Genetics at University of Massachusetts Medical School Worcester

Leads a grant in this department

38 contact PIs of these awards, by the funding they lead. Other principal investigators on an award are listed with it and under Co-investigators.

1. Erik J. Sontheimer

   Leads 3 awards · $7,266,525

   • 1U01NS145218-01Department: NIH department code

     Precision Editing of Granulin Mutations that Cause Frontotemporal Dementia

     Principal investigators: Erik J. Sontheimer (contact PI), Fen-Biao Gao, Jonathan K Watts, Scot A Wolfe

     $6,580,415

     award amount
   • 5R01GM150273-03Department: NIH department code

     Advanced Delivery Platforms for Base Editing In Vivo

     Principal investigators: Erik J. Sontheimer (contact PI), Wen Xue

     $583,738

     award amount
   • 3R01GM150273-03S1Department: NIH department code

     Advanced Delivery Platforms for Base Editing In Vivo

     Principal investigators: Erik J. Sontheimer (contact PI), Wen Xue

     $102,372

     award amount

2. A. J. Marian Walhout

   Leads 2 awards · $1,510,440

   • 5R35GM122502-09Department: NIH department code

     Gene regulatory and metabolic network structure, function and evolution
     $843,915

     award amount
   • 5R01DK068429-19Department: NIH department code

     C. elegans models of metabolism in health and disease
     $666,525

     award amount

3. Jennifer Eileen Adair

   Leads 2 awards · $1,449,306

   • 7R01AI167009-04Department: NIH department code

     In vivo CRISPR engineering of B cells to produce anti-HIV broadly neutralizing antibodies using novel nanoparticles

     Principal investigators: Jennifer Eileen Adair (contact PI), Justin J Taylor

     $830,363

     award amount
   • 7R01AI158728-04Department: NIH department code

     Targeted genetic engineering of B cells to induce protective antibody responses to pathogens

     Principal investigators: Jennifer Eileen Adair (contact PI), Justin J Taylor

     $618,943

     award amount

4. Amir Mitchell

   Leads 2 awards · $1,383,529

   • 4R01AI170722-04Department: NIH department code

     Mechanisms underlying bacterial sensitivity to host-targeted drugs
     $922,904

     award amount
   • 2R35GM133775-06Department: NIH department code

     Interactions underlying resilient bacterial communities and successful colonization of host niches
     $460,625

     award amount

5. Heather L Gray-Edwards

   Leads 2 awards · $1,268,372

   • 5R01NS139268-02Department: NIH department code

     AAV Gene Therapy for Sialidosis: from Mice to IND
     $654,844

     award amount
   • 1R01NS145295-01Department: NIH department code

     Evaluating the efficiency of in vivo gene transfer to correct the molecular neuropathology causing psychiatric disease in MSUD
     $613,528

     award amount

6. Athma A Pai

   Leads 2 awards · $1,219,395

   • 5R01HG012967-03Department: NIH department code

     A kinetic framework to map the genetic determinants of alternative RNA isoform expression

     Principal investigators: Athma A Pai (contact PI), Barbara Engelhardt

     $740,345

     award amount
   • 2R35GM133762-06Department: NIH department code

     Tracking transcriptome diversity in real-time
     $479,050

     award amount

7. Jae-Hyuck Shim

   Leads 2 awards · $1,178,220

   • 1R01AR086572-01Department: NIH department code

     Development of a long-lasting, bone-targeted gene therapy for osteogenesis imperfecta
     $667,125

     award amount
   • 5R01AR078230-04Department: NIH department code

     Novel approaches to promote healing of bone loss in inflammatory arthritis

     Principal investigators: Jae-Hyuck Shim (contact PI), Ellen M Gravallese

     $511,095

     award amount

8. Anastasia Khvorova

   Leads 2 awards · $1,148,821

   • 5R01NS104022-08Department: NIH department code

     Expanding the Chemical Diversity of Therapeutic Oligonucleotides
     $688,196

     award amount
   • 2R35GM131839-06Department: NIH department code

     Chemical engineering of therapeutic RNAs for extrahepatic delivery
     $460,625

     award amount

9. Michael Jungho Lee

   Leads 2 awards · $834,241

   • 5R35GM152194-02Department: NIH department code

     Systems and Network-level Regulation of Cell Death
     $418,750

     award amount
   • 1U01CA305435-01Department: NIH department code

     MEDUSA(GM): an analysis platform for resolving mechanisms of action for anti-cancer drugs
     $415,491

     award amount

10. Wen Xue

    Leads 1 award · $672,615

    • 5R01CA275945-03Department: NIH department code

      In vivo prime editing for precision cancer mouse models
      $672,615

      award amount

    Also a principal investigator on 5R01GM150273-03, led by Erik J. Sontheimer; 3R01GM150273-03S1, led by Erik J. Sontheimer.

