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3,650 results for “antibody”
Antibody features towards VAR2CSA and CSA binding infected erythrocytes in a cohort of pregnant women from PNG
<p><i>Plasmodium falciparum </i>causes placental malaria, which results in adverse outcomes for mother and child. <i>P. falciparum</i> infected erythrocytes that express the parasite protein VAR2CSA on their surface can bind to placental chondroitin sulfate-A. It has been hypothesized that naturally acquired antibodies towards VAR2CSA protect against placental infection, but it has proven difficult to use measures of antibody to identify individuals protected from disease. We used a systems serology approach to identify naturally acquired antibody features mid pregnancy that were associated with protection from placental malaria at delivery. Machine learning techniques selected six out of 169 measured antibody features towards VAR2CSA that could predict (with 86% accuracy) whether a woman would subsequently have active placental malaria infection at delivery. Selected features were associated with inhibition of placental binding and/or opsonic phagocytosis of infected erythrocytes, and network analysis indicated that there are not one but multiple pathways to protection from placental malaria.</p>
Analysis of antibody signal loss for elongating RNA polymerase II upon transcription inhibition
<p>This data set assesses the loss of antibody signal for elongating RNA polymerase II in zebrafish embryos upon transcription inhibition with flavopiridol. Polymerase was labeled by immunofluorescence, microscopy images were acquired by instant-SIM micrscopy, and analyzed using MatLab scripts and the bioformats importer. This data set contains the raw image data as well as all further analysis scripts.</p>
Code related to article "The antibody response to SARS-CoV-2 infection persists over at least 8 months in symptomatic patients"
<p>This code is related to article "The antibody response to SARS-CoV-2 infection persists over at least 8 months in symptomatic patients"</p> <p>Abstract</p> <p>The factors involved in the persistence of antibodies to SARS-CoV-2 are unknown. We evaluated the antibody response to SARS-CoV-2 in personnel from 10 healthcare facilities and its association with individuals’ characteristics and COVID-19 symptoms in an observational study. We enrolled 4735 subjects (corresponding to 80% of all personnel) over a period of 5 months when the spreading of the virus was drastically reduced. For each participant, we determined the rate of antibody increase or decrease over time in relation to 93 features analyzed in univariate and multivariate analyses through a machine learning approach. In individuals positive for IgG ( ≥ 12 AU/mL) at the beginning of th study, we found an increase [p= 0.0002] in antibody response in symptomatic subjects, particularly with anosmia/dysgeusia (OR 2.75, 95% CI 1.753 – 4.301), in a multivariate logistic regression analysis. This may be linked to the persistence of SARS-CoV-2 in the olfactory bulb.</p>
Protective efficacy of anti-Hyr1p monoclonal antibody against systemic candidiasis due to multi-drug resistant Candida au-ris
<p>Supplementary Data</p>
Antibody accessibility determines location of spike surface mutations in SARS-CoV-2 variants
<p>Scripts and Data to reproduce plots in</p> <p>Sören von Bülow, Mateusz Sikora, Florian E.C. Blanc, Roberto Covino, Gerhard Hummer, "Antibody accessibility determines location of spike surface mutations in SARS-CoV-2 variants", PLoS Computational Biology 202X</p>
Supplementary Table 1. Antibodies used in the study.
<p>Dasen et al. Supplementary Table 1. Antibodies used in the study.</p> <p> </p>
In silico Antibody-Peptide Epitope prediction for Personalized cancer therapy publication data
<p>In silico Antibody-Peptide Epitope prediction for Personalized cancer therapy publication data</p>
longitudinal BA.1 breakthrough antibody dataset
<p>Characterization of all antibodies isolated at the late time point following BA.1 breakthrough infection.</p>
LC-MS results for unconjugated antibody (Atezolizumab (AtZ)) , pemetrexed-PEG-Atezolizumab (PemPEG-AtZ conjugate), and pemetrexed-GABA-Atezolizumab (PemGABA-AtZ conjugate)
<p>This data represent the figures of LC-MS results for unconjugated antibody (Atezolizumab (AtZ)) , pemetrexed-PEG-Atezolizumab (PemPEG-AtZ conjugate), and pemetrexed-GABA-Atezolizumab (PemGABA-AtZ conjugate)</p>
Strategy of selection and optimization of single domain antibodies targeting the PHF6 linear peptide within the Tau intrinsically disordered protein
<p>Dataset pertaining to Strategy of selection and optimization of single domain antibodies targeting the PHF6 linear peptide within the Tau intrinsically disordered protein</p>
Fig. 2 in Triterpene glycosides from Blighia welwitschii and evaluation of their antibody recognition capacity in multiple sclerosis
Fig. 2. Data distribution of IgM antibody responses to saponins 2, 6, 7, hederagenin monodesmoside and giganteaside J from B. welwitschii, in MS patients' sera, determined by ELISA. CSF114(Glc) and its unglucosylated analogue, CSF114, were tested as positive and negative controls, respectively. Glc oleanolate from O. obtusifolia, whose glycoside part is significantly different from B. welwitschii saponins, was tested as a reference compound. Data are reported as absorbance at 405 nm of sera diluted 1:100. Horizontal lines represent mean values with their SD. Mann-Witney U test showed that the CSF114(Glc) distribution significantly differs from this of CSF114 (p value <0.0001, two-tailed). Kruskal-Wallis test including multiple comparison of natural glycosides distributions showed statistical differences between compound 2 and 6 (p value <0.05), 2 and 7 (p value <0.0001), 2 and hederagenin monodesmoside (p value <0.01), Glc oleanolate and hederagenin monodesmoside (p value <0.05), Glc oleanolate and 7 (p value <0.0001) and Glc oleanolate and 6 (p value <0.05).
