The notices it replaced
- Reissues: RFA-TR-22-030 Pilot Projects Investigating Understudied Proteins Associated with Rare Diseases (R03 Clinical Trial Not Allowed)
Who won it before
58 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $9,402,381 in first-year total cost, median $157,750.
Most frequent study sections
- Special Emphasis Panel[ZTR1 RD-7 (01)]24
- Special Emphasis Panel[ZTR1 RD-1 (01)]13
- Special Emphasis Panel[ZTR1 RD-8 (01)]11
- Special Emphasis Panel[ZTR1 RD-1 (02)]10
Most frequent institutions
- CHILDREN'S HOSP OF PHILADELPHIA4
- WASHINGTON UNIVERSITY3
- BOSTON CHILDREN'S HOSPITAL2
- JOHNS HOPKINS UNIVERSITY2
- UNIVERSITY OF CALIFORNIA, SAN DIEGO2
| FY | Project | PIs | Institution | First-year cost | Study section |
|---|---|---|---|---|---|
| 2025 | Development of Bone Marrow Organoid System to Study RUNX1-Familial Platelet Disorder with Associated Myeloid Malignancy (RUNX1-FPD/MM)1R03TR004848-01A1 · under RFA-TR-22-030 | CANTOR, ALAN B. | BOSTON CHILDREN'S HOSPITAL, MA | $178,000 | ZTR1 |
| 2025 | Localization and function of SLC24A5 in skin pigmentation1R03TR006113-01A1 · under RFA-TR-22-030 | MARKS, MICHAEL SSVIDERSKAYA, ELENA V | CHILDREN'S HOSP OF PHILADELPHIA, PA | $178,000 | ZTR1 |
| 2025 | Identifying the downstream targets of neural FOXP11R03MH133952-01A1 · under RFA-TR-22-030 | PEARSON, CAROLINE ALAYNE | WEILL MEDICAL COLL OF CORNELL UNIV, NY | $169,500 | ZTR1 |
| 2025 | Evaluating the therapeutic potential of gene replacement for SCYL1 deficiency syndrome1R03TR004825-01A1 · under RFA-TR-22-030 | PELLETIER, STEPHANE | INDIANA UNIVERSITY INDIANAPOLIS, IN | $158,500 | ZTR1 |
| 2025 | Characterization of CLIC21R03TR005313-01A1 · under RFA-TR-22-030 | SINGH, HARPREET | OHIO STATE UNIVERSITY, OH | $157,500 | ZTR1 |
| 2025 | Mechanisms for control of mitoribosome assembly by the GTPase ERAL11R03TR005620-01 · under RFA-TR-22-030 | KARDON, JULIA R. | BRANDEIS UNIVERSITY, MA | $157,260 | ZTR1 |
| 2025 | Profiling the specificity of SPI1 and SPIB activity for drug discovery1R03TR004842-01A1 · under RFA-TR-22-030 | POON, GREGORY MAN KAI | GEORGIA STATE UNIVERSITY, GA | $156,000 | ZTR1 |
| 2025 | Sine Oculis Homeobox Homolog 1 and clusterin in Pulmonary Hypertension associated with Systemic Sclerosis1R03TR005085-01A1 · under RFA-TR-22-030 | KARMOUTY-QUINTANA, HARRY | UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TX | $156,000 | ZTR1 |
| 2025 | Impact of a Histone H3K9 Methyltransferase on Mitochondria1R03TR005626-01 · under RFA-TR-22-030 | TANIS, JESSICA E | UNIVERSITY OF DELAWARE, DE | $155,559 | ZTR1 |
| 2025 | High-Content Analysis to Accelerate Mechanistic and Therapeutic Identification for ABCA3 Deficiency1R03TR004845-01A1 · under RFA-TR-22-030 | WAMBACH, JENNIFER | WASHINGTON UNIVERSITY, MO | $155,500 | ZTR1 |
| 2025 | The ubiquitin ligase Itch limits mTORC1 nutrient sensing in B cells1R03TR005001-01A1 · under RFA-TR-22-030 | MOSER, EMILY K. | UNIVERSITY OF FLORIDA, FL | $152,500 | ZTR1 |
| 2025 | A mouse model of HUWE1 syndrome1R03TR005627-01 · under RFA-TR-22-030 | KUROKAWA, MANABU | KENT STATE UNIVERSITY, OH | $151,809 | ZTR1 |
