Pharmacology at University of North Carolina at Chapel Hill

Leads a grant in this department

62 contact PIs of these awards, by the funding they lead. Other principal investigators on an award are listed with it and under Co-investigators.

1. Roth, Bryan L.

   Leads 3 awards · $3,478,520

   • 5U24DK116195-05Department: NIH department code

     Illuminating the Druggable GPCR-ome
     $2,241,036

     award amount
   • 5R37DA045657-04Department: NIH department code

     Mechanistic insights into LSD actions at 5-HT2A serotonin receptors
     $635,456

     award amount
   • 5R01MH112205-05Department: NIH department code

     Molecular Details of Psychoactive Drug Actions
     $602,028

     award amount

2. Kash, Thomas L.

   Leads 6 awards · $3,409,567

   • 5P60AA011605-24Department: NIH department code

     Molecular and Circuit Pathogenesis of Alcohol Addiction
     $1,743,681

     award amount
   • 5U01AA020911-10Department: NIH department code

     6/8: INIA Stress and Chronic Alcohol Interactions: Deconstructing the role of extended amygdala circuits in stress regulated alcohol drinking
     $447,515

     award amount
   • 1R01NS122230-01Department: NIH department code

     Determining the impact of BNST CRF systems on inflammatory pain-induced disruptions of behavior
     $431,179

     award amount
   • 5R01AA019454-12Department: NIH department code

     The Role of Serotonin in Alcohol-Withdrawal Induced Anxiety
     $403,692

     award amount
   • 5U24AA025475-05Department: NIH department code

     Core 1: Brain Circuit Validation Core
     $228,000

     award amount
   • 3P60AA011605-24S1Department: NIH department code

     Dietary choline mitigation of adolescent alcohol-induced deficits in adult cognitive flexibility: P60-AA011605 Administrative Supplement
     $155,500

     award amount

3. Song, Juan

   Leads 3 awards · $2,919,806

   • 1RF1AG071000-01Department: NIH department code

     Glutamatergic neural circuit modulation for treating Alzheimer’s disease
     $1,887,386

     award amount
   • 5R01MH122692-02Department: NIH department code

     Sex-dependent role of 5HT1A receptors in adult neurogenesis and hippocampal function
     $571,019

     award amount
   • 1R01NS121300-01Department: NIH department code

     Role of Cholecystokinin in the Dentate Gyrus
     $461,401

     award amount

4. Johnson, Gary L.

   Leads 1 award · $2,251,844

   • 5U24DK116204-05Department: NIH department code

     Illuminating Function of the Understudied Druggable Kinome
     $2,251,844

     award amount

5. Crews, Fulton T

   Leads 3 awards · $1,543,697

   • 5U01AA020023-12Department: NIH department code

     5/8 NADIA U01 Effects of Adolescent Alcohol on adult brain Neurocircuitry
     $570,876

     award amount
   • 5U24AA020024-12Department: NIH department code

     1/1 NADIA U24 Administrative Core
     $486,895

     award amount
   • 5T32AA007573-24Department: NIH department code

     Molecular and Cellular Alcohol Research Training
     $485,926

     award amount

6. Lai, Samuel

   Leads 2 awards · $1,195,299

   • 5R01HL141934-04Department: NIH department code

     Overcoming anti-PEG immunity to restore prolonged circulation and efficacy of PEGylated therapeutics
     $674,568

     award amount
   • 5R01HD101562-02Department: NIH department code

     Engineering bispecific antibodies for non-hormonal contraception
     $520,731

     award amount

7. Baldwin, Albert Sidney

   Leads 1 award · $1,195,189

   • 1U01TR003715-01Department: NIH department code

     A consortium effort to translate therapies for neurological diseases via an ex vivo organotypic platform
     $1,195,189

     award amount

8. Gonzalez, Daniel

   Leads 2 awards · $995,067

   • 5R01HD096435-04Department: NIH department code

     Physiologically-Based Pharmacokinetic Modeling to Guide Drug Dosing in Children with Obesity
     $509,276

