Other Basic Sciences at Cleveland Clinic

Leads a grant in this department

97 contact PIs of these awards, by the funding they lead. Other principal investigators on an award are listed with it and under Co-investigators.

1. Feixiong Cheng

   Leads 6 awards · $4,237,784

   • 1R01AG092591-01Department: NIH department code

     A Multimodal, Multiscale and Multistage Systems Biology (M3SB) Infrastructure for Precision Medicine in Alzheimer’s Disease and Longevity

     Cleveland Clinic Lerner College of Medicine

     Principal investigators: Feixiong Cheng (contact PI), Andrew J Saykin, Pengyue Zhang

     $802,034

     award amount
   • 5R01AG082118-03Department: NIH department code

     Characterize neuronal and glial cell-specific vulnerability to proteinopathies in Alzheimer's disease using multimodal single-nuclei genomic and epigenomic approaches

     Cleveland Clinic Lerner College of Medicine

     Principal investigators: Feixiong Cheng (contact PI), Andrew A Pieper, Borna Bonakdarpour, Margaret E Flanagan

     $783,415

     award amount
   • 5R01AG076448-04Department: NIH department code

     TREM2 Genotype-Informed Drug Repurposing and Combination Therapy Design for Alzheimer’s Disease

     Cleveland Clinic Lerner College of Medicine

     Principal investigators: Feixiong Cheng (contact PI), Fei Wang, Li Gan

     $781,379

     award amount
   • 5U01AG073323-05Department: NIH department code

     Alzheimer's MultiOme Data Repurposing: Artificial Intelligence, Network Medicine, and Therapeutics Discovery

     Cleveland Clinic Lerner College of Medicine

     Principal investigators: Feixiong Cheng (contact PI), James Bruce Leverenz, Lynn Bekris

     $780,607

     award amount
   • 4R33AG083003-02Department: NIH department code

     Precision Medicine Digital Twins for Alzheimer’s Target and Drug Discovery and Longevity

     Cleveland Clinic Lerner College of Medicine
     $552,045

     award amount
   • 5R01AG084250-03Department: NIH department code

     Microglial Activation and Inflammatory Endophenotypes Underlying Sex Differences of Alzheimer’s Disease

     Cleveland Clinic Lerner College of Medicine

     Principal investigators: Feixiong Cheng (contact PI), Justin D. Lathia

     $538,304

     award amount

2. Michaela Ulrike Gack

   Leads 4 awards · $2,563,945

   • 5DP1AI169444-05Department: NIH department code

     Defining the viral PTMome: Towards the development of novel antiviral approaches

     Cleveland Clinic Lerner College of Medicine
     $1,127,000

     award amount
   • 1R01AI186249-01A1Department: NIH department code

     Host Regulation of Flavivirus Infection

     Cleveland Clinic Lerner College of Medicine
     $530,385

     award amount
   • 5R01AI165502-05Department: NIH department code

     Novel Role for Host Immunostimulatory RNA in Antiviral Immune Defense

     Cleveland Clinic Lerner College of Medicine
     $459,982

     award amount
   • 5R37AI087846-16Department: NIH department code

     Regulation of Host Innate Immunity Against Viral Infection

     Cleveland Clinic Lerner College of Medicine
     $446,578

     award amount

3. Stanley L Hazen

   Leads 3 awards · $2,370,791

   • 1R01HL172805-01A1Department: NIH department code

     Artificial sweeteners and cardiovascular disease

     Cleveland Clinic Lerner College of Medicine
     $796,395

     award amount
   • 5R01HL167831-02Department: NIH department code

     Gut microbial dietary phenylalanine metabolism and heart failure

     Cleveland Clinic Lerner College of Medicine
     $790,067

     award amount
   • 5R01HL169290-02Department: NIH department code

     Nutrition, terminal NAD metabolites and cardiovascular disease

     Cleveland Clinic Lerner College of Medicine
     $784,329

     award amount

4. Jae U Jung

   Leads 3 awards · $2,225,394

   • 5U01CA294881-02Department: NIH department code

     Development of three KSHV vaccine platforms and chimeric MHV68-K-G for in vivo mouse infection study

     Cleveland Clinic Lerner College of Medicine
     $972,133

     award amount
   • 5R01AI181758-02Department: NIH department code

     KSHV-mediated metabolic reprogramming for LANA expression and viral persistency

     Cleveland Clinic Lerner College of Medicine
     $675,416

     award amount
   • 5R01AI171201-04Department: NIH department code

     Reassortment of Bunyavirus in ticks and animal models

     Cleveland Clinic Lerner College of Medicine
     $577,845

     award amount

5. Sathyamangla V Prasad

   Leads 3 awards · $1,832,153

   • 1R01HL173543-01A1Department: NIH department code

     Mitochondria in cardiomyocyte-fibroblast transcellular cross-talk

     Cleveland Clinic Lerner College of Medicine
     $639,621

     award amount
   • 5R01HL162772-03Department: NIH department code

     Novel regulation of beta-adrenergic receptor function by phosphoinositide 3-kinase

     Cleveland Clinic Lerner College of Medicine
     $637,731

     award amount
   • 5R61HL171717-02Department: NIH department code

     Small Molecule Therapeutic for Heart Failure

     Cleveland Clinic Lerner College of Medicine

     Principal investigators: Sathyamangla V Prasad (contact PI), Vara Prasad Vn Josyula

     $554,801

     award amount

6. Justin D. Lathia

   Leads 2 awards · $1,793,651

   • 5P01CA245705-06Department: NIH department code

     Sex-based Differences in Glioma

     Cleveland Clinic Lerner College of Medicine
     $1,138,914

     award amount
   • 5R35NS127083-04Department: NIH department code

     Contribution of Myeloid-Derived Suppressor Cells to Neuro-Inflammatory Alterations and Disease Progression in Glioblastoma

     Cleveland Clinic Lerner College of Medicine
     $654,737

     award amount

   Also a principal investigator on 5R01AG084250-03, led by Feixiong Cheng.

