Biochemistry at Columbia University

Leads a grant in this department

39 contact PIs of these awards, by the funding they lead. Other principal investigators on an award are listed with it and under Co-investigators.

1. Lomvardas, Stavros

   Leads 7 awards · $3,120,790

   • 5U01DA052783-04Department: NIH department code

     Interrogating genome folding trajectories in health and disease
     $622,658

     award amount
   • 5R01DC015451-07Department: NIH department code

     Converting stochastic olfactory receptor expression to stereotypic axon guidance programs
     $530,688

     award amount
   • 5R01DC018744-04Department: NIH department code

     Olfactory receptor mRNAs as lncRNAs that regulate genomic interactions
     $480,534

     award amount
   • 5R01DC018745-04Department: NIH department code

     Principles of zonal olfactory receptor gene expression
     $458,789

     award amount
   • 3R01DC015451-07S1Department: NIH department code

     ER stress as the cause for dementia-associated olfactory dysfunction
     $411,248

     award amount
   • 3R01DC018744-03S1Department: NIH department code

     Non-cell autonomous disruption of genomic interactions as a cause of dementia
     $411,248

     award amount
   • 5R21DA056348-02Department: NIH department code

     The "olfactosome" as a biomolecular condensate
     $205,625

     award amount

2. Zhang, Chaolin

   Leads 5 awards · $2,229,098

   • 5R35GM145279-02Department: NIH department code

     Complexity and evolution of splicing-regulatory networks
     $906,022

     award amount
   • 5R01NS125018-02Department: NIH department code

     RNA Regulatory Networks in Neuronal Cell Type Diversity and Function
     $620,562

     award amount
   • 1R01HG012359-01A1Department: NIH department code

     Mapping proximal and distal splicing-regulatory elements
     $608,024

     award amount
   • 3R35GM145279-01S1Department: NIH department code

     Complexity and evolution of splicing-regulatory networks
     $65,000

     award amount
   • 3R01NS125018-02S1Department: NIH department code

     RNA Regulatory Networks in Neuronal Cell Type Diversity and Function
     $29,490

     award amount

3. Al-Hashimi, Hashim M

   Leads 3 awards · $1,614,937

   • 1R01AI178848-01Department: NIH department code

     Development and application of a quantitive model for HIV-1 transcriptional activation driven by TAR RNA conformational dynamics
     $846,046

     award amount
   • 1S10OD034339-01Department: NIH department code

     Acquisition of 600 MHz NMR QCI-P CryoProbe and CryoPlatform
     $456,827

     award amount
   • 5R01GM089846-14Department: NIH department code

     Role of DNA structural dynamics in mutagenesis and oncogenesis
     $312,064

     award amount

4. Tavazoie, Saeed F

   Leads 3 awards · $1,469,500

   • 5R01CA257153-03Department: NIH department code

     Mapping the regulatory landscape of RNA binding proteins and their causal roles in tumorigenesis and patient survival
     $536,228

     award amount
   • 5R01AI077562-14Department: NIH department code

     Systems biological interrogation of bacterial persistence
     $530,830

     award amount
   • 5R01GM139215-04Department: NIH department code

     Stochastic tuning: a novel regulatory mechanism for cellular adaptation
     $402,442

     award amount

5. Sobolevsky, Alexander

   Leads 3 awards · $1,457,299

   • 5R01AR078814-02Department: NIH department code

     Structural and functional principles of activation and regulation of the transient receptor potential channel TRPV3.
     $585,686

     award amount
   • 2R01CA206573-06A1Department: NIH department code

     Structure and function of Transient Receptor Potential Channels
     $460,501

     award amount
   • 2R01NS107253-06Department: NIH department code

     Single-Particle Cryo-EM Characterization of AMPA Receptor Functional States
     $411,112

     award amount

6. Maniatis, Thomas P

   Leads 2 awards · $1,340,399

   • 1R01MH130592-01A1Department: NIH department code

     The impact of loss of function DNA sequence variants in the human protocadherin gene cluster on neural circuit assembly.
     $748,572

     award amount
   • 5R01MH108579-08Department: NIH department code

     The role of the clustered protocadherins in neural circuit formation and implications for neurodevelopmental disorders
     $591,827

     award amount

7. Wang, Harris H

   Leads 2 awards · $1,188,621

   • 2R01AI132403-06A1Department: NIH department code

     Micron-scale Spatial Metagenomic Mapping of Microbial Biogeography in the Gastrointestinal Tract
     $736,246

