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461 results for “Plasmodium falciparum”
Molecular and functional properties of human Plasmodium falciparum CSP C-terminus antibodies
<p>AIRR Community-compliant information comprising all antibodies described in EMBO Mol Med 15:e17454 [DOI:10.15252/emmm.202317454].</p>
A dataset of human and Plasmodium falciparum genotypes in severe malaria cases from The Gambia and Kenya
<p>This data release contains human and <em>Plasmodium falciparum</em> malaria genotypes from the article:</p> <p><strong>Malaria protection due to sickle haemoglobin depends on parasite genotype</strong></p> <p>Gavin Band, Ellen M. Leffler, Muminatou Jallow, Fatoumatta Sisay-Joof, Carolyne<br> M. Ndila, Alexander W. Macharia, Christina Hubbart, Anna E. Jeffreys, Kate Rowlands, Thuy<br> Nguyen, Sónia Gonçalves, Cristina V. Ariani, Jim Stalker, Richard D. Pearson, Roberto<br> Amato, Eleanor Drury, Giorgio Sirugo, Umberto d'Alessandro, Kalifa A. Bojang, Kevin<br> Marsh, Norbert Peshu, Joseph W. Saelens, Mahamadou Diakité, Steve M. Taylor10, David J.<br> Conway, Thomas N. Williams, Kirk A. Rockett, Dominic P. Kwiatkowski</p> <p>Nature (2021) doi: <a href="https://doi.org/10.1038/s41586-021-04288-3">10.1038/s41586-021-04288-3</a> <strong>bioRxiv link</strong>: <a href="http://doi.org/10.1101/2021.03.30.437659">doi.org/10.1101/2021.03.30.437659</a>.</p> <p>The release contains genotypes from human and <em>Plasmodium falciparum</em> genetic variants, genotyped using blood samples from 4,171 children ascertained with severe symptoms of malaria at the Royal Victoria Teaching Hospital (now the Edward Francis Small Teaching Hospital), The Gambia, and from the Kilifi District Hospital (now Kilifi County Hospital), Kenya in the period 1995-2009.</p> <p>An accompanying set of association test summary statistics has also been released on Zenodo (doi: <a href="https://doi.org/10.5281/zenodo.5722497">10.5281/zenodo.5722497</a>). Please see <a href="http://www.malariagen.net/resource/32">www.malariagen.net/resource/32</a> for full details of other resources associated with the above manuscript.</p> <p> </p>
Validation data for a Microwave Exposure Prototype for In Vitro Growth Inhibition of Plasmodium falciparum
<p>The dataset presented in this article revolves around the validation of an innovative irradiation device designed for <em>in vitro</em> malaria tests. The motivation stems from the escalating need for new malaria treatments due to the high mortality rates, the absence of an effective vaccine, and rising antimalarial drug resistance. The theoretical background for generating this data is based on prior studies indicating that microwave exposure can non-thermally kill malaria parasites by interacting with hemozoin crystals within infected erythrocytes, a process in which healthy cells remain unaffected, probably due to the absence of these crystals. This dataset aims to provide a thorough validation of the device's biological and electrical efficacy, by providing models to simulate various parameters such as the magnetic and electric field strength, and experimentally validate the biological effects on parasite viability under controlled microwave exposure. This contribution is pivotal for advancing research in electromagnetic therapy as a potential treatment for malaria, providing a foundational dataset for future experimental and theoretical work.</p>
Application of optical tweezer technology reveals that PfEBA and PfRH ligands, not PfMSP1, play a central role in Plasmodium-falciparum merozoite-erythrocyte attachment, Supporting Information