11. Jonathan K Watts

    Leads 1 award · $665,737

    • 5R01NS111990-07Department: NIH department code

      Multi-Targeting Oligonucleotide Therapeutics for Familial and Sporadic Amyotrophic Lateral Sclerosis

      Principal investigators: Jonathan K Watts (contact PI), Robert H Brown

      $665,737

      award amount

    Also a principal investigator on 1U01NS145218-01, led by Erik J. Sontheimer.

12. Job Dekker

    Leads 1 award · $658,597

    • 5R01HG003143-20Department: NIH department code

      Structural Annotation of the Human Genome
      $658,597

      award amount

13. Andrei Korostelev

    Leads 1 award · $645,311

    • 5R35GM127094-08Department: NIH department code

      Translational Control: Discovery and Mechanisms
      $645,311

      award amount

14. Guocai Zhong

    Leads 1 award · $617,738

    • 1R01EB037025-01Department: NIH department code

      Synthetic RNA Switch-Based Temporal and Dose Control of in Vivo Gene Therapies
      $617,738

      award amount

15. Cynthia N Fuhrmann

    Leads 1 award · $541,331

    • 1R25GM160996-01Department: NIH department code

      Mentorship Education to Advance Biomedical Research Career Development

      Principal investigators: Cynthia N Fuhrmann (contact PI), Christine E Pfund

      $541,331

      award amount

16. Guangping Gao

    Leads 1 award · $533,982

    • 2R01NS076991-11A1Department: NIH department code

      Oligodendrocyte-focused rAAV gene therapy strategies for Canavan disease and Leukodystrophies
      $533,982

      award amount

17. Craig C Mello

    Leads 1 award · $460,625

    • 5R35GM153442-02Department: NIH department code

      Investigation of RNA interference and related gene regulatory mechanisms
      $460,625

      award amount

18. Emma V. Watson

    Leads 1 award · $460,625

    • 1R35GM160085-01Department: NIH department code

      Modeling Aneuploidy-Driven Phenotypes Across Tissues
      $460,625

      award amount

19. Fen-Biao Gao

    Leads 1 award · $460,625

    • 1R21NS143648-01Department: NIH department code

      Investigating the Roles of the Deubiquitylation Pathway in TDP-43 Pathology in ALS/FTD
      $460,625

      award amount

    Also a principal investigator on 1U01NS145218-01, led by Erik J. Sontheimer.

20. Elizabeth Anne Shank

    Leads 2 awards · $431,170

    • 5R35GM145261-04Department: NIH department code

      Investigating the molecules and mechanisms of bacterial cell-cell interactions
      $418,750

      award amount
    • 3R35GM145261-04S1Department: NIH department code

      Investigating the molecules and mechanisms of bacterial cell-cell interactions
      $12,420

      award amount

21. Li Li

    Leads 1 award · $418,750

    • 5R35GM155169-02Department: NIH department code

      IRES-mediated translation: mechanisms and applications in mRNA therapeutics
      $418,750

      award amount

22. Wenwen Fang

    Leads 1 award · $418,750

    • 5R35GM150953-03Department: NIH department code

      Understanding double-stranded RNA recognition in human cells
      $418,750

      award amount

23. Phillip Tai

    Leads 1 award · $284,331

    • 1R21AI183080-01A1Department: NIH department code

      In vitro and in vivo modeling of gene therapy vector stability when challenged by natural virus infection in human hepatocytes
      $284,331

      award amount

24. Qi Tang

    Leads 1 award · $249,000

    • 4R00AR082987-03Department: NIH department code

      Developing a programmable siRNA-based therapeutic platform for gene silencing in the skin
      $249,000

      award amount

25. Qinglan Ling

    Leads 1 award · $245,217

    • 5R00HD109359-04Department: NIH department code

      First murine animal model and adeno-associated virus (AAV)-based gene therapy for MTATP6 mitochondrial diseases
      $245,217