7. Robert L Fairchild

   Leads 3 awards · $1,740,374

   • 5R01AI167939-04Department: NIH department code

     Chronic Antibody-Mediated Rejection of Kidney Allografts

     Cleveland Clinic Lerner College of Medicine
     $626,971

     award amount
   • 5R01AI158421-05Department: NIH department code

     Acute Antibody Mediated Kidney Allograft Rejection

     Cleveland Clinic Lerner College of Medicine
     $607,527

     award amount
   • 2R01AI040459-26Department: NIH department code

     Post-Transplant Inflammatory Response

     Cleveland Clinic Lerner College of Medicine
     $505,876

     award amount

8. Srinivasan Dasarathy

   Leads 4 awards · $1,633,092

   • 5U01DK130180-05Department: NIH department code

     Prospective evaluation of outcomes in cirrhosis of different etiologies: impact of HIV infection and simvastatin therapy

     Cleveland Clinic Lerner College of Medicine
     $733,101

     award amount
   • 5U01AA026976-07Department: NIH department code

     Integrated Therapies for Alcohol use in Alcohol-associated Liver Disease (ITAALD)- Cleveland Clinic Clinical Center

     Cleveland Clinic Lerner College of Medicine

     Principal investigators: Srinivasan Dasarathy (contact PI), David Streem

     $354,195

     award amount
   • 5R01DK133905-03Department: NIH department code

     Mechanistic basis of exercise responses in liver disease

     Cleveland Clinic Lerner College of Medicine
     $296,183

     award amount
   • 5U01DK061732-24Department: NIH department code

     Continuation of the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) Clinical Center-Cleveland site

     Cleveland Clinic Lerner College of Medicine
     $249,613

     award amount

9. Jennifer S Yu

   Leads 3 awards · $1,588,418

   • 1R01NS145466-01Department: NIH department code

     Role of SMARCA5 in Glioblastoma

     Cleveland Clinic Lerner College of Medicine

     Principal investigators: Jennifer S Yu (contact PI), Liangqi Xie

     $638,697

     award amount
   • 5R01NS124081-04Department: NIH department code

     lncRNA regulation of glioblastoma progression and therapeutic resistance

     Cleveland Clinic Lerner College of Medicine

     Principal investigators: Jennifer S Yu (contact PI), Jianjun Zhao

     $547,221

     award amount
   • 5R01NS130798-03Department: NIH department code

     Sema3C Signaling as an Alternative Activator of Canonical Wnt Signaling in Glioblastoma

     Cleveland Clinic Lerner College of Medicine
     $402,500

     award amount

10. Anna Valujskikh

    Leads 3 awards · $1,390,861

    • 5R01AI160740-05Department: NIH department code

      Mechanisms of alloantibody production following renal transplantation

      Cleveland Clinic Lerner College of Medicine
      $578,905

      award amount
    • 5R01AI113142-10Department: NIH department code

      Designing induction therapies to target memory T cells in high risk recipients

      Cleveland Clinic Lerner College of Medicine
      $479,266

      award amount
    • 1R56AI189535-01Department: NIH department code

      The impact of antinuclear antibodies on alloimmune responses to renal transplants

      Cleveland Clinic Lerner College of Medicine
      $332,690

      award amount

11. Hod Michael Dana

    Leads 2 awards · $1,313,816

    • 5U01NS123658-04Department: NIH department code

      Optimization of CaMPARI for large-scale, cellular-resolution activity recording in freely-moving mice

      Cleveland Clinic Lerner College of Medicine

      Principal investigators: Hod Michael Dana (contact PI), Marie-Eve Paquet, Robert E. Campbell

      $679,301

      award amount
    • 5R01NS134577-02Department: NIH department code

      Calcium imaging-based insights and guidance of deep brain stimulation to enhance chronic, post-stroke rehabilitation in a rodent model of ischemia

      Cleveland Clinic Lerner College of Medicine

      Principal investigators: Hod Michael Dana (contact PI), Kenneth B Baker

      $634,515

      award amount

12. Jacob Gardinier Scott

    Leads 4 awards · $1,206,844

    • 4R37CA244613-06Department: NIH department code

      Exploiting Ecology and Evolution to Prevent Therapy Resistance in EGFR-Driven Lung Cancer

      Cleveland Clinic Lerner College of Medicine
      $497,509

      award amount
    • 5U01CA280829-03Department: NIH department code

      Extending experimental evolutionary game theory in cancer in vivo to enable clinical translation: integrating spatio-temporal dynamics using mathematical modeling

      Cleveland Clinic Lerner College of Medicine

      Principal investigators: Jacob Gardinier Scott (contact PI), Andriy Marusyk

      $363,660

      award amount
    • 3U01CA280829-03S2Department: NIH department code

      Extending experimental evolutionary game theory in cancer in vivo to enable clinical translation: integrating spatio-temporal dynamics using mathematical modeling

      Cleveland Clinic Lerner College of Medicine

      Principal investigators: Jacob Gardinier Scott (contact PI), Andriy Marusyk

      $185,401

      award amount
    • 3U01CA280829-03S1Department: NIH department code

      Extending experimental evolutionary game theory in cancer in vivo to enable clinical translation: integrating spatio-temporal dynamics using mathematical modeling

      Cleveland Clinic Lerner College of Medicine

      Principal investigators: Jacob Gardinier Scott (contact PI), Andriy Marusyk

      $160,274

      award amount

13. Laura E. Nagy

    Leads 2 awards · $1,157,612

    • 5R01AA030699-03Department: NIH department code

      IRAKM and MINCLE in ALD

      Cleveland Clinic Lerner College of Medicine
      $602,163

      award amount
    • 5R01AA027456-05Department: NIH department code

      Transcriptional and non-transcriptional function of IRF3 in ALD

      Cleveland Clinic Lerner College of Medicine
      $555,449

      award amount

14. Apollo Stacy

    Leads 3 awards · $1,134,500

    • 1R21DE035249-01Department: NIH department code

      A Pathomimetic Gingiva-on-a-Chip for Assessing Microbiota-Directed Anti-Inflammatory Therapeutics

