Track Plasticity.
Quantify Change.
The first ML-assisted 4D analysis platform for dendritic spine dynamics.
Align, track, and classify spines across days or weeks — automatically.
Longitudinal Imaging is an Alignment Nightmare.
Three challenges that make manual spine tracking unsustainable at scale.
The Drift
Brains deform. Samples drift. Rigid alignment tools fail to capture non-linear tissue warping across weeks.
Classification Subjectivity
Is that a "Thin" or a "Mushroom"? Manual classification varies between raters and sessions.
The Manual Slog
Click, click, click. Hundreds of spines per segment per timepoint — manually — is unsustainable.
Rigorous 4D Spine Analysis
Three pillars of automated plasticity quantification — registration, tracking, and classification.
Elastic 4D Registration
Non-rigid alignment corrects tissue drift at sub-micron precision across unlimited timepoints.
Longitudinal Event Tracking
Automatically detect new, stable, and lost spines across imaging sessions.
Morphology & Survival
ML classifies spine types. Survival curves quantify plasticity across conditions.
Plasticity Quantification, Automated
From raw time-lapse stacks to publication-ready plasticity statistics.
Drift? What Drift?
Elastic 4D registration aligns dendrites across timepoints — even through tissue warping and sample drift.
Birth, Death, and Stability
Track the full life cycle of every synapse. Generate survival curves and turnover metrics instantly.
Beyond "Point and Click"
ML classifies spines into Filopodia, Thin, Stubby, and Mushroom based on volumetric geometry — not subjective labeling.
The ConductScience Pipeline
ConductSpine sits downstream of ConductTrace, using reconstructed dendrites for automated spine analysis.
Built for 4D Data.
Input
- 2-Photon / Confocal Time-Lapse
- OME-TIFF, CZI, IMS, LIF
- 3D + Time datasets
- Compatible with any fluorescence microscope
Capabilities
- Elastic Alignment
- Spine Density & Turnover Rate
- Survival Fraction
- Head Volume & Neck Length
- Export: CSV, SWC, JSON
Quantify Your Plasticity.
Ideal for LTP/LTD research, Alzheimer’s models, and drug discovery studies.