| 2025 | Mechanisms of Zic2 function in zebrafish.1R03NS135565-01A1 · under RFA-TR-22-030 | GRINBLAT, YEVGENYA | UNIVERSITY OF WISCONSIN-MADISON, WI | $149,294 | ZTR1 |
| 2025 | Screening Variants of Unknown Significance to Identify Pathogenic Variants of the Manganese Transporter SLC39A81R03TR005599-01 · under RFA-TR-22-030 | HU, JIAN | MICHIGAN STATE UNIVERSITY, MI | $148,248 | ZTR1 |
| 2024 | Analysis of CTCF Function in Neurodevelopment1R03NS138561-01 · under RFA-TR-22-030 | WATSON, LAUREN ASHLEY | UNIVERSITY OF CALIFORNIA, SAN DIEGO, CA | $216,000 | ZTR1 |
| 2024 | High Resolution Analysis of FOXP1 in the Developing Human Cerebellum1R03NS137458-01 · under RFA-TR-22-030 | ALDINGER, KIMBERLY ANNE | SEATTLE CHILDREN'S HOSPITAL, WA | $196,900 | ZTR1 |
| 2024 | Structure-function analysis of ALX4 disease alleles1R03TR004875-01 · under RFA-TR-22-030 | KOVALL, RHETT ALLEN | UNIVERSITY OF CINCINNATI, OH | $177,125 | ZTR1 |
| 2024 | Delineating pathogenic effects of ATP2C1 loss-of-function in human keratinocytes and organotypic epidermis to identify therapeutic strategies for Hailey-Hailey disease1R03TR005428-01A1 · under RFA-TR-22-030 | SIMPSON, CORY L | UNIVERSITY OF WASHINGTON, WA | $176,500 | ZTR1 |
| 2024 | Impact of ATP-binding cassette A3 (ABCA3) mutations on alveolar type 2 cell function and genetic complementation1R03TR004814-01A1 · under RFA-TR-22-030 | MCCRAY, PAUL B | UNIVERSITY OF IOWA, IA | $173,175 | ZTR1 |
| 2024 | Developing a Diurnal Rodent Model for Smith-Magenis Syndrome1R03NS137487-01A1 · under RFA-TR-22-030 | IWASE, SHIGEKIYAN, LILY | UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI | $170,499 | ZTR1 |
| 2024 | A transgenic toolbox to dissect molecular pathologies caused by OTX2 deficiency during ex vivo human ectoderm development1R03NS135564-01 · under RFA-TR-22-030 | STADTFELD, MATTHIAS | WEILL MEDICAL COLL OF CORNELL UNIV, NY | $169,500 | ZTR1 |
| 2024 | Role of hypothalamic MAGEL2 in motivation1R03MH137614-01A1 · under RFA-TR-22-030 | JO, YOUNG-HWAN | ALBERT EINSTEIN COLLEGE OF MEDICINE, NY | $168,000 | ZTR1 |
| 2024 | Towards a targeted therapy for Hailey Hailey Disease1R03TR005427-01A1 · under RFA-TR-22-030 | RAO, RAJINI | JOHNS HOPKINS UNIVERSITY, MD | $163,750 | ZTR1 |
| 2024 | Role of Phox2b in mouse respiratory chemoreceptor neurons1R03TR004719-01A1 · under RFA-TR-22-030 | SHI, YINGTANG | UNIVERSITY OF VIRGINIA, VA | $161,500 | ZTR1 |
| 2024 | Osteogenesis imperfecta caused by TMEM38B mutation: a deep investigation of cellular and extracellular consequences to identify new therapeutic targets1R03AR084261-01A1 · under RFA-TR-22-030 | CARRIERO, ALESSANDRAFORLINO, ANTONELLA | CITY COLLEGE OF NEW YORK, NY | $159,594 | ZTR1 |
| 2024 | Illuminating the function of CACNA2D4 in inherited retinal dystrophies1R03TR005086-01 · under RFA-TR-22-030 | LEE, AMY | UNIVERSITY OF TEXAS AT AUSTIN, TX | $158,750 | ZTR1 |
| 2024 | The role of GATAD1 in cardiomyocyte and cardiomyopathy1R03TR004997-01 · under RFA-TR-22-030 | FANG, XI | UNIVERSITY OF CALIFORNIA, SAN DIEGO, CA | $158,000 | ZTR1 |