      Cleveland Clinic Lerner College of Medicine
      $442,750

      award amount
    • 1R35GM160210-01Department: NIH department code

      Role of nitrate in microbiota ecology

      Cleveland Clinic Lerner College of Medicine
      $442,750

      award amount
    • 5R00DE031372-04Department: NIH department code

      Role of sulfide in oral microbiota-host interactions that promote periodontitis

      Cleveland Clinic Lerner College of Medicine
      $249,000

      award amount

    Also a principal investigator on 1R21DE035242-01, led by Daniel James McGrail.

15. Feng C Lin

    Leads 2 awards · $1,067,511

    • 5R61HL171747-02Department: NIH department code

      Development of a first-in-class complement inhibitor for treating complement-mediated hematologic diseases

      Cleveland Clinic Lerner College of Medicine
      $563,500

      award amount
    • 5R01EY034077-03Department: NIH department code

      Role of CDCP1 in the pathogenesis of autoimmune uveitis

      Cleveland Clinic Lerner College of Medicine
      $504,011

      award amount

16. Paul L Fox

    Leads 2 awards · $1,060,350

    • 5R01NS124581-03Department: NIH department code

      Childhood-onset hypomyelinating leukodystrophy and the multi-tRNA synthetase complex

      Cleveland Clinic Lerner College of Medicine

      Principal investigators: Paul L Fox (contact PI), Ranjan Dutta

      $626,635

      award amount
    • 5R01NS124547-04Department: NIH department code

      The mammalian multi-tRNA synthetase complex

      Cleveland Clinic Lerner College of Medicine

      Principal investigators: Paul L Fox (contact PI), Valentin Gogonea

      $433,715

      award amount

17. Xianfang Wu

    Leads 2 awards · $1,006,477

    • 5R01AA031226-02Department: NIH department code

      Studying alcohol-associated liver disease and its interaction with rs738409 variant in PNPLA3 in a liver culture model

      Cleveland Clinic Lerner College of Medicine
      $523,477

      award amount
    • 5DP2AI170515-04Department: NIH department code

      Developing a renewable and dissectible human liver for the study of HBV/HCV infection

      Cleveland Clinic Lerner College of Medicine
      $483,000

      award amount

18. Andrei Ivanovich Ivanov

    Leads 2 awards · $985,926

    • 5R01DK131550-04Department: NIH department code

      Novel cytoskeletal mechanisms of pathogenic bacteria interactions with intestinal epithelium

      Cleveland Clinic Lerner College of Medicine
      $506,825

      award amount
    • 5R01DK137822-02Department: NIH department code

      Actin methylation as a novel mechanism that regulates gut barrier integrity and repair

      Cleveland Clinic Lerner College of Medicine
      $479,101

      award amount

    Also a principal investigator on 5R01DK132038-03, led by Florian Rieder.

19. Emilio Daniel Poggio

    Leads 2 awards · $973,403

    • 5U01DK129980-05Department: NIH department code

      Cleveland COPE-AKI Clinical Center

      Cleveland Clinic Lerner College of Medicine

      Principal investigators: Emilio Daniel Poggio (contact PI), Anne Marie Huml, Sevag Demirjian

      $696,022

      award amount
    • 5U01DK116097-08Department: NIH department code

      7/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Center

      Cleveland Clinic Lerner College of Medicine

      Principal investigators: Emilio Daniel Poggio (contact PI), Mona Devang Doshi

      $277,381

      award amount

    Also a principal investigator on 5U01DK114908-09, led by John F. O'Toole.

20. Christine M O'Connor

    Leads 2 awards · $900,357

    • 5R01AI150931-05Department: NIH department code

      Manipulation of host factors that promote HCMV latency

      Cleveland Clinic Lerner College of Medicine
      $477,589

      award amount
    • 5R01AI153348-05Department: NIH department code

      HCMV GPCR functions during latency and reactivation

      Cleveland Clinic Lerner College of Medicine
      $422,768

      award amount

21. Daniel James McGrail

    Leads 2 awards · $811,038

    • 1R21DE035242-01Department: NIH department code

      Systematic identification of drivers controlling Fusobacterium and oral squamous cell carcinoma interactions

      Cleveland Clinic Lerner College of Medicine

      Principal investigators: Daniel James McGrail (contact PI), Apollo Stacy

      $442,750

      award amount
    • 1R37CA295609-01Department: NIH department code

      Molecular mediators of disparate outcomes experienced by patients of African ancestry with lung cancer

      Cleveland Clinic Lerner College of Medicine
      $368,288

      award amount

22. Peiwen Chen

    Leads 2 awards · $805,528

    • 5R01NS127824-03Department: NIH department code

      Targeting macrophage reprogramming in glioblastoma

      Cleveland Clinic Lerner College of Medicine
      $403,028

      award amount
    • 5R01NS124594-04Department: NIH department code

      Mechanism and therapeutic potential of microglia regulation in glioblastoma

      Cleveland Clinic Lerner College of Medicine
      $402,500

      award amount

23. Vidula Vachharajani

    Leads 2 awards · $794,801

    • 5R35GM149240-03Department: NIH department code

      Immune Function in Sepsis: Role of Sirtuin

      Cleveland Clinic Lerner College of Medicine
      $402,500

      award amount
    • 5R01AA028763-05Department: NIH department code

      Immuno-metabolic dysfunction in alcohol with sepsis

      Cleveland Clinic Lerner College of Medicine
      $392,301

      award amount

24. Thaddeus S Stappenbeck

    Leads 1 award · $771,486

    • 5R01AI168411-02Department: NIH department code

      Innate immune responses to tissue infection by intestinal fungi inhibit wound repair

