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5,448 results for “Neuron”
Data from: Developmental changes in hippocampal CA1 single neuron firing and theta activity during associative learning
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Dissociable control of unconditioned responses and associative fear learning by parabrachial CGRP neurons
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Synaptic connectivity and neuronal network activity changes after extracellular matrix depletion
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Neuronal activity in sensory cortex predicts the specificity of learning
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Data from: Attention-related modulation of caudate neurons depends on superior colliculus activity
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Neuronal octopamine signaling regulates mating-induced germline stem cell increase in female Drosophila melanogaster
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Nicotinamide riboside and pterostilbene cooperatively delay motor neuron failure in ALS SOD1G93A mice
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Behavioral context affects social signal representations within single primate prefrontal cortex neurons
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Pyramidal neuron 1
Drawing uploaded to scidraw.io on: 21 May 2020
pyramidal neuron
Drawing uploaded to scidraw.io on: 15 August 2019
neuron silhouette
Drawing uploaded to scidraw.io on: 06 August 2019
Pyramidal neuron 2
Drawing uploaded to scidraw.io on: 21 May 2020
Simple pyramidal neuron
Drawing uploaded to scidraw.io on: 16 August 2019
Data from: Persistent firing in LEC III neurons is differentially modulated by learning and aging
Whether and how persistent firing in lateral entorhinal cortex layer III (LEC III) supports temporal associative learning is still unknown. In this study, persistent firing was evoked <em>in vitro</em> from LEC III neurons from young and aged rats that were behaviorally naïve or trained on trace eyeblink conditioning. Persistent firing ability from neurons from behaviorally naïve aged rats was lower compared to neurons from young rats. Neurons from learning impaired aged animals also exhibited reduced persistent firing capacity, which may contribute to aging-related learning impairments. Successful acquisition of the trace eyeblink task, however, increased persistent firing ability in both young and aged rats. These changes in persistent firing ability are due to changes to the afterdepolarization, which may in turn be modulated by the postburst afterhyperpolarization. Together, these data indicate that successful learning increases persistent firing ability and d ecreases in persistent firing ability contribute to learning impairments in aging.
Gene Delivery to Neurons in the Auditory Brainstem of Barn Owls using Standard Recombinant Adeno-associated Virus Vectors
<div> <p>Recombinant adeno-associated virus (rAAV) vectors are a commonly used tool for gene delivery. There is a large choice of different serotypes whose transduction efficiency varies for different animal species. In this study, three rAAV vectors were tested for transduction efficiency in the auditory brainstem of adult barn owls (<i>Tyto alba</i>) which are not standard laboratory animals. Injections with rAAV serotypes 2/1 and 2/5 resulted in reliable expression in various nuclei of the auditory brainstem of barn owls. Both vectors showed evidence of being spread by axonal transport. However, only rAAV2/5 also showed expression in regions far distant from the injection site, suggesting long-range axonal transport in connections along the auditory pathway. In contrast, injections with rAAV2/9 resulted in no expression. Our results demonstrate for the first time that commercially available rAAV vectors can be used for reliable gene expression in the barn owl auditory brainstem and pave the way toward optogenetic manipulation of neural activity in this important animal species in neuroethology and auditory physiology.</p> </div>
Short-term exposure to the simple polyphenolic compound gallic acid induces neuronal hyperactivity in zebrafish larvae
<p>Zebrafish locomotor test</p> <p>Larval locomotion in zebrafish was investigated at 72 hpf using the automated analyzer DanioVision<sup>TM</sup> Observation Chamber (Noldus Information Technology). Larvae were individually exposed to 50 µg/ml GA dissolved in E3 medium. The activity was measured at three time points: 30, 60, and 180 min. The activity measured in treated and control larvae included: 1) total distance covered by each larva (total distance, in mm), 2) total time larvae spent moving (movement, in seconds), 3) mean velocity of each larva across movement measures (velocity, in mm/sec), 4) total number of rotations completed by each larva during the experiment (one rotation was counted every time larvae turned more than 180° left or right with respect to its own body axis, counted as the frequency of left and right rotations).