Biochemistry at Columbia University

Leads a grant in this department

40 contact PIs of these awards, by the funding they lead. Other principal investigators on an award are listed with it and under Co-investigators.

1. Leong, Kam W

   Leads 3 awards · $2,738,912

   • 4UH3NS115598-04Department: NIH department code

     Focused Ultrasound-mediated Delivery of Gene-editing Elements to the Brain for Neurodegenerative Disorders
     $1,250,720

     award amount
   • 5UH3TR002151-05Department: NIH department code

     Integrated Microphysiological System of Cerebral Organoid and Blood Vessel for Disease Modeling and Neuropsychiatric Drug screening
     $1,166,451

     award amount
   • 3UH3NS115598-04S1Department: NIH department code

     Evaluation of nonviral gene editing systems in the brain assisted by focused ultrasound
     $321,741

     award amount

2. Zhang, Chaolin

   Leads 4 awards · $2,400,125

   • 1R35GM145279-01Department: NIH department code

     Complexity and evolution of splicing-regulatory networks
     $689,596

     award amount
   • 1R01NS125018-01Department: NIH department code

     RNA regulatory networks in neuronal cell type diversity and function
     $624,986

     award amount
   • 1R56HG012359-01Department: NIH department code

     Mapping proximal and distal splicing-regulatory elements
     $568,846

     award amount
   • 5R01GM136856-02Department: NIH department code

     Integrative analysis of tissue-specific alternative splicing regulation under adaptive selection
     $516,697

     award amount

3. Lomvardas, Stavros

   Leads 5 awards · $2,339,419

   • 5U01DA052783-03Department: NIH department code

     Interrogating genome folding trajectories in health and disease
     $622,658

     award amount
   • 2R01DC015451-06Department: NIH department code

     Converting stochastic olfactory receptor expression to stereotypic axon guidance programs
     $530,688

     award amount
   • 5R01DC018744-03Department: NIH department code

     Olfactory receptor mRNAs as lncRNAs that regulate genomic interactions
     $480,534

     award amount
   • 5R01DC018745-03Department: NIH department code

     Principles of zonal olfactory receptor gene expression
     $458,789

     award amount
   • 1R21DA056348-01Department: NIH department code

     The "olfactosome" as a biomolecular condensate
     $246,750

     award amount

4. Tavazoie, Saeed F

   Leads 4 awards · $1,712,503

   • 5R01CA257153-02Department: NIH department code

     Mapping the regulatory landscape of RNA binding proteins and their causal roles in tumorigenesis and patient survival
     $536,231

     award amount
   • 5R01AI077562-13Department: NIH department code

     Systems biological interrogation of bacterial persistence
     $530,830

     award amount
   • 5R01GM139215-03Department: NIH department code

     Stochastic tuning: a novel regulatory mechanism for cellular adaptation
     $402,442

     award amount
   • 5R21AI157298-02Department: NIH department code

     Single-cell characterization of antibiotic-induced heteroresistance
     $243,000

     award amount

5. Fitzpatrick, Anthony William Paul

   Leads 1 award · $1,629,162

   • 5U01NS110438-05Department: NIH department code

     Patient-Based Structural Biology of Tauopathies and TDP-43 Proteinopathies using Cryo-Electron Microscopy and Mass Spectrometry
     $1,629,162

     award amount

6. Greene, Eric C

   Leads 3 awards · $1,300,174

   • 5R35GM118026-07Department: NIH department code

     Mechanisms of Genome Integrity
     $551,971

     award amount
   • 5R01CA221858-03Department: NIH department code

     Defining the contributions of BRCA1, BRCA2, and RAD52 to genome stability
     $385,039

     award amount
   • 5R01CA236606-04Department: NIH department code

     Helicase regulation during homologous recombination
     $363,164

     award amount

7. Vitkup, Dennis

   Leads 2 awards · $1,102,293

   • 5R01DK118044-05Department: NIH department code

     Ecological dynamics and metabolic interactions in thegut microbiome across space and time
     $662,932

