Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
29,897
datasets available to search
ShareScore release 0.9.0
Dataset results
29,897 results for “activism”
Fig. 2 in Funiculosone, a substituted dihydroxanthene-1,9-dione with two of its analogues produced by an endolichenic fungus Talaromyces funiculosus and their antimicrobial activity
Fig. 2. ORTEP view of funiculosone (1) showing atomic labeling. Displacement ellipsoids are drawn at the 30% probability level.
Fig. 5. C2C12 in Insulin-mimetic activity of 23-glycosyl oleanane triterpenoids isolated from Gymnema latifolium
Fig. 5. C2C12 myotube cells were exposed to compounds 2 and 4 (5 μM and 20 μM, respectively) and incubated for 1 h. The phosphorylation of the protein AMPK in the cells was assessed by Western blot analysis. Fold expression was calculated as p-AMPK/AMPK and normalized to the protein level of β-actin. Values are expressed as the mean ± SD (n = 3).
Fig. 2. Key 1H–1H in Insulin-mimetic activity of 23-glycosyl oleanane triterpenoids isolated from Gymnema latifolium
Fig. 2. Key 1H–1H COSY (bold) and HMBC (1H → 13C, green arrows) correlations for compounds 1, 2, 5, and 7. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Fig. 4 in Insulin-mimetic activity of 23-glycosyl oleanane triterpenoids isolated from Gymnema latifolium
Fig. 4. Stimulatory effects of compounds 1⎯9 on glucose uptake in 3T3-L1 adipocytes using the fluorescent glucose derivative 2-NBDG. (A) Differentiated adipocytes were treated with isolated compounds (1–9) at a concentration of 20 μM and insulin (100 nM) as a positive control. After 1 h of incubation with or without 2-NBDG, images were captured by fluorescence microscopy. (B) The fluorescence signal in the adipocytes was measured and analyzed. After the cells were incubated for 1 h with or without 2-NBDG, the fluorescence signals were measured at Ex/Em = 450/535 nm. The results are presented as the mean ± SD (n = 3) of experiments performed in triplicate; *p <0.05, **p <0.01, and ***p <0.001, compared to the vehicle group. (C) Differentiated 3T3-L1 adipocytes were treated with compounds 2 and 4 at concentrations of 1, 5, and 20 μM or insulin at 100 nM. After 1 h of incubation, the fluorescence intensities were measured using a fluorescence microscope. (D) The concentration–response effects on glucose uptake in 3T3-L1 adipocytes. Cells were exposed to compounds at various concentrations (5, 10, and 20 μM) and incubated for 1 h. The cells were lysed, and the fluorescence signals were measured at Ex/Em =450/535 nm. Data are expressed as the mean ±SD (n =3) of experiments performed in triplicate; *p <0.05, **p <0.01, and ***p <0.001, compared to the negative control.
Fig. 4 in Increase in isoflavonoid content in Glycine max cells transformed by the constitutively active Ca independent form of the AtCPK1 gene
Fig. 4. Expression of the G. max genes (a) - of the upstream enzymes - 4- coumarate:CoA ligase (4CL), (b) – of the downstream enzymes - isoflavones synthase (IFS) and the final step of daidzein and genistein biosynthesis - 2- hydroxyisoflavanone dehydratase (HID) and (c) - enzymes involve in prenilation of daidzein and coumestrol - isoflavone dimethylallyltransferase (IDT1) and coumestrol 4-dimethylallyltransferase (C4DT) in the control callus culture (Gm) and callus line transformed with the constitutively active AtCPK1 (GmCa1 and GmCa2). Data (mean ± standard error) represent measurements of three independent replicates from two different RNA isolations and are presented as relative expression levels normalized to the expression of the G. max housekeeping genes. Different letters above the bars indicate statistically significant differences of means (P <0.05), Fisher's LSD.
Fig. 2. A in Increase in isoflavonoid content in Glycine max cells transformed by the constitutively active Ca independent form of the AtCPK1 gene
Fig. 2. A representative HPLC-UV profile of the AtCPK1-transformed callus culture of G. max – GmCa2 (A) and the control callus culture Gm (B). The callus tissue extracts recorded at 254 nm. Peak numbers correspond to each of the identified components and are listed in Table 3.
Fig. 3 in Increase in isoflavonoid content in Glycine max cells transformed by the constitutively active Ca independent form of the AtCPK1 gene
Fig. 3. Content (mg/g DW) of isoflavones-aglycones (a) and their glucosides and malonyl-glucosides derivatives (b–d) and prenylated isoflavones (e) in the control calli (Gm) and the AtCPK-transformed callus cultures - GmCa1 and GmCa2. Data are presented as the mean ± SE from four subcultures (biological replicates) with two technical replicates for each experiment. Different letters above the bars indicate statistically significant differences of means (P <0.05), Fisher's LSD.