| 2024 | Fragile X messenger ribonucleoprotein-1 mediated regulation of the Clathrin-Associated Adaptor Complex Protein-2 (AP2)1R03MH135518-01 · under RFA-TR-22-030 | BASSELL, GARY J | EMORY UNIVERSITY, GA | $156,500 | ZTR1 |
| 2024 | A novel murine model of 2-Hydroxyglutaric aciduria1R03TR004871-01A1 · under RFA-TR-22-030 | AVANTAGGIATI, MARIA L | GEORGETOWN UNIVERSITY, DC | $156,000 | ZTR1 |
| 2024 | Conditional knock-in of Gnb3/Gngt2 in mouse rod photoreceptors1R03TR005223-01 · under RFA-TR-22-030 | KISSELEV, OLEG G | SAINT LOUIS UNIVERSITY, MO | $151,500 | ZTR1 |
| 2024 | Phenotypic Analysis of SLC17A5 Neuromodulation in Salla Disease1R03NS135559-01 · under RFA-TR-22-030 | CALDWELL, GUY A | UNIVERSITY OF ALABAMA IN TUSCALOOSA, AL | $149,000 | ZTR1 |
| 2024 | Study of Nedd4L in Periventricular Nodular Heterotopia1R03NS137490-01A1 · under RFA-TR-22-030 | LEE, KWAN YOUNGTSAI, NIEN-PEI | UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL | $147,937 | ZTR1 |
| 2024 | Researching understudied proteins of Chiari Malformation1R03NS135570-01 · under RFA-TR-22-030 | EVANS, JAMES E | BATTELLE PACIFIC NORTHWEST LABORATORIES, WA | $141,698 | ZTR1 |
| 2024 | Functional characterization of clinically-identified coding variants in the transcription factor gene ZEB21R03TR004835-01A1 · under RFA-TR-22-030 | PARTRIDGE, EDWIN CHRISTOPHER | HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY, AL | $140,500 | ZTR1 |
| 2023 | Identifying understudied protein-related glycoproteome disruption in Congenital Disorders of Glycosylation1R03TR004626-01 · under RFA-TR-22-030 | EDMONDSON, ANDREW CHARLES | CHILDREN'S HOSP OF PHILADELPHIA, PA | $188,000 | ZTR1 |
| 2023 | Mechanistic and Therapeutic Studies using a Xenotransplanted RUNX1-Haploinsufficient Murine Model1R03TR004604-01 · under RFA-TR-22-030 | PONCZ, MORTIMER | CHILDREN'S HOSP OF PHILADELPHIA, PA | $178,000 | ZTR1 |
| 2023 | The Role of FOXM1 in Eosinophilic Esophagitis Pathogenesis1R03TR004578-01 · under RFA-TR-22-030 | MUIR, AMANDA BROOKE | CHILDREN'S HOSP OF PHILADELPHIA, PA | $178,000 | ZTR1 |
| 2023 | Characterization and Early Assays Development in FOXG1 Deficient Neurons1R03TR004660-01 · under RFA-TR-22-030 | HUBBS, JED L | BOSTON CHILDREN'S HOSPITAL, MA | $177,000 | ZTR1 |
| 2023 | FLI1 in Pulmonary Arterial Hypertension1R03TR004667-01 · under RFA-TR-22-030 | HEMNES, ANNA R | VANDERBILT UNIVERSITY MEDICAL CENTER, TN | $175,000 | ZTR1 |
| 2023 | ARID1a and Chromatin Landscape in Pulmonary Vascular Disease1R03TR004673-01 · under RFA-TR-22-030 | HADRI, LAHOUARIA | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY | $169,000 | ZTR1 |
| 2023 | Implications for Speckled proteins 110 and 140 in adaptive immunity1R03TR004623-01 · under RFA-TR-22-030 | BARNES, BETSY J | FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, NY | $167,500 | ZTR1 |
| 2023 | Molecular and Biochemical Basis of SMAD4 Mutation in Myhre Syndrome1R03TR004595-01 · under RFA-TR-22-030 | MOU, HONGMEI | MASSACHUSETTS GENERAL HOSPITAL, MA | $164,856 | ZTR1 |
| 2023 | The role of Poorly Characterized Disease-related Proteins in Cortical Development1R03TR004616-01 · under RFA-TR-22-030 | KOLODKIN, ALEX L | JOHNS HOPKINS UNIVERSITY, MD | $163,750 | ZTR1 |
