FY2025 NIH awards · Principal investigators

Internal Medicine at University of Pittsburgh

Pittsburgh, PA

Funding

$154.1M

$154,113,067

Awards

249

FY2025 NIH awards in Internal Medicine

Principal investigators

252

181 lead a grant here, 71 co-investigators

Department rank

of 115 · Ranking

NIH names only the principal investigators on an award, so this page lists only them. The department is the award's: it is where ScienceDex counts the award, not a list of the department's members.
These are the awards in the Internal Medicine row of the University of Pittsburgh page.

Leads a grant in this department

181 contact PIs of these awards, by the funding they lead. Other principal investigators on an award are listed with it and under Co-investigators.

Steven E Reis
Leads 3 awards · $16,462,637
- 5UL1TR001857-10Department: NIH department code
  University of Pittsburgh Clinical and Translational Science Institute
  $10,147,484
  award amount
- 5U24TR004111-04Department: NIH department code
  ENACT: Translating Health Informatics Tools to Research and Clinical Decision Making
  Principal investigators: Steven E Reis (contact PI), Shyam Visweswaran
  $4,665,153
  award amount
- 3OT2OD037639-01S2Department: NIH department code
  All of Us Pennsylvania (AOU PA) Research Program
  Principal investigators: Steven E Reis (contact PI), Shyam Visweswaran
  $1,650,000
  award amount
Charles R Rinaldo
Leads 2 awards · $4,673,882
- 5U01HL146208-07Department: NIH department code
  University of Pittsburgh MACS/WIHS CCS
  Principal investigators: Charles R Rinaldo (contact PI), Jeremy James Martinson
  $3,961,545
  award amount
- 5R01AI167711-05Department: NIH department code
  Immune response to COVID-19 vaccine in HIV infected men and women
  Principal investigators: Charles R Rinaldo (contact PI), Robbie B Mailliard
  $712,337
  award amount
Sharon Riddler
Leads 4 awards · $4,534,403
- 5UM1AI069494-19Department: NIH department code
  Pitt-Ohio State Clinical Trials Unit
  Principal investigators: Sharon Riddler (contact PI), John W Mellors, Susan L Koletar
  $2,382,302
  award amount
- 3UM1AI069494-19S2Department: NIH department code
  Pitt-Ohio State Clinical Trials Unit
  Principal investigators: Sharon Riddler (contact PI), John W Mellors, Susan L Koletar
  $1,083,959
  award amount
- 4U01AI152969-06Department: NIH department code
  Native-like Envelope Trimer Therapeutic Vaccination for Induction of Broadly Neutralizing Antibodies to Facilitate HIV Functional Cure
  $948,892
  award amount
- 3UM1AI069494-19S1Department: NIH department code
  Pitt-Ohio State Clinical Trials Unit
  Principal investigators: Sharon Riddler (contact PI), John W Mellors, Susan L Koletar, Urvi M. Parikh
  $119,250
  award amount
Wei Du
Leads 2 awards · $3,618,855
- 1RF1AG093995-01Department: NIH department code
  A beneficial persistent DNA damage-induced immune response in aging
  $3,101,237
  award amount
- 5R01CA285400-02Department: NIH department code
  Role of LAM-specific TREM1 in leukemogenesis
  $517,618
  award amount
Kathryn H. Schmitz
Leads 4 awards · $2,927,171
- 5U01CA271277-05Department: NIH department code
  TeleHealth Resistance exercise Intervention to preserve dose intensity and Vitality in Elder breast cancer patients (THRIVE)
  Principal investigators: Kathryn H. Schmitz (contact PI), Jennifer A. Ligibel
  $1,211,647
  award amount
- 5R01CA268017-04Department: NIH department code
  Increasing Physical Activity in Rural Pennsylvanians: The PA Moves Trial
  Principal investigators: Kathryn H. Schmitz (contact PI), Mack T. Ruffin
  $977,596
  award amount
- 5R01CA254659-06Department: NIH department code
  Nurse AMIE: Addressing Metastatic Individuals Everyday in Rural PA and WV
  $637,928
  award amount
- 3R01CA268017-04S1Department: NIH department code
  PSE obesity supplement to PA Moves
  Principal investigators: Kathryn H. Schmitz (contact PI), Mack T. Ruffin
  $100,000
  award amount
Doris M Rubio
Leads 3 awards · $2,855,004
- 5KL2TR001856-10Department: NIH department code
  Institutional Career Development Core
  Principal investigators: Doris M Rubio (contact PI), Kristin N Ray
  $1,545,059
  award amount
- 5R01GM155395-02Department: NIH department code
  Promoting Inclusive Excellence
  Principal investigators: Doris M Rubio (contact PI), Gretchen White, Ronald Idoko
  $825,647
  award amount
- 5R25GM116740-10Department: NIH department code
  LEADS 2.0
  $484,298
  award amount
Also a principal investigator on 5TL1TR001858-10, led by Thomas Radomski.
Erin L Winstanley
Leads 2 awards · $2,695,746
- 5RM1DA055311-04Department: NIH department code
  Tailored Retention and Engagement for Effective integrated Treatment of OUD and Pain (TREETOP)
  Principal investigators: Erin L Winstanley (contact PI), Jessica S Merlin, Megan Hamm
  $2,355,842
  award amount
- 5T32DA057926-02Department: NIH department code
  Building an interprofessional and diverse workforce in substance use and pain
  Principal investigators: Erin L Winstanley (contact PI), Jessica S Merlin
  $339,904
  award amount
Beibei Chen
Leads 1 award · $2,299,463
- 5U01AG079828-03Department: NIH department code
  Developing a NAMPT activator for Alzheimer’s disease
  Principal investigators: Beibei Chen (contact PI), Stacey J Rizzo
  $2,299,463
  award amount
Jing Hong Wang
Leads 1 award · $1,899,042
- 1R01DE034974-01Department: NIH department code
  Analysis of high dimensional genomic dataset to reveal mechanistic insights on divergent outcomes of head and neck cancer using system biology modeling coupled with experimental validation
  Principal investigators: Jing Hong Wang (contact PI), Heath Devin Skinner, Jianhua Xing
  $1,899,042
  award amount
John J Pacella
Leads 3 awards · $1,888,646
- 1R01HL173319-01A1Department: NIH department code
  Focal Myocardial Delivery of Small Molecule Nitroalkenes using Ultrasound Targeted Microbubble Cavitation to Improve Ventricular Recovery Following Myocardial Infarction
  $720,676
  award amount
- 5R01HL157497-05Department: NIH department code
  Ultrasound Targeted Microbubble Cavitation to Treat Coronary Microvascular Obstruction
  $692,494
  award amount
- 5R33HL171775-02Department: NIH department code
  A Novel Ticagrelor Coated Stent to Eliminate the Need for Dual Anti Platelet Therapy Post PCI
  $475,476
  award amount
Bruce Lawrence Rollman
Leads 2 awards · $1,853,336
- 5UH3HL165839-03Department: NIH department code
  Peer suppoRt for adolescents and Emerging adults with Sickle cell pain: promoting ENgagement in Cognitive behavioral thErapy
  Principal investigators: Bruce Lawrence Rollman (contact PI), Alicia Colvin, Ana Radovic-Stakic, Charles Richard Jonassaint
  $1,502,212
  award amount
- 3UH3HL165839-03S1Department: NIH department code
  Peer suppoRt for adolescents and Emerging adults with Sickle cell pain: promoting ENgagement in Cognitive behavioral thErapy
  Principal investigators: Bruce Lawrence Rollman (contact PI), Alicia Colvin, Ana Radovic-Stakic, Charles Richard Jonassaint
  $351,124
  award amount
Thomas R Kleyman
Leads 3 awards · $1,839,088
- 2R01HL147818-25A1Department: NIH department code
  ENaC regulation and its role in blood pressure homeostasis
  Principal investigators: Thomas R Kleyman (contact PI), Annet Kirabo
  $749,328
  award amount
- 5TL1DK143271-02Department: NIH department code
  PCT-KUH: Pittsburgh center for training in kidney, urology and hematology
  $545,735
  award amount
- 5R01DK129285-04Department: NIH department code
  Role of piezo channels in intercalated cells
  Principal investigators: Thomas R Kleyman (contact PI), Lisa M. Satlin
  $544,025
  award amount
Chandan K Sen
Leads 3 awards · $1,818,794
- 5U01DK119099-09Department: NIH department code
  Diabetic Foot Consortium Clinical Research Unit
  Principal investigators: Chandan K Sen (contact PI), Gayle M Gordillo, Sashwati Roy
  $769,260
  award amount
- 1R01DK141513-01Department: NIH department code
  Vasculogenic Regenerative Medicine Technology
  $543,826
  award amount