     award amount
   • 5R35GM131884-04Department: NIH department code

     Systems Biology of Protein and Phenotypic Evolution
     $439,361

     award amount

8. Mann, Richard S

   Leads 2 awards · $1,092,101

   • 5R35GM118336-07Department: NIH department code

     Interpreting and Deploying Genomic Information During Animal Development
     $630,577

     award amount
   • 5R01NS070644-13Department: NIH department code

     Development and function of an adult locomotion circuit in Drosophila
     $461,524

     award amount

9. Sobolevsky, Alexander

   Leads 2 awards · $973,688

   • 1R01AR078814-01A1Department: NIH department code

     Structural and functional principles of activation and regulation of the transient receptor potential channel TRPV3.
     $599,600

     award amount
   • 5R01NS107253-05Department: NIH department code

     Single-particle cryo-EM characterization of AMPA receptor functional states
     $374,088

     award amount

10. Frank, Joachim

    Leads 2 awards · $886,067

    • 5R35GM139453-02Department: NIH department code

      Structural Studies of Macromolecular Assemblies Using Cryo-EM
      $763,655

      award amount
    • 3R35GM139453-02S1Department: NIH department code

      Acquisition of Equipment for Structural Studies of Macromolecular Assemblies Using Cryo-EM
      $122,412

      award amount

11. Bussemaker, Harmen J

    Leads 1 award · $776,594

    • 5R01MH106842-06Department: NIH department code

      Integrative analysis of genetic variation and transcription factor networks to elucidate mechanisms of mental health disorders
      $776,594

      award amount

12. Landweber, Laura F

    Leads 1 award · $771,697

    • 2R35GM122555-06Department: NIH department code

      Understanding Complex Genome Editing and RNA Biology in Oxytricha
      $771,697

      award amount

13. Gogos, Joseph A

    Leads 1 award · $757,941

    • 5R01MH124923-03Department: NIH department code

      Discovery and analysis of brain circuits and cell types affected in autism and schizophrenia
      $757,941

      award amount

14. Korem, Tal

    Leads 1 award · $683,554

    • 5R01HD106017-02Department: NIH department code

      A large scale investigation of the vaginal metagenome and metabolome and their role in spontaneous preterm birth
      $683,554

      award amount

15. Sternberg, Samuel Henry

    Leads 1 award · $676,224

    • 5R01EB031935-02Department: NIH department code

      A high-performance and versatile technology for precision microbiome engineering
      $676,224

      award amount

16. Mueller, Ulrich

    Leads 1 award · $647,665

    • 5R01DC016960-05Department: NIH department code

      Integrative Structural and Functional Characterization of Tip-Link Cadherins Deafness
      $647,665

      award amount

17. Barasch, Jonathan M.

    Leads 1 award · $631,410

    • 5R01DK124667-03Department: NIH department code

      Structure and mechanism of the protein-capture receptors of the kidney proximal tubule
      $631,410

      award amount

18. Maniatis, Thomas P

    Leads 1 award · $624,708

    • 5R01MH108579-07Department: NIH department code

      The role of the clustered protocadherins in neural circuit formation and implications for neurodevelopmental disorders
      $624,708

      award amount

19. Goff, Stephen Paine

    Leads 1 award · $578,496

    • 5R01CA030488-41Department: NIH department code

      Mechanisms of Silencing of Retroviral DNAs in Embryonic Cell Lines
      $578,496

      award amount

20. Palmer, Arthur G

    Leads 1 award · $559,114

    • 5R35GM130398-04Department: NIH department code

      Macromolecular dynamics and conformational changes in biological function
      $559,114

      award amount

21. Kurnikova, Maria G

    Leads 1 award · $500,974

    • 5R01NS083660-10Department: NIH department code

      Structure and Function of AMPA subtype ionotropic glutamate receptors
      $500,974

      award amount

22. Shapiro, Lawrence S

    Leads 1 award · $487,197

    • 5R01AR073846-05Department: NIH department code

      Structure and mechanism of pemphigus autoantibodies
      $487,197

      award amount

23. Rubin, Mishaela R

    Leads 1 award · $283,500

    • 5R01DK126479-02Department: NIH department code

      Continuous calcium sensor patch for hypoparathyroid patients
      $283,500

      award amount

24. Henen, Morkos

    Leads 1 award · $257,283

    • 1R21AI171827-01Department: NIH department code

      Small molecule inhibitors targeting the SARS-CoV-2 pathogenicity factor Nsp1
      $257,283

