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NIH funding notice RFA-CA-27-019

Early-Stage Development of Informatics Technologies for Cancer Research and Management (U01 Clinical Trial Optional)

Open. Closes October 19, 2027.

Posted
May 21, 2026
Close date
October 19, 2027
Activity codes
U01
Institutes taking part
NCI

Read the notice on Grants.gov

The notices it replaced

  1. Reissues: RFA-CA-24-017 Early-Stage Development of Informatics Technologies for Cancer Research and Management (U01 Clinical Trial Optional)
  2. 2 steps back: RFA-CA-23-015 Early-Stage Development of Informatics Technologies for Cancer Research and Management (U01 Clinical Trial Optional)
  3. 3 steps back: RFA-CA-22-022 Early-Stage Development of Informatics Technologies for Cancer Research and Management (U01 Clinical Trial Optional)
  4. 4 steps back: RFA-CA-21-014 Early-Stage Development of Informatics Technologies for Cancer Research and Management (U01 Clinical Trial Optional)
  5. 5 steps back: RFA-CA-20-008 Early-Stage Development of Informatics Technologies for Cancer Research and Management (U01 Clinical Trial Optional)
  6. 6 steps back: RFA-CA-19-039 Early-Stage Development of Informatics Technologies for Cancer Research and Management (U01 Clinical Trial Optional)

Who won it before

32 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $13,001,032 in first-year total cost, median $403,482.

Most frequent study sections

  1. Special Emphasis Panel[ZCA1 TCRB-T (J1)]5
  2. Special Emphasis Panel[ZCA1 RTRB-R (M3)]4
  3. Special Emphasis Panel[ZCA1 SRB-X (J1)]4
  4. Special Emphasis Panel[ZCA1 TCRB-5 (J1)]3
  5. Special Emphasis Panel[ZCA1 TCRB-5 (J2)]3