     award amount
   • 1R01HD102949-01A1Department: NIH department code

     Application of Physiologically-Based Pharmacokinetic Modeling to Characterize Drug-Drug Interactions in Infants
     $485,791

     award amount

9. Aube, Jeffrey

   Leads 2 awards · $970,561

   • 1R01AI155510-01A1Department: NIH department code

     Discovery of Phospopantetheinyl Transferse Inhibitors Against Mycobacterium tuberculosis
     $807,677

     award amount
   • 1T32GM135122-01A1Department: NIH department code

     UNC Chemical Biology Interface Training Program
     $162,884

     award amount

10. Ritola, Kimberly

    Leads 2 awards · $958,249

    • 1R01FD007476-01Department: NIH department code

      Nanopore Methods for Determining Capsid Viability
      $572,610

      award amount
    • 1U24NS124025-01Department: NIH department code

      BRAIN Viral Vector Services and Distribution Core
      $385,639

      award amount

11. Ainslie, Kristy M

    Leads 2 awards · $955,094

    • 5R01AI147497-02Department: NIH department code

      Optimizing a Universal Influenza Subunit Nano/Microparticulate Vaccine
      $578,536

      award amount
    • 5R01AI137525-04Department: NIH department code

      Biomaterials to study tolerance immune induction kinetics
      $376,558

      award amount

12. Der, Channing J.

    Leads 1 award · $921,017

    • 5R35CA232113-04Department: NIH department code

      Targeting undruggable RAS for cancer treatment
      $921,017

      award amount

13. Lawrence, David S.

    Leads 2 awards · $902,215

    • 1R01HL153744-01A1Department: NIH department code

      Design and Application of Photoresponsive Modules in Circulating Erythrocytes
      $562,059

      award amount
    • 5R01NS103486-04Department: NIH department code

      Spatiotemporal Control of Migratory Cellular Behavior
      $340,156

      award amount

14. Emanuele, Michael James

    Leads 3 awards · $879,523

    • 5T32GM135095-02Department: NIH department code

      Predoctoral Training in the Pharmacological Sciences
      $487,629

      award amount
    • 5R01GM134231-02Department: NIH department code

      Deubiquitinases in Cell Cycle Control
      $352,617

      award amount
    • 3R01GM134231-02S1Department: NIH department code

      Deubiquitinases in Cell Cycle Control
      $39,277

      award amount

15. Graham, Douglas K

    Leads 2 awards · $844,161

    • 5R01CA249190-02Department: NIH department code

      MERTK/AXL dual inhibitors provide novel treatment for cancer by targeting tumor cells and activating anti-tumor immunity
      $507,204

      award amount
    • 1R01CA259077-01Department: NIH department code

      Novel TYRO3 inhibitors for treatment of cancer
      $336,957

      award amount

16. Hahn, Klaus M.

    Leads 1 award · $789,940

    • 5R35GM122596-05Department: NIH department code

      Dissecting signaling in vivo via precise control and visualization of protein activity
      $789,940

      award amount

17. Dumond, Julie Brumer

    Leads 1 award · $784,048

    • 1R01AI153007-01A1Department: NIH department code

      Quantifying Sex-and-Age-Related Differences in Antiretroviral Exposure and Adverse Effects in the MACS/WIHS Combined Cohort Study
      $784,048

      award amount

18. Kashuba, Angela D

    Leads 1 award · $749,632

    • 4R01AI122319-06Department: NIH department code

      Novel Mass Spectrometry Imaging Methods to Quantify Antiretroviral Adherence
      $749,632

      award amount

19. Coleman, Leon Garland

    Leads 3 awards · $734,323

    • 5R01AA028924-02Department: NIH department code

      Microglia Activation and TLR-induced Neurodegeneration by Alcohol Promotes Progression of Alzheimer Pathology
      $388,750

      award amount
    • 1R21AA028599-01A1Department: NIH department code

      Ethanol Inhibition of anti-PD-1 Immunotherapy via T-cell Dysfunction and Intestinal Dysbiosis
      $217,482