- 5R01DK135447-03Department: NIH department code
  Cell Specific Gene Editing to Close Diabetic Wounds
  $505,708
  award amount
Lianghui Zhang
Leads 3 awards · $1,785,274
- 1R01HL176849-01A1Department: NIH department code
  Pathogenic mechanisms of chronic lung sequelae following respiratory viral infection
  Principal investigators: Lianghui Zhang (contact PI), John F Alcorn
  $754,729
  award amount
- 1R01HL176493-01Department: NIH department code
  Pathogenic Mechanism and Therapeutic Approaches for Exercise Intolerance in Post-Acute Sequelae of COVID-19
  Principal investigators: Lianghui Zhang (contact PI), Michael G Risbano
  $633,045
  award amount
- 5R01HL157489-06Department: NIH department code
  Endothelial antigen presentation to T cells as a pathogenic mechanism in influenza-induced acute lung injury
  $397,500
  award amount
Richard A Steinman
Leads 1 award · $1,750,351
- 5T32GM144300-04Department: NIH department code
  Medical Scientist Training Program
  Principal investigators: Richard A Steinman (contact PI), Russell S Schwartz
  $1,750,351
  award amount
Shihui Liu
Leads 3 awards · $1,702,791
- 1R01CA296154-01A1Department: NIH department code
  Highly tumor-selective pan RAS inactivators for targeting oncogenic RAS-driven cancers
  $657,776
  award amount
- 5R01AI170574-03Department: NIH department code
  Mechanisms of anthrax lethal toxin-induced mortality and the novel biological-based targeted therapies
  $592,728
  award amount
- 5R01CA254938-05Department: NIH department code
  Developmental therapy for selectively targeting MEK-ERK pathway in cancer cells and tumor stromal compartment
  $452,287
  award amount
Renee M Cloutier
Leads 1 award · $1,639,053
- 5RM1DA059395-03Department: NIH department code
  HEALing Measurement Center: Enhancing Opioid Use Disorder Recovery through Measurement Based Care
  Principal investigators: Renee M Cloutier (contact PI), Arnie Paul Aldridge, Kelli Scott
  $1,639,053
  award amount
Sruti Shiva
Leads 3 awards · $1,571,103
- 5R01HL166985-03Department: NIH department code
  Platelet Metabolic Stress Induces Thrombo-Inflammation to Drive Endothelial Dysfunction in PH
  $721,423
  award amount
- 5R01AG072734-04Department: NIH department code
  The relationship between blood based bioenergetics and muscle function, mobility, and aging
  Principal investigators: Sruti Shiva (contact PI), Anthony J Molina
  $592,699
  award amount
- 5T32HL110849-14Department: NIH department code
  Training in Translational Research in Pulmonary Vascular Biology
  $256,981
  award amount
Lori A Birder
Leads 1 award · $1,571,034
- 4R01DK135076-02Department: NIH department code
  PNPase inhibition as an effective treatment for chronic bladder pain
  Principal investigators: Lori A Birder (contact PI), Edwin Kerry Jackson
  $1,571,034
  award amount
Corrine R Kliment
Leads 3 awards · $1,555,768
- 1R61AG095927-01Department: NIH department code
  Inhaled Stressors and Lung Aging
  Principal investigators: Corrine R Kliment (contact PI), Melanie Koenigshoff
  $667,664
  award amount
- 5R01HL168050-03Department: NIH department code
  The Role of Adenine Nucleotide Translocase in Mitochondrial Dysfunction Associated Senescence in Chronic Obstructive Pulmonary Disease (COPD)
  $629,588
  award amount
- 1R21HL179368-01Department: NIH department code
  Mitochondrial Derived Peptides in Chronic Obstructive Pulmonary Disease
  $258,516
  award amount
Also a principal investigator on 1R13HL182216-01, led by Charles S Dela Cruz.
Kang Kim
Leads 2 awards · $1,496,529
- 5R01HL157465-04Department: NIH department code
  Super Resolution Ultrasound Imaging of Vasa Vasorum to Characterize the Progression of Atherosclerotic Plaques and Predict Rupture Vulnerability
  $770,324
  award amount
- 1R01HL178101-01Department: NIH department code
  Dual frequency intravascular ultrasound for super-resolution imaging of vasa vasorum and thin fibrous cap of vulnerable atherosclerotic plaques
  Principal investigators: Kang Kim (contact PI), Qifa Zhou, Xiaoning Jiang
  $726,205
  award amount
Delphine Gomez
Leads 2 awards · $1,449,561
- 2R01HL146465-06Department: NIH department code
  Epigenetic control of smooth muscle cell phenotype during microvascular remodeling
  $785,106
  award amount
- 5R01HL166425-02Department: NIH department code
  Mechano-epigenetic disruption in aortic aneurysm
  $664,455
  award amount
Stephen Y Chan
Leads 2 awards · $1,447,898
- 5R01HL124021-10Department: NIH department code
  An endothelial-fibroblast axis connecting senescence to amino acid metabolism for control of vascular stiffness in PAH
  $760,713
  award amount
- 5R01HL151228-03Department: NIH department code
  Genetic and hypoxic control of a lncRNA axis orchestrates endothelial reprogramming in pulmonary hypertension
  $687,185
  award amount
Christine E Kistler
Leads 2 awards · $1,408,499
- 5R01AG083828-03Department: NIH department code
  Improving Primary Care Clinicians' Advance Care Planning for Alzheimer's Disease and Related Dementias
  $755,721
  award amount
- 5R01AG081359-03Department: NIH department code
  Preserving Geriatric Muscle with an Osteoporosis Medication
  $652,778
  award amount
Jason Becker
Leads 2 awards · $1,398,049
- 5R01HL167955-02Department: NIH department code
  MDM2-HIF signaling in pathological ventricular remodeling
  $744,195
  award amount
- 5R01HL169784-02Department: NIH department code
  Cardiomyocyte selective modulation of natriuretic peptide signaling in cardiomyopathy
  $653,854
  award amount
Sarah L Gaffen
Leads 3 awards · $1,387,880
- 5R01AI162616-04Department: NIH department code
  RNA binding proteins in end-organ autoimmune pathology
  $618,244
  award amount
- 5R37DE022550-14Department: NIH department code
  Host and Fungal Regulation of Type 17 Immunity to Oral Candidiasis
  $572,656
  award amount
- 5R21AI185365-02Department: NIH department code
  Mucosal host defense against vaginal candidiasis
  $196,980
  award amount
Kaleab Z Abebe
Leads 2 awards · $1,379,904
- 5U01DK130010-05Department: NIH department code
  The Pittsburgh Scientific and Data Research Center for the COPE-AKI Consortium (Pitt-SDRC)
  Principal investigators: Kaleab Z Abebe (contact PI), Linda Faith Fried, Paul M Palevsky, Sandra L Kane-Gill
  $995,078
  award amount
- 5U24HL153846-05Department: NIH department code
  (2/2) Randomized Evaluation of Bromocriptine In Myocardial Recovery THerapy for Peripartum Cardiomyopathy (REBIRTH)
  $384,826
  award amount
Babak Razani
Leads 2 awards · $1,368,129
- 2R01HL125838-12Department: NIH department code
  Sensing and Clearance of Damaged Lysosomes in Macrophages and Atherosclerosis
  $760,737
  award amount
- 5R01HL159461-04Department: NIH department code
  Dissecting the Impact of Dietary Protein on Macrophage mTOR Signaling and Atherosclerosis
  Principal investigators: Babak Razani (contact PI), Bettina Mittendorfer
  $607,392
  award amount
Amy L Hartman
Leads 2 awards · $1,366,286
- 5R01AI178378-03Department: NIH department code
  Mechanisms of Neuronal Infection by Prototype Emerging Bunyaviruses
  $757,645
  award amount
- 5R01AI150792-05Department: NIH department code
  Live-attenuated Rift Valley fever vaccines: comparative mechanisms of trans-placental transmission and vaccine efficacy for developing fetuses
  $608,641
  award amount
Randall Brand
Leads 2 awards · $1,287,925
- 5U01CA200466-08Department: NIH department code
  Validation of biomarkers for risk prediction and early diagnosis of Pancreatic Adenocarcinoma
  Principal investigators: Randall Brand (contact PI), Surinder K. Batra
  $1,264,325
  award amount
- 1R13DK145190-01Department: NIH department code
  PancreasFest 2025: Pancreas Disease Across the Lifespan
  $23,600
  award amount
Paul J Joudrey
Leads 2 awards · $1,273,310
- 5R37DA060183-02Department: NIH department code
  Localize Opioid Use Disorder (LOUD) response to increase medication access
  Principal investigators: Paul J Joudrey (contact PI), Marynia Kolak
  $784,976
  award amount
- 1R61DA063659-01Department: NIH department code
