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NIH funding notice RFA-TR-22-030

Pilot Projects Investigating Understudied Proteins Associated with Rare Diseases (R03 Clinical Trial Not Allowed)

Closed on July 15, 2024.

Posted
June 28, 2022
Close date
July 15, 2024
Activity codes
R03
Institutes taking part
NCATS, NIMH, NINDS, NIAMS

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

Its page names no earlier notice: it is new, or it does not say.

Replaced by PAR-25-122.

Who won it before

58 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $9,402,381 in first-year total cost, median $157,750.

Most frequent study sections

  1. Special Emphasis Panel[ZTR1 RD-7 (01)]24
  2. Special Emphasis Panel[ZTR1 RD-1 (01)]13
  3. Special Emphasis Panel[ZTR1 RD-8 (01)]11
  4. Special Emphasis Panel[ZTR1 RD-1 (02)]10

Most frequent institutions

  1. CHILDREN'S HOSP OF PHILADELPHIA4
  2. WASHINGTON UNIVERSITY3
  3. BOSTON CHILDREN'S HOSPITAL2
  4. JOHNS HOPKINS UNIVERSITY2
  5. UNIVERSITY OF CALIFORNIA, SAN DIEGO2
Competing awards under RFA-TR-22-030 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2025Development of Bone Marrow Organoid System to Study RUNX1-Familial Platelet Disorder with Associated Myeloid Malignancy (RUNX1-FPD/MM)1R03TR004848-01A1CANTOR, ALAN B.BOSTON CHILDREN'S HOSPITAL, MA$178,000ZTR1
2025Localization and function of SLC24A5 in skin pigmentation1R03TR006113-01A1MARKS, MICHAEL SSVIDERSKAYA, ELENA VCHILDREN'S HOSP OF PHILADELPHIA, PA$178,000ZTR1
2025Identifying the downstream targets of neural FOXP11R03MH133952-01A1PEARSON, CAROLINE ALAYNEWEILL MEDICAL COLL OF CORNELL UNIV, NY$169,500ZTR1
2025Evaluating the therapeutic potential of gene replacement for SCYL1 deficiency syndrome1R03TR004825-01A1PELLETIER, STEPHANEINDIANA UNIVERSITY INDIANAPOLIS, IN$158,500ZTR1
2025Characterization of CLIC21R03TR005313-01A1SINGH, HARPREETOHIO STATE UNIVERSITY, OH$157,500ZTR1
2025Mechanisms for control of mitoribosome assembly by the GTPase ERAL11R03TR005620-01KARDON, JULIA R.BRANDEIS UNIVERSITY, MA$157,260ZTR1
2025Profiling the specificity of SPI1 and SPIB activity for drug discovery1R03TR004842-01A1POON, GREGORY MAN KAIGEORGIA STATE UNIVERSITY, GA$156,000ZTR1
2025Sine Oculis Homeobox Homolog 1 and clusterin in Pulmonary Hypertension associated with Systemic Sclerosis1R03TR005085-01A1KARMOUTY-QUINTANA, HARRYUNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TX$156,000ZTR1
2025Impact of a Histone H3K9 Methyltransferase on Mitochondria1R03TR005626-01TANIS, JESSICA EUNIVERSITY OF DELAWARE, DE$155,559ZTR1
2025High-Content Analysis to Accelerate Mechanistic and Therapeutic Identification for ABCA3 Deficiency1R03TR004845-01A1WAMBACH, JENNIFERWASHINGTON UNIVERSITY, MO$155,500ZTR1
2025The ubiquitin ligase Itch limits mTORC1 nutrient sensing in B cells1R03TR005001-01A1MOSER, EMILY K.UNIVERSITY OF FLORIDA, FL$152,500ZTR1
2025A mouse model of HUWE1 syndrome1R03TR005627-01KUROKAWA, MANABUKENT STATE UNIVERSITY, OH$151,809ZTR1
2025Mechanisms of Zic2 function in zebrafish.1R03NS135565-01A1GRINBLAT, YEVGENYAUNIVERSITY OF WISCONSIN-MADISON, WI$149,294ZTR1
2025Screening Variants of Unknown Significance to Identify Pathogenic Variants of the Manganese Transporter SLC39A81R03TR005599-01HU, JIANMICHIGAN STATE UNIVERSITY, MI$148,248ZTR1
2024Analysis of CTCF Function in Neurodevelopment1R03NS138561-01WATSON, LAUREN ASHLEYUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$216,000ZTR1
2024High Resolution Analysis of FOXP1 in the Developing Human Cerebellum1R03NS137458-01ALDINGER, KIMBERLY ANNESEATTLE CHILDREN'S HOSPITAL, WA$196,900ZTR1