| 2023 | Develop a human liver system to study SLC25A13 mutations in citrin deficiency1R03TR004584-01 · under RFA-TR-22-030 | WU, XIANFANG | CLEVELAND CLINIC LERNER COM-CWRU, OH | $161,000 | ZTR1 |
| 2023 | Modeling Progressive Familial Intrahepatic Cholestasis Type I Caused by ATP8B1 deficiency1R03TR004601-01 · under RFA-TR-22-030 | YIN, CHUNYUE | CINCINNATI CHILDRENS HOSP MED CTR, OH | $160,500 | ZTR1 |
| 2023 | Establishing foundational tools and datasets for investigation of NSD1 gene function in neural development1R03TR004561-01 · under RFA-TR-22-030 | BARRETT, LINDY ELISE | BROAD INSTITUTE, INC., MA | $158,000 | ZTR1 |
| 2023 | Development of high-throughput cellular models for ASXL1-related diseases1R03TR004645-01 · under RFA-TR-22-030 | ARBOLEDA, VALERIE A | UNIVERSITY OF CALIFORNIA LOS ANGELES, CA | $157,041 | ZTR1 |
| 2023 | Pilot Studies of PAX3-FOXO1 Fusions Proteins in Alveolar Rhabdomyosarcoma1R03TR004687-01 · under RFA-TR-22-030 | SHOWALTER, SCOTT A | PENNSYLVANIA STATE UNIVERSITY, THE, PA | $156,136 | ZTR1 |
| 2023 | 3D Methodology for Interpreting Disease-Associated Genomic Variation in RAG21R03TR004589-01 · under RFA-TR-22-030 | ZIMMERMANN, MICHAEL T | MEDICAL COLLEGE OF WISCONSIN, WI | $156,000 | ZTR1 |
| 2023 | Role of SETD5 in Moyamoya Disease Pathogenesis1R03TR004580-01 · under RFA-TR-22-030 | KWARTLER, CALLIE S | UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TX | $156,000 | ZTR1 |
| 2023 | Developing tools for calcium imaging in ITPR2-linked liver pathogenesis1R03TR004644-01 · under RFA-TR-22-030 | HAJNOCZKY, GYORGY | THOMAS JEFFERSON UNIVERSITY, PA | $156,000 | ZTR1 |
| 2023 | Bivalent degraders of the understudied transcription factor TBXT for the rare cancer chordoma1R03TR004628-01 · under RFA-TR-22-030 | DREWRY, DAVID HAROLD | UNIV OF NORTH CAROLINA CHAPEL HILL, NC | $155,500 | ZTR1 |
| 2023 | Popliteal Pterygium syndrome, IRf6, and the periderm1R03TR004674-01 · under RFA-TR-22-030 | DUNNWALD, MARTINE | UNIVERSITY OF IOWA, IA | $155,500 | ZTR1 |
| 2023 | Enabling temporal and spatial restriction of MYT1L to identify molecular and postnatal circuit-level druggable targets1R03MH133948-01 · under RFA-TR-22-030 | MALONEY, SUSAN EILEEN | WASHINGTON UNIVERSITY, MO | $155,500 | ZTR1 |
| 2023 | Development of tools and knowledge to facilitate the investigation of chloride channel regulator CLCA2 in rare human diseasses1R03TR004639-01 · under RFA-TR-22-030 | BRETT, THOMAS JOHN | WASHINGTON UNIVERSITY, MO | $155,500 | ZTR1 |
| 2023 | Configuration-specific cofactors of Oct41R03TR004568-01 · under RFA-TR-22-030 | TANTIN, DEAN | UNIVERSITY OF UTAH, UT | $154,000 | ZTR1 |
| 2023 | Preliminary Functional Studies of an Understudied NDD Gene in Mice1R03MH133908-01 · under RFA-TR-22-030 | POWELL, CRAIG M | UNIVERSITY OF ALABAMA AT BIRMINGHAM, AL | $148,500 | ZTR1 |
| 2023 | Pilot Project Investigating the PAX3-FOXO1 Protein in the Rare Disease Rhabdomyosarcoma1R03TR004666-01 · under RFA-TR-22-030 | KELLER, CHARLES | CHILDREN'S CANCER THERAPY DEVELOP/INST, OR | $140,000 | ZTR1 |
Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-09-0.1.0. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.