  PeRsOnlized MethadOne TrEatment (PROMOTE) by implementing shared decision making
  Principal investigators: Paul J Joudrey (contact PI), Cristina Murray-Krezan
  $488,334
  award amount
Anuradha Ray
Leads 2 awards · $1,268,430
- 5R35HL166219-03Department: NIH department code
  Dysregulated Immunometabolism and Premature Senescence in Corticosteroid-Refractory Severe Asthma
  $740,230
  award amount
- 5R01AI176632-02Department: NIH department code
  Mechanisms of Antigen-Induced Tolerance in the Lung
  Principal investigators: Anuradha Ray (contact PI), Prabir Ray
  $528,200
  award amount
Jeremy M Kahn
Leads 2 awards · $1,206,110
- 5R35HL144804-07Department: NIH department code
  Organizational strategies for improving evidence-uptake in intensive care
  $917,190
  award amount
- 5T32HL007820-27Department: NIH department code
  Multidisciplinary Training in Critical Care Outcomes Research
  Principal investigators: Jeremy M Kahn (contact PI), Timothy D Girard
  $288,920
  award amount
Daria N Van Tyne
Leads 1 award · $1,196,555
- 4R01AI165519-04Department: NIH department code
  Adaptation of vancomycin-resistant enterococci during bloodstream infection
  $1,196,555
  award amount
Mehret Birru Talabi
Leads 2 awards · $1,186,017
- 1R01HD118690-01Department: NIH department code
  Effects of health policy on the health of people with systemic autoimmune and rheumatic diseases
  Principal investigators: Mehret Birru Talabi (contact PI), Marian Patricia Jarlenski
  $673,538
  award amount
- 5R33HD113515-03Department: NIH department code
  Time-Sensitive Research to Assess the Effects of Reproductive Health Policy on the Health Outcomes of People with Chronic Diseases
  $512,479
  award amount
Jonathan K. Alder
Leads 2 awards · $1,170,345
- 5R01HL135062-07Department: NIH department code
  Mechanisms of Telomere-Mediated Lung Disease
  $747,166
  award amount
- 1R21AG086744-01A1Department: NIH department code
  SASP-ER platform to identify spatiotemporal senescence-associated secretome
  Principal investigators: Jonathan K. Alder (contact PI), Aditi U Gurkar
  $423,179
  award amount
Also a principal investigator on 5R01HL166265-03, led by John F McDyer; 1R01DK138967-01A1, led by Michael J. Jurczak.
Kj Suda
Leads 2 awards · $1,149,217
- 5R01DE030657-04Department: NIH department code
  Pediatric Adverse Event Risk Reduction for High Risk Medications in Children and Adolescents: Improving Pediatric Patient Safety in Dental Practices
  $749,221
  award amount
- 5R01HS027985-05Department: NIH department code
  Impact of COVID-19 on Drug Shortages
  $399,996
  award amount
John F McDyer
Leads 2 awards · $1,146,920
- 5R01HL166265-03Department: NIH department code
  The Role of Telomeres in Lung Transplant Recipient Immunity and Outcomes
  Principal investigators: John F McDyer (contact PI), Jonathan K. Alder
  $707,484
  award amount
- 5U01HL163294-04Department: NIH department code
  The Clinical and Molecular Impacts of Lung Primary Graft Dysfunction
  Principal investigators: John F McDyer (contact PI), Christian A Merlo, John Greenland
  $439,436
  award amount
Hassane M Zarour
Leads 2 awards · $1,113,981
- 5U01CA268806-04Department: NIH department code
  Therapy with fecal microbiota transplantation and immune checkpoint blockade for solid tumors
  $632,135
  award amount
- 5R01CA257265-05Department: NIH department code
  Neoadjuvant Immunotherapy with Intratumoral CPG and PD-1 Blockade in Melanoma
  Principal investigators: Hassane M Zarour (contact PI), Diwakar Davar
  $481,846
  award amount
Juliane I Beier
Leads 3 awards · $1,105,715
- 5R01DK133454-04Department: NIH department code
  Vinyl chloride modifies the risk for nonalcoholic fatty liver disease
  $466,452
  award amount
- 1OT2ES038710-01Department: NIH department code
  The East Palestine Train Derailment Health Research Program
  $440,513
  award amount
- 5R21ES036032-02Department: NIH department code
  East Palestine Community-Engaged Environmental Exposure, Health Data, and Biospecimen Bank
  Principal investigators: Juliane I Beier (contact PI), Maureen Y. Lichtveld
  $198,750
  award amount
Sanjay R Patel
Leads 1 award · $1,104,408
- 5R01DA059465-03Department: NIH department code
  The impact of central sleep apnea in patients receiving medications for opioid use disorder
  $1,104,408
  award amount
Flordeliza S Villanueva
Leads 2 awards · $1,097,739
- 1R01HL178726-01Department: NIH department code
  Treatment of post-infarction cardiac remodeling using image-guided delivery of microRNA-loaded microbubbles and ultrasound-mediated cavitation
  $791,485
  award amount
- 5T32HL129964-10Department: NIH department code
  Training Program in Imaging Sciences in Translational Cardiovascular Research
  $306,254
  award amount
Dhiraj Yadav
Leads 2 awards · $1,065,300
- 2U01DK108306-11Department: NIH department code
  UPMC Clinical Center for the Study of Chronic Pancreatitis and Diabetes
  Principal investigators: Dhiraj Yadav (contact PI), Frederico G. S. Toledo
  $556,500
  award amount
- 2U01DK127377-06Department: NIH department code
  UPMC Clinical Center for the Study of Diabetes after Acute Pancreatitis
  Principal investigators: Dhiraj Yadav (contact PI), Frederico G. S. Toledo
  $508,800
  award amount
Marcelo Daniel Carattino
Leads 2 awards · $1,008,451
- 1R01DK138907-01A1Department: NIH department code
  Role of fibroblasts in bladder mucosal function
  Principal investigators: Marcelo Daniel Carattino (contact PI), Gerard L Apodaca
  $690,451
  award amount
- 5R01DK134431-03Department: NIH department code
  Role of acid-sensing ion channels in bladder sensory signaling
  $318,000
  award amount
Robert E. Schoen
Leads 1 award · $999,847
- 5U01CA271884-04Department: NIH department code
  Blood-Based Testing for Advanced Adenoma
  Principal investigators: Robert E. Schoen (contact PI), Cristian Tomasetti
  $999,847
  award amount
Elizabeth Miller
Leads 2 awards · $998,179
- 5U01CE003524-04Department: NIH department code
  CE22-013 A community-centered collective efficacy intervention for prevention of community violence
  $548,244
  award amount
- 1U01CE003759-01Department: NIH department code
  CE25-025 - Promising Futures: Healing-centered systems to prevent adverse childhood experiences
  Principal investigators: Elizabeth Miller (contact PI), Tien Ung
  $449,935
  award amount
Frank Sciurba
Leads 1 award · $965,315
- 5U18HS029924-03Department: NIH department code
  The Pitt IMProving Access to Culturally relevant long COVID care and Treatment (IMPACCT) Program
  Principal investigators: Frank Sciurba (contact PI), Howard B Degenholtz
  $965,315
  award amount
Sadeesh Kumar Ramakrishnan
Leads 2 awards · $942,054
- 5R01DK133406-04Department: NIH department code
  Role of Hypoxia-inducible factor-2a in L-cell nutrient sensing and metabolic homeostasis
  $471,136
  award amount
- 5R01DK134581-02Department: NIH department code
  Deciphering the physiology of neonatal beige adipocytes
  $470,918
  award amount
Anna Evans Phillips
Leads 2 awards · $935,679
- 5R01DK127042-05Department: NIH department code
  P-QST Project: Pancreatic Quantitative Sensory Testing (P-QST) to Predict Treatment Response for Pain in Chronic Pancreatitis
  $580,687
  award amount
- 1R01DK140381-01A1Department: NIH department code
  Malabsorption Blood Test (MBT) to Determine Exocrine Pancreatic Function and Related Quality of Life in Chronic Pancreatitis
  Principal investigators: Anna Evans Phillips (contact PI), Virginia A. Stallings
  $354,992
  award amount
Thomas Radomski
Leads 1 award · $930,444
- 5TL1TR001858-10Department: NIH department code
  J. NRSA Training Core
  Principal investigators: Thomas Radomski (contact PI), Doris M Rubio
  $930,444
  award amount
Xiaojun Tan
Leads 2 awards · $882,994
- 5R01DK134341-03Department: NIH department code
  Deciphering a Novel Mechanism for Iron-sensing at Mitochondria and Its Role in Erythropoiesis
  $485,494
  award amount
- 5R35GM150506-03Department: NIH department code