      Cleveland Clinic Lerner College of Medicine

      Principal investigators: Thaddeus S Stappenbeck (contact PI), Deborah A Hogan

      $771,486

      award amount

25. Shideng Bao

    Leads 2 awards · $770,788

    • 5R01NS128938-04Department: NIH department code

      Reprograming Macrophages and Targeting Glioma Stem Cells in Glioblastoma

      Cleveland Clinic Lerner College of Medicine
      $402,500

      award amount
    • 5R01CA277966-03Department: NIH department code

      Macrophage-based Therapy and Immune Checkpoint Blockade for Glioblastoma

      Cleveland Clinic Lerner College of Medicine
      $368,288

      award amount

26. Tatiana V Byzova

    Leads 1 award · $767,342

    • 5R01AG082382-02Department: NIH department code

      Novel oxidative pathway targets microglia in Alzheimer's disease

      Cleveland Clinic Lerner College of Medicine

      Principal investigators: Tatiana V Byzova (contact PI), Eugene A Podrez

      $767,342

      award amount

27. Xiaojuan Li

    Leads 1 award · $767,019

    • 5R01AR077452-05Department: NIH department code

      Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry

      Cleveland Clinic Lerner College of Medicine
      $767,019

      award amount

    Also a principal investigator on 5R01AR084758-02, led by John J Elias.

28. Ruth A. Keri

    Leads 3 awards · $758,273

    • 5R01CA257502-05Department: NIH department code

      Discovering the role of YES1 in triple negative breast cancer

      Cleveland Clinic Lerner College of Medicine
      $461,334

      award amount
    • 5R21CA288795-02Department: NIH department code

      Targeting NEK2 to potentiate standard of care therapies for breast cancer

      Cleveland Clinic Lerner College of Medicine
      $225,803

      award amount
    • 3R01CA257502-05S1Department: NIH department code

      Discovering the role of YES1 in triple negative breast cancer

      Cleveland Clinic Lerner College of Medicine
      $71,136

      award amount

29. Jonathan Mark Brown

    Leads 1 award · $743,302

    • 1R01HL179780-01Department: NIH department code

      Gut Microbe-Derived Lipids Shape Chronic Inflammation in Cardiometabolic Disease

      Cleveland Clinic Lerner College of Medicine
      $743,302

      award amount

30. Serpil C. Erzurum

    Leads 1 award · $732,225

    • 1R01HL174511-01A1Department: NIH department code

      Mitochondrial Mechanisms in Asthma

      Cleveland Clinic Lerner College of Medicine
      $732,225

      award amount

31. Keith R. McCrae

    Leads 1 award · $720,736

    • 5R01HL164516-03Department: NIH department code

      Mechanisms of cancer immunotherapy-associated thrombosis

      Cleveland Clinic Lerner College of Medicine

      Principal investigators: Keith R. McCrae (contact PI), Alok A Khorana, Claudia Marcela Diaz-Montero

      $720,736

      award amount

32. Timothy An-Thy Chan

    Leads 1 award · $713,601

    • 1R01CA294640-01A1Department: NIH department code

      Homologous recombination repair pathway mutations and genetic mechanisms shaping anti-tumor immunity and immunotherapy efficacy

      Cleveland Clinic Lerner College of Medicine

      Principal investigators: Timothy An-Thy Chan (contact PI), Nadeem Riaz

      $713,601

      award amount

33. Stephanie L. Schmit

    Leads 1 award · $679,508

    • 5R01CA248931-05Department: NIH department code

      Variation in tumor-associated immune profiles and colorectal cancer outcomes

      Cleveland Clinic Lerner College of Medicine
      $679,508

      award amount

34. Jaroslaw P. MacIejewski

    Leads 1 award · $658,812

    • 5R01DK131923-04Department: NIH department code

      Eltombopag: Novel Mode of Action on Normal and Aplastic Anemia Hematopoietic Stem Cells

      Cleveland Clinic Lerner College of Medicine

      Principal investigators: Jaroslaw P. MacIejewski (contact PI), Babal K Jha

      $658,812

      award amount

    Also a principal investigator on 1R01CA302819-01, led by Li Lily Wang.

35. Jeannette Sophia Messer

    Leads 1 award · $656,988

    • 1R01HL178625-01Department: NIH department code

      The role of HMGB1 in the lung response to bacterial injury

      Cleveland Clinic Lerner College of Medicine
      $656,988

      award amount

36. Li Lily Wang

    Leads 1 award · $654,837

    • 1R01CA302819-01Department: NIH department code

      Investigating the Role of VISTA in Driving Immune Evasion in Acute Myeloid Leukemia

      Cleveland Clinic Lerner College of Medicine

      Principal investigators: Li Lily Wang (contact PI), Jaroslaw P. MacIejewski

      $654,837

      award amount

37. Hoonkyo Suh

    Leads 1 award · $632,575

    • 5R01AA031028-03Department: NIH department code

      Activity and connectivity of hippocampal newborn neurons underlie alcohol withdrawal-associated syndromes

      Cleveland Clinic Lerner College of Medicine
      $632,575

      award amount

38. Florian Rieder

    Leads 1 award · $630,078

    • 5R01DK132038-03Department: NIH department code

      Septins in intestinal fibrosis

      Cleveland Clinic Lerner College of Medicine

      Principal investigators: Florian Rieder (contact PI), Andrei Ivanovich Ivanov

      $630,078

      award amount

39. William M Baldwin

    Leads 1 award · $625,596

    • 5R01AI165513-05Department: NIH department code

      Complement regulates macrophage and platelet function in kidney transplants

      Cleveland Clinic Lerner College of Medicine
      $625,596

      award amount

40. John R. Sedor

    Leads 1 award · $615,838

    • 5R01DK135265-03Department: NIH department code

      Mechanisms of Kidney Diseases Associated With APOL1 Variation

      Cleveland Clinic Lerner College of Medicine

      Principal investigators: John R. Sedor (contact PI), John F. O'Toole, Leslie A Bruggeman, Oliver Wessely

      $615,838

      award amount

    Also a principal investigator on 5R01DK127638-05, led by Leslie A Bruggeman; 5U01DK114908-09, led by John F. O'Toole.