Fig. 1 in Increase in isoflavonoid content in Glycine max cells transformed by the constitutively active Ca independent form of the AtCPK1 gene
Fig. 1. The branch of phenylpropanoid pathway leading to flavonoids. PAL, phenylalanine ammonia-lyase; C4H, cinnamate 4-hydroxylase; CHS, chalkone synthase; CHR, chalkone reductase; CHI, chalkone isomerase; FN3H, flavanone 3-hydroxylase; IFS, isoflavone synthase; HID, 2-hydroxyisoflavanone dehydratase, IDT1, isoflavone dimethylallyltransferase 1; IDT2, isoflavone dimethylallyltransferase 2; C4DT, coumestrol 4-dimethylallyltransferase.
Future changes in Tropical Cyclone activity due GhGs and the atmospheric effect of future aerosols
<p>This dataset compiles the output of selected fields of high resolutions E3SM experiments performed to decouple the effects of changes in GhGs and the atmospheric effect of future aerosols on the projected changes in tropical cyclone activity.</p> <p>The study describing these experiemnts was submitted to publication with the title "The Atmospheric Effect of Aerosols on Future Tropical Cyclone Frequency and Precipitation in the Energy Exascale Earth System Model"</p> <p>The full dataset is available at NERSC's HPSS. Please contact the Dr. Sena at anasena@iastate.edu for more information on how to obtain them.</p>
Functional and structural insights into activation of TRPV2 by weak acids
Open the record for dataset details and reuse information.
Arctic Sea Ice Type Products Based on Active and Passive Microwave Remote Sensing (2002-2021)
<p>Based on FY-3 MWRI and other microwave radiometer and scatterometer data, this dataset explores the distribution of Arctic sea ice types from 2002 to 2021 using the K-means clustering method. Spatial and temporal resolutions are 12.5 km and 1 day, respectively. The dataset is of integer type, where 0 represents open water, 1 represents first-year ice, 2 represents multi-year ice, 3 represents land, and 4 represents data gaps. The data is stored in .tiff format.</p>
Molecular docking and quantum-chemical characterization of inhibitory activity of procyanidins and flavonol glucosides from Graptopetalum paraguayense E. Walther against nonstructural proteins of SARS-Cov-2
<p>The dataset includes:</p> <ol> <li><span>Optimized geometries of all ligands, NSPs and their complexes in gas phase</span></li> <li><span>Total energies (a.u.) and interaction energies (a.u. and kcal mol-1) of the complexes, ligands and NSPs in gas phase and in argon</span></li> <li><span>Mass spectra (full ms) and product ion spectra (ms2) of standards and identified components from GP. </span></li> <li><span>Output files from quantum-chemical calculations.</span></li> <li><span>pdb files of NSPs</span></li> <li><span>mol files of all complexes</span></li> </ol>
Active establishments in the neighbourhoods of Nicosia Municipality, 2008-2020
<p>Active establishments in the neighbourhoods of Nicosia Municipality, 2008-2020</p> <div> <p><em>This project has received funding from the Research and Promotion Foundation's, RESTART <<Excellence Hubs (Bridge Programmes)>> and Pillar IV-Bridge Programmes, RIF Proposal No: EXCELLENCE/0421/0566.</em></p> </div> <h2></h2>
Raw data for: Active feedback stabilization of super-efficient microcombs in photonic molecules
<p>This dataset includes the raw data and Python scripts to plot the figures included in the paper "<span>Active feedback stabilization of super-efficient </span><span>microcombs in photonic molecules</span>".</p>
Dataset for "Activation of the mPFC-NAc pathway reduces motor impulsivity but does not affect risk-related decision-making in innately high-impulsive male rats"
<p><span>Attention-deficit/hyperactivity disorder (ADHD) and substance use disorders</span><span> (SUD) are characterized by exacerbated motor and risk-related impulsivities, which are associated with decreased cortical activity. In rodents, the medial prefrontal cortex (mPFC) and nucleus accumbens (NAc) have been separately implicated in impulsive behaviors, but studies on the specific role of the mPFC-NAc pathway in these behaviors are limited. Here, we investigated whether heightened impulsive behaviors are associated with reduced mPFC activity in rodents, and determined the involvement of the mPFC-NAc pathway in motor and risk-related impulsivities. We used the Roman High- (RHA) and Low-Avoidance (RLA) rat lines, which display divergent phenotypes in impulsivity. To investigate alterations in cortical activity in relation to impulsivity, regional brain glucose metabolism was measured using positron emission tomography and [<sup>18</sup>F]-fluorodeoxyglucose ([<sup>18</sup>F]FDG). Using chemogenetics, the activity of the mPFC-NAc pathway was either selectively activated in high-impulsive RHA rats or inhibited in low-impulsive RLA rats, and the effects of these manipulations on motor and risk-related impulsivity were concurrently assessed using the rat gambling task. We showed that basal [<sup>18</sup>F]FDG uptake was lower in the mPFC and NAc of RHA compared to RLA rats. Activation of the mPFC-NAc pathway in RHA rats reduced motor impulsivity, without affecting risk-related decision-making. Conversely, inhibition of the mPFC-NAc pathway had no effect in RLA rats. Our results suggest that the mPFC-NAc pathway controls motor impulsivity, but has limited involvement in risk-related decision-making. Our findings suggest that reducing fronto-striatal activity may help attenuate motor impulsivity in patients with impulse control dysregulation like ADHD or SUD.</span></p>
Fig. (4). Respondents' answers regarding physical activity.