  Lysosomal quality control through lipid remodeling
  $397,500
  award amount
Adam M Brufsky
Leads 1 award · $865,242
- 3UG1CA233184-06S1Department: NIH department code
  NCI NCTN-Network Lead Academic Participating Site at UPMC Hillman Cancer Center
  Principal investigators: Adam M Brufsky (contact PI), John Munn Kirkwood
  $865,242
  award amount
Walid F. Gellad
Leads 2 awards · $846,677
- 5R01DA044985-07Department: NIH department code
  Machine-Learning Prediction and Reducing Overdoses with EHR Nudges (mPROVEN)
  $688,470
  award amount
- 3R01DA044985-07S1Department: NIH department code
  Machine-Learning Prediction and Reducing Overdoses with EHR Nudges (mPROVEN)
  $158,207
  award amount
Timothy D Girard
Leads 1 award · $834,157
- 5U01HL159882-05Department: NIH department code
  The Maximizing Extubation outcomes Through Educational and Organizational Research (METEOR) Trial
  $834,157
  award amount
Also a principal investigator on 5T32HL007820-27, led by Jeremy M Kahn.
Alison Bloom Kohan
Leads 1 award · $812,621
- 1R01DK143623-01Department: NIH department code
  Deciphering the role of the Cystic Fibrosis Transmembrane Receptor (CFTR) in dietary fatty acid transport in the small intestine
  Principal investigators: Alison Bloom Kohan (contact PI), Craig A Hodges
  $812,621
  award amount
Jared W. Magnani
Leads 2 awards · $810,257
- 5R01HL160749-04Department: NIH department code
  Multilevel mobile health program to improve rural hypertension
  Principal investigators: Jared W. Magnani (contact PI), Matthew F Muldoon
  $690,304
  award amount
- 5K24HL160527-04Department: NIH department code
  Mentoring in patient-oriented research in social determinants and atrial fibrillation
  $119,953
  award amount
John W Evankovich
Leads 2 awards · $806,233
- 1R01HL174649-01A1Department: NIH department code
  Indole Metabolites as Xenobiotic Danger signals in Acute Lung Injury
  $688,163
  award amount
- 5R03HL173071-02Department: NIH department code
  Fibronectin Extra Domain A Degradation as an Antifibrotic Approach in Lung Fibrosis
  $118,070
  award amount
Barbara Methe
Leads 1 award · $785,014
- 5R01HL164177-04Department: NIH department code
  Relationship of fungal translocation, inflammation, and pulmonary function in HIV
  Principal investigators: Barbara Methe (contact PI), Alison Morris
  $785,014
  award amount
Yuan Liu
Leads 1 award · $779,817
- 5R01AI172935-03Department: NIH department code
  Host Defense Small Molecule Development for COVID-19 Treatment by Targeting Lysosome
  Principal investigators: Yuan Liu (contact PI), Simon M Barratt-Boyes
  $779,817
  award amount
Melanie Koenigshoff
Leads 1 award · $777,723
- 5T32HL007563-38Department: NIH department code
  Translational Training Program in Pulmonary Biology and Medicine
  $777,723
  award amount
Also a principal investigator on 1R61AG095927-01, led by Corrine R Kliment.
Cristian Apetrei
Leads 1 award · $775,683
- 5R01DK131476-04Department: NIH department code
  Impact of metabolic programing of T cells from the GI tract and related tissues on HIV reservoir seeding, maintenance and reactivation
  $775,683
  award amount
Lee H Harrison
Leads 1 award · $774,146
- 5R01AI127472-10Department: NIH department code
  Enhanced Detection System for Healthcare-Associated Transmission of Infection
  $774,146
  award amount
Kambez Hajipouran Benam
Leads 1 award · $773,781
- 5R01HL159494-03Department: NIH department code
  Emulating Immune Dysregulation by Trisomy 21 in a Multi-Organ-on-a-Chip System
  $773,781
  award amount
Daniel J Kass
Leads 1 award · $773,440
- 1R01HL173817-01A1Department: NIH department code
  E-Box Accessibility in Myofibroblasts in Pulmonary Fibrosis
  Principal investigators: Daniel J Kass (contact PI), Robert A. Lafyatis
  $773,440
  award amount
Gilles Clermont
Leads 1 award · $766,019
- 5R01NR013912-11Department: NIH department code
  Predicting Patient Instability Noninvasively for Nursing Care – Three (PPINNC-3)
  Principal investigators: Gilles Clermont (contact PI), Salah S Al-Zaiti
  $766,019
  award amount
Divay Chandra
Leads 1 award · $761,346
- 1R01HL179364-01Department: NIH department code
  Developing Lithium as a Disease-Modifying Therapy for Emphysema Using a Precision Medicine Approach
  $761,346
  award amount
Cynthia St. Hilaire
Leads 1 award · $761,042
- 1R01HL176595-01Department: NIH department code
  Medial Arterial Calcification in Peripheral Artery Disease
  $761,042
  award amount
Warren D Shlomchik
Leads 1 award · $747,995
- 2R01HL143349-05A1Department: NIH department code
  Graft-versus-Host Disease: Local Maintenance by Tissue Resident Progenitor T cells
  $747,995
  award amount
Oliver Eickelberg
Leads 1 award · $747,239
- 5R01HL172493-02Department: NIH department code
  Role of plasma cells in chronic rejection after lung transplantation
  Principal investigators: Oliver Eickelberg (contact PI), Marta Bueno Fernandez
  $747,239
  award amount
Mark Eugene Snyder
Leads 1 award · $743,120
- 5R01HL167901-03Department: NIH department code
  Tissue resident memory T cells and chronic lung allograft dysfunction
  $743,120
  award amount
Nicolas Paul Sluis-Cremer
Leads 1 award · $728,506
- 5R01AI162615-04Department: NIH department code
  Elucidating the role of B cell mediated trans infection in the establishment of the latent HIV-1 reservoir
  $728,506
  award amount
Georgios Kitsios
Leads 1 award · $719,195
- 1R01HL176668-01A1Department: NIH department code
  Airspace Candida Colonization and Lung Injury (AirCCoLIN)
  $719,195
  award amount
Haodi Wu
Leads 1 award · $706,519
- 1R01HL179359-01Department: NIH department code
  The non-canonical roles of NIPBL in cardiomyocytes
  $706,519
  award amount
Elias K. Halvas
Leads 1 award · $699,041
- 5R01AI165031-05Department: NIH department code
  Understanding Immune Evasion by HIV-1 Repliclones
  $699,041
  award amount
Anthony John Kanai
Leads 1 award · $698,978
- 5R01DK134386-03Department: NIH department code
  Nitric Oxide-Soluble Guanylate Cyclase Pathway as a Target for Male Bladder Outlet Obstruction and Lower Urinary Tract Symptoms in Aging
  $698,978
  award amount
Gavin E Arteel
Leads 1 award · $697,731
- 5R01DK130294-04Department: NIH department code
  Novel Biomarkers for Post-Liver Transplant NASH Fibrosis
  Principal investigators: Gavin E Arteel (contact PI), Andres Duarte-Rojo, Michael L Merchant, Panagiotis V Benos
  $697,731
  award amount
William R Wagner
Leads 1 award · $695,865
- 1R01HL174945-01A1Department: NIH department code
  Minimally Invasive Targeted Injection of Thermoresponsive Hydrogels for Cardiomyopathy
  $695,865
  award amount
Gretchen White
Leads 1 award · $683,715
- 5R01NR020031-05Department: NIH department code
  Opioid therapy for pain in individuals with metastatic cancer: benefits, harms and stakeholder perspectives
  Principal investigators: Gretchen White (contact PI), Christine S Ritchie, Jessica S Merlin
  $683,715
  award amount
Also a principal investigator on 5R01GM155395-02, led by Doris M Rubio.
Dennis M. McNamara
Leads 1 award · $677,240
- 5UH3HL153847-05Department: NIH department code
  (1/2) Randomized Evaluation of Bromocriptine in Myocardial Recovery Therapy for Peripartum Cardiomyopathy (REBIRTH)
  $677,240
  award amount
Manisha Jhamb
Leads 1 award · $675,287
- 5R01DK114085-07Department: NIH department code
  Technology Assisted Collaborative Care Implementation Trial
  Principal investigators: Manisha Jhamb (contact PI), Mark Lynn Unruh
  $675,287
  award amount
Pouneh Khadejeh Fazeli
Leads 1 award · $666,071
- 5R01DK133578-03Department: NIH department code
  Beneficial reprogramming of lipid metabolism with intermittent fasting
  Principal investigators: Pouneh Khadejeh Fazeli (contact PI), Matthew Steinhauser
  $666,071
  award amount
Michael J. Jurczak
Leads 1 award · $659,199
- 1R01DK138967-01A1Department: NIH department code
  Novel aspects of Gdf15 biology and function
  Principal investigators: Michael J. Jurczak (contact PI), Jonathan K. Alder
  $659,199
  award amount
Sonya B. Borrero
