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NIH funding notice PAR-22-089

Development of Biomarkers or Biomarker Signatures for Neurological and Neuromuscular Disorders (R61/R33 Clinical Trial Optional)

Closed on October 27, 2024.

Posted
February 23, 2022
Close date
October 27, 2024
Activity codes
R61, R33
Institutes taking part
NINDS, NIA

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

  1. Reissues: PAR-19-315 Discovery of Biomarkers and Biomarker Signatures for Neurological and Neuromuscular Disorders (R61/R33 Clinical Trial Optional)

Replaced by PAR-25-024.

Who won it before

25 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $24,144,245 in first-year total cost, median $824,668.

Most frequent study sections

  1. Neurological Sciences and Disorders A Study Section[NSD-A]14
  2. Neurological Sciences and Disorders B Study Section[NSD-B]11

Most frequent institutions

  1. MASSACHUSETTS GENERAL HOSPITAL3
  2. BOSTON CHILDREN'S HOSPITAL2
  3. ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER2
  4. BOSTON UNIVERSITY MEDICAL CAMPUS1
  5. BRIGHAM AND WOMEN'S HOSPITAL1
Competing awards under PAR-22-089 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2025Advancing a Prognostic and Monitoring Biomarker of Neutrophil-driven Secondary Brain Injury in Spontaneous Intracerebral Hemorrhage for Neurotherapeutics Development1R61NS135285-01A1GREER, DAVID MATTHEWHERRERA, VICTORIA LBOSTON UNIVERSITY MEDICAL CAMPUS, MA$704,313NSD
2024Discovery and validation of multi-omic plasma biomarkers for Adrenomyeloneuropathy1R61NS131928-01A1FATEMI, S. ALISINGH, JASPREETHUGO W. MOSER RES INST KENNEDY KRIEGER, MD$829,626NSD
2024Development and Validation of a Nocturnal Sleep Signature for the Diagnosis of Idiopathic Hypersomnia1R61NS130215-01A1MASKI, KIRAN PRASADBOSTON CHILDREN'S HOSPITAL, MA$785,153NSD
2023Biomarkers to Predict Outcome from Responsive Brain Stimulation for Epilepsy1R61NS125568-01A1 · under PAR-19-315DAVIS, KATHRYN ADAMIAKUNIVERSITY OF PENNSYLVANIA, PA$1,299,779NSD
2023Development of Translatable Neurophysiological Biomarkers to Accelerate Therapeutic Development in Rett Syndrome1R61NS130216-01 · under PAR-19-315MARSH, ERIC DNEUL, JEFFREY LCHILDREN'S HOSP OF PHILADELPHIA, PA$941,744NSD
2023Electrographic Seizure Pattern Modulation Biomarkers in Responsive Neurostimulation for Epilepsy1R61NS126776-01A1RICHARDSON, ROBERT MARKMASSACHUSETTS GENERAL HOSPITAL, MA$836,917NSD
2023Diffusion MRI Biomarkers of Peripheral Nerve Trauma1R61NS127268-01A1 · under PAR-19-315DORTCH, RICHARDMAHAN, MARKTHAYER, WESLEY PST. JOSEPH'S HOSPITAL AND MEDICAL CENTER, AZ$824,668NSD
2023Subtype-Selective Metabotropic Glutamate Receptor PET Ligands1R61NS130128-01 · under PAR-19-315LIANG, STEVEN HEMORY UNIVERSITY, GA$816,387NSD
2023tRNA-derived RNA Fragments (tRF) as Prognostic and Diagnostic Biomarkers for Alzheimer’s Disease1R61AG075725-01A1 · under PAR-19-315BAO, XIAOYONGFANG, XIANGUNIVERSITY OF TEXAS MED BR GALVESTON, TX$799,998NSD
2023Sensory Amplifications as Biomarkers of Migraine Progression1R61NS125153-01A1 · under PAR-19-315BRENNAN, KEVIN CHRISTOPHERUNIVERSITY OF UTAH, UT$750,148NSD