41. Leslie A Bruggeman

    Leads 1 award · $564,933

    • 5R01DK127638-05Department: NIH department code

      Intracellular functions of APOL1 in the kidney

      Cleveland Clinic Lerner College of Medicine

      Principal investigators: Leslie A Bruggeman (contact PI), John F. O'Toole, John R. Sedor

      $564,933

      award amount

    Also a principal investigator on 5R01DK135265-03, led by John R. Sedor.

42. Yuxin Wang

    Leads 1 award · $563,500

    • 5R01HL166544-02Department: NIH department code

      The vital role of T403 phosphorylation of STAT2 in post-viral bacterial pneumonia

      Cleveland Clinic Lerner College of Medicine
      $563,500

      award amount

43. Sarah Marie Schumacher

    Leads 1 award · $563,168

    • 5R01HL160755-04Department: NIH department code

      AS160 as a nodal regulator of the cardiac response to metabolic stress

      Cleveland Clinic Lerner College of Medicine
      $563,168

      award amount

44. Ina Nemet

    Leads 1 award · $558,107

    • 5R01HL160747-04Department: NIH department code

      Gut-microbial metabolism of aromatic amino acids and cardiovascular disease

      Cleveland Clinic Lerner College of Medicine
      $558,107

      award amount

45. Jun Qin

    Leads 1 award · $550,409

    • 5R01HL058758-24Department: NIH department code

      Molecular basis of ILK-mediated cell adhesion

      Cleveland Clinic Lerner College of Medicine
      $550,409

      award amount

46. Dennis J Stuehr

    Leads 1 award · $530,159

    • 5R01GM148664-03Department: NIH department code

      Defining a pathway for mitochondrial heme trafficking

      Cleveland Clinic Lerner College of Medicine
      $530,159

      award amount

47. Neetu Gupta

    Leads 1 award · $529,302

    • 5R01AI172916-03Department: NIH department code

      Novel unconventional myosins in B cell homeostasis

      Cleveland Clinic Lerner College of Medicine
      $529,302

      award amount

48. Bin Zhang

    Leads 1 award · $518,074

    • 5R01HL169427-02Department: NIH department code

      Developing hemophilia A therapeutics by targeting translational and posttranslational regulation of FVIII

      Cleveland Clinic Lerner College of Medicine
      $518,074

      award amount

49. Christopher Michael Hine

    Leads 1 award · $515,147

    • 5R01NS127374-03Department: NIH department code

      Hydrogen sulfide functions as a tumor suppressor in glioblastoma

      Cleveland Clinic Lerner College of Medicine
      $515,147

      award amount

50. John F. O'Toole

    Leads 1 award · $490,577

    • 5U01DK114908-09Department: NIH department code

      Cleveland Precision Medicine Chronic Kidney Disease Cohort

      Cleveland Clinic Lerner College of Medicine

      Principal investigators: John F. O'Toole (contact PI), Emilio Daniel Poggio, John R. Sedor

      $490,577

      award amount

    Also a principal investigator on 5R01DK135265-03, led by John R. Sedor; 5R01DK127638-05, led by Leslie A Bruggeman.

51. Shuyang Chen

    Leads 1 award · $487,468

    • 1R37CA295784-01A1Department: NIH department code

      Exploring palmitoylation dynamics: impacts on Cadherin-Catenin adhesion and lipid metabolism in the progression of melanoma lung metastasis

      Cleveland Clinic Lerner College of Medicine
      $487,468

      award amount

52. Oliver Wessely

    Leads 1 award · $483,000

    • 5U01DK131383-05Department: NIH department code

      High resolution transcriptome and gene regulatory mapping of human ureter and bladder across the lifespan

      Cleveland Clinic Lerner College of Medicine

      Principal investigators: Oliver Wessely (contact PI), Angela H Ting, Byron H Lee

      $483,000

      award amount

    Also a principal investigator on 5R01DK135265-03, led by John R. Sedor.

53. Jianjun Zhao

    Leads 1 award · $472,634

    • 5R01CA251141-05Department: NIH department code

      New mouse model of cisplatin-induced AKI and development of prevention therapy

      Cleveland Clinic Lerner College of Medicine
      $472,634

      award amount

    Also a principal investigator on 5R01NS124081-04, led by Jennifer S Yu.

54. Jianjun Wu

    Leads 1 award · $467,502

    • 5R37CA288747-02Department: NIH department code

      Deciphering the Roles of STING-Mediated T cell Pyroptosis in Antitumor Immunity

      Cleveland Clinic Lerner College of Medicine
      $467,502

      award amount

55. Liangqi Xie

    Leads 1 award · $442,750

    • 1R21NS144792-01Department: NIH department code

      Induce and Image extrachromosomal DNA in human glioblastoma avatar

      Cleveland Clinic Lerner College of Medicine
      $442,750

      award amount

    Also a principal investigator on 1R01NS145466-01, led by Jennifer S Yu.

56. Suneel S Apte

    Leads 1 award · $434,682

    • 1R01AR085047-01A1Department: NIH department code

      Degradomics of proteolytic mechanisms in post-traumatic osteoarthritis

      Cleveland Clinic Lerner College of Medicine
      $434,682

      award amount

57. Ranjan Dutta

    Leads 1 award · $427,291

    • 5R01NS123532-04Department: NIH department code

      Understanding role of circadian disruption in pathogenesis of MS

      Cleveland Clinic Lerner College of Medicine

      Principal investigators: Ranjan Dutta (contact PI), Sujata Rao

      $427,291

      award amount

    Also a principal investigator on 5R01NS124581-03, led by Paul L Fox.