      award amount
    • 5K08AA024829-05Department: NIH department code

      Ethanol modulate central and peripheral immune responses via HMGB1, IL-1Beta, and other Immune Signaling Molecules
      $128,091

      award amount

20. Brouwer, Kim L.r.

    Leads 1 award · $706,465

    • 2T32GM086330-11Department: NIH department code

      UNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program
      $706,465

      award amount

21. Calabrese, Joseph Mauro

    Leads 2 awards · $702,915

    • 5R01GM136819-02Department: NIH department code

      Cooperative control of Polycomb Repressive Complexes by long noncoding RNAs, CpG island DNA, and RNA-binding proteins
      $386,771

      award amount
    • 5R01GM121806-05Department: NIH department code

      Mechanisms of gene silencing induced by long noncoding RNAs
      $316,144

      award amount

22. Crino, Peter B

    Leads 1 award · $689,617

    • 5R01NS115017-02Department: NIH department code

      Defining disease mechanisms in SLC35A2 epilepsy
      $689,617

      award amount

23. Dohlman, Henrik G.

    Leads 1 award · $659,119

    • 2R35GM118105-06Department: NIH department code

      Negative and positive feedback in cell signaling
      $659,119

      award amount

24. Batrakova, Elena

    Leads 2 awards · $636,148

    • 5R01NS102412-04Department: NIH department code

      Cell-based Platform for Gene Delivery to the Brain
      $338,580

      award amount
    • 5R01NS112019-03Department: NIH department code

      Extracellular Vesicles for CNS Delivery of Therapeutic Enzymes to Treat Lysosomal Storage Disorders
      $297,568

      award amount

25. Nguyen, Juliane

    Leads 3 awards · $631,936

    • 5R01CA241679-02Department: NIH department code

      Polarizing Macrophages to Tumor Suppressors by Blocking Multiple CCR2 Chemokine Receptor Epitopes
      $351,954

      award amount
    • 5R21GM135853-02Department: NIH department code

      Antibody Fragments as Biochemical Tools to Interrogate CD9 Function in Inflammatory Diseases
      $229,335

      award amount
    • 3R01CA241679-02S1Department: NIH department code

      Polarizing Macrophages to Tumor Suppressors by Blocking Multiple CCR2 Chemokine Receptor Epitopes
      $50,647

      award amount

26. Kabanov, Alexander V

    Leads 1 award · $613,059

    • 1R01CA264488-01Department: NIH department code

      TOWARD TRANSLATION OF NANFORMULATED PACLITAXEL-PLATINUM COMBINATION
      $613,059

      award amount

27. Chang, Sha X

    Leads 1 award · $569,509

    • 1R01CA247652-01A1Department: NIH department code

      Minibeam Radiation Therapy Enhanced Delivery of Nanoparticle Anticancer Agents to Pancreatic Cancer Tumors
      $569,509

      award amount

28. Schisler, Jonathan C.

    Leads 1 award · $462,833

    • 5R01AG066710-02Department: NIH department code

      Protein quality control in age-related diseases
      $462,833

      award amount

29. Elston, Timothy C

    Leads 1 award · $450,950

    • 5R35GM127145-04Department: NIH department code

      Mathematical modeling of cellular signaling systems
      $450,950

      award amount

30. Bryant, Kirsten L

    Leads 1 award · $446,895

    • 5R37CA251877-02Department: NIH department code

      Mechanistic dissection and inhibitor targeting of autophagy in RAS driven cancers
      $446,895

      award amount

31. Frankowski, Kevin J.

    Leads 2 awards · $427,625

    • 1UG3DA050820-01A1Department: NIH department code

      Negative allosteric modulators of the D3 dopamine receptor as therapeutic leads for substance use disorders
      $233,250

      award amount
    • 1R21AG068833-01A1Department: NIH department code

      D1 dopamine receptor positive allosteric modulators as a practical treatment for cognitive decline
      $194,375

