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3,583 results for “elevations”
Expression of miR-381-3p is elevated in the retina of OIR mice, but the role in the retinal neovascularization is elusive，and its mechanism of action was investigated by vitreous injection of miR-381-
GEO Series GSE231376. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Decades-long elevation of interferon-alpha can initiate and drive Sjogren syndrome II
GEO Series GSE273098. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Renal Expression of Dahl SS/Jr (S) and Congenic Rats after 28 days of dietary salt elevation
GEO Series GSE12423. Rattus norvegicus. 24 samples. Type: Expression profiling by array.
Elevated C-reactive protein levels across diagnoses: The first comparison among inpatients with major depressive disorder, bipolar disorder, or obsessive–compulsive disorder
<p>Elevated C-reactive protein levels across diagnoses: The first comparison among inpatients with major depressive disorder, bipolar disorder, or obsessive–compulsive disorder</p> <p>Objective: We addressed elevated C-reactive protein level (eCRP) specificity comparing, for the first time, eCRP (i.e., serum CRP > 3 and ≤10 mg/L) in patients with major depressive disorder (MDD), bipolar disorder (BD), or obsessive–compulsive disorder (OCD). We also assessed to what extent multiple variables that can potentially increase inflammation may have influenced eCRP in our sample.<br> Methods: We performed a retrospective, observational, cross-sectional study using information documented in the electronic medical records (EMRs) of patients hospitalized for a 4-week psychiatric rehabilitation program. We collected all information according to the standardized procedures of the hospital’s clinical practice and applied a logistic regression model (α = 0.05).<br> Results: We included 388 inpatients, that is, 156 (40.2%) with MDD, 135 (34.8%) with BD, and 97 (25.0%) with OCD, and found considerable eCRP rates among them (36.5%, 47.4%, and 29.9% in MDD, BD, and OCD, respectively) but without significant differences across groups. In the whole sample, eCRP variations were only partially attributable (approximately for one-third) to potential confounders. All groups presented considerable rates of cardiovascular risk factors, and we classified most patients as having medium or high CRP-based cardiovascular risk.<br> Conclusion: This first study comparing eCRP in MDD, BD, and OCD suggests that eCRP may be a transdiagnostic feature of different psychiatric disorders, and other mechanisms beyond the effects of multiple confounders may explain the presence of eCRP in a substantial portion of psychiatric patients. Therefore, we encourage the routine measurement of CRP in psychiatric clinical practice.</p> <p> </p>
Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder [bulkSeq]
GEO Series GSE272097. Mus musculus. 181 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide microRNAs analysis of peripheral blood mononuclear cells reveals elevated miR-142-3p expression as a potential biomarker for secondary syphilis
GEO Series GSE156421. synthetic construct; Homo sapiens. 12 samples. Type: Non-coding RNA profiling by array.
Root and shoot performance of Arabidopsis thaliana exposed to elevated CO2: a physiologic, metabolic and transcriptomic response
GEO Series GSE70560. Arabidopsis thaliana. 24 samples. Type: Expression profiling by array.
SMARCA4-loss increases RNA Polymerase II pausing and elevates R-loops to inhibit BRCA1-mediated repair in ovarian cancer
GEO Series GSE275845. Homo sapiens. 7 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Brown adipocyte-derived exosomes in type 2 diabetes mellitus impair endothelial function via elevated intracellular calcium load
GEO Series GSE287534. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Decades-long elevation of interferon-alpha can initiate and drive Sjogren syndrome I
GEO Series GSE273095. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Circular RNA TMEM87A promotes cell proliferation and metastasis of gastric cancer by elevating ULK1 via sponging miR-142-5p (miRNA)
GEO Series GSE157015. Homo sapiens. 6 samples. Type: Non-coding RNA profiling by high throughput sequencing.
DS1 DIGITAL ELEVATION MAPS OF COMET 19P/BORRELLY V1.0
This data set contains both the USGS and DLR versions of the digital elevation model of the surface areas of comet 19P/Borrelly 1 (1904 Y2) that were visible and illuminated during the Deep Space 1 encounter. The model was computed using the parallax, caused by the spacecraft's motion, between the highest resolution images. The USGS data set also includes the surface normal directions at each location.
Dataset related to article: "THE NEVERENDING DEBATE ON PROGESTERONE ELEVATION: POSSIBLE SOLUTIONS."