58. Rachel Greenberg Scheraga

    Leads 1 award · $425,473

    • 5R01HL155064-05Department: NIH department code

      TRPV4 Regulates Mechanosensitive Macrophage Functions in Lung Injury

      Cleveland Clinic Lerner College of Medicine
      $425,473

      award amount

59. Zihua Gong

    Leads 1 award · $405,116

    • 5R01CA222195-07Department: NIH department code

      The role of NUDT16 in DNA damage response and tumorigenesis

      Cleveland Clinic Lerner College of Medicine
      $405,116

      award amount

60. Jun Zhao

    Leads 1 award · $404,468

    • 5R01DE033632-02Department: NIH department code

      CDK6-dependent metabolic reprogramming in KSHV pathogenesis

      Cleveland Clinic Lerner College of Medicine
      $404,468

      award amount

61. Jan Claesen

    Leads 1 award · $402,500

    • 5R01AI153173-05Department: NIH department code

      Uncovering aryl polyene biology to identify new drug targets in Gram-negative bacterial pathogens

      Cleveland Clinic Lerner College of Medicine
      $402,500

      award amount

62. Mohammed Dwidar

    Leads 1 award · $402,500

    • 1R35GM156762-01Department: NIH department code

      Synthetic biology tools and strategies to streamline the sensing and responding to disease cues in engineered theragnostic bacteria.

      Cleveland Clinic Lerner College of Medicine
      $402,500

      award amount

63. Weiqiang Chen

    Leads 1 award · $402,500

    • 5R01DE033391-02Department: NIH department code

      Molecular mechanism of Zika virus-induced premature craniofacial suture closure

      Cleveland Clinic Lerner College of Medicine
      $402,500

      award amount

64. Michelle S Longworth

    Leads 1 award · $401,222

    • 5R01GM147138-03Department: NIH department code

      Interplay between LINE-1 retrotransposons, condensins, and IFN

      Cleveland Clinic Lerner College of Medicine
      $401,222

      award amount

65. Hyun Jung Kim

    Leads 1 award · $400,890

    • 1R33CA286797-01A1Department: NIH department code

      Microbiome-Mediated Tumor Immunomodulation in a Pathomimetic Colorectal Cancer Chip

      Cleveland Clinic Lerner College of Medicine
      $400,890

      award amount

66. Claudio Fiocchi

    Leads 1 award · $391,380

    • 5T32DK083251-15Department: NIH department code

      Combined Training Program in Digestive Disease Sciences

      Cleveland Clinic Lerner College of Medicine

      Principal investigators: Claudio Fiocchi (contact PI), Fabio Cominelli

      $391,380

      award amount

67. Jennifer J Gassman

    Leads 1 award · $374,835

    • 5U24HL175028-02Department: NIH department code

      Master - 2/2 Empaglifozin To Improve Right Ventricular Function in Pulmonary Arterial Hypertension

      Cleveland Clinic Lerner College of Medicine
      $374,835

      award amount

68. Donal Luse

    Leads 1 award · $373,119

    • 5R01GM121428-06Department: NIH department code

      The effect of nucleosomes on the earliest stages of RNA polymerase II transcription

      Cleveland Clinic Lerner College of Medicine
      $373,119

      award amount

69. Jan J Melenhorst

    Leads 1 award · $368,288

    • 5R01CA244958-05Department: NIH department code

      Mechanisms of nuclear Mcl-1 mediated chemoresistance

      Cleveland Clinic Lerner College of Medicine
      $368,288

      award amount

70. Jessica L Williams

    Leads 1 award · $362,250

    • 5R01NS119178-05Department: NIH department code

      The role of the astrocyte immunoproteasome during chronic CNS autoimmunity

      Cleveland Clinic Lerner College of Medicine
      $362,250

      award amount

71. Takuya Sakaguchi

    Leads 1 award · $354,200

    • 5R01DK103637-09Department: NIH department code

      Forward genetic analysis of biliary system formation

      Cleveland Clinic Lerner College of Medicine
      $354,200

      award amount

72. Asha R Kallianpur

    Leads 1 award · $353,731

    • 5R01MH124530-05Department: NIH department code

      Iron Dysregulation and Neuropsychiatric Complications of HIV Across the Lifespan: Impact of Biologic Factors, Antiretroviral Therapy and Genetics

      Cleveland Clinic Lerner College of Medicine
      $353,731

      award amount

73. Ying Ni

    Leads 1 award · $351,252

    • 5R01HD105049-04Department: NIH department code

      Modeling Autism and Comorbid Cancer Risk in Individuals with Germline PTEN Mutations

      Cleveland Clinic Lerner College of Medicine

      Principal investigators: Ying Ni (contact PI), Sujata Patil

      $351,252

      award amount

74. Nicole Welch

    Leads 2 awards · $340,129

    • 5K08AA028794-05Department: NIH department code

      Mechanisms of HIF1 alpha mediated dysregulated skeletal muscle proteostasis in alcoholic liver disease

      Cleveland Clinic Lerner College of Medicine
      $179,129

      award amount
    • 1R03AA032324-01Department: NIH department code

      Metabolic basis of sarcopenia in alcohol-related liver disease

      Cleveland Clinic Lerner College of Medicine
      $161,000

      award amount

75. Kenneth M. Merz

    Leads 1 award · $329,648

    • 5R01GM130641-06Department: NIH department code

      Modeling Transition Metal Ion Binding to Proteins

      Cleveland Clinic Lerner College of Medicine
      $329,648

      award amount

76. Hannelore Heemers

    Leads 1 award · $322,764

    • 5R01CA248048-05Department: NIH department code

      A novel determinant of prostate cancer growth

      Cleveland Clinic Lerner College of Medicine
      $322,764

      award amount

77. Jonathan D Smith

    Leads 1 award · $321,270

    • 5T32GM137868-05Department: NIH department code

      Molecular Medicine Training Program at Cleveland Clinic/Case Western Reserve University