      award amount

32. Frye, Stephen Vernon

    Leads 1 award · $425,839

    • 1R35GM139514-01Department: NIH department code

      PROBING ALLOSTERY IN METHYL-LYSINE READER DOMAINS
      $425,839

      award amount

33. Sondek, John E

    Leads 1 award · $425,572

    • 5R01GM057391-21Department: NIH department code

      Regulation of phospholipase C
      $425,572

      award amount

34. Lee, Andrew L

    Leads 2 awards · $425,316

    • 5R01GM127698-03Department: NIH department code

      Structural and Dynamic Mechanisms in Classical Protein Allostery
      $348,273

      award amount
    • 3R01GM127698-03S1Department: NIH department code

      Structural and Dynamic Mechanisms in Classical Protein Allostery
      $77,043

      award amount

35. Bowers, Albert A

    Leads 2 awards · $420,875

    • 5R35GM125005-05Department: NIH department code

      Chemoenzymatic Synthesis, Mode of Action and Evolution of Natural Product-based Macrocycles
      $383,398

      award amount
    • 3R35GM125005-04S1Department: NIH department code

      MIRA Equipment Supplement
      $37,477

      award amount

36. Lee, Craig R

    Leads 1 award · $407,747

    • 5R01HD098742-02Department: NIH department code

      Mechanisms of Altered Hepatic Drug Metabolism and Transport in Pregnancy
      $407,747

      award amount

37. Aleman, Maria M.

    Leads 1 award · $401,946

    • 5R01DK124773-02Department: NIH department code

      Iron-sensitive RNA regulation during erythropoiesis
      $401,946

      award amount

38. Davis, Ian J

    Leads 1 award · $401,503

    • 1R01GM138912-01A1Department: NIH department code

      Development of a cavitation enhancement technology to access archived tissues for epigenetic-based biomedical research
      $401,503

      award amount

39. Brown, Nicholas Gene

    Leads 1 award · $388,750

    • 5R35GM128855-04Department: NIH department code

      Spindle Assembly Checkpoint Silencing
      $388,750

      award amount

40. Dominguez, Daniel Issac

    Leads 1 award · $388,750

    • 1R35GM142864-01Department: NIH department code

      Protein Disorder as a Mechanism of RNA Binding and Regulation
      $388,750

      award amount

41. Li, Chengwen

    Leads 1 award · $388,750

    • 1R01HL151348-01A1Department: NIH department code

      Development of AAV vectors for CF therapy
      $388,750

      award amount

42. McGinty, Robert

    Leads 1 award · $382,895

    • 5R35GM133498-03Department: NIH department code

      Molecular Mechanisms of Chromatin Recognition
      $382,895

      award amount

43. Anselmo, Aaron C

    Leads 1 award · $382,018

    • 5R35GM137898-02Department: NIH department code

      Delivery Strategies for Microbe Therapeutics
      $382,018

      award amount

44. Herman, Melissa A

    Leads 1 award · $349,875

    • 5R01AA026858-03Department: NIH department code

      The role of a nucleus tractus solitarius-central amygdala circuit in alcohol-induced plasticity and drinking behavior
      $349,875

      award amount

45. Hathaway, Nathaniel A.

    Leads 2 awards · $339,978

    • 5R01GM118653-05Department: NIH department code

      MECHANISM OF HP1-MEDIATED HETEROCHROMATIN ASSEMBLY AND DURABILITY IN LIVE CELLS
      $309,972

      award amount
    • 3R01GM118653-05S1Department: NIH department code

      MECHANISM OF HP1-MEDIATED HETEROCHROMATIN ASSEMBLY AND DURABILITY IN LIVE CELLS
      $30,006

      award amount

46. Graves, Lee M

    Leads 1 award · $314,448

    • 5R01GM138520-02Department: NIH department code

      Elucidating the mechanism of action of novel ClpP activators in activation of the mitochondrial unfolded protein response.
      $314,448