Leads 1 award · $657,825
- 5R01HD110557-03Department: NIH department code
  Addressing factors related to disparities in vasectomy
  Principal investigators: Sonya B. Borrero (contact PI), Kari L White
  $657,825
  award amount
David J Levinthal
Leads 1 award · $656,104
- 1R01DK144729-01Department: NIH department code
  TMS Neuromodulation of Brain-to-Stomach Circuits in Chronic Nausea
  $656,104
  award amount
Evan Cross Ray
Leads 1 award · $650,004
- 1R01DK139177-01A1Department: NIH department code
  Regulation of Renal Tubular Mg2+ Handling by MUC1 and Lactation
  $650,004
  award amount
Vijay K Yechoor
Leads 1 award · $643,423
- 5R01DK128972-05Department: NIH department code
  Clock modulation in circadian desynchrony induced diabetes and atherovascular disease - mechanisms and interventions
  Principal investigators: Vijay K Yechoor (contact PI), Antonio Paul, Mariana Gross Figueiro
  $643,423
  award amount
Gerard L Apodaca
Leads 1 award · $636,114
- 5R01DK129473-05Department: NIH department code
  Role of AJC in umbrella cell function and dysfunction
  $636,114
  award amount
Also a principal investigator on 1R01DK138907-01A1, led by Marcelo Daniel Carattino.
Samit Ghosh
Leads 1 award · $628,139
- 5R01DK132145-03Department: NIH department code
  Renal endothelium and the development of chronic kidney disease in sickle cell disorders
  $628,139
  award amount
Jami Lynn Saloman
Leads 1 award · $622,548
- 5R01CA285585-02Department: NIH department code
  Peripheral Nerve Regulation of Pancreas Cancer Progression
  $622,548
  award amount
Arohan R Subramanya
Leads 1 award · $619,772
- 5R01DK098145-08Department: NIH department code
  Control of the Renal WNK Signaling Pathway by Phase Transitions
  Principal investigators: Arohan R Subramanya (contact PI), Aylin Rachel Rodan
  $619,772
  award amount
Robbie B Mailliard
Leads 1 award · $618,659
- 5R01AI152655-04Department: NIH department code
  Antigen-specific ‘kick and kill’ of the latent HIV reservoir using dendritic cells
  Principal investigators: Robbie B Mailliard (contact PI), Moses Turkle Bility
  $618,659
  award amount
Also a principal investigator on 5R01AI167711-05, led by Charles R Rinaldo.
Payel Jhoom Roy
Leads 1 award · $609,370
- 4R01DE033322-02Department: NIH department code
  Comparative Risk of Oral Complications Associated with Medications for Opioid Use Disorder: A Mixed-Methods Approach
  Principal investigators: Payel Jhoom Roy (contact PI), Anne Mobley Butler
  $609,370
  award amount
Becky D Clarkson
Leads 1 award · $607,821
- 5R01AG065288-05Department: NIH department code
  Investigation of brain mechanisms involved in the Urinary Continence mechanism associated with aging
  $607,821
  award amount
Yufei Huang
Leads 2 awards · $600,978
- 5U01CA279618-03Department: NIH department code
  m6A-suite: an informatics pipeline and resource for elucidating roles of m6A epitranscriptome in cancer
  $393,468
  award amount
- 3U01CA279618-03S1Department: NIH department code
  m6A-suite: an informatics pipeline and resource for elucidating roles of m6A epitranscriptome in cancer
  $207,510
  award amount
Wei-Hsuan Jenny Lo-Ciganic
Leads 1 award · $595,973
- 5R01DA050676-05Department: NIH department code
  Developing and Evaluating a Machine-Learning Opioid Prediction & Risk-Stratification E-Platform (DEMONSTRATE)
  $595,973
  award amount
Galen E. Switzer
Leads 1 award · $581,857
- 5R01HL171117-02Department: NIH department code
  Donor health-related quality-of-life and physician decision-making in the context of haploidentical hematopoietic stem cell transplantation (HaploQOL)
  Principal investigators: Galen E. Switzer (contact PI), Michael A Pulsipher
  $581,857
  award amount
Aditi U Gurkar
Leads 1 award · $566,000
- 5R01ES035733-02Department: NIH department code
  Telomere dysfunction driven molecular outputs in the cardiac unit
  $566,000
  award amount
Also a principal investigator on 1R21AG086744-01A1, led by Jonathan K. Alder.
Enrico M Novelli
Leads 1 award · $554,636
- 5R01HL154629-04Department: NIH department code
  PET Imaging of Vaso-Occlussive Crisis in Sickle Cell Disease
  Principal investigators: Enrico M Novelli (contact PI), Carolyn J. Anderson
  $554,636
  award amount
Ann-Marie Rosland
Leads 2 awards · $552,578
- 5R01DK136788-02Department: NIH department code
  Patient-generated health data connections to empower diabetes management success
  Principal investigators: Ann-Marie Rosland (contact PI), Carissa A Low
  $314,412
  award amount
- 3R01DK136788-02S1Department: NIH department code
  Understanding the Impact of Digital Health Literacy and Health Supporters on Technology Use for Self-Management among Adults with Type 2 Diabetes
  Principal investigators: Ann-Marie Rosland (contact PI), Carissa A Low
  $238,166
  award amount
Matthew Steinhauser
Leads 1 award · $541,806
- 5R01DK137913-02Department: NIH department code
  Defining the molecular regulation and physiological role of a novel lysosomal mechanism of adipocyte lipolysis
  $541,806
  award amount
Also a principal investigator on 5R01DK133578-03, led by Pouneh Khadejeh Fazeli.
Yvette Y Yien
Leads 1 award · $533,386
- 5R01DK137107-03Department: NIH department code
  Regulation of erythroid iron metabolism by the CLPX unfoldase
  $533,386
  award amount
Iain Scott
Leads 1 award · $528,275
- 5R01HL156874-04Department: NIH department code
  Fatty acid oxidation in female cardioprotection
  $528,275
  award amount
Gang Li
Leads 1 award · $526,916
- 5R01AG065229-05Department: NIH department code
  Comprehensive functional genomic analysis of the multi-disease associated CDKN2A/B locus
  Principal investigators: Gang Li (contact PI), Toren Finkel
  $526,916
  award amount
Keven Mara Robinson
Leads 1 award · $513,956
- 5R01AI153337-05Department: NIH department code
  Influenza Attenuates Innate Pulmonary Host Defense against Invasive Pulmonary Aspergillosis
  $513,956
  award amount
Anna Christine Zemke
Leads 1 award · $509,101
- 5R01HL162964-04Department: NIH department code
  Tracheobronchitis in the Critically Ill
  $509,101
  award amount
Mohammad Al-Bataineh
Leads 1 award · $494,045
- 5R01DK135862-02Department: NIH department code
  Role of MUC1 in the host defense against urinary tract infection
  $494,045
  award amount
Shari S Rogal
Leads 1 award · $492,348
- 1U48DP006942-01Department: NIH department code
  Implementing lifestyle change interventions to improve health outcomes
  Principal investigators: Shari S Rogal (contact PI), Charles Richard Jonassaint
  $492,348
  award amount
Yohei Doi
Leads 1 award · $481,214
- 1R21AI185663-01A1Department: NIH department code
  Defining high-risk genomic groups of Stenotrophomonas maltophilia
  $481,214
  award amount
Sashwati Roy
Leads 1 award · $480,105
- 4R33DK131909-04Department: NIH department code
  Diabetic Foot Ulcer Wound Fluid Biomarker
  $480,105
  award amount
Also a principal investigator on 5U01DK119099-09, led by Chandan K Sen.
Roderick Jason Tan
Leads 1 award · $477,801
- 5R01DK131991-04Department: NIH department code
  Effect of Renal Nerves on Chronic Kidney Disease
  $477,801
  award amount
Andrey A Parkhitko
Leads 2 awards · $477,000
- 5R35GM146869-04Department: NIH department code
  Deciphering the crosstalk between methionine metabolism and methyltransferases in health and disease
  $397,500
  award amount
- 5R03CA286521-02Department: NIH department code
  Combined targeting of synthetic lethal partners in RB1-deficient cells
  $79,500
  award amount
Richard H Duerr
Leads 1 award · $477,000
- 5R01DK138458-02Department: NIH department code
  Trans-ancestry, single-cell multiomics dissection of IBD-associated loci in CD4 memory T cells
  Principal investigators: Richard H Duerr (contact PI), Wei Chen
  $477,000
  award amount
Audrey Jeanette Murrell
Leads 1 award · $475,831
- 5R25GM143262-05Department: NIH department code
  TRANSforming Bio-medical Research & Academic Faculty through Opportunity, TRaining, & Mentorship (TRANSFORM)
  Principal investigators: Audrey Jeanette Murrell (contact PI), Esa M Davis