<p><strong>Background.</strong> The association between serum progesterone (P) levels, measured on the day of ovulation trigger, and the outcome of in vitro fertilization cycles, has been one of the major controversies in the field of ovarian stimulation endocrinology.</p> <p><strong>Objective.</strong> The aim is to review the dataset of a single tertiary care academic center in order to evaluate the impact of premature high serum P levels on the outcome of embryo transfer (ET) cycles in terms of Clinical Pregnancy Rates (CPR) and Live Birth Rates (LBR). Furthermore, the present study retrospectively investigates whether the transfer on day 5 post-fertilization may improve the CPR and the LBR in patients with P rise</p> <p><strong>Methods.</strong> This is a single-center retrospective cohort study. All fresh ET both at cleavage stage and blastocyst stage, performed from January 2012 to December 2016, were included. Main clinical features were analyzed and the impact of P level on CPR and LBR was explored using a multivariable logistic regression.</p> <p><strong>Results.</strong> During the study period 8,034 ET were performed: 7,597 cleavage-stage transfers and 437 blastocyst transfers. Serum P levels demonstrated to be inversely related to CPR (OR 0.72, p<0.001) and LBR (OR 0.73, p<0.001). The decrease already started when P levels were ³1 ng/mL, and a further decrease was observed with P levels ³1.75 ng/mL. Analyzing the day of embryo transfer: in the day 3 group, a P level ≥1ng/mL significantly reduced CPR and LBR. With a P level ≥1.75 ng/mL CPR and LBR decreased even more. The relationship between serum P level and CPR and LBR in the day 5 group instead is not particularly evident when the values are <1.75 ng/mL; on the other hand, CPR and LBR are half their value when P level is ≥1.75 ng/mL. To evaluate eventual differences in CPR depending on different P thresholds, the analysis was subsequently performed separately in different subgroups. In the cleavage ET subgroup patients with good prognosis, the effect of P increase was found to be significant for P values >1 ng/mL, while in patients with worse prognosis it appeared to be significant only for P values ≥1.75 ng/mL. In the blastocyst ET subgroup, the negative effect of P elevation on LBR and CPR was reported only if P was >1.75 ng/mL. CPR and LBR in thawed cycles resulted statistically significantly higher than in fresh cycles. Considering the cleavage subgroup, the thawed cycles group resulted in better CPR and LBR, even compared with patients with P level <1 ng/mL. In the blastocyst group, no significant difference resulted between thawed and fresh cycles, independently of P levels.</p> <p><strong>Conclusion.</strong> High P levels decrease CPR as well as LBR in both cleavage and blastocyst ET. Interestingly, a different impact of P levels elevation was observed in different patient categories. In the cleavage group, for P levels below 1.75 ng/mL, it could be recommended to wait until day 5 for ET, and if P level is ≥1.75 ng/mL it should be considered to freeze all embryos and postpone the ET until P levels normalize.</p>
Dataset related to the article "Reduced Cardiorenal Function Accounts for Most of the In-Hospital Morbidity and Mortality Risk Among Patients With Type 2 Diabetes Undergoing Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction"
<p>This record contains raw data related to the article "Reduced Cardiorenal Function Accounts for Most of the In-Hospital Morbidity and Mortality Risk Among Patients With Type 2 Diabetes Undergoing Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction"</p> <p><strong>ABSTRACT</strong> ST-segment elevation myocardial infarction (STEMI) patients with diabetes mellitus<br> (DM) have higher in-hospital mortality than those without. Since cardiac and renal<br> functions are the main variables associated with outcome in STEMI, we hypothesized<br> that this prognostic disparity may depend on a higher rate of cardiac and<br> renal dysfunction in DM patients.<br> RESEARCH DESIGN AND METHODS<br> We retrospectively analyzed 5,152 STEMI patients treated with primary angioplasty.<br> Left ventricular ejection fraction (LVEF) and estimated glomerular filtration rate<br> (eGFR) were evaluated at hospital admission. The primary end point was in-hospital<br> mortality. A composite of in-hospital mortality, cardiogenic shock, and acute kidney<br> injury was the secondary end point.