      award amount

47. Liu, Jian

    Leads 1 award · $306,242

    • 5R01HL144970-03Department: NIH department code

      Synthesis and Pharmacological Evaluation of Homogenous Ultra-Low Molecular Weight Heparins
      $306,242

      award amount

48. Hathaway, Nathaniel A.

    Leads 1 award · $304,179

    • 5R01GM132299-02Department: NIH department code

      Computational and experimental insights into the structure and dynamics of heterochromatin
      $304,179

      award amount

49. Asrican, Brent

    Leads 1 award · $233,250

    • 1R21AG074293-01Department: NIH department code

      Altered Diversity of Astrocyte sub-types and Signaling Capabilities in Alzheimer's Disease
      $233,250

      award amount

50. Cottrell, MacKenzie

    Leads 1 award · $231,230

    • 1R21AI157853-01A1Department: NIH department code

      Accelerating to the Cure: A Novel IVIVE Model for Advancing HIV Eradication Strategies
      $231,230

      award amount

51. Liu, Rihe

    Leads 1 award · $224,925

    • 1R21AI163793-01Department: NIH department code

      Trimerization of the N-terminal Domain of ACE2 for Bifunctional Trapping of Future SARS-CoV-2 Variants
      $224,925

      award amount

52. James, Lindsey Ingerman

    Leads 1 award · $188,310

    • 5R01CA242305-03Department: NIH department code

      DISCOVERY OF FIRST-IN-CLASS NSD2 DEGRADERS FOR CANCER THERAPY
      $188,310

      award amount

53. Pina, Melanie M

    Leads 1 award · $126,357

    • 5K99AA028298-02Department: NIH department code

      Alcohol-induced alterations in orbitofrontal cortex serotonin signaling
      $126,357

      award amount

54. Mercer-Smith, Alison R.

    Leads 1 award · $51,036

    • 5F30CA243270-03Department: NIH department code

      Therapeutic Engineered Stem Cells as a New Adjuvant Therapy for Non-Small Cell Lung Cancer Brain Metastases
      $51,036

      award amount

55. Truong, Andrew

    Leads 1 award · $46,036

    • 5F31CA247250-02Department: NIH department code

      Effect of APOBEC3 on Bladder Cancer Biology and Response to Immunotherapy
      $46,036

      award amount

56. Zhu, Manhua

    Leads 1 award · $39,251

    • 1F31DA053064-01Department: NIH department code

      Impact of electronic nicotine vapor on mouse mesolimbic CRFR1 circuitry and motivated behavior
      $39,251

      award amount

57. Cartaya, Ana

    Leads 1 award · $37,955

    • 1F31HL156427-01A1Department: NIH department code

      Selective delivery of superoxide dismutase and catalase for restenosis prevention
      $37,955

      award amount

58. Cherney, Rachel Elizabeth

    Leads 1 award · $37,693

    • 5F31HD103334-02Department: NIH department code

      Regulation of Polycomb by long noncoding RNAs during pre-implantation development
      $37,693

      award amount

59. Zarmer, Sandra

    Leads 1 award · $34,454

    • 1F31CA257224-01Department: NIH department code

      Identifying targets for combination therapy with FOLFIRINOX and investigating cell polarity loss as a potential driver of invasion in basal-like PDAC
      $34,454

      award amount

60. Quintanilla, Luis

    Leads 1 award · $34,376

    • 5F31AG067718-02Department: NIH department code

      The role of the septo-hippocampal cholinergic circuit in regulating hippocampal function
      $34,376

      award amount

61. Murphy, Ryan Mary

    Leads 1 award · $29,100

    • 5F31DE028749-03Department: NIH department code

      Investigating the role of NRF2 in promoting radioresistance in oral squamous cell carcinoma.
      $29,100

      award amount

62. Roberts, Megan C.

    Leads 1 award · $21,479

    • 1R13CA261073-01Department: NIH department code

      Transdisciplinary Conference for Future Leaders in Precision Public Health
      $21,479

      award amount