health outcomes after curative therapies in individuals with sickle cell disease1U01HL156620-01 · under PAR-18-951DEBAUN, MICHAEL R.FITZHUGH, COURTNEY DFRIEDMAN, DEBRA L.JONES, RICHARD JVANDERBILT UNIVERSITY MEDICAL CENTER, TN$691,115ZHL1
2021Underlying Mechanisms in CADASIL1U01HL151203-01A1 · under PAR-18-951BOEHM, MANFREDIRUELA-ARISPE, M. LUISAKOZEL, BETH ANORTHWESTERN UNIVERSITY AT CHICAGO, IL$654,979ZHL1
2021Investigation and Treatment of Undiagnosed Neuroinflammatory Diseases1U01NS120836-01 · under PAR-18-951MISHRA, NISCHAYNATH, AVINDRAWILSON, MICHAEL RUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$617,274ZNS1
2021Quantifying and Personalizing the Clinical Benefit of Metastasis-Directed Therapy in Men with De Novo Oligometastatic Prostate Cancer1U01CA257638-01 · under PAR-18-951SPRATT, DANIEL EIDELBERGSUN, YILUNCASE WESTERN RESERVE UNIVERSITY, OH$513,265ZCA1
2020The Molecular and Genetic Pathogenesis of LAM2U01HL131022-04 · under PAR-18-951EL-CHEMALY, SOUHEILHENSKE, ELIZABETH PBRIGHAM AND WOMEN'S HOSPITAL, MA$877,667ZHL1
2020Collaborative Research to Explore Genetic Variation and Phenotypic Spectrum of Elastin and Related Genes1U01HL146188-01A1 · under PAR-18-951KOZEL, BETH AWILLIAMS, MARC S.GEISINGER CLINIC, PA$538,094ZHL1
2020Deciphering Clonal Evolution in Hereditary Renal Cell Carcinomas1U01CA247439-01 · under PAR-18-951TURAJLIC, SAMRAFRANCIS CRICK INSTITUTE, LTD$317,425ZCA1
2019Biologic correlatives of chronic GVHD onset1U01CA236229-01 · under PAR-18-646LEE, STEPHANIE JPAVLETIC, STEVENFRED HUTCHINSON CANCER RESEARCH CENTER, WA$993,954ZCA1
2019Developing a Translation Pipeline for VHL Mutant Malignancies1U01CA236489-01 · under PAR-18-646LINEHAN, MARSTONMCDERMOTT, DAVIDSRINIVASAN, RAMAPRASADBETH ISRAEL DEACONESS MEDICAL CENTER, MA$649,803ZCA1
2019Chemoprotection & Immune Remodeling after Hematopoietic Progenitor Cell Gene Therapy for Glioblastoma1U01CA236215-01 · under PAR-18-646GERSON, STANTON L.SLOAN, ANDREW ECASE WESTERN RESERVE UNIVERSITY, OH$565,191ZCA1
2019A collaborative approach to analyze and target the EWS-FLI1 transcription factor in patients with Ewing sarcoma1U01CA236220-01 · under PAR-18-646GROHAR, PATRICK JSARC, MI$473,617ZCA1
2018Protective Role of Nonclassical Monocytes in Immunotherapies for Solid Cancers1U01CA224766-01 · under PAR-15-287HEDRICK, CATHERINE CKAPLAN, ROSANDRASTRONCEK, DAVID FRANKLA JOLLA INSTITUTE FOR IMMUNOLOGY, CA$418,320ZCA1
2018Treatment of CGD with the PPAR-gamma agonist, pioglitazone, enhances phagocyte anti-inflammatory and antimicrobial responses1U01AI122269-01A1 · under PAR-15-287BRATTON, DONNA LHOLLAND, STEVEN MNATIONAL JEWISH HEALTH, CO$166,582ZAI1
2017Evaluation of the Safety and Efficacy of Angiotensin 1-7 to Enhance Cognitive Function in Participants Undergoing Coronary Artery Bypass Graft (CABG) Surgery1U01HL131014-01A1 · under PAR-15-287ARAI, ANDREW EHAY, MEREDITHRYAN, LEESWEITZER, NANCY KUNIVERSITY OF ARIZONA, AZ$745,065ZHL1
2017Immuno-Genetic Basis for Human Disseminated Coccidioidomycosis1U01AI122275-01A1 · under PAR-15-287GALGIANI, JOHN NHOLLAND, STEVEN MLUSSIER, YVES AUNIVERSITY OF ARIZONA, AZ$573,884ZAI1
2017Intravenous delivery of 2-hydroxypropyl-Beta-cyclodextrin for treatment of Niemann-Pick C disease1U01HD090845-01 · under PAR-15-287ORY, DANIEL SWASHINGTON UNIVERSITY, MO$529,267ZRG1
2017SINGLE-CELL TRANSCRIPTOMIC ANALYSIS OF HIV-INFECTED CD4 T CELLS IN BLOOD AND LYMPHOID TISSUE USING PCR-ACTIVATED CELL SORTING1U01AI129206-01 · under PAR-15-287ABATE, ADAM R.BORITZ, ELI AUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$481,092ZAI1
2017Optical and electromagnetic tracking guidance for hepatic interventions1U01CA202934-01A1 · under PAR-15-287MAHMOOD, UMARMASSACHUSETTS GENERAL HOSPITAL, MA$421,989ZCA1
2017Bench to bedside: non-invasive treatment of tumors in children1U01CA202947-01A1 · under PAR-15-287KIM, PETER CWSHARMA, KARUN VWOOD, BRADFORD JCHILDREN'S RESEARCH INSTITUTE, DC$350,585ZCA1
2017Genetic Diagnosis of Childhood Growth Disorders1U01HD086838-01A1 · under PAR-15-287BARON, JEFFREYJEE, YOUN HEERADOVICK, SALLYJOHNS HOPKINS UNIVERSITY, MD$168,712ZRG1