2023Pharmacodynamic Biomarker of Myotonic Dystrophy1R61NS131932-01HAMEL, JOHANNATHORNTON, CHARLES AUNIVERSITY OF ROCHESTER, NY$421,172NSD
2022Discovery and Validation of a Novel Response Biomarker Signature for Painful Peripheral Neuropathy1R61NS122298-01A1 · under PAR-19-315NEMENOV, MIKHAIL I.SINGLETON, JOHN ROBINSONLASMED, LLC, CA$1,000,168NSD
2022Consortium Of MRI Biomarkers In Neonatal Encephalopathy (COMBINE)1R61NS126792-01 · under PAR-19-315GRANT, PATRICIA ELLENLAPTOOK, ABBOT ROU, YANGMINGBOSTON CHILDREN'S HOSPITAL, MA$942,614NSD
2022Relaxivity Contrast Imaging as Biomarker of Muscle Degeneration in ALS1R61NS119642-01A1 · under PAR-19-315QUARLES, CHRISTOPHER CHADST. JOSEPH'S HOSPITAL AND MEDICAL CENTER, AZ$809,219NSD
2022Discovery of Plasma Biomarkers of Delayed Cerebral Ischemia after Subarachnoid Hemorrhage1R61NS119640-01A1 · under PAR-19-315CHOI, HUIMAHN ALEXSAVARRAJ, JUDE PJUNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TX$655,819NSD
2022Biomarker Signatures for Duchenne Muscular Dystrophy1R61NS119639-01A1 · under PAR-19-315DANG, UTKARSH JHATHOUT, YETRIBSTATE UNIVERSITY OF NY,BINGHAMTON, NY$515,364NSD
2022Biomarker development in patients with HNPP1R61NS119434-01A1 · under PAR-19-315CHEN, YONGSHENGLI, JUNWAYNE STATE UNIVERSITY, MI$472,230NSD
2022Intracranial D-2-Hydroxyglutarate as a Monitoring Biomarker for IDH-mutant Glioma.1R61NS122096-01A1 · under PAR-19-315BURNS, TERRYMAYO CLINIC ROCHESTER, MN$397,500NSD
2021Identification and Verification of S-Nitrosylated Proteins in Bodily Fluids as Biomarkers for Parkinson's Disease and Lewy Body Dementia1R61NS122098-01 · under PAR-19-315NAKAMURA, TOMOHIROSCRIPPS RESEARCH INSTITUTE, THE, CA$2,199,931NSD
2021Extracellular RNA biomarkers of myotonic dystrophy type 11R61NS117210-01A1 · under PAR-19-315WHEELER, THURMAN MMASSACHUSETTS GENERAL HOSPITAL, MA$2,126,281NSD
2021Plasma metabolite and proteome signatures for migraine classification1R61NS122074-01 · under PAR-19-315CHASMAN, DANIEL IANRIST, PAMELA M.BRIGHAM AND WOMEN'S HOSPITAL, MA$2,065,041NSD
2021Biomarker Signatures for Delayed Cerebral Ischemia and Outcome Following Subarachnoid Hemorrhage1R61NS119345-01 · under PAR-19-315ANDER, BRADLEY PEARCESHARP, FRANK RSTAMOVA, BORYANAUNIVERSITY OF CALIFORNIA AT DAVIS, CA$681,385NSD
2020Objective tests utilizing Vibrational Spectroscopy for Diagnosis and Severity of Fibromyalgia and Related Pain Syndromes1R61NS117211-01 · under PAR-19-315HACKSHAW, KEVIN VICTORRODRIGUEZ-SAONA, LUIS EUNIVERSITY OF TEXAS AT AUSTIN, TX$1,466,498NSD
2020Plasma MicroRNA Biomarkers to Guide Rehabilitation Therapy After Stroke1R61NS117196-01 · under PAR-19-315EDWARDSON, MATTHEW AGEORGETOWN UNIVERSITY, DC$969,858NSD
2020Molecular imaging of RIPK1/necroptosis as a key biomarker in Alzheimer's disease1R61AG067916-01 · under PAR-19-315WANG, CHANGNINGZHANG, CAN MARTINMASSACHUSETTS GENERAL HOSPITAL, MA$832,432NSD

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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