  $475,831
  award amount
Christopher W. Seymour
Leads 1 award · $473,447
- 5R35GM119519-10Department: NIH department code
  Sepsis online: learning while doing to understand biology and treatment
  $473,447
  award amount
Liza Cosca Villaruz
Leads 1 award · $468,866
- 5UM1CA186690-09Department: NIH department code
  NCI ETCTN Pittsburgh Cancer Consortium (PCC)
  Principal investigators: Liza Cosca Villaruz (contact PI), Farshid Dayyani, John C. Byrd
  $468,866
  award amount
Tatiana V Kudryashova
Leads 2 awards · $463,099
- 5R01HL166932-03Department: NIH department code
  HIPK2 signaling in Pulmonary Arterial Hypertension
  $358,824
  award amount
- 3R01HL166932-03S1Department: NIH department code
  Administrative Supplement for R01HL166932
  $104,275
  award amount
Daniel E. Forman
Leads 1 award · $462,028
- 5T32AG021885-22Department: NIH department code
  Pitt Integrated Clinical and Geroscience Research Training Program
  $462,028
  award amount
Debra Kaye Weiner
Leads 1 award · $455,197
- 5R01AT012534-03Department: NIH department code
  Optimizing Impact of Manual Therapy and Exercise on Lumbar Spinal Stenosis with Neurogenic Claudication: A Multi-Site Feasibility Study
  Principal investigators: Debra Kaye Weiner (contact PI), Paul E Dougherty
  $455,197
  award amount
Bokai Zhu
Leads 1 award · $452,250
- 1R35GM157978-01Department: NIH department code
  Decoding the functions of nuclear speckle in protein quality control
  $452,250
  award amount
Shachi Tyagi
Leads 1 award · $448,524
- 5R01AG076575-04Department: NIH department code
  Sleep and Bladder Study
  $448,524
  award amount
Faraaz Ali Shah
Leads 1 award · $437,250
- 1R35GM160146-01Department: NIH department code
  Improving Characterization of Individualized Treatment Effects in Critical Illness
  $437,250
  award amount
Partha Dutta
Leads 1 award · $433,787
- 5R01DK129339-04Department: NIH department code
  The role of SerpinB2 in insulin resistance and inflammation
  $433,787
  award amount
Joo Heung Yoon
Leads 1 award · $433,710
- 1R35GM159939-01Department: NIH department code
  Designing a Comprehensive Machine Learning-driven Prescriptive Clinical Decision Support System for Shock and Associated Critical Care Conditions
  $433,710
  award amount
Prabir Ray
Leads 1 award · $430,760
- 1R21AI193306-01Department: NIH department code
  Training of Neutrophils to Defend Against a Lethal Bacterial Infection of the Lung
  $430,760
  award amount
Also a principal investigator on 5R01AI176632-02, led by Anuradha Ray.
Robert M O'Doherty
Leads 2 awards · $398,433
- 5T32DK007052-50Department: NIH department code
  T32 Research Training in Diabetes and Endocrinology
  $375,167
  award amount
- 3T32DK007052-50S1Department: NIH department code
  T32 Research Training in Diabetes and Endocrinology
  $23,266
  award amount
Kevin Raymond McCarthy
Leads 1 award · $397,500
- 5R35GM154844-02Department: NIH department code
  Hosts Going Viral: Building The Tools And Systems To Determine How Human-Relevant Biology Evolved Through The Capture Of Viral Genes In Our Distant Ancestors
  $397,500
  award amount
Laura Anzaldi Mike
Leads 1 award · $397,500
- 5R35GM150588-03Department: NIH department code
  Control of Klebsiella capsule biosynthesis and attachment
  $397,500
  award amount
Matthew J Culyba
Leads 1 award · $397,500
- 1R35GM159885-01Department: NIH department code
  Evolution and adaptation of Staphylococcus aureus to nutrient stress
  $397,500
  award amount
Ravy Kuppalapalle Vajravelu
Leads 1 award · $388,425
- 5R01DK135876-03Department: NIH department code
  Determining medications associated with drug-induced pancreatic injury through novel pharmacoepidemiology techniques that assess causation
  $388,425
  award amount
Kanhaiya Singh
Leads 1 award · $382,455
- 5R01DK136814-03Department: NIH department code
  Regulatory Mechanisms Addressing Diabetic Vasculopathy
  $382,455
  award amount
Subhadip Ghatak
Leads 1 award · $345,802
- 5R01DK129592-03Department: NIH department code
  Exosomes in wound healing
  $345,802
  award amount
Charles S Dela Cruz
Leads 2 awards · $324,329
- 5R38HL150207-06Department: NIH department code
  Pittsburgh Innovation in Collaborative Training of Residents Alliance
  Principal investigators: Charles S Dela Cruz (contact PI), Alison Morris
  $289,329
  award amount
- 1R13HL182216-01Department: NIH department code
  2025 Pittsburgh Lung Conference: The Science of Medicine: Developing the Next Generation of Physician Scientists
  Principal investigators: Charles S Dela Cruz (contact PI), Alison Morris, Corrine R Kliment
  $35,000
  award amount
Hernando Gomez Danies
Leads 1 award · $318,000
- 5R01DK133142-03Department: NIH department code
  A Randomized Clinical Trial of the Safety and FeasibiLity of Metformin as a Treatment for sepsis induced AKI (LiMiT AKI)
  $318,000
  award amount
Shujie Shi
Leads 1 award · $318,000
- 5R01DK130901-05Department: NIH department code
  Role of PON3 in regulating renal Na+ and K+ homeostasis
  $318,000
  award amount
Robert A. Lafyatis
Leads 2 awards · $295,904
- 5R21AR084251-02Department: NIH department code
  Pathways regulating profibrotic macrophages in a novel explant model of systemic sclerosis-associated interstitial lung disease
  $148,064
  award amount
- 3P50AR080612-04S1Department: NIH department code
  Clinical-Translational Studies in Skin, Lung, and Vascular Complications in Systemic Sclerosis
  $147,840
  award amount
Also a principal investigator on 1R01HL173817-01A1, led by Daniel J Kass.
Manling Zhang
Leads 2 awards · $279,738
- 5K08HL157616-05Department: NIH department code
  The Role of GCN5L1 Mediated Mitochondria to Nucleus Retrograde Cardiac Metabolism Reprogramming in Exercise and Heart Failure
  $160,488
  award amount
- 5R03HL174881-02Department: NIH department code
  Mettl14 mediated mRNA methylation orchestrates postnatal cardiac development
  $119,250
  award amount
Daniel J Shiwarski
Leads 1 award · $249,000
- 5R00HL155777-05Department: NIH department code
  Development of a Collagen-based 3D Bioprinted Microfluidic Platform for Vascular Tissue Engineering and Disease Modeling
  $249,000
  award amount
Niranjana Natarajan
Leads 1 award · $249,000
- 5R00HL157689-04Department: NIH department code
  Investigating the Role of Macrophages in Heart Failure with Preserved Ejection Fraction
  $249,000
  award amount
Caitlin Stoddard
Leads 1 award · $248,999
- 7R00AI171000-04Department: NIH department code
  Innate immune factors governing restriction of human coronaviruses
  $248,999
  award amount
Ilana Hull
Leads 1 award · $246,727
- 1R21DA062129-01A1Department: NIH department code
  Effects of Xylazine Exposure on Maternal, Perinatal and Infant outcomes
  $246,727
  award amount
Timothy S Anderson
Leads 1 award · $238,099
- 5K76AG074878-05Department: NIH department code
  Optimizing prescribing decisions for hospitalized older adults with chronic conditions
  $238,099
  award amount
Margaret Zupa
Leads 2 awards · $236,849
- 5K23DK135794-02Department: NIH department code
  Increasing Reach of Effective Virtual Specialty Care for Adults with Diabetes Through Tailored Modalities
  $161,250
  award amount
- 3K23DK135794-02S1Department: NIH department code
  Increasing Reach of Effective Virtual Specialty Care for Adults with Diabetes Through Tailored Modalities
  $75,599
  award amount
M. Hong Thi Nguyen
Leads 1 award · $205,990
- 5R21AI176369-02Department: NIH department code
  Within-host diversity of Gram negative bacteria from bloodstream infections
  $205,990
  award amount
Jessica S Merlin
Leads 1 award · $192,671
- 5K24DA056837-03Department: NIH department code
  Mentoring the next generation of researchers at the intersection of opioid use disorder and chronic pain
  $192,671
  award amount
Also a principal investigator on 5RM1DA055311-04, led by Erin L Winstanley; 5R01NR020031-05, led by Gretchen White; 5T32DA057926-02, led by Erin L Winstanley.
Hua Zhang
Leads 1 award · $189,756
- 5K22CA276357-02Department: NIH department code