     award amount
   • 1R21HG013161-01Department: NIH department code

     Rapid and efficient generation of sequence variants by templated synthesis
     $452,375

     award amount

8. Mann, Richard S

   Leads 3 awards · $1,103,598

   • 5R35GM118336-08Department: NIH department code

     Interpreting and Deploying Genomic Information During Animal Development
     $630,577

     award amount
   • 5R01NS070644-14Department: NIH department code

     Development and Function of an Adult Locomotion Circuit in Drosophila
     $461,524

     award amount
   • 3R35GM118336-08S1Department: NIH department code

     Interpreting and Deploying Genomic Information During Animal Development
     $11,497

     award amount

9. Greene, Eric C

   Leads 4 awards · $1,084,948

   • 5R35GM118026-08Department: NIH department code

     Mechanisms of Genome Integrity
     $551,971

     award amount
   • 5R01CA221858-04Department: NIH department code

     Defining the contributions of BRCA1, BRCA2, and RAD52 to genome stability
     $385,039

     award amount
   • 3R35GM118026-08S1Department: NIH department code

     Laser Scanning Imaging System in Support of Single-Molecule Studies of Genome Integrity
     $147,937

     award amount
   • 5R01CA236606-05Department: NIH department code

     Helicase regulation during homologous recombination
     $1

     award amount

10. Landweber, Laura F

    Leads 3 awards · $924,115

    • 5R35GM122555-07Department: NIH department code

      Understanding Complex Genome Editing and RNA Biology in Oxytricha
      $771,697

      award amount
    • 3R35GM122555-07S1Department: NIH department code

      Understanding Complex Genome Editing and RNA Biology in Oxytricha
      $135,642

      award amount
    • 3R35GM122555-06S1Department: NIH department code

      Understanding Complex Genome Editing and RNA Biology in Oxytricha
      $16,776

      award amount

11. Bussemaker, Harmen J

    Leads 1 award · $776,594

    • 5R01MH106842-07Department: NIH department code

      Integrative analysis of genetic variation and transcription factor networks to elucidate mechanisms of mental health disorders
      $776,594

      award amount

12. Korem, Tal

    Leads 2 awards · $768,777

    • 5R01HD106017-03Department: NIH department code

      A large scale investigation of the vaginal metagenome and metabolome and their role in spontaneous preterm birth
      $672,571

      award amount
    • 3R01HD106017-03S2Department: NIH department code

      A large scale investigation of the vaginal metagenome and metabolome and their role in spontaneous preterm birth
      $96,206

      award amount

13. Frank, Joachim

    Leads 1 award · $767,819

    • 5R35GM139453-03Department: NIH department code

      Structural Studies of Macromolecular Assemblies Using Cryo-EM
      $767,819

      award amount

14. Gogos, Joseph A

    Leads 1 award · $755,412

    • 5R01MH124923-04Department: NIH department code

      Discovery and analysis of brain circuits and cell types affected in autism and schizophrenia
      $755,412

      award amount

15. Sternberg, Samuel Henry

    Leads 1 award · $656,837

    • 5R01EB031935-03Department: NIH department code

      A high-performance and versatile technology for precision microbiome engineering
      $656,837

      award amount

16. Barasch, Jonathan M.

    Leads 1 award · $631,431

    • 5R01DK124667-04Department: NIH department code

      Structure and mechanism of the protein-capture receptors of the kidney proximal tubule
      $631,431

      award amount

17. Goff, Stephen Paine

    Leads 1 award · $590,302

    • 5R01CA030488-42Department: NIH department code

      Mechanisms of Silencing of Retroviral DNAs in Embryonic Cell Lines
      $590,302

      award amount

18. Shen, Yufeng

    Leads 2 awards · $566,527

    • 1R35GM149527-01Department: NIH department code

      Computational methods to interpret genomic variation and integrate functional genomics data in genetic analysis of human diseases
      $406,912

      award amount
    • 5R03HL161595-02Department: NIH department code

      Computational analysis of whole genome sequence data for discovering novel risk genes of structural birth defects
      $159,615

      award amount

19. Palmer, Arthur G

    Leads 1 award · $559,114

    • 5R35GM130398-05Department: NIH department code

      Macromolecular dynamics and conformational changes in biological function
      $559,114

      award amount

20. Vitkup, Dennis

    Leads 1 award · $439,361

    • 5R35GM131884-05Department: NIH department code

      Systems Biology of Protein and Phenotypic Evolution
      $439,361

      award amount

21. Alquraishi, Mohammed Nazar

    Leads 1 award · $411,250

    • 1R35GM150546-01Department: NIH department code

      Machine learning of biomolecular interactions and the human signaling networks they comprise
      $411,250