Open the record for dataset details and reuse information.
Source Data for Infralimbic activity during REM sleep facilitates fear extinction memory
<p>Source data for the manuscript Infralimbic activity during REM sleep facilitates fear extinction memory</p>
Spatial patterns and effects of invasive plants on soil microbial activity and diversity along river corridors - dataset
<p>environmental data, plant community data, CLPP profiles, microbial activity data</p>
Code and exemplificative data for publication titled: Synaptic inputs to motor neurons underlying muscle co-activation for functionally different tasks have different spectral characteristics.
<p>Code implemented in the publication</p> <p>Titled: Synaptic inputs to motor neurons underlying muscle co-activation for functionally different tasks have different spectral characteristics</p> <p>Authors: Borzelli,D; Vieira,TMM; Botter,A; Gazzoni,M; Lacquaniti,F; d’Avella,A</p> <p>Published in: Journal of Neurophysiology</p> <p>Year: 2024</p> <p>When running the function 'coherenceAnalysis_Borzelli_et_al_JNeurophysiol_2024.m', the code load the firings of the motor units identified during two exemplificative trials performed by a participant, saved in 'data_Borzelli_et_al_JNeurophysiol_2024'. One trial was directed toward an horizontal target of the perturbed block and the other was directed toward a supination target of the baseline block.</p> <p>Then the code calculates the coherence between the MUs identified on the BB and on the TB (cross-muscle coherence) and the cross-muscle coherence after excluding the components synchronized with the norm of the endpoint force.</p> <p>Finally, the code plots the results.</p> <p>This code could easily be modified to compute all the relevant analyses presented in the paper, such as the total within muscle coherence and the within muscle coherences after excluding the components synchronized with the norm of the force or the sum of the firings of the antagonist muscle.</p>
Data for: Identification of activating mutations in the transmembrane and extracellular domains of EGFR
<p>The epidermal growth factor receptor (EGFR) is frequently mutated in human cancer, most notably non-small-cell lung cancer and glioblastoma. While many frequently occurring EGFR mutations are known to confer constitutive EGFR activation, the situation is less clear for rarely detected variants. In fact, more than 1000 distinct EGFR mutations are listed in the Catalogue of Somatic Mutations in Cancer (COSMIC), but for most of them, the functional consequence is unknown. To identify additional, previously unknown activating mutations in EGFR, we screened a randomly mutated EGFR library for constitutive EGFR phosphorylation using a recently developed high-throughput approach termed PhosphoFlowSeq. Enrichment of the well-known activating mutations S768I, T790M, and L858R validated the experimental approach. Importantly, we also identified the activating mutations S442I and L658Q located in the extracellular and transmembrane domains of EGFR, respectively. To the best of our knowledge, neither S442I nor L658Q has been associated with an activating phenotype before. However, both have been detected in cancer samples. Interestingly, molecular dynamics (MD) simulations suggest that the L658Q mutation located in the hydrophobic transmembrane region forms intermolecular hydrogen bonds, thereby promoting EGFR dimerization and activation. Based on these findings, we screened the COSMIC database for additional hydrophilic mutations in the EGFR transmembrane region and indeed detected moderate constitutive activation of EGFR-G652R. Together, this study demonstrates that unbiased screening for activating mutations in EGFR not only yields well-established substitutions located in the kinase domain but also activating mutations in other regions of EGFR, including the extracellular and transmembrane domains.</p> <p> </p> <p>A. Wagner, E. Galicia-Andrés, M. Teufl, L. Gold, C. Obinger, P. Sykacek, C. Oostenbrink and M.W. Traxlmayr<br>Identification of activating mutations in the transmembrane and extracellular domains of EGFR<br>Biochemistry <strong>61</strong> (2022) 2049 – 2062<br>doi: <a href="https://doi.org/10.1021/acs.biochem.2c00384" target="_blank" rel="noopener">10.1021/acs.biochem.2c00384</a></p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.