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65 results for “Design methods”
Factorial design assisted RP-HPLC method for simultaneous determination of fluconazole, itraconazole, and terbinafine
<p>A 2<sup>3</sup> full factorial design model was utilized for development of a new HPLC method with UV detection to estimate three antifungal drugs simultaneously. Fluconazole (FLU), itraconazole (ITR) and terbinafine (TRH), which are co-administered for severe fungal infections have been determined using MOS-1 Hypersil C18 column and an isocratic eluent; methanol 95% and phosphate buffer 5% with 0.001% triethylamine. The pH adjusted 7, and flow rate of 0.7 mL/min. The three drugs were separated within less than 7 minutes at 210 nm. The developed method gave linear response over 5-80, 5-50 and 1-50 μg/mL for FLU, ITR and TRH, respectively. It showed detection limits of 0.8761, 0.293 and 0.1965 μg/mL and quantification limits of 2.655, 0.8788 and 0.5956 μg/mL for the three drugs, respectively. The design of experiment facilitated the optimization of different variables affecting the separation of the three drugs. The designed method sensitivity permitted the simultaneous estimation of ITR and TRH in spiked human plasma successfully.</p>
Dataset for publication 'Reconnecting Stochastic Methods with Hydrogeological Applications: Uncertainty Analysis and Risk Assessment for the Design of Optimal Monitoring Networks'
<p>This dataset includes all data and information on how to reproduce the results and the figures of the paper 'Reconnecting Stochastic Methods with Hydrogeological Applications: Uncertainty Analysis and Risk Assessment for the Design of Optimal Monitoring Networks'.</p>
Human-centred design methods to empower 'teachers as designers'
<p>The present datasets have been used for the paper entitled "Human-centred design methods to empower ‘teachers as designers’".</p> <p>Abstract</p> <p>Teachers are learning designers, often unwittingly. To facilitate this role of ‘teachers as designers’, educators of all sectors need to adopt a design mindset and acquire the skills needed to address the design challenges they encounter in their everyday practice. Human-centred design (HCD) provides professional designers with the methods needed to address complex problems. It emphasises the human perspective throughout the design lifecycle and provides a practice-oriented, context-aware, empathetic and incremental approach which naturally fits educators realities.</p> <p>This research reports on a MOOC designed to ‘walk’ educators through the design of an ICT-based learning activity following an HCD process and its techniques. A mixed methods approach is used to gauge how participants experienced the MOOC and the various design tasks it comprises. Although the perceived level of difficulty and value on the different methods varied - and, significant differences were seen between the experience of novice and expert educators-, the participants felt the overall approach constituted a powerful means for them to design technology-enhanced learning activities. The results support the idea of HCD as a valuable framework for educators and inform ongoing international efforts to shape a science and practice of learning design for teaching. </p>
Dataset for publication: 'Search Space Representation and Reduction Methods to Enhance Multi-Objective Water Supply Monitoring Design'
<p>This is the dataset the publication "Search Space Representation and Reduction Methods to Enhance Multi-Objective Water Supply Monitoring Design" is based on.</p>
Redesign of Sumber Alam 2 Retail by Using Green Design Method and Dialux Evo Simulation
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Data of "Optimization of concrete mix designs toward the bond properties of steel reinforcement in self-healing concrete by Taguchi method"
<p>Dataset for the hardened properties of self-healing concrete and the bond properties of steel reinforcement in self-healing concrete used for the optimization via Taguchi method</p>
Fig. 5 in To design, or not to design? Comparison of beetle ultraconserved element probe set utility based on phylogenetic distance, breadth, and method of probe
Fig. 5. Phylogenetic trees of Scarabaeidae generated using UCEs; node values indicate bootstrap support. A)The tree produced with the Scarab 3kv1 probe set. B) The topology produced with the Adephaga 2.9kv1 probe set.