2016The Molecular and Genetic Pathogensis of LAM1U01HL131022-01 · under PAR-13-358HENSKE, ELIZABETH PBRIGHAM AND WOMEN'S HOSPITAL, MA$754,946ZHL1
2016Developing a translational pipeline for NF1-mutant malignancies1U01CA202943-01 · under PAR-13-358CICHOWSKI, KAREN MWIDEMANN, BRIGITTEBRIGHAM AND WOMEN'S HOSPITAL, MA$578,917ZCA1
2016Underlying Mechanisms of Vascular Disease1U01HL131019-01 · under PAR-13-358BOEHM, MANFREDIRUELA-ARISPE, M. LUISAUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$524,790ZHL1
2016Developing clinical, immunologic and radiographic tools to measure the clinical effect of immunotherapy in biochemically recurrent prostate cancer1U01CA202939-01 · under PAR-13-358GULLEY, JAMES L.KANTOFF, PHILIP WSLOAN-KETTERING INST CAN RESEARCH, NY$470,524ZCA1
2016Microbial, immune, metabolic perturbations by antibiotics (MIME study)1U01AI122285-01 · under PAR-13-358BLASER, MARTIN JNEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$423,750ZAI1
2015Choroid Plexus-Directed Gene Therapy for Alpha-Mannosidosis1U01HD079066-01A1 · under PAR-13-358WOLFE, JOHN HCHILDREN'S HOSP OF PHILADELPHIA, PA$656,702ZRG1
2015Sofosbuvir and Ledipasvir in HIV/HCV Coinfected Pre and Post Liver Transplant1U01AI115714-01 · under PAR-13-358MASUR, HENRYSTOCK, PETER GUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$601,291ZAI1
2015Phase II Study of AAV9-GAA Gene Transfer in Pompe Disease1U01HL121842-01A1 · under PAR-13-358BYRNE, BARRY JUNIVERSITY OF FLORIDA, FL$601,129ZHL1
2015Tesamorelin Effects on Liver Fat and Histology in HIV: A Collaborative U01 Grant1U01AI115711-01 · under PAR-13-358GRINSPOON, STEVEN K.HADIGAN, COLLEEN MMASSACHUSETTS GENERAL HOSPITAL, MA$587,655ZAI1
2015Beyond the reproductive tract: The future of Y chromosome research1U01HG007587-01A1 · under PAR-13-358MUENKE, MAXIMILIANPAGE, DAVID C.WHITEHEAD INSTITUTE FOR BIOMEDICAL RES, MA$487,619GNOM
2015Cerebellar Structure and Function Studies in Very Early Abstinence1U01AA023674-01 · under PAR-13-358FEIN, GEORGENEUROBEHAVIORAL RESEARCH, INC., HI$464,024ZRG1
2015Mucosal and Systemic Immune Responses to Influenza Virus1U01AI115715-01 · under PAR-13-358GREENBERG, HARRY BERNARDPALO ALTO VETERANS INSTIT FOR RESEARCH, CA$427,852ZAI1
2015PSMA Directed Imaging of Prostate Cancer Focus on Androgen Receptor Dynamics1U01CA183031-01A1 · under PAR-13-358DEWEESE, THEODORE LPOMPER, MARTIN GJOHNS HOPKINS UNIVERSITY, MD$410,209ZCA1
2015Antiretroviral Therapy in Aicardi Goutieres Syndrome1U01HD082806-01 · under PAR-13-358GAHL, WILLIAM ALLENVANDERVER, ADELINE LUCIECHILDREN'S RESEARCH INSTITUTE, DC$288,019ZRG1
2015Single chain urokinase plasminogen activator (scuPA) for treatment of loculated complicated parapneumonic effusions and empyema1U01HL121841-01A1 · under PAR-13-358IDELL, STEVENMASUR, HENRYWOODS, CHRISTIAN JUNIVERSITY OF TEXAS HLTH CTR AT TYLER, TX$74,071ZHL1
2014MRI-safe 3Dl intracardiac ultrasound catheter for cardiovascular intervention1U01HL121838-01 · under PAR-13-029DEGERTEKIN, F. LEVENTLEDERMAN, ROBERT JGEORGIA INSTITUTE OF TECHNOLOGY, GA$683,344ZHL1
2014Therapeutic Elimination of Stem Cells for Relapsed Pediatric AML1U01CA183030-01 · under PAR-13-029LIU, YANGSCHORE, REUVEN JCHILDREN'S RESEARCH INSTITUTE, DC$653,666ZCA1
2014Stem Cell Gene Therapy Following R-EPOCH for Non-Hodgkin Lymphoma in AIDS Patient1U01CA183012-01 · under PAR-13-029ZAIA, JOHN ABECKMAN RESEARCH INSTITUTE/CITY OF HOPE, CA$465,641ZCA1
2014Integrative molecular imaging and sequencing of prostate cancer1U01CA183027-01 · under PAR-13-029CHINNAIYAN, ARUL MLINEHAN, MARSTONUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$416,880ZCA1
2014Birth Defects: Moebius syndrome and related facial weakness disorders1U01HD079068-01 · under PAR-13-029BROOKS, BRIAN PATRICKENGLE, ELIZABETH C.JABS, ETHYLIN WANGMANOLI, IRINIPIERPAOLI, CARLOICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$388,120ZRG1
2014A Phase 1 Dose Escalation Study of Vorinostat in Niemann-Pick C1 Disease1U01HD079065-01 · under PAR-13-029MAXFIELD, FREDERICK R.ORY, DANIEL SWASHINGTON UNIVERSITY, MO$360,223ZRG1

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