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ShareScore release 0.9.0
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106 results for “nephrotoxicity”
Screening the Sigma LOPAC®1280 library of compounds for protective effects against cisplatin-induced oto- and nephrotoxicity
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Figure 1 from: Fouad AA, Moussa NA, Kareem MMA, Akl UI, Abdelghany MI, Abdel-Aziz AM (2022) Thymol exerts antioxidant, anti-inflammatory, and anti-apoptotic protective effects against gentamicin nephrotoxicity in rats. Pharmacia 69(1): 181-186. https://doi.org/10.3897/pharmacia.69.e77338
Figure 1 Results of thymol (TML) on: A. Serum creatinine and neutrophil gelatinase-associated lipocalin (NGAL); B. Renal malondialdehyde (MDA), nitric oxide (NO), and total antioxidant capacity (TAC); C. Renal tumor necrosis factor-α (TNF-α) and interleukin-18 (IL-18); D. Renal Bax; E. Renal caspase-3, and caspase-9 in gentamicin (GN)-challenged rats. Results are mean ± S.E.M., *p < 0.05 vs. control, ≠p < 0.05 vs GN.
Figure 2 from: Fouad AA, Moussa NA, Kareem MMA, Akl UI, Abdelghany MI, Abdel-Aziz AM (2022) Thymol exerts antioxidant, anti-inflammatory, and anti-apoptotic protective effects against gentamicin nephrotoxicity in rats. Pharmacia 69(1): 181-186. https://doi.org/10.3897/pharmacia.69.e77338
Figure 2 H&E (200×) of rat kidneys of: A. Control showing normal renal architecture; B. Gentamicin (GN) group demonstrating marked distortion of kidney architecture, renal tubular necrosis and dilatation, desquamation of lining epithelium (white arrow), cytoplasmic vacuolization (black arrow), interstitial edema, coagulative necrosis (black head), and inflammatory cell infiltration (white head); C. Thymol (TML) + GN showing preservation of the normal kidney histological picture; D. Score of tubular injury. Results are mean ± S.E.M., *p < 0.05 vs. control, ≠p < 0.05 vs. GN.
Figure 4 from: Fouad AA, Moussa NA, Kareem MMA, Akl UI, Abdelghany MI, Abdel-Aziz AM (2022) Thymol exerts antioxidant, anti-inflammatory, and anti-apoptotic protective effects against gentamicin nephrotoxicity in rats. Pharmacia 69(1): 181-186. https://doi.org/10.3897/pharmacia.69.e77338
Figure 4 Immunohistochemistry (200×) of kidney injury molecule-1 (KIM-1) of rat kidneys of: A. Control showing no staining (NS); B. Gentamicin (GN) group demonstrating a significant increment of KIM-1 immunopositivity in brown color; C. Thymol (TML) + GN showing a significant decrement of KIM-1 immunoreactivity; D. Immunoreactive area (µm2). Results are mean ± S.E.M., *p < 0.05 vs. control, ≠p < 0.05 vs. GN.
Figure 3 from: Fouad AA, Moussa NA, Kareem MMA, Akl UI, Abdelghany MI, Abdel-Aziz AM (2022) Thymol exerts antioxidant, anti-inflammatory, and anti-apoptotic protective effects against gentamicin nephrotoxicity in rats. Pharmacia 69(1): 181-186. https://doi.org/10.3897/pharmacia.69.e77338
Figure 3 Immunohistochemistry (200×) of nuclear factor-κB p65 (NF-κB p65) of rat kidneys of: A. Control showing no staining (NS); B. Gentamicin (GN) group demonstrating a significant increment of NF-κB p65 immunopositivity in brown color; C. Thymol (TML) + GN showing a significant decrement of NF-κB p65 immunoreactivity; D. Immunoreactive area (µm2). Results are mean ± S.E.M., *p < 0.05 vs. control, ≠p < 0.05 vs. GN.
Effect of N-Acetylcysteine Infusion on Preventing Colicitin-Induced Nephrotoxicity
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Effect of N-Acetylcysteine Infusion on Preventing Colicitin-Induced Nephrotoxicity
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Effect of N-Acetylcysteine Infusion on Preventing Colicitin-Induced Nephrotoxicity
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Effect of Sodium Thiosulfate on Nephrotoxicity of Cisplatin Intraperitoneal Heat-perfusion Chemotherapy
ClinicalTrials.gov study NCT05877911. IPD Sharing: NO. Countries: 0. Publications: 19.
Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients
ClinicalTrials.gov study NCT01734694. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluation of Acute and Chronic Nephrotoxicity in Acute Lymphatic Leukemia Patients Using Ultrasound Localization Microscopy
ClinicalTrials.gov study NCT07313878. IPD Sharing: YES. Countries: 1. Publications: 0.
Assessment of Urinary NGAL to Predict AKI in Children Receiving Multiple Nephrotoxic Medications
ClinicalTrials.gov study NCT03527160. IPD Sharing: NO. Countries: 1. Publications: 0.
Comparison of Ibandronate - Zoledronate Regarding Nephrotoxicity in Multiple Myeloma
ClinicalTrials.gov study NCT02739594. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Contrast Agent-associated Nephrotoxicity in Intensive Care Unit Patients
ClinicalTrials.gov study NCT01017796. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Evaluation of Intravenous N-acetylcysteine to Prevent Contrast Media Induced Nephrotoxicity in an Emergency Center
ClinicalTrials.gov study NCT01467154. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Tacrolimus-induced nephrotoxicity in mice is associated with microRNA deregulation [transcriptome analysis]
GEO Series GSE102513. Mus musculus. 8 samples. Type: Expression profiling by array.
Dichloroacetate (DCA) prevents cisplatin-induced nephrotoxicity without compromising its anti-cancer properties.
GEO Series GSE69652. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Tacrolimus-induced nephrotoxicity in mice is associated with microRNA deregulation
GEO Series GSE102515. Mus musculus. 16 samples. Type: Expression profiling by array; Non-coding RNA profiling by array.
Comprehensive transcriptomic and m6A epitranscriptomic reveals colchicine-induced nephrotoxicity via DNA damage and autophagy in HK2 cells
GEO Series GSE295178. Homo sapiens. 12 samples. Type: Other.
Mechanism and Reversal of Nephrotoxicity on a Chip
GEO Series GSE147735. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
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