  Targeted degradation of KRAS oncoproteins triggers antitumor immunity and abolishes lung tumor
  $189,756
  award amount
Bryant Shuey
Leads 1 award · $189,500
- 1K23DA062822-01Department: NIH department code
  Lowering Cardiovascular Disease Among People with Opioid Use Disorder
  $189,500
  award amount
Raagini Jawa
Leads 1 award · $188,995
- 1K23DA063654-01Department: NIH department code
  Prescribe to Prevent HIV
  $188,995
  award amount
Alicia N Rizzo
Leads 1 award · $188,740
- 1K23HL173662-01A1Department: NIH department code
  The impact of glycocalyx degradation on ARDS pathogenesis and outcomes
  $188,740
  award amount
Karlyn Ann Edwards
Leads 1 award · $188,307
- 1K23DA063868-01Department: NIH department code
  Using Human Centered Design to Tailor a Web-based Behavioral Treatment for Chronic Pain and Opioid Use Disorder
  $188,307
  award amount
Kristina Elizabeth Rudd
Leads 1 award · $181,944
- 5K23GM141463-05Department: NIH department code
  The Syndemic of Sepsis, Multimorbidity, Aging, and Low Healthcare Access and Quality in the United States
  $181,944
  award amount
Ghady Haidar
Leads 1 award · $179,145
- 5K23AI154546-05Department: NIH department code
  The Gut Microbiome in Carbapenem-Resistant Enterobacteriaceae Colonization, Persistence, Infection, and Tolerance after Lung or Liver Transplantation
  $179,145
  award amount
Jason Colditz
Leads 1 award · $172,476
- 5K01AA030809-03Department: NIH department code
  Toward measures and behavioral trials for effective online AUD recovery support
  $172,476
  award amount
Madison Elaine Stellfox
Leads 1 award · $171,089
- 5K08AI185312-02Department: NIH department code
  Genetic and phenotypic adaptations of vancomycin-resistant Enterococcus faecium during recurrent bloodstream infection
  $171,089
  award amount
Patrizia Fuschiotti
Leads 1 award · $168,516
- 5R21CA280445-02Department: NIH department code
  Develop IL13Ra1 for diagnosis of early-stage mycosis fungoides
  Principal investigators: Patrizia Fuschiotti (contact PI), Larisa J Geskin
  $168,516
  award amount
Ioannis Konstantinidis
Leads 1 award · $163,188
- 5K08HL169023-03Department: NIH department code
  Risk factors for chronic obstructive pulmonary disease exacerbations, quality of care, and outcomes in people with HIV
  $163,188
  award amount
Marc Gauthier
Leads 1 award · $163,188
- 5K08HL164887-03Department: NIH department code
  An Alternative Pathobiology underlying Severe Asthma
  $163,188
  award amount
Nami Safai Haeri
Leads 1 award · $162,020
- 1K23AG088498-01A1Department: NIH department code
  Impact of Different Classes of Osteoporosis Medications on Muscle Health in Older Adults
  $162,020
  award amount
Anita Saraf
Leads 1 award · $161,136
- 5K08HL161440-04Department: NIH department code
  Molecular and Functional Evaluation of NOTCH1 Deficient iPSC Derived Cardiomyocytes in Hypoplastic Left Heart Syndrome
  $161,136
  award amount
Eleanor Valenzi
Leads 1 award · $161,136
- 5K08HL161258-04Department: NIH department code
  Uncovering the genomic regulatory network of myofibroblast differentiation in systemic sclerosis-associated interstitial lung disease
  $161,136
  award amount
Tomeka L Suber
Leads 1 award · $160,736
- 5K08HL163324-04Department: NIH department code
  Intrapulmonary itaconate as a host-protective metabolite during ER Stress and Klebsiella pneumoniae infection
  $160,736
  award amount
Martina Anto-Ocrah
Leads 1 award · $151,166
- 5K01NS121199-06Department: NIH department code
  K01 Menstrual Phase, Sexual Dysfunction, mTBI
  $151,166
  award amount
Katherine E Shipman
Leads 1 award · $151,069
- 1K01DK140628-01A1Department: NIH department code
  Impact of sex, flow, and glomerular permeability on endocytic uptake along the kidney proximal tubule
  $151,069
  award amount
Neil Jeremiah Kelly
Leads 1 award · $149,857
- 1K08ES037420-01Department: NIH department code
  Airborne particulates exacerbate vascular remodeling in pulmonary hypertension
  $149,857
  award amount
Andrew J Nickerson
Leads 1 award · $148,986
- 1K01DK140634-01A1Department: NIH department code
  Role of BK gamma subunits in renal K secretion
  $148,986
  award amount
Corry Dominic Bondi
Leads 1 award · $147,722
- 5K01DK124357-05Department: NIH department code
  The Role of MCP-1 in Tubular-to-Glomerular Crosstalk in Proteinuric Kidney Disease
  $147,722
  award amount
Cynthia Marie McMillen
Leads 1 award · $124,838
- 5K01AI165965-03Department: NIH department code
  Host and Viral Determinants of Orthobunyavirus Vertical Transmission: Novel Model Systems to Understand the Mechanisms of Congenital Disease in Humans and Ruminants
  $124,838
  award amount
Douglas B White
Leads 1 award · $124,381
- 5K24HL148314-07Department: NIH department code
  Mentored Patient Oriented Research in Improving Surrogate Decision Making for Patients with Advanced Respiratory Failure
  $124,381
  award amount
Charles Richard Jonassaint
Leads 1 award · $122,040
- 5R25HL130600-07Department: NIH department code
  Pittsburgh Undergraduate Research Diversity Program (PURDIP)
  $122,040
  award amount
Also a principal investigator on 5UH3HL165839-03, led by Bruce Lawrence Rollman; 1U48DP006942-01, led by Shari S Rogal; 3UH3HL165839-03S1, led by Bruce Lawrence Rollman.
Mengqi Huang
Leads 1 award · $113,090
- 1K01AR085206-01Department: NIH department code
  Deciphering the Regulation of TGF-b3 in Driving Myofibroblast Differentiation in Systemic Sclerosis
  $113,090
  award amount
Cary Ragan Boyd-Shiwarski
Leads 1 award · $104,936
- 5R03DK138215-02Department: NIH department code
  Establishing new model systems to study low potassium induced kidney injury
  $104,936
  award amount
Hiam Naiditch
Leads 1 award · $94,964
- 5F32MD019534-02Department: NIH department code
  Optimizing Generalizability in Predictive Modeling Among Survivors of Critical Illness
  $94,964
  award amount
Rachael Rush Watkins
Leads 1 award · $85,540
- 1F32AI191453-01Department: NIH department code
  Role of Myeloid Cell Lrp1 in Rift Valley Fever Virus Infection and Dissemination
  $85,540
  award amount
Anna Kirillova
Leads 1 award · $54,538
- 5F30HL170649-03Department: NIH department code
  ACTN4 Binding to Functional SNP rs9277336 Controls the Genome Architecture and Endothelial Pathophenotypes in Pulmonary Arterial
  $54,538
  award amount
Brandon Lehrich
Leads 1 award · $54,538
- 5F30CA284540-03Department: NIH department code
  Investigating Immunosuppression in Beta-catenin-mutated Hepatocellular Carcinoma for Improved Precision Medicine Therapeutics
  $54,538
  award amount
Grace Conway
Leads 1 award · $54,538
- 5F30AG077800-04Department: NIH department code
  Treatment of Alzheimer’s Disease using Ultrasound-Targeted Microbubble Cavitation-Mediated Blood Brain Barrier Opening to Facilitate Drug Delivery to the Brain
  $54,538
  award amount
Kenta Yamamoto
Leads 1 award · $54,538
- 1F30AI186235-01A1Department: NIH department code
  Post-transcriptional regulation in T cells
  $54,538
  award amount
Ankit Sharma
Leads 1 award · $51,884
- 5F30DK138641-02Department: NIH department code
  Defining the role of IGF2 in regulating adipocyte progenitor proliferation and adipogenesis
  $51,884
  award amount
Stacey J Rizzo
Leads 1 award · $49,394
- 5R13AG060708-07Department: NIH department code
  Improving Preclinical Translation in Alzheimer's Disease Research
  $49,394
  award amount
Also a principal investigator on 5U01AG079828-03, led by Beibei Chen.
Neil Carleton
Leads 1 award · $44,942
- 5F30CA264963-05Department: NIH department code
  Promotion of ER+ Breast Cancer Progression in the Elderly
  $44,942
  award amount
William Aaron Dion
Leads 1 award · $20,817
- 5F31AG080998-03Department: NIH department code
  Nuclear speckle liquid-liquid phase separation dynamics in senescence and aging
  $20,817
  award amount
Yael Schenker
Leads 1 award · $10,983
- 5K24AG070285-05Department: NIH department code
  Midcareer Investigator Award in Patient-Oriented Research: Yael Schenker, MD, MAS
  $10,983
  award amount