</p> <p> </p> <p>Cadmium treatment of zebrafish larvae</p> <p>Two batches of wild-type larvae were exposed for 3 h (from 69 to 72 hpf) to 50 and 100 µM CdCl<sub>2</sub>·H<sub>2</sub>O in an E3 medium, respectively. Half of the 50 µM and half of the 100 µM treated larvae underwent the exposition to 50 µg/ml GA. The four obtained subgroups were: <em>i.</em> Cd 50 µM only treated larva; <em>ii.</em> <em>Cd 100</em> µM only treated; <em>iii</em>. Cd 50 µM exposed to GA larvae; and <em>iv</em>. 100 µM exposed to GA larvae. All the groups underwent the behavioral observations reported above. As control groups were used: one group (Control E3) consisting of larvae in E3 medium only, and a second control with larvae exposed to 50 µg/ml GA for 30 minutes only. Larval locomotion was evaluated in a 96-well plate using the automated analyzer DanioVision<sup>TM</sup> Observation Chamber (Noldus Information Technology). Each experiment was performed in triplicate.</p> <p> </p> <p>Neurotransmitter analyses</p> <p>Neur_data report the final concentration expressed as ng of neurotransmitter per larva.</p>
CA1 pyramidal neuron
SciDraw upload
Neuronal cell labelled with anti PSD95 and homer antibodies - sample image for software testing of Easy SODA
<p><strong>Hippocampal neurons</strong> in culture seeded on glass coverslip. This 16 bits confocal picture of hippocampal neuron in culture has been taken at 63x (1024x1024 pixels - pixel size 92,45 nm) in sequential mode with two channels : one dedicated to the PSD95 protein, and the other one to Homer protein. Those protein are expressed at glutamatergic post-synaptic sites and can be found close within Post Synaptic Density. This is a good sample to test colocalization and association analysis. The homer channel can be used both to infere neuronal shape thanks to hk-means segmentation (<a href="http://icy.bioimageanalysis.org/protocol/easy-cell-shape-with-hk-means/">http://icy.bioimageanalysis.org/protocol/easy-cell-shape-with-hk-means/</a>), or to detect clusters thanks to wavelet segmentation (<a href="http://icy.bioimageanalysis.org/protocol/rainbow-spot-detector-scale-finder/">http://icy.bioimageanalysis.org/protocol/rainbow-spot-detector-scale-finder/</a>). This sample image can be used with Easy SODA protocol (Standard Object Distance Analysis) on Icy software (<a href="http://icy.bioimageanalysis.org/protocol/easy-soda-2-colors-1-image/">http://icy.bioimageanalysis.org/protocol/easy-soda-2-colors-1-image/) </a>to detect association between PSD95 and homer clusters.</p>
Neuronal cell labelled with anti MAP2 antibody - sample image for software testing
<p><strong>Hippocampal neurons</strong> in culture seeded on glass coverslip. Dendritic extensions are labeled with antibody against <strong>MAP2, a protein associated with microtubules and nucleus is labeled with DAPI</strong>. The resulting signal give acces to the neuronal cell body and dendrite. Here the axon is not labeled. This picture has been taken on a Leica DMRE microscope with a 40x objective. This is a sample demo to be used to test our automatic segmentation of neuronal cells thanks to the <strong>Easy cell shape protocol</strong>, available freely on Icy software. You can download the software (PC, Mac or linux) and have access to the full documentation of this solution on <a href="http://icy.bioimageanalysis.org/protocol/easy-cell-shape-with-hk-means/">http://icy.bioimageanalysis.org/protocol/easy-cell-shape-with-hk-means/ (</a>Publication ID: ICY-77638). It segments in a user friendly mode the cell shape using the hk-mean plugin that applies a N-class thresholding based on a K-Means classification of the image histogram.</p>
Dendritic coincidence detection in Purkinje neurons of awake mice
<p><span>Dendritic coincidence detection is thought fundamental to neuronal processing yet remains largely unexplored in awake animals. Specifically, the underlying dendritic voltage-calcium relationship has not been directly addressed. Here, using simultaneous voltage and calcium two-photon imaging of Purkinje neuron spiny dendrites, we show how coincident synaptic inputs and resulting dendritic spikes modulate dendritic calcium signaling during sensory stimulation in awake mice.<span> </span></span><span>Sensory stimulation increase</span><span>d</span><span><span> </span>the rate of post</span><span>-</span><span>synaptic potentials and dendritic calcium spikes evoked by climbing<span> </span></span><span>fiber<span> </span></span><span>and parallel fiber</span><span><span> </span>synaptic input. These inputs are integrated in a time-dependent and non-linear fashion to enhance the sensory evoked dendritic calcium signal. Intrinsic supralinear dendritic mechanisms, including voltage-gated calcium channels and metabotropic glutamate receptors, are recruited cooperatively to expand the dynamic range of sensory evoked dendritic calcium signals. This establishes how dendrites can use multiple interplaying mechanisms to perform coincidence detection, as a fundamental and ongoing feature of dendritic integration in behaving animals.</span></p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.