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opennotspecifiedOct 2022View details →

Fig. 10. Compound 4 induced HepG2 cells apoptosis. HepG2 in Artemidubolides A T, cytotoxic unreported guaiane-type sesquiterpenoid dimers against three hepatoma cell lines from Artemisia dubia

Fig. 10. Compound 4 induced HepG2 cells apoptosis. HepG2 cells were treated with different concentrations (0.0, 3.5, 7.0, and 10.5 μM) of 4 for 48 h. (A) and (B) Flow cytometric analysis and cell apoptosis quantification of HepG2 cells. (C) and (D) The apoptosis-related protein levels in hepatoma cells treated with compound 4 for 48 h. Western blot and statistical results of Bax, BCL-2, PARP-1, and cleaved-PARP-1. The results were normalized to the β-actin loading control. *P <0.05, **P <0.01, and ***P <0.001, n = 3.

opennotspecifiedOct 2020View details →

Fig. 7. Compounds 1a, 1b, 4a and 4b reduced H2O2-induced apoptosis. The cells were treated with 1a, 1b, 4a and 4b in Lignans and neolignans with isovaleroyloxy moiety from Solanum lyratum Thunb.: Chiral resolution, configurational assignment and neuroprotective effects

Fig. 7. Compounds 1a, 1b, 4a and 4b reduced H2O2-induced apoptosis. The cells were treated with 1a, 1b, 4a and 4b at 50 μM for 48 h. The nuclear changes were determined by Hoechst 33258 staining observed with a fluorescence microscope. Arrows: apoptotic cells. Scale bar: 50 μm.

opennotspecifiedJan 2021View details →

Fig. 7 in Cardiac glycosides from the roots of Streblus asper Lour. and their apoptosis-inducing activities in A549 cells

Fig. 7. Western blot analysis of caspases-3, -8, -9, Bax, and Bcl-2 in A549 cells with compound 3 (1 μM) for 8 and 24 h. The results are from one representative experiment among three runs, showed similar patterns. Significantly different (***p <0.001) compared with the initial model group.

opennotspecifiedJan 2021View details →

Fig. 6 in Cardiac glycosides from the roots of Streblus asper Lour. and their apoptosis-inducing activities in A549 cells

Fig. 6. Induction of apoptosis against A549 cells treated with compound 3. (PI: propidium iodide; N: negative control; C: compound 3) (A) Apoptotic cells in the compound 3 (1 μM) treated A549 cells at 12, 24, and 48 h. (B) Negative, control group DMSO at 48 h. (C) Early apoptosis and late apoptosis of A549 cells compared with negative group at 48 h. Each value is the mean of three experiments. Significant different (***p <0.001) compared with control model group.

opennotspecifiedJan 2021View details →

Fig. 5 in Cardiac glycosides from the roots of Streblus asper Lour. and their apoptosis-inducing activities in A549 cells

Fig. 5. Detection of cell shrinkage induced by compound 3, and fragmentation by nuclear staining with Hoechst 33342 in A549 cells, which were cultured for 24 h.

opennotspecifiedAug 2020View details →

Fig. 5. Compound 7 induced apoptosis through a mitochondria-dependent pathway. A in Bufadienolide glycosides and bufadienolides from the whole plants of Helleborus lividus, and their cytotoxic activity

Fig. 5. Compound 7 induced apoptosis through a mitochondria-dependent pathway. A, Mitochondrial membrane morphology of HL- 60 cells treated with 7. HL-60 cells were stained with MitoCapture™ reagent after treatment with either 0.21 μM of 7 or 33 μM of cisplatin for 6 h and observed under a fluorescence microscope. B, Release of cytochrome c from mitochondria of HL-60 cells treated with 7. HL-60 cells were treated with either 0.21 μM of 7 or 33 μM of cisplatin for 8 h, and the release of cytochrome c into the cytoplasm was evaluated by Western blot analysis.

opennotspecifiedApr 2020View details →

Fig. 5. Compound 2 induced apoptosis through a mitochondria-dependent pathway. A in Bufadienolides from the whole plants of Helleborus foetidus and their cytotoxicity

Fig. 5. Compound 2 induced apoptosis through a mitochondria-dependent pathway. A, Mitochondrial membrane morphology of HL-60 cells treated with 2. HL-60 cells were stained with MitoCapture™ reagent after treatment with either 0.5 μM of 2 or 33 μM of cisplatin for 10 h and observed under a fluorescence microscope. B, Release of cytochrome c from mitochondria of HL-60 cells treated with 2. HL-60 cells were treated with either 0.5 μM of 2 or 33 μM of cisplatin for 6 h, and the release of cytochrome c into the cytoplasm was evaluated by Western blot analysis.