Fig. 3 in Triterpene glycosides from Blighia welwitschii and evaluation of their antibody recognition capacity in multiple sclerosis
Fig. 3. Data distribution of IgM antibody responses to saponins 2, 6, 7, hederagenin monodesmoside and giganteaside J from B. welwitschii as well as Glc oleanolate from O. obtusifolia, in the sera of multiple sclerosis (MS) and ctrl patients, determined by ELISA. CSF114(Glc) and the unglucosylated peptide CSF114 were tested as controls. Data are reported as absorbance at 405 nm of sera diluted 1:100. Horizontal lines represent mean values with their SD. MannWitney U test showed that MS and ctrl distributions significantly differ for CSF114(Glc), CSF114 (p value <0.0001, two-tailed) and for Glc oleanolate (p value <0.05, two-tailed). In contrast, saponins 2, 6, 7, hederagenin monodesmoside and giganteaside J did not show any statistical differences between the two sera distributions (p value> 0.05, two-tailed).
Strengthening E-cadherin adhesion via antibody mediated binding stabilization
<p>Simulation files for the publication: "Strengthening E-cadherin adhesion via antibody mediated binding stabilization". This includes starting structure files, GROMACS parameters files, GROMACS run input files and sample protein trajectory files for all conditions: +ab strong (set 1), +ab weak (set 5), -ab (set 1), K14E +ab (set 1), and 1ab (set 1) conditions. Due to the limitation of the maximum upload size (50GB), only protein trajectories were uploaded without solvent. </p>
Strengthening E-cadherin adhesion via antibody mediated binding stabilization(3)
<p>Simulation files for the publication: "Strengthening E-cadherin adhesion via antibody mediated binding stabilization". This includes protein trajectory files: K14E (sets 2-5), and 1ab (sets 2-5). Due to the limitation of the maximum upload size (50GB), only protein trajectories were uploaded without solvent. </p>
Strengthening E-cadherin adhesion via antibody mediated binding stabilization(2)
<p>Simulation files for the publication: "Strengthening E-cadherin adhesion via antibody mediated binding stabilization". This includes protein trajectory files: +ab (sets 2-4), and -ab (sets 2-5). Due to the limitation of the maximum upload size (50GB), only protein trajectories were uploaded without solvent. </p>
A Trial of Anti-TNF Chimeric Monoclonal Antibody (cA2) in Korean Patients With Active Rheumatoid Arthritis Despite Methorexate (Extension Part)(Study P05645)(COMPLETED)
ClinicalTrials.gov study NCT00732875. IPD Sharing: YES. Countries: 0. Publications: 1.
Anti-PD-1 Antibody Plus DEB-TACE for BCLC Stage A/B HCC
ClinicalTrials.gov study NCT04174781. IPD Sharing: NO. Countries: 1. Publications: 1.
Monoclonal Antibody With or Without gp100 Peptides Plus Montanide ISA-51 in Treating Patients With Stage IV Melanoma
ClinicalTrials.gov study NCT00077532. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Generation of Heparin-induced Thrombocytopenia (HIT)-Antibodies Without Prior Heparin Exposure
ClinicalTrials.gov study NCT01102790. IPD Sharing: Not stated. Countries: 1. Publications: 3.
The Effect of Monoclonal Vascular Endothelial Growth Factor (VEGF) Antibody (Bevacizumab) on Pituitary Function
ClinicalTrials.gov study NCT00973557. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.