Most frequent institutions

  1. JOHNS HOPKINS UNIVERSITY3
  2. CASE WESTERN RESERVE UNIVERSITY2
  3. UNIV OF MASSACHUSETTS MED SCH WORCESTER2
  4. UNIVERSITY OF MINNESOTA2
  5. UNIVERSITY OF PENNSYLVANIA2
Competing awards under RFA-CA-27-019 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2025MEDUSA(GM): an analysis platform for resolving mechanisms of action for anti-cancer drugs1U01CA305435-01 · under RFA-CA-24-017LEE, MICHAEL JUNGHOUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$415,491ZCA1
2025Deep learning based 3D network biology knowledge portal for precision oncology1U01CA294154-01A1 · under RFA-CA-24-017CHENG, FEIXIONGYU, HAIYUANCORNELL UNIVERSITY, NY$413,509ZCA1
2025Image informatics tools for curation and prognostic modeling in pediatric brain tumors1U01CA294415-01A1 · under RFA-CA-24-017TIWARI, PALLAVIVISWANATH, SATISH EASWARUNIVERSITY OF WISCONSIN-MADISON, WI$398,532ZCA1
2025Advancing Protein Isoform Analysis through an Integrated Computational Framework.1U01CA299401-01 · under RFA-CA-24-017DOU, YONGCHAOZHANG, BINGBAYLOR COLLEGE OF MEDICINE, TX$398,398ZCA1
2024Computational tools for accurate inference of genetic ancestry from cancer-derived molecular data1U01CA289357-01 · under RFA-CA-23-015KRASNITZ, ALEXANDERCOLD SPRING HARBOR LABORATORY, NY$457,549ZCA1
2024A Multilevel Data Analytic Solution to Advance Population Cancer Research1U01CA284198-01A1 · under RFA-CA-23-015ROSE, JOHNIECASE WESTERN RESERVE UNIVERSITY, OH$417,236ZCA1
2024Integrative Analysis and Visualization Platform for Cancer Regulatory Genomics1U01CA294209-01 · under RFA-CA-23-015WENG, ZHIPINGUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$416,745ZCA1
2024The immunoPeptidoGenomic (iPepGen) informatics resource forimmuno-oncology research1U01CA288888-01 · under RFA-CA-23-015GRIFFIN, TIMOTHY J.JAGTAP, PRATIK DNESVIZHSKII, ALEXEY IUNIVERSITY OF MINNESOTA, MN$400,530ZCA1
2024A liver digital twin for personalized cancer therapy1U01CA289068-01A1 · under RFA-CA-23-015RONCALI, EMILIEUNIVERSITY OF CALIFORNIA AT DAVIS, CA$357,939ZCA1
2023Visual Analytics for Exploration and Hypothesis Generation Using Highly MultiplexedSpatial Data of Tissues and Tumors1U01CA284207-01 · under RFA-CA-22-022PFISTER, HANSPETERSANTAGATA, SANDROHARVARD MEDICAL SCHOOL, MA$415,436ZCA1
2023Robust privacy preserving distributed analysis platform for cancer research: addressing data bias and disparities1U01CA274576-01A1 · under RFA-CA-22-022JIANG, XIAOQIANLONG, QIUNIVERSITY OF PENNSYLVANIA, PA$411,901ZCA1
2023m6A-suite: an informatics pipeline and resource for elucidating roles of m6A epitranscriptome in cancer1U01CA279618-01 · under RFA-CA-22-022HUANG, YUFEIUNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA$408,557ZCA1
2023Matching genotypes with personalized therapies: Development of a decision support infrastructure to augment the value of precision medicine1U01CA274631-01A1 · under RFA-CA-22-022ANAGNOSTOU, VALSAMOBOTSIS, TAXIARCHISJOHNS HOPKINS UNIVERSITY, MD$407,738ZCA1
2023Inferring Kinase Activity from Tumor Phosphoproteomic Data1U01CA284193-01 · under RFA-CA-22-022NAEGLE, KRISTEN MUNIVERSITY OF VIRGINIA, VA$404,886ZCA1
2023Personalization of graphical models using multi-omics data for subtype discovery and prognosis1U01CA274573-01A1 · under RFA-CA-22-022LUU, HUNG NNGUYEN, TIN CAUBURN UNIVERSITY AT AUBURN, AL$392,740ZCA1
2022GEARBOx - a multisite clinical trial matching tool for children with relapsed or refractory cancer1U01CA269420-01 · under RFA-CA-21-014VOLCHENBOUM, SAMUELUNIVERSITY OF CHICAGO, IL$531,117ZCA1
2022Analytical tools for studying the tumor microenvironment leveraging spatial transcriptomics1U01CA274489-01 · under RFA-CA-21-014FRIDLEY, BROOKE LH. LEE MOFFITT CANCER CTR & RES INST, FL$415,728ZCA1
2022muMS2: an open source R package for analyzing and integrating multi-omics datasets to improve early detection and understanding of colorectal cancer1U01CA264071-01A1 · under RFA-CA-21-014BALUNAS, MARCY JSCHLOSS, PATRICK DAVIDUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$408,122ZCA1
2022Developing informatics tools for optimized MRS for brain cancer research1U01CA269110-01 · under RFA-CA-21-014MARJANSKA, MALGORZATAUNIVERSITY OF MINNESOTA, MN$380,671ZCA1
2022A data-driven bioinformatics platform for the design and analysis of multiplexed antibody-based cytometry experiments in cancer research1U01CA269409-01A1 · under RFA-CA-21-014GONZALEZ CAMARA, PABLOUNIVERSITY OF PENNSYLVANIA, PA$359,378ZCA1
2022Development of Small Area Interactive Risk Maps for Cancer Control Efforts1U01CA258400-01A1 · under RFA-CA-21-014OLESON, JACOBUNIVERSITY OF IOWA, IA$349,606ZCA1
2021Advanced development of Lancet, an emerging tool for complex variant calling in cancer genomics1U01CA253405-01A1 · under RFA-CA-20-008NARZISI, GIUSEPPENEW YORK GENOME CENTER, NY$506,507ZCA1
2021Informatics Tools To Analyze And Model Whole Slide Image Data At The Single Cell Level1U01CA249245-01A1 · under RFA-CA-20-008XIAO, GUANGHUAUT SOUTHWESTERN MEDICAL CENTER, TX$407,930ZCA1
2021PROTEAN-CR: Proteomics Toolkit for Ensemble Analysis in Cancer Research1U01CA258512-01 · under RFA-CA-20-008KAVRAKI, LYDIA E.LIZEE, GREGORY ARICE UNIVERSITY, TX$402,077ZCA1
2021Utilizing Bayesian modeling to improve mutational signature inference in large-scale datasets1U01CA253500-01A1 · under RFA-CA-20-008CAMPBELL, JOSHUA DYAJIMA, MASANAOBOSTON UNIVERSITY MEDICAL CAMPUS, MA$401,917ZCA1
2021An informatics bridge over the valley of death for cancer Phase I trials of drug-combination therapies1U01CA248240-01A1 · under RFA-CA-20-008LI, LANGOHIO STATE UNIVERSITY, OH$387,617ZCA1
2021Integrative genomic and epigenomic analysis of cancer using long read sequencing1U01CA253481-01A1 · under RFA-CA-20-008SCHATZ, MICHAELJOHNS HOPKINS UNIVERSITY, MD$383,463ZCA1
2020Single-cell and imaging data integration software to spatially resolve the tumor microenvironment1U01CA253403-01 · under RFA-CA-19-039FERTIG, ELANAJOHNS HOPKINS UNIVERSITY, MD$405,874ZCA1
2020Informatics for Functional Integration of Heterogeneous Cancer Genome and Transcriptome Sequencing Data1U01CA247760-01 · under RFA-CA-19-039CHEN, KENUNIVERSITY OF TX MD ANDERSON CAN CTR, TX$398,399ZCA1
2020Informatics tools for identification, prioritization and clinical application of neoantigens1U01CA248235-01 · under RFA-CA-19-039GRIFFITH, MALACHIWASHINGTON UNIVERSITY, MO$391,732ZCA1
2020RadxTools for assessing tumor treatment response on imaging1U01CA248226-01 · under RFA-CA-19-039TIWARI, PALLAVIVISWANATH, SATISH EASWARCASE WESTERN RESERVE UNIVERSITY, OH$383,017ZCA1
2020Technology for efficient simulation of cancer cell transport1U01CA253511-01 · under RFA-CA-19-039RANDLES, AMANDA EDUKE UNIVERSITY, NC$370,690ZCA1

Data: Grants.gov's daily extract and NIH's notice pages and award files, in ScienceGraph release conductgrants-2026-11-10-0.1.1. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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