Co-investigators

Named as principal investigators on these awards, which someone else leads. They may belong to another department or institution: their own, below, comes from the awards they lead.

Shyam Visweswaran
Co-investigator on 5U24TR004111-04, led by Steven E Reis; 3OT2OD037639-01S2, led by Steven E Reis
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Jeremy James Martinson
Co-investigator on 5U01HL146208-07, led by Charles R Rinaldo
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
John W Mellors
Co-investigator on 5UM1AI069494-19, led by Sharon Riddler; 3UM1AI069494-19S2, led by Sharon Riddler; 3UM1AI069494-19S1, led by Sharon Riddler
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Susan L Koletar
Co-investigator on 5UM1AI069494-19, led by Sharon Riddler; 3UM1AI069494-19S2, led by Sharon Riddler; 3UM1AI069494-19S1, led by Sharon Riddler
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Megan Hamm
Co-investigator on 5RM1DA055311-04, led by Erin L Winstanley
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Heath Devin Skinner
Co-investigator on 1R01DE034974-01, led by Jing Hong Wang
From the FY2025 awards this person leads
- University of Pittsburgh · Radiology (NIH department code, 1 award)
- University of Pittsburgh (no department on record, 1 award)
Jianhua Xing
Co-investigator on 1R01DE034974-01, led by Jing Hong Wang
From the FY2025 awards this person leads
- University of Pittsburgh · Anatomy & Cell Biology (NIH department code, 1 award)
Alicia Colvin
Co-investigator on 5UH3HL165839-03, led by Bruce Lawrence Rollman; 3UH3HL165839-03S1, led by Bruce Lawrence Rollman
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Ana Radovic-Stakic
Co-investigator on 5UH3HL165839-03, led by Bruce Lawrence Rollman; 3UH3HL165839-03S1, led by Bruce Lawrence Rollman
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Russell S Schwartz
Co-investigator on 5T32GM144300-04, led by Richard A Steinman
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Arnie Paul Aldridge
Co-investigator on 5RM1DA059395-03, led by Renee M Cloutier
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Kelli Scott
Co-investigator on 5RM1DA059395-03, led by Renee M Cloutier
From the FY2025 awards this person leads
- Northwestern University · Public Health (NIH department code, 1 award)
Edwin Kerry Jackson
Co-investigator on 4R01DK135076-02, led by Lori A Birder
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Kristin N Ray
Co-investigator on 5KL2TR001856-10, led by Doris M Rubio
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Surinder K. Batra
Co-investigator on 5U01CA200466-08, led by Randall Brand
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Jennifer A. Ligibel
Co-investigator on 5U01CA271277-05, led by Kathryn H. Schmitz
From the FY2025 awards this person leads
- Dana-Farber Cancer Institute (no department on record, 1 award)
Alison Morris
Co-investigator on 5R01HL164177-04, led by Barbara Methe; 5R38HL150207-06, led by Charles S Dela Cruz; 1R13HL182216-01, led by Charles S Dela Cruz
From the FY2024 awards this person leads
- University of Pittsburgh · Internal Medicine (NIH department code, 2 awards)
Mack T. Ruffin
Co-investigator on 5R01CA268017-04, led by Kathryn H. Schmitz; 3R01CA268017-04S1, led by Kathryn H. Schmitz
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Frederico G. S. Toledo
Co-investigator on 2U01DK108306-11, led by Dhiraj Yadav; 2U01DK127377-06, led by Dhiraj Yadav
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Cristian Tomasetti
Co-investigator on 5U01CA271884-04, led by Robert E. Schoen
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Linda Faith Fried
Co-investigator on 5U01DK130010-05, led by Kaleab Z Abebe
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Paul M Palevsky
Co-investigator on 5U01DK130010-05, led by Kaleab Z Abebe
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Sandra L Kane-Gill
Co-investigator on 5U01DK130010-05, led by Kaleab Z Abebe
From the FY2025 awards this person leads
- University of Pittsburgh · Pharmacology (NIH department code, 1 award)
Howard B Degenholtz
Co-investigator on 5U18HS029924-03, led by Frank Sciurba
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
John Munn Kirkwood
Co-investigator on 3UG1CA233184-06S1, led by Adam M Brufsky
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Ronald Idoko
Co-investigator on 5R01GM155395-02, led by Doris M Rubio
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Craig A Hodges
Co-investigator on 1R01DK143623-01, led by Alison Bloom Kohan
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Marynia Kolak
Co-investigator on 5R37DA060183-02, led by Paul J Joudrey
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Simon M Barratt-Boyes
Co-investigator on 5R01AI172935-03, led by Yuan Liu
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Gayle M Gordillo
Co-investigator on 5U01DK119099-09, led by Chandan K Sen
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Salah S Al-Zaiti
Co-investigator on 5R01NR013912-11, led by Gilles Clermont
From the FY2025 awards this person leads
- University of Rochester (no department on record, 1 award)
John F Alcorn
Co-investigator on 1R01HL176849-01A1, led by Lianghui Zhang
From the FY2025 awards this person leads
- University of Pittsburgh · Pediatrics (NIH department code, 2 awards)
Annet Kirabo
Co-investigator on 2R01HL147818-25A1, led by Thomas R Kleyman
From the FY2025 awards this person leads
- Vanderbilt University Medical Center (no department on record, 2 awards)
Marta Bueno Fernandez
Co-investigator on 5R01HL172493-02, led by Oliver Eickelberg
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Qifa Zhou
Co-investigator on 1R01HL178101-01, led by Kang Kim
From the FY2025 awards this person leads
- University of Southern California · Ophthalmology (NIH department code, 1 award)
- University of Southern California (no department on record, 1 award)
Xiaoning Jiang
Co-investigator on 1R01HL178101-01, led by Kang Kim
From the FY2025 awards this person leads
- North Carolina State University Raleigh · Engineering (NIH department code, 2 awards)
Andres Duarte-Rojo
Co-investigator on 5R01DK130294-04, led by Gavin E Arteel
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Michael L Merchant
Co-investigator on 5R01DK130294-04, led by Gavin E Arteel
From the FY2024 awards this person leads
- University of Louisville (no department on record, 1 award)
Panagiotis V Benos
Co-investigator on 5R01DK130294-04, led by Gavin E Arteel
From the FY2025 awards this person leads
- University of Florida · Internal Medicine (NIH department code, 1 award)
Matthew F Muldoon
Co-investigator on 5R01HL160749-04, led by Jared W. Magnani
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Christine S Ritchie
Co-investigator on 5R01NR020031-05, led by Gretchen White
From the FY2025 awards this person leads
- Massachusetts General Hospital (no department on record, 4 awards)
Mark Lynn Unruh
Co-investigator on 5R01DK114085-07, led by Manisha Jhamb
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Marian Patricia Jarlenski
Co-investigator on 1R01HD118690-01, led by Mehret Birru Talabi
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Kari L White
Co-investigator on 5R01HD110557-03, led by Sonya B. Borrero
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Antonio Paul
Co-investigator on 5R01DK128972-05, led by Vijay K Yechoor
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Mariana Gross Figueiro
Co-investigator on 5R01DK128972-05, led by Vijay K Yechoor
From the FY2025 awards this person leads
- Icahn School of Medicine at Mount Sinai · Public Health (NIH department code, 1 award)
Michael G Risbano
Co-investigator on 1R01HL176493-01, led by Lianghui Zhang
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Aylin Rachel Rodan
Co-investigator on 5R01DK098145-08, led by Arohan R Subramanya
From the FY2025 awards this person leads
- University of Utah · Internal Medicine (NIH department code, 1 award)
Moses Turkle Bility
Co-investigator on 5R01AI152655-04, led by Robbie B Mailliard
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Anne Mobley Butler
Co-investigator on 4R01DE033322-02, led by Payel Jhoom Roy
From the FY2025 awards this person leads
- Washington University in St. Louis · Internal Medicine (NIH department code, 2 awards)
Bettina Mittendorfer
Co-investigator on 5R01HL159461-04, led by Babak Razani
From the FY2025 awards this person leads
- Washington University in St. Louis (no department on record, 1 award)
Anthony J Molina
Co-investigator on 5R01AG072734-04, led by Sruti Shiva
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Michael A Pulsipher
Co-investigator on 5R01HL171117-02, led by Galen E. Switzer
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Carolyn J. Anderson
Co-investigator on 5R01HL154629-04, led by Enrico M Novelli
From the FY2024 awards this person leads
- Gordon Research Conferences (no department on record, 1 award)
Carissa A Low
Co-investigator on 5R01DK136788-02, led by Ann-Marie Rosland; 3R01DK136788-02S1, led by Ann-Marie Rosland
From the FY2025 awards this person leads
- University of Pittsburgh · Radiology (NIH department code, 1 award)
Lisa M. Satlin
Co-investigator on 5R01DK129285-04, led by Thomas R Kleyman
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Toren Finkel
Co-investigator on 5R01AG065229-05, led by Gang Li
From the FY2025 awards this person leads
- University of Pittsburgh (no department on record, 2 awards)
Cristina Murray-Krezan
Co-investigator on 1R61DA063659-01, led by Paul J Joudrey
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Diwakar Davar
Co-investigator on 5R01CA257265-05, led by Hassane M Zarour
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Wei Chen
Co-investigator on 5R01DK138458-02, led by Richard H Duerr
From the FY2025 awards this person leads
- University of Pittsburgh (no department on record, 1 award)
Esa M Davis
Co-investigator on 5R25GM143262-05, led by Audrey Jeanette Murrell
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Farshid Dayyani
Co-investigator on 5UM1CA186690-09, led by Liza Cosca Villaruz
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
John C. Byrd
Co-investigator on 5UM1CA186690-09, led by Liza Cosca Villaruz
From the FY2025 awards this person leads
- University of Cincinnati · Internal Medicine (NIH department code, 2 awards)
- University of Pittsburgh (no department on record, 1 award)
Paul E Dougherty
Co-investigator on 5R01AT012534-03, led by Debra Kaye Weiner
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Tien Ung
Co-investigator on 1U01CE003759-01, led by Elizabeth Miller
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Christian A Merlo
Co-investigator on 5U01HL163294-04, led by John F McDyer
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
John Greenland
Co-investigator on 5U01HL163294-04, led by John F McDyer
From the FY2025 awards this person leads
- University of California, San Francisco · Internal Medicine (NIH department code, 4 awards)
Virginia A. Stallings
Co-investigator on 1R01DK140381-01A1, led by Anna Evans Phillips
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Maureen Y. Lichtveld
Co-investigator on 5R21ES036032-02, led by Juliane I Beier
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Larisa J Geskin
Co-investigator on 5R21CA280445-02, led by Patrizia Fuschiotti
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.
Urvi M. Parikh
Co-investigator on 3UM1AI069494-19S1, led by Sharon Riddler
Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.