      Cleveland Clinic Lerner College of Medicine
      $321,270

      award amount

78. Evi X. Stavrou

    Leads 1 award · $303,436

    • 5TL1DK132770-05Department: NIH department code

      KUH-TN Training Core

      Cleveland Clinic Lerner College of Medicine
      $303,436

      award amount

79. Deanna Marie Tiek

    Leads 1 award · $249,000

    • 4R00CA279896-03Department: NIH department code

      Ferroptosis in drug resistant glioma

      Cleveland Clinic Lerner College of Medicine
      $249,000

      award amount

80. Antoine Louveau

    Leads 1 award · $241,500

    • 1R01MH133584-01A1Department: NIH department code

      Lymphatic dysfunction in neurodevelopmental disorders and associated behaviors

      Cleveland Clinic Lerner College of Medicine
      $241,500

      award amount

81. Rodrigo Lopez Gonzalez

    Leads 1 award · $236,668

    • 1K01NS136791-01A1Department: NIH department code

      Analysis of C9ORF72-associated poly (GR) interactions on BAF chromatin remodeling complex structure and function

      Cleveland Clinic Lerner College of Medicine
      $236,668

      award amount

82. Seth Joel Corey

    Leads 1 award · $231,801

    • 5R01DK132812-03Department: NIH department code

      Genetic Dissection of Stress Responses in Shwachman-Diamond Syndrome

      Cleveland Clinic Lerner College of Medicine
      $231,801

      award amount

83. Raed A. Dweik

    Leads 1 award · $218,178

    • 5T32HL155005-05Department: NIH department code

      Supporting Multidisciplinary Achievement in Respiratory Research Training (SMARRT)

      Cleveland Clinic Lerner College of Medicine
      $218,178

      award amount

84. Vladimir Makarov

    Leads 1 award · $212,567

    • 5R50CA293821-02Department: NIH department code

      Immunogenomics platform for the analysis of cancer

      Cleveland Clinic Lerner College of Medicine
      $212,567

      award amount

85. John J Elias

    Leads 1 award · $195,213

    • 5R01AR084758-02Department: NIH department code

      Evaluating Over Constraint of the Patella following MPFL Reconstruction as a Contributing Factor to Progressive Cartilage Degradation

      Cleveland Clinic Lerner College of Medicine

      Principal investigators: John J Elias (contact PI), Xiaojuan Li

      $195,213

      award amount

86. Brian P Rubin

    Leads 1 award · $188,169

    • 5R21CA288673-02Department: NIH department code

      Forging a new path with cyclin-dependent kinase inhibitors to treat epithelioid hemangioendothelioma

      Cleveland Clinic Lerner College of Medicine

      Principal investigators: Brian P Rubin (contact PI), Ajaybabu Pobbati

      $188,169

      award amount

87. Richa Sharma

    Leads 1 award · $166,852

    • 5K08DK134873-05Department: NIH department code

      Consequences of gain-of-function RPA1 mutations on telomere function and hematopoiesis

      Cleveland Clinic Lerner College of Medicine
      $166,852

      award amount

88. Logan Harper

    Leads 1 award · $159,992

    • 5K23MD017284-04Department: NIH department code

      Improving sarcoidosis patients’ care with a collaboratively developed, patient centered program

      Cleveland Clinic Lerner College of Medicine
      $159,992

      award amount

89. Amy Attaway

    Leads 1 award · $151,578

    • 1K08HL168348-01A1Department: NIH department code

      Nocturnal hypoxemia dysregulates skeletal muscle protein homeostasis in COPD

      Cleveland Clinic Lerner College of Medicine
      $151,578

      award amount

90. Anu Aggarwal

    Leads 1 award · $118,919

    • 1K99HL181079-01Department: NIH department code

      Platelets as therapeutic and diagnostic entity in fibromuscular dysplasia

      Cleveland Clinic Lerner College of Medicine
      $118,919

      award amount

91. Noha Abdelwahab Hassan Ali Hassan

    Leads 1 award · $113,868

    • 7K01AI163412-05Department: NIH department code

      Immune-Related Adverse Events in Melanoma Patients Receiving Adjuvant Immune Checkpoint Inhibitor Therapy

      Cleveland Clinic Lerner College of Medicine
      $113,868

      award amount

92. Julie Y. Zhou

    Leads 1 award · $78,520

    • 5F32DK136180-02Department: NIH department code

      Internalization of dead cells governs intestinal stem cell activity

      Cleveland Clinic Lerner College of Medicine
      $78,520

      award amount

93. Mary Talley

    Leads 1 award · $76,756

    • 5F32HD114499-02Department: NIH department code

      The role of retrotransposonable elements in neurodevelopment and disease

      Cleveland Clinic Lerner College of Medicine
      $76,756

      award amount

94. Vanessa Salazar

    Leads 1 award · $54,538

    • 5F31AI174784-02Department: NIH department code

      Host and microbe-dependent mechanisms of enhanced autoimmune susceptibility driven by checkpoint inhibitors

      Cleveland Clinic Lerner College of Medicine
      $54,538

      award amount

95. Taylor Lynn Brzozowski

    Leads 1 award · $49,248

    • 5F31CA284668-02Department: NIH department code

      Ribonucleotide Reductase as a Driver of Breast Cancer Aggressiveness

      Cleveland Clinic Lerner College of Medicine
      $49,248

      award amount

96. Andras Kristopher Ponti

    Leads 1 award · $43,138

    • 1F31NS141426-01Department: NIH department code

      Investigating the role of sulfide oxidation and declining hydrogen sulfide in glioblastoma

      Cleveland Clinic Lerner College of Medicine
      $43,138

      award amount

97. Molly Guthrie

    Leads 1 award · $41,876

    • 1F31CA290723-01A1Department: NIH department code

      SMARCA5 Inhibition as a Therapeutic Target for Glioblastoma

      Cleveland Clinic Lerner College of Medicine
      $41,876

      award amount

Co-investigators

Named as principal investigators on these awards, which someone else leads. They may belong to another department or institution: their own, below, comes from the awards they lead.