2024Structure-function analysis of ALX4 disease alleles1R03TR004875-01KOVALL, RHETT ALLENUNIVERSITY OF CINCINNATI, OH$177,125ZTR1
2024Delineating pathogenic effects of ATP2C1 loss-of-function in human keratinocytes and organotypic epidermis to identify therapeutic strategies for Hailey-Hailey disease1R03TR005428-01A1SIMPSON, CORY LUNIVERSITY OF WASHINGTON, WA$176,500ZTR1
2024Impact of ATP-binding cassette A3 (ABCA3) mutations on alveolar type 2 cell function and genetic complementation1R03TR004814-01A1MCCRAY, PAUL BUNIVERSITY OF IOWA, IA$173,175ZTR1
2024Developing a Diurnal Rodent Model for Smith-Magenis Syndrome1R03NS137487-01A1IWASE, SHIGEKIYAN, LILYUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$170,499ZTR1
2024A transgenic toolbox to dissect molecular pathologies caused by OTX2 deficiency during ex vivo human ectoderm development1R03NS135564-01STADTFELD, MATTHIASWEILL MEDICAL COLL OF CORNELL UNIV, NY$169,500ZTR1
2024Role of hypothalamic MAGEL2 in motivation1R03MH137614-01A1JO, YOUNG-HWANALBERT EINSTEIN COLLEGE OF MEDICINE, NY$168,000ZTR1
2024Towards a targeted therapy for Hailey Hailey Disease1R03TR005427-01A1RAO, RAJINIJOHNS HOPKINS UNIVERSITY, MD$163,750ZTR1
2024Role of Phox2b in mouse respiratory chemoreceptor neurons1R03TR004719-01A1SHI, YINGTANGUNIVERSITY OF VIRGINIA, VA$161,500ZTR1
2024Osteogenesis imperfecta caused by TMEM38B mutation: a deep investigation of cellular and extracellular consequences to identify new therapeutic targets1R03AR084261-01A1CARRIERO, ALESSANDRAFORLINO, ANTONELLACITY COLLEGE OF NEW YORK, NY$159,594ZTR1
2024Illuminating the function of CACNA2D4 in inherited retinal dystrophies1R03TR005086-01LEE, AMYUNIVERSITY OF TEXAS AT AUSTIN, TX$158,750ZTR1
2024The role of GATAD1 in cardiomyocyte and cardiomyopathy1R03TR004997-01FANG, XIUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$158,000ZTR1
2024Fragile X messenger ribonucleoprotein-1 mediated regulation of the Clathrin-Associated Adaptor Complex Protein-2 (AP2)1R03MH135518-01BASSELL, GARY JEMORY UNIVERSITY, GA$156,500ZTR1
2024A novel murine model of 2-Hydroxyglutaric aciduria1R03TR004871-01A1AVANTAGGIATI, MARIA LGEORGETOWN UNIVERSITY, DC$156,000ZTR1
2024Conditional knock-in of Gnb3/Gngt2 in mouse rod photoreceptors1R03TR005223-01KISSELEV, OLEG GSAINT LOUIS UNIVERSITY, MO$151,500ZTR1
2024Phenotypic Analysis of SLC17A5 Neuromodulation in Salla Disease1R03NS135559-01CALDWELL, GUY AUNIVERSITY OF ALABAMA IN TUSCALOOSA, AL$149,000ZTR1
2024Study of Nedd4L in Periventricular Nodular Heterotopia1R03NS137490-01A1LEE, KWAN YOUNGTSAI, NIEN-PEIUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$147,937ZTR1
2024Researching understudied proteins of Chiari Malformation1R03NS135570-01EVANS, JAMES EBATTELLE PACIFIC NORTHWEST LABORATORIES, WA$141,698ZTR1
2024Functional characterization of clinically-identified coding variants in the transcription factor gene ZEB21R03TR004835-01A1PARTRIDGE, EDWIN CHRISTOPHERHUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY, AL$140,500ZTR1
2023Identifying understudied protein-related glycoproteome disruption in Congenital Disorders of Glycosylation1R03TR004626-01EDMONDSON, ANDREW CHARLESCHILDREN'S HOSP OF PHILADELPHIA, PA$188,000ZTR1
2023Mechanistic and Therapeutic Studies using a Xenotransplanted RUNX1-Haploinsufficient Murine Model1R03TR004604-01PONCZ, MORTIMERCHILDREN'S HOSP OF PHILADELPHIA, PA$178,000ZTR1
2023The Role of FOXM1 in Eosinophilic Esophagitis Pathogenesis1R03TR004578-01MUIR, AMANDA BROOKECHILDREN'S HOSP OF PHILADELPHIA, PA$178,000ZTR1