<p>This repository contains the dataset and analysis scripts associated with the upcoming publication titled <em>Application of optical tweezer technology reveals that PfEBA and PfRH ligands, not PfMSP1, play a central role in Plasmodium-falciparum merozoite-erythrocyte attachment</em>. The repository includes a comprehensive collection of data and scripts related to optical tweezer experiments, growth assays, qPCR data, and supplementary information. It is organized into several sections, each detailing different aspects of the study:</p> <ul> <li><strong>Growth Assays:</strong> Includes raw and processed data on parasitemia levels, invasion rates, and growth rate assays, along with corresponding Jupyter notebooks and Python scripts for data visualization (e.g., <code>GrowthAssayPlotlib.py</code>, <code>Plot GA1.ipynb</code>, and <code>GA2_df_melted.json</code>).</li> <li><strong>qPCR Data:</strong> Contains results from multiple qPCR runs, including quantification data for various samples, as well as analysis scripts and plotted results (<code>qpcr_plotbench.ipynb</code>, <code>qPCR_plotting.py</code>, etc.). Data files such as <code>.xlsx</code> and <code>.json</code> contain gene expression data and fold changes to NF54.</li> <li><strong>Optical Tweezer Experiments:</strong> Includes detailed results and plots from optical tweezer measurements of attachment forces, time dependence, and multiple merozoite attachments. Notebooks (<code>tweezer_plots.ipynb</code>, <code>Antibody_binding_assay_plots.ipynb</code>) and data files support these analyses.</li> <li><strong>Optical Tweezer Images</strong>: Includes images that were used to measure RBC diameters for deformation and force measurements in <code>.tiff</code> format.</li> <li><strong>Supplementary Information (SI):</strong> Provides additional data and visualizations, such as scatter plots of two stretched RBCs, time post-egress vs. detachment force, and antibody GIA flow data. The accompanying figures (e.g., <code>SupFig1d_egress time vs force_3D7.svg</code>, <code>SupFig5a_GIA.svg</code>) are provided as <code>.svg</code> files.</li> </ul> <p>This repository offers all necessary resources to replicate the findings, including the complete codebase, raw data, and graphical representations of results. Researchers are encouraged to explore the included notebooks and datasets for detailed insights.</p>
Plasmodium falciparum infection in febrile Congolese children: prevalence of clinical malaria ten years after introduction of Artemisinin-combination therapies
<p>dataset used in the paper.</p>
Summary statistics for association tests between human and Plasmodium falciparum genetic variants in 3,346 severe malaria cases from The Gambia and Kenya
<p>This dataset contains summary statistics for association tests between human and<br> <em>Plasmodium falciparum</em> malaria parasite genetic variants, using data from 3,346 severe malaria cases from The Gambia and Kenya. These results underlie the analysis described in our paper:</p> <p><strong>"Malaria protection due to sickle haemoglobin depends on parasite genotype"</strong></p> <p>Gavin Band, Ellen M. Leffler, Muminatou Jallow, Fatoumatta Sisay-Joof, Carolyne M. Ndila, Alexander W. Macharia, Christina Hubbart, Anna E. Jeffreys, Kate Rowlands, Thuy Nguyen, Sónia M. Gonçalves, Cristina V. Ariani, Jim Stalker, Richard D. Pearson, Roberto Amato, Eleanor Drury, Giorgio Sirugo, Umberto d'Alessandro, Kalifa A. Bojang, Kevin Marsh, Norbert Peshu, Joseph W. Saelens, Mahamadou Diakité, Steve M. Taylor, David J. Conway, Thomas N. Williams, Kirk A. Rockett, Dominic P. Kwiatkowski</p> <p>Nature (2021) doi: <a href="https://doi.org/10.1038/s41586-021-04288-3">10.1038/s41586-021-04288-3</a> <strong>bioRxiv link</strong>:: <a href="https://doi.org/10.1101/2021.03.30.437659">doi.org/10.1101/2021.03.30.437659</a><br> <br> The genotype data underlying these summary statistics has also been deposited on Zenodo<br> (<a href="https://zenodo.org/record/4973477">doi:10.5281/zenodo.4973477</a>). The <a href="https://www.well.ox.ac.uk/~gav/hptest)">HPTEST software</a> used to generate these results has also been deposited (<a href="https://doi.org/10.5281/zenodo.5685580">doi:10.5281/zenodo.5685580</a>). Please see the <a href="https://www.malariagen.net/resource/32">MalariaGEN website</a> for a full list of datasets which have been released with this manuscript.</p> <p><strong>Data contents.</strong></p> <p>The dataset consists of a single <a href="http://sqlite.org">sqlite database file</a> containing the results, and an accompanying README file in markdown and html format. Please see the README file for full details of the data contents.</p> <p> </p>
Tutorial DAPCy: the Plasmodium falciparum (Pf7) genotype dataset from MalariaGEN
Open the record for dataset details and reuse information.