<br> RESULTS<br> There were 879 patients (17%) with DM. The incidence of LVEF £40% (30% vs. 22%),<br> eGFR £60 mL/min/1.73m2 (27% vs. 18%), or both (12% vs. 6%) was higher (P < 0.001<br> for all comparisons) inDMpatients. In-hospital mortality was higher inDMpatients<br> than in non-DM patients (6.1% vs. 3.5%; P = 0.002), with an unadjusted odds ratio<br> (OR) of 1.81 (95% CI 1.31–2.49; P < 0.001). However, DM was no longer associated<br> with an increased mortality risk after adjustment for cardiac and renal function (OR<br> 1.03, 95% CI 0.68–1.56; P = 0.89). A similar behavior was observed for the secondary<br> end point, with an unadjusted OR for DM of 1.52 (95% CI 1.25–1.85; P < 0.001) and<br> an OR after adjustment for cardiac and renal function of 1.07 (95% CI 0.85–1.36;<br> P = 0.53).<br> CONCLUSIONS<br> The study indicates that the increased in-hospital mortality and morbidity of DM<br> patients with STEMI is mainly driven by their underlying cardiorenal dysfunction.</p>
Dataset related to the article "Iron deficiency in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention"
<p>This record contains raw data related to the article "Iron deficiency in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention"</p> <p><strong>ABSTRACT</strong> Background: Iron deficiency (ID) is a known co-morbidity and a potential therapeutic target in heart failure.<br> Whether ID is frequent also in ST-segment elevation acute myocardial infarction (STEMI) patients and is associated<br> with worse in-hospital outcomes has never been evaluated.<br> Methods: We defined ID as a serum ferritin b 100 μg/L or transferrin saturation b 20% at hospital admission.We<br> assessed the association between ID and the primary endpoint (a composite of in-hospital mortality and Killip<br> class ≥ 3). We explored the potential association between ID, circulating cell-free mitochondrial DNA<br> (mtDNA), and cardiac magnetic resonance (CMR) parameters.<br> Results: Four-hundred-twenty STEMI patients undergoing primary percutaneous coronary intervention (pPCI)<br> were included. Of them, 237 (56%) had ID. They had significantly higher admission high-sensitivity troponin<br> and mtDNA levels as compared to non-ID patients (145 ± 35 vs. 231 ± 66 ng/L, P b 0.001; 917 [404–1748] vs.<br> 1368 [908–4260] copies/μL; P b 0.003, respectively). A lower incidence of the primary endpoint (10% vs. 18%, P<br> =0.01) was observed in ID patients (adjusted OR 0.50 [95% CI 0.27–0.93]; P=0.02). At CMR (n=192), ID patients<br> had a similar infarct size (21±18 vs. 21±19 g; P=0.95), but a higher myocardial salvage index (0.56±<br> 0.30 vs. 0.43 ± 0.27; P = 0.002), and a smaller microvascular obstruction extent (3.6 ± 2.2 vs. 6.9 ± 3.9 g; P b<br> 0.001).<br> Conclusions: Iron deficiency is frequent in STEMI patients, it is coupled with mitochondrial injury, and, paradoxically,<br> with a better in-hospital outcome. This unexpected clinical result seems to be associated with a smaller<br> myocardial reperfusion injury. The mechanisms underlying our findings and their potential clinical implications<br> warrant further investigation.</p>
Wind-generated Gravity Waves Retrieval from Sea Surface Elevation by Airborne Ka-band Interferometric Altimeter
<p>This dataset contains WSSE simulation data , AirKaIA data and sea state data used in the paper "Wind-generated Gravity Waves Retrieval from Sea Surface Elevation by Airborne Ka-band Interferometric Altimeter".</p>
Wind-generated Gravity Waves Retrieval from Sea Surface Elevation by Airborne Ka-band Interferometric Altimeter
<p>This dataset contains WSSE simulation data , AirKaIA data and sea state data used in the paper "Wind-generated Gravity Waves Retrieval from Sea Surface Elevation by Airborne Ka-band Interferometric Altimeter".</p>
Measurement of the Bossons lac elevation since 31 May 2022
<p>This new version update the previous dataset with the 2023 data. </p><p>piezoBOSSONS_LAC.csv: elevation (in m NGF IGN69) of the lac surface as a function of time (UTC) since the 31 May 2022 until 31 July 2023 (start of the lake drainage) </p><p>GPSLacLevel.csv: ponctual measurements of the lac level (in m NGF IGN69) for different dates (UTC)</p><p>Note that the piezometer has certainly move by -0.248m during winter 2022/2023 but it not possible to see exactly when or if it is a continuous process. </p><p> </p>
Daily SPEI-90 Days Values – Elevation Below 1500 m a.s.l., 1950–2023