Fig. 1 in To design, or not to design? Comparison of beetle ultraconserved element probe set utility based on phylogenetic distance, breadth, and method of probe
Fig. 1. Phylogenetic relationships based on McKenna et al. (2019) among select Coleoptera taxa relevant to or included in UCE probe design. Color (online),
Fig. 3 in To design, or not to design? Comparison of beetle ultraconserved element probe set utility based on phylogenetic distance, breadth, and method of probe
Fig. 3. UCE loci recovery during in silico testing plotted against different metrics: A) average genetic distance estimated based on common gene fragments used in phylogenetics; B) average genetic distance estimated using BUSCO genes; C) N50 assembly metrics; and D) BUSCO S values.
Fig. 2 in To design, or not to design? Comparison of beetle ultraconserved element probe set utility based on phylogenetic distance, breadth, and method of probe
Fig. 2. Schematical overview of the workflow for the present study.Workflow proceeds from left to right and top to bottom.The tablets correspond to the three broader segments of the study: genomic resource generation, probe design, and in silico testing; within tablet boundaries can be found associated taxon sets, data, experimentation, and results. Arrows indicate the flow of data, associated results, and the location results can ultimately be found. Color corresponds to membership within a taxon set or probe set.The red boxes around Hydro 2.7kv1 and Scarab 3kv1 denote final optimized, tailored probe set design tailored for Hydrophiloidea and Scarabaeidae based on the results of this study. Length of 75CM box corresponds to alignment length. Abbreviations used: NCBI, National Center for Biotechnology Information; 75CM, 75% complete matrix; AMAS, alignment manipulation and summary statistics (Borowiec 2016); R-F, Robinson– Foulds distance (Robinson and Foulds 1981).
Testing Interference-based Methods to Mitigate Gambling Craving - A Multiple Single Case Design
ClinicalTrials.gov study NCT03493399. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Rationale, Design and Methods for the Early Surgery in Infective Endocarditis Study (ENDOVAL)
ClinicalTrials.gov study NCT00624091. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Stroke Rehabilitation Utilizing Therapeutical Methods Designed for Nature Environments
ClinicalTrials.gov study NCT06633146. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Prosthetic Limbs After Leg Amputation: Alternative Method of Socket Design
ClinicalTrials.gov study NCT00061217. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Design and Methods of the Mood Disorder Cohort Research Consortium (MDCRC) Study
ClinicalTrials.gov study NCT03088657. IPD Sharing: NO. Countries: 1. Publications: 15.
Data from: An experimental evaluation of the effects of geolocator design and attachment method on between-year survival on whinchats Saxicola rubetra
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Factorial design assisted RP-HPLC method for simultaneous determination of fluconazole, itraconazole, and terbinafine
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Data from: The relative power of genome scans to detect local adaptation depends on sampling design and statistical method
Although genome scans have become a popular approach towards understanding the genetic basis of local adaptation, the field still does not have a firm grasp on how sampling design and demographic history affect the performance of genome scans on complex landscapes. To explore these issues, we compared 20 different sampling designs in equilibrium (i.e. island model and isolation by distance) and nonequilibrium (i.e. range expansion from one or two refugia) demographic histories in spatially heterogeneous environments. We simulated spatially complex landscapes, which allowed us to exploit local maxima and minima in the environment in 'pair' and 'transect' sampling strategies. We compared FST outlier and genetic–environment association (GEA) methods for each of two approaches that control for population structure: with a covariance matrix or with latent factors. We show that while the relative power of two methods in the same category (FST or GEA) depended largely on the number of individuals sampled, overall GEA tests had higher power in the island model and FST had higher power under isolation by distance. In the refugia models, however, these methods varied in their power to detect local adaptation at weakly selected loci. At weakly selected loci, paired sampling designs had equal or higher power than transect or random designs to detect local adaptation. Our results can inform sampling designs for studies of local adaptation and have important implications for the interpretation of genome scans based on landscape data.
Design and Analysis of Chiral and Achiral Metasurfaces with the Finite Element Method
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Supplementary material 2 from: Jakobsberg GO, Mooney WD, Rangel-Sanchez J (2022) Assessment of an inexpensive trap design and survey method for vespine wasps (Hymenoptera, Vespidae, Vespinae). Journal of Hymenoptera Research 89: 171-182. https://doi.org/10.3897/jhr.89.80284
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ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.