2023Characterization and Early Assays Development in FOXG1 Deficient Neurons1R03TR004660-01HUBBS, JED LBOSTON CHILDREN'S HOSPITAL, MA$177,000ZTR1
2023FLI1 in Pulmonary Arterial Hypertension1R03TR004667-01HEMNES, ANNA RVANDERBILT UNIVERSITY MEDICAL CENTER, TN$175,000ZTR1
2023ARID1a and Chromatin Landscape in Pulmonary Vascular Disease1R03TR004673-01HADRI, LAHOUARIAICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$169,000ZTR1
2023Implications for Speckled proteins 110 and 140 in adaptive immunity1R03TR004623-01BARNES, BETSY JFEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, NY$167,500ZTR1
2023Molecular and Biochemical Basis of SMAD4 Mutation in Myhre Syndrome1R03TR004595-01MOU, HONGMEIMASSACHUSETTS GENERAL HOSPITAL, MA$164,856ZTR1
2023The role of Poorly Characterized Disease-related Proteins in Cortical Development1R03TR004616-01KOLODKIN, ALEX LJOHNS HOPKINS UNIVERSITY, MD$163,750ZTR1
2023Develop a human liver system to study SLC25A13 mutations in citrin deficiency1R03TR004584-01WU, XIANFANGCLEVELAND CLINIC LERNER COM-CWRU, OH$161,000ZTR1
2023Modeling Progressive Familial Intrahepatic Cholestasis Type I Caused by ATP8B1 deficiency1R03TR004601-01YIN, CHUNYUECINCINNATI CHILDRENS HOSP MED CTR, OH$160,500ZTR1
2023Establishing foundational tools and datasets for investigation of NSD1 gene function in neural development1R03TR004561-01BARRETT, LINDY ELISEBROAD INSTITUTE, INC., MA$158,000ZTR1
2023Development of high-throughput cellular models for ASXL1-related diseases1R03TR004645-01ARBOLEDA, VALERIE AUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$157,041ZTR1
2023Pilot Studies of PAX3-FOXO1 Fusions Proteins in Alveolar Rhabdomyosarcoma1R03TR004687-01SHOWALTER, SCOTT APENNSYLVANIA STATE UNIVERSITY, THE, PA$156,136ZTR1
20233D Methodology for Interpreting Disease-Associated Genomic Variation in RAG21R03TR004589-01ZIMMERMANN, MICHAEL TMEDICAL COLLEGE OF WISCONSIN, WI$156,000ZTR1
2023Role of SETD5 in Moyamoya Disease Pathogenesis1R03TR004580-01KWARTLER, CALLIE SUNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TX$156,000ZTR1
2023Developing tools for calcium imaging in ITPR2-linked liver pathogenesis1R03TR004644-01HAJNOCZKY, GYORGYTHOMAS JEFFERSON UNIVERSITY, PA$156,000ZTR1
2023Bivalent degraders of the understudied transcription factor TBXT for the rare cancer chordoma1R03TR004628-01DREWRY, DAVID HAROLDUNIV OF NORTH CAROLINA CHAPEL HILL, NC$155,500ZTR1
2023Popliteal Pterygium syndrome, IRf6, and the periderm1R03TR004674-01DUNNWALD, MARTINEUNIVERSITY OF IOWA, IA$155,500ZTR1
2023Enabling temporal and spatial restriction of MYT1L to identify molecular and postnatal circuit-level druggable targets1R03MH133948-01MALONEY, SUSAN EILEENWASHINGTON UNIVERSITY, MO$155,500ZTR1
2023Development of tools and knowledge to facilitate the investigation of chloride channel regulator CLCA2 in rare human diseasses1R03TR004639-01BRETT, THOMAS JOHNWASHINGTON UNIVERSITY, MO$155,500ZTR1
2023Configuration-specific cofactors of Oct41R03TR004568-01TANTIN, DEANUNIVERSITY OF UTAH, UT$154,000ZTR1
2023Preliminary Functional Studies of an Understudied NDD Gene in Mice1R03MH133908-01POWELL, CRAIG MUNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$148,500ZTR1
2023Pilot Project Investigating the PAX3-FOXO1 Protein in the Rare Disease Rhabdomyosarcoma1R03TR004666-01KELLER, CHARLESCHILDREN'S CANCER THERAPY DEVELOP/INST, OR$140,000ZTR1

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-10-0.1.1. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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