<table> <tbody> <tr> <td> <p><strong>Science Case Name</strong> </p> </td> <td> <p>Multi-Hazards in the Downstream Area of the Adige River Basin. </p> </td> </tr> <tr> <td> <p><strong>Dataset Name/Title</strong> </p> </td> <td> <p>Daily SPEI-90 Days Values – Elevation Below 1500 m a.s.l., 1950–2023</p> </td> </tr> <tr> <td> <p><strong>Dataset Description</strong> </p> </td> <td> <p>SPEI (Standardized Precipitation Evapotranspiration Index) data calculated using the E-OBS daily gridded data with a spatial resolution of 0.1° for the period from 1950 to 2023. The dataset describes the anomalies of the balance between precipitation and potential evapotranspiration with respect to the average conditions (Vicente-Serrano et al., 2010), considering both temperature and precipitation as inputs. </p> </td> </tr> <tr> <td> <p><strong>Key Methodologies</strong> </p> </td> <td> <p>Daily SPEI is here calculated at a time scale of 90 days (3 months). The SPEI calculation is based on the ‘SPEI’ R package by Beguería and Vicente-Serrano (2023) (https://github.com/sbegueria/SPEI) with the potential evapotranspiration derived from Hargreaves-Samani formulation. Based on E-OBS orography, SPEI values for altitudes above 1500 m a.s.l. are excluded from the current analysis to focus on low and mid-elevation areas only.</p> </td> </tr> <tr> <td> <p><strong>Temporal Domain</strong> </p> </td> <td> <p>1950–2023</p> </td> </tr> <tr> <td> <p><strong>Spatial Domain</strong> </p> </td> <td> <p>The dataset is provided over the [7.10, 44.10, 15.30, 49.10] spatial domain (min longitude, min latitude, max longitude, max latitude in WGS84, EPSG:4326).</p> </td> </tr> <tr> <td> <p><strong>Key Variables/Indicators</strong> </p> </td> <td> <p>Standardized Precipitation Evapotranspiration Index 90-days (SPEI-90 days)</p> </td> </tr> <tr> <td> <p><strong>Data Format</strong> </p> </td> <td> <p>netCDF </p> </td> </tr> <tr> <td> <p><strong>Source Data</strong> </p> </td> <td> <p>E-OBS dataset (v29.0e)</p> </td> </tr> <tr> <td> <p><strong>Accessibility</strong> </p> </td> <td> <p>https://doi.org/10.5281/zenodo.13778103</p> </td> </tr> <tr> <td> <p><strong>Stakeholder Relevance</strong> </p> </td> <td> <p>SPEI represents a valuable insight for researchers working on drought related issues, technical experts from public agencies and practitioners, as it is a comprehensive index able to identify drought hazard (dry event), while also considering temperature in the computation. Moreover, it can foster the use of Earth Observation when coupled with event identification methods by providing a robust meteorological-based event identification. This can be then further refined by the use of higher spatial resolution EO data capable of capturing subtle spatial patterns (e.g., soil moisture as influenced by droughts).</p> </td> </tr> <tr> <td> <p><strong>Limitations/Assumptions</strong> </p> </td> <td> <p>Excludes areas above 1500 m a.s.l. </p> </td> </tr> <tr> <td> <p><strong>Additional Outputs/Information</strong> </p> </td> <td> <p>DBSCAN 3D Clusters of SPEI-90 Days Values – Italian NUTS3 (ITH31, 32, 34, 35, 36, 37), 1950–2023 (https://zenodo.org/records/13785996) </p> <p>The dataset access is currently restricted due to pending related publication.</p> </td> </tr> <tr> <td> <p><strong>Contact Information</strong></p> </td> <td> <p>Crespi, Alice (Center for Climate Change and Transformation, Eurac Research, Bolzano, Italy) - Data manager<br>Lemus i Cánovas, Marc (Center for Climate Change and Transformation, Eurac Research, Bolzano, Italy, CRETUS, Non-linear Physics Group, Universidade de Santiago de Compostela, Galicia, Spain)- Data curator<br>Maines, Elena (Center for Climate Change and Transformation, Eurac Research, Bolzano, Italy) - Data curator<br>Masina, Marinella (CMCC Foundation - Euro-Mediterranean Center on Climate Change)- Data curator<br>Maraschini, Margherita (CMCC Foundation - Euro-Mediterranean Center on Climate Change) - Data curator<br>Ferrario, Davide Mauro (CMCC Foundation - Euro-Mediterranean Center on Climate Change) - Data curator<br>Furlanetto, Jacopo (CMCC Foundation - Euro-Mediterranean Center on Climate Change, National Biodiversity Future Center) - Data manager<br>Pittore, Massimiliano (Center for Climate Change and Transformation, Eurac Research, Bolzano, Italy) - Data manager<br>Terzi, Stefano (Center for Climate Change and Transformation, Eurac Research, Bolzano, Italy) - Data manager<br>Torresan, Silvia (CMCC Foundation - Euro-Mediterranean Center on Climate Change, National Biodiversity Future Center) - Data manager</p> </td> </tr> </tbody> </table>
Seasonal variation in dorsal skin reflectance and thermic rates along an elevation gradient in a high-altitude montane lizard
<p>Data generated for the article: "Seasonal variation in dorsal skin reflectance and thermic rates along an elevation gradient in a high-altitude montane lizard".</p> <p>The file contains the following variables by altitude and season in the lizard Sceloporus grammicus:</p> <p>--Body mass<br> --SVL<br> --Back reflectance<br> --Heating rate<br> --Cooling rate<br> --Thermal lapse</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.