Fig. 7 in Triterpenoids from Liquidambar Fructus induced cell apoptosis via a PI3KAKT related signal pathway in SMMC7721 cancer cells

Fig. 7. Effects of compounds 5, 7 and 8 on expression of apoptosis related genes in SMMC7721 cells. (A). Representative Western blot results. *P <0.05 vs control. (B) RT-qPCR results of three independent experiments. *P <0.05 vs control.

Fig. 5 in Triterpenoids from Liquidambar Fructus induced cell apoptosis via a PI3KAKT related signal pathway in SMMC7721 cancer cells

Fig. 5. Induction of apoptosis by compounds 5, 7 and 8 in SMMC7721 cancer cells at 36 h *P <0.05 vs control.

Fig. 9 in Triterpenoids from Liquidambar Fructus induced cell apoptosis via a PI3KAKT related signal pathway in SMMC7721 cancer cells

Fig. 9. Expression changes of PI3K-AKT signal pathway related genes. (A) Representative Western blot results of compounds 5, 7 and 8 inducing expression changes of PI3K-AKT signal pathway related proteins in SMMC7721 cells; (B) Statistical analysis of protein expression levels in (A). The results shown were representative of three independent experiments. *P <0.05 vs control.

Fig. 8 in Triterpenoids from Liquidambar Fructus induced cell apoptosis via a PI3KAKT related signal pathway in SMMC7721 cancer cells

Fig. 8. Effects of compounds 5, 7 and 8 on expression of PI3K-AKT pathway related genes on SMMC7721 cell. The RT-qPCR results shown were representative of three independent experiments. *P <0.05 vs control.

Apoptosis in Polymorphonuclear Cells and Inflammatory Cytokines of Trauma Patients

ClinicalTrials.gov study NCT03319017. IPD Sharing: UNDECIDED. Countries: 1. Publications: 14.

Effect of Ovarian Stimulation With r-hLH/r-hFSH,r-hFSH and hMG in Reducing Apoptosis Rate in Cumulus Cells of Patients Undergoing ICSI

ClinicalTrials.gov study NCT01872247. IPD Sharing: Not stated. Countries: 1. Publications: 2.

Microculture Kinetic (MiCK) Apoptosis Test Results With Drug Treatment Results in Cancer Patients

ClinicalTrials.gov study NCT00901264. IPD Sharing: Not stated. Countries: 2. Publications: 1.

Evaluation of Mucoadhesive Tacrolimus Patch on Caspase-3 Inducing Apoptosis in Oral Lichen Planus

ClinicalTrials.gov study NCT05139667. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.

"Neo-Adjuvant Treatment With Palbociclib: Effect on Ki67 and Apoptosis Before, During and After Treatment "

ClinicalTrials.gov study NCT02530424. IPD Sharing: Not stated. Countries: 1. Publications: 3.

The Comparison of Granulosa Cell Apoptosis Rates With or Without Luteinizing Hormone Administration in Poor Responders.

ClinicalTrials.gov study NCT03527823. IPD Sharing: UNDECIDED. Countries: 1. Publications: 9.

closedIPD-NOFeb 2026View details →

Enhancing Effect on Tumour Apoptosis With the Use of Pentoxifylline in Patients With Hodgkin Lymphoma

ClinicalTrials.gov study NCT05490953. IPD Sharing: NO. Countries: 1. Publications: 18.

Skeletal Muscle Apoptosis and Physical Performance; Oxidative RNA/DNA Damage and Repair in Aged Human Muscle

ClinicalTrials.gov study NCT01644279. IPD Sharing: Not stated. Countries: 1. Publications: 5.

Apoptosis May Have a Role in Etiopathogenesis of Obstetric Cholestasis.

ClinicalTrials.gov study NCT02192177. IPD Sharing: Not stated. Countries: 1. Publications: 2.