pH-dependence of the Plasmodium falciparum chloroquine resistance transporter is linked to the transport cycle
<p>This file contains the original data underpinning the following study:</p> <p>The chloroquine resistance transporter, PfCRT, of the human malaria parasite <em>Plasmodium falciparum </em>displays a strong pH-sensitivity in the weakly acidic range. Consequently, PfCRT operates only at 60% of its maximal drug transport activity at the pH of 5.2 of the digestive vacuole, a proteolytic organelle from which PfCRT expels drugs that interfere with heme detoxification. Despite structural information, the molecular mechanism by which PfCRT senses pH changes has remained unclear. Here we show, by alanine-scanning mutagenesis and functional transport studies, that E207 plays a critical role in pH sensing. The E207A mutant displayed a pH-insensitive transport activity, while preserving drug substrate specificity. Replacement of E207 by Asp or His, but not by any other proteinogenic amino acid, reconstituted pH sensitivity. Molecular dynamics simulations and kinetics analyses suggest an allosteric binding model in which PfCRT can simultaneously accept both protons and chloroquine in a partial non-competitive manner, with increasing proton concentrations reducing the drug transport activity. Molecular dynamics simulations of the open-to-vacuole, the occluded and the open-to-cytosol conformation of PfCRT revealed a drastic relocation of E207 from a peripheral to an engaged location during the transport cycle, resulting in E207 forming a salt bridge with residue K80. We propose that the ionized carboxyl group of E207 acts as a hydrogen acceptor for interactions accelerating progression through the transport cycle and that the pH sensing is a by-product of this function.</p>
Study to Investigate the Clinical and Parasiticidal Activity and Pharmacokinetics of Different Doses of Artefenomel and Ferroquine in Patients With Uncomplicated Plasmodium Falciparum Malaria
ClinicalTrials.gov study NCT03660839. IPD Sharing: YES. Countries: 5. Publications: 1.
To Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of a Single Dose Regimen of Ferroquine and Artefenomel in Adults and Children With Uncomplicated Plasmodium Falciparum Malaria
ClinicalTrials.gov study NCT02497612. IPD Sharing: YES. Countries: 7. Publications: 1.
Safety of KAE609 in Adults With Uncomplicated Plasmodium Falciparum Malaria.
ClinicalTrials.gov study NCT03334747. IPD Sharing: YES. Countries: 5. Publications: 2.
Efficacy, Safety and Tolerability of KAF156 in Combination With Lumefantrine Solid Dispersion Formulation (LUM-SDF) in Pediatric Population With Uncomplicated Plasmodium Falciparum Malaria
ClinicalTrials.gov study NCT04546633. IPD Sharing: YES. Countries: 5. Publications: 1.
Efficacy and Safety of KAF156 in Combination With LUM-SDF in Adults and Children With Uncomplicated Plasmodium Falciparum Malaria
ClinicalTrials.gov study NCT03167242. IPD Sharing: YES. Countries: 9. Publications: 2.
Pharmacokinetics, Safety, Tolerability and Efficacy of a New Artemether-lumefantrine Dispersible Tablet in Infants and Neonates <5 kg Body Weight With Acute Uncomplicated Plasmodium Falciparum Malaria
ClinicalTrials.gov study NCT04300309. IPD Sharing: YES. Countries: 2. Publications: 1.
Convergent evolution of artemisinin and chloroquine resistance in Ethiopian Plasmodium falciparum parasites
Open the record for dataset details and reuse information.
pH-dependence of the Plasmodium falciparum chloroquine resistance transporter is linked to the transport cycle
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Heterogeneous mosquito exposure increases Plasmodium vivax and Plasmodium falciparum coinfections: a modelling study