• Andrew J Saykin

  Co-investigator on 1R01AG092591-01, led by Feixiong Cheng

  From the FY2025 awards this person leads

  • Indiana University Indianapolis · Radiology (NIH department code, 2 awards)
  • Northern California Institute/Res/Edu (no department on record, 1 award)
  • Indiana University Indianapolis (no department on record, 1 award)

• Pengyue Zhang

  Co-investigator on 1R01AG092591-01, led by Feixiong Cheng

  Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.

• Andrew A Pieper

  Co-investigator on 5R01AG082118-03, led by Feixiong Cheng

  Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.

• Borna Bonakdarpour

  Co-investigator on 5R01AG082118-03, led by Feixiong Cheng

  Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.

• Margaret E Flanagan

  Co-investigator on 5R01AG082118-03, led by Feixiong Cheng

  From the FY2025 awards this person leads

  • UT Health Science Center Houston (no department on record, 1 award)

• Fei Wang

  Co-investigator on 5R01AG076448-04, led by Feixiong Cheng

  From the FY2025 awards this person leads

  • Weill Cornell Medicine · Public Health (NIH department code, 2 awards)

• Li Gan

  Co-investigator on 5R01AG076448-04, led by Feixiong Cheng

  From the FY2025 awards this person leads

  • Weill Cornell Medicine · Neurosciences (NIH department code, 2 awards)

• James Bruce Leverenz

  Co-investigator on 5U01AG073323-05, led by Feixiong Cheng

  From the FY2025 awards this person leads

  • Seattle Inst for Biomedical/Clinical Res (no department on record, 1 award)
  • Cleveland Clinic Lerner College of Medicine (no department on record, 1 award)

• Lynn Bekris

  Co-investigator on 5U01AG073323-05, led by Feixiong Cheng

  From the FY2025 awards this person leads

  • Cleveland Clinic Lerner College of Medicine (no department on record, 1 award)

• Deborah A Hogan

  Co-investigator on 5R01AI168411-02, led by Thaddeus S Stappenbeck

  From the FY2025 awards this person leads

  • Dartmouth College · Microbiology & Immunology (NIH department code, 2 awards)
  • Dartmouth College (no department on record, 1 award)

• Eugene A Podrez

  Co-investigator on 5R01AG082382-02, led by Tatiana V Byzova

  Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.

• Alok A Khorana

  Co-investigator on 5R01HL164516-03, led by Keith R. McCrae

  Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.

• Claudia Marcela Diaz-Montero

  Co-investigator on 5R01HL164516-03, led by Keith R. McCrae

  From the FY2025 awards this person leads

  • Cleveland Clinic Lerner College of Medicine (no department on record, 1 award)

• Nadeem Riaz

  Co-investigator on 1R01CA294640-01A1, led by Timothy An-Thy Chan

  Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.

• Andriy Marusyk

  Co-investigator on 5U01CA280829-03, led by Jacob Gardinier Scott; 3U01CA280829-03S2, led by Jacob Gardinier Scott; 3U01CA280829-03S1, led by Jacob Gardinier Scott

  From the FY2025 awards this person leads

  • Moffitt Cancer Center (no department on record, 1 award)

• Anne Marie Huml

  Co-investigator on 5U01DK129980-05, led by Emilio Daniel Poggio

  Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.

• Sevag Demirjian

  Co-investigator on 5U01DK129980-05, led by Emilio Daniel Poggio

  Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.

• Marie-Eve Paquet

  Co-investigator on 5U01NS123658-04, led by Hod Michael Dana

  Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.

• Robert E. Campbell

  Co-investigator on 5U01NS123658-04, led by Hod Michael Dana

  Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.

• Babal K Jha

  Co-investigator on 5R01DK131923-04, led by Jaroslaw P. MacIejewski

  Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.

• Kenneth B Baker

  Co-investigator on 5R01NS134577-02, led by Hod Michael Dana

  From the FY2024 awards this person leads

  • Cleveland Clinic Lerner College of Medicine · Other Basic Sciences (NIH department code, 1 award)

• Vara Prasad Vn Josyula

  Co-investigator on 5R61HL171717-02, led by Sathyamangla V Prasad

  Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.

• Angela H Ting

  Co-investigator on 5U01DK131383-05, led by Oliver Wessely

  Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.

• Byron H Lee

  Co-investigator on 5U01DK131383-05, led by Oliver Wessely

  Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.

• Valentin Gogonea

  Co-investigator on 5R01NS124547-04, led by Paul L Fox

  Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.

• Sujata Rao

  Co-investigator on 5R01NS123532-04, led by Ranjan Dutta

  From the FY2025 awards this person leads

  • Cleveland Clinic Lerner College of Medicine · Ophthalmology (NIH department code, 1 award)

• Fabio Cominelli

  Co-investigator on 5T32DK083251-15, led by Claudio Fiocchi

  From the FY2025 awards this person leads

  • Case Western Reserve University · Internal Medicine (NIH department code, 1 award)
  • Case Western Reserve University (no department on record, 1 award)

• David Streem

  Co-investigator on 5U01AA026976-07, led by Srinivasan Dasarathy

  Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.

• Sujata Patil

  Co-investigator on 5R01HD105049-04, led by Ying Ni

  Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.

• Mona Devang Doshi

  Co-investigator on 5U01DK116097-08, led by Emilio Daniel Poggio

  Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.

• Ajaybabu Pobbati

  Co-investigator on 5R21CA288673-02, led by Brian P Rubin

  Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.