      award amount

22. Steckelberg, Anna-Lena

    Leads 1 award · $411,250

    • 1R35GM150778-01Department: NIH department code

      Understanding the antiviral roles of acellular RNA quality control pathway
      $411,250

      award amount

23. Rubin, Mishaela R

    Leads 1 award · $283,500

    • 5R01DK126479-03Department: NIH department code

      Continuous calcium sensor patch for hypoparathyroid patients
      $283,500

      award amount

24. Glasgow, Anum Azam

    Leads 1 award · $249,000

    • 5R00GM135529-04Department: NIH department code

      Mapping and rewiring protein allostery
      $249,000

      award amount

25. Sternberg, Samuel Henry

    Leads 1 award · $243,000

    • 5R21AI168976-02Department: NIH department code

      Impact of CRISPR-associated transposons on anti-phage immunity in Vibrio cholerae
      $243,000

      award amount

26. Henen, Morkos

    Leads 1 award · $201,125

    • 5R21AI171827-02Department: NIH department code

      Small molecule inhibitors targeting the SARS-CoV-2 pathogenicity factor Nsp1
      $201,125

      award amount

27. Zaccara, Sara

    Leads 1 award · $192,456

    • 5K22CA258954-02Department: NIH department code

      The DF phospho-code regulating the degradation of m6A mRNA
      $192,456

      award amount

28. Flaherty, Erin

    Leads 1 award · $131,733

    • 1K99MH132889-01A1Department: NIH department code

      The role of the protocadherin gene cluster in neurodevelopment and the implications for neurodevelopmental disorders
      $131,733

      award amount

29. Pulupa, Joan M.

    Leads 1 award · $125,442

    • 1K99DC021219-01Department: NIH department code

      Identifying the mechanism of olfactory receptor gene regulation in olfactory neurons with live-cell imaging
      $125,442

      award amount

30. Wang, Wei

    Leads 1 award · $114,597

    • 5K99GM147598-02Department: NIH department code

      Deciphering atomic-level enzymatic activity by time-resolved crystallography and computational enzymology
      $114,597

      award amount

31. Kuppa, Sahiti

    Leads 1 award · $88,646

    • 4K00CA274696-02Department: NIH department code

      Role of nuclear chaperones in genomic instability and carcinogenesis
      $88,646

      award amount

32. Meers, Chance

    Leads 1 award · $71,792

    • 5F32GM143924-02Department: NIH department code

      Uncovering the molecular function of novel transposon-encoded Cas9 homologs
      $71,792

      award amount

33. Tuddenham, John

    Leads 1 award · $52,694

    • 5F30CA261090-03Department: NIH department code

      Elucidating transcriptomic and functional heterogeneity of microglia in low-grade glioma and glioma-associated epilepsy.
      $52,694

      award amount

34. Kindschuh, William Francis

    Leads 1 award · $48,694

    • 5F30HD108886-02Department: NIH department code

      Quantifying the interactions among maternal race, vaginal metabolites, and microbes in preterm birth
      $48,694

      award amount

35. King, Rebeca Teresa

    Leads 1 award · $48,666

    • 1F31HL167530-01Department: NIH department code

      Leveraging CRISPR RNA-guided DNA Transposases for Gene Insertion at the CFTR Locus
      $48,666

      award amount

36. Pourmorady, Ariel David

    Leads 1 award · $47,694

    • 5F30DC020900-02Department: NIH department code

      Deciphering mechanisms for olfactory receptor choice in single cells
      $47,694

      award amount

37. Shayya, Hani John

    Leads 1 award · $47,039

    • 5F30DC019263-04Department: NIH department code

      The unfolded protein response as a mechanism for cellular identity in the developing olfactory system
      $47,039

      award amount

38. Hobson, Benjamin

    Leads 1 award · $35,716

    • 5F30DA047775-05Department: NIH department code

      Gene Expression Programs in Maturing Dopamine Neurons: Temporal Regulation, Subcellular Localization, and Alteration by Amphetamine
      $35,716

      award amount

39. Akinade, Tolulope Olatokunbo

    Leads 1 award · $25,061

    • 5F31CA257399-03Department: NIH department code

      Design and Application of Cationic Nanocarriers to Inhibit Breast Cancer Progression in Primary and Metastatic Sites
      $25,061

      award amount