      award amount

25. Glasgow, Anum Azam

    Leads 1 award · $249,000

    • 4R00GM135529-03Department: NIH department code

      Mapping and rewiring protein allostery
      $249,000

      award amount

26. Sternberg, Samuel Henry

    Leads 1 award · $202,500

    • 1R21AI168976-01Department: NIH department code

      Impact of CRISPR-associated transposons on anti-phage immunity in Vibrio cholerae
      $202,500

      award amount

27. Zaccara, Sara

    Leads 1 award · $192,456

    • 1K22CA258954-01Department: NIH department code

      The DF phospho-code regulating the degradation of m6A mRNA
      $192,456

      award amount

28. Al-Hashimi, Hashim M

    Leads 1 award · $186,259

    • 7R01GM089846-13Department: NIH department code

      Role of DNA structural dynamics in mutagenesis and oncogenesis
      $186,259

      award amount

29. Shen, Yufeng

    Leads 1 award · $159,615

    • 1R03HL161595-01Department: NIH department code

      Computational analysis of whole genome sequence data for discovering novel risk genes of structural birth defects
      $159,615

      award amount

30. Campbell, Melissa McKenzie

    Leads 1 award · $109,935

    • 5K99MH126430-02Department: NIH department code

      mRNA Alternative Splicing Regulatory Networks in the Specification of Cortical Interneuron Subtypes
      $109,935

      award amount

31. Wang, Wei

    Leads 1 award · $99,999

    • 1K99GM147598-01Department: NIH department code

      Deciphering atomic-level enzymatic activity by time-resolved crystallography and computational enzymology
      $99,999

      award amount

32. Zamurrad, Sumaira

    Leads 1 award · $77,302

    • 5F32MH123012-03Department: NIH department code

      Mapping the neural circuitry underlying walking
      $77,302

      award amount

33. Meers, Chance

    Leads 1 award · $67,582

    • 1F32GM143924-01A1Department: NIH department code

      Uncovering the molecular function of novel transposon-encoded Cas9 homologs
      $67,582

      award amount

34. Hobson, Benjamin

    Leads 1 award · $51,752

    • 5F30DA047775-04Department: NIH department code

      Gene Expression Programs in Maturing Dopamine Neurons: Temporal Regulation, Subcellular Localization, and Alteration by Amphetamine
      $51,752

      award amount

35. Martorella, Molly

    Leads 1 award · $51,752

    • 5F30HG011194-03Department: NIH department code

      Experimental and Computational Methods for Scaling-up Transcriptome Analyses and Improving Disease Risk Predictions
      $51,752

      award amount

36. Shayya, Hani John

    Leads 1 award · $51,752

    • 5F30DC019263-03Department: NIH department code

      The unfolded protein response as a mechanism for cellular identity in the developing olfactory system
      $51,752

      award amount

37. Tuddenham, John

    Leads 1 award · $51,752

    • 5F30CA261090-02Department: NIH department code

      Elucidating transcriptomic and functional heterogeneity of microglia in low-grade glioma and glioma-associated epilepsy.
      $51,752

      award amount

38. Kindschuh, William Francis

    Leads 1 award · $47,256

    • 1F30HD108886-01A1Department: NIH department code

      Quantifying the interactions among maternal race, vaginal metabolites, and microbes in preterm birth
      $47,256

      award amount

39. Akinade, Tolulope Olatokunbo

    Leads 1 award · $46,752

    • 5F31CA257399-02Department: NIH department code

      Design and Application of Cationic Nanocarriers to Inhibit Breast Cancer Progression in Primary and Metastatic Sites
      $46,752

      award amount

40. Pourmorady, Ariel David

    Leads 1 award · $46,752

    • 1F30DC020900-01Department: NIH department code

      Deciphering mechanisms for olfactory receptor choice in single cells
      $46,752

      award amount