      award amount

26. Zintis Inde

    Leads 1 award · $132,472

    • 1K99AG086405-01A1Department: NIH department code

      Apoptotic Dysregulation Across Cell Types in Aging and Neurodegeneration
      $132,472

      award amount

27. Hyun Youk

    Leads 1 award · $92,388

    • 5R35GM147508-04Department: NIH department code

      Dynamics in Eukaryotic Dormancy: Gene Expression and Aging
      $92,388

      award amount

28. Julianna E Buchwald

    Leads 1 award · $51,431

    • 5F30DK131853-04Department: NIH department code

      Investigating siRNA-mediated inhibition of ischemia-reperfusion injury during the liver transplantation process
      $51,431

      award amount

29. Emily Sholi

    Leads 1 award · $34,370

    • 1F31HL180041-01Department: NIH department code

      Translational control in heart and lung disease by RNase A family
      $34,370

      award amount

30. Grace Schiefelbein

    Leads 1 award · $34,370

    • 1F31HD118787-01Department: NIH department code

      Probing the Mammalian piRISC Cleavage Mechanism
      $34,370

      award amount

31. Jesse William Lehman

    Leads 1 award · $34,370

    • 1F31AI189160-01Department: NIH department code

      Temporal Regulation of mRNA Biogenesis in Immune Responses
      $34,370

      award amount

32. Nicholas Gaston

    Leads 1 award · $34,370

    • 5F31HL176178-02Department: NIH department code

      A single prime editing strategy for correcting diverse mutations responsible for RBM20-associated dilated cardiomyopathy
      $34,370

      award amount

33. Jenny Gao

    Leads 1 award · $34,344

    • 5F30HL176024-02Department: NIH department code

      Developing a novel adenine base editor tool for in vivo alpha-1 antitrypsin deficiency gene correction.
      $34,344

      award amount

34. Johan Girgenrath

    Leads 1 award · $34,344

    • 5F31HD113307-03Department: NIH department code

      Investigating the role of Sumo in piRNA-mediated germline heterochromatin maintenance in C.elegans
      $34,344

      award amount

35. Sarah Jane Allen

    Leads 1 award · $34,344

    • 5F31NS137681-02Department: NIH department code

      Examining the Role of a Pathogenic HTT Isoform, HTT1a, in Somatic Expansion and RNA Aggregation in Huntington's Disease
      $34,344

      award amount

36. Alejandro Felix Mejia

    Leads 1 award · $33,780

    • 1F31GM157877-01Department: NIH department code

      Engineering bacterial group I introns for efficient production of safe and durable nucleoside-modified circular mRNA therapeutics
      $33,780

      award amount

37. David G. Keener

    Leads 1 award · $7,006

    • 5F31NS127555-03Department: NIH department code

      Establishing and Optimizing a Prime Editing Method in Neurons for Treatment of Rett Syndrome
      $7,006

      award amount

38. Jillian Belgrad

    Leads 1 award · $5,612

    • 5F31NS132424-03Department: NIH department code

      Modulation of Somatic Repeat Expansion as a Therapeutic Approach to Huntington's Disease
      $5,612

      award amount

Co-investigators

Named as principal investigators on these awards, which someone else leads. They may belong to another department or institution: their own, below, comes from the awards they lead.

• Scot A Wolfe

  Co-investigator on 1U01NS145218-01, led by Erik J. Sontheimer

  Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.

• Justin J Taylor

  Co-investigator on 7R01AI167009-04, led by Jennifer Eileen Adair; 7R01AI158728-04, led by Jennifer Eileen Adair

  From the FY2025 awards this person leads

  • University of Washington (no department on record, 1 award)

• Barbara Engelhardt

  Co-investigator on 5R01HG012967-03, led by Athma A Pai

  From the FY2025 awards this person leads

  • J. David Gladstone Institutes (no department on record, 1 award)

• Robert H Brown

  Co-investigator on 5R01NS111990-07, led by Jonathan K Watts

  Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.

• Christine E Pfund

  Co-investigator on 1R25GM160996-01, led by Cynthia N Fuhrmann

  Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.

• Ellen M Gravallese

  Co-investigator on 5R01AR078230-04, led by Jae-Hyuck Shim

  From the FY2025 awards this person leads

  • Brigham and Women's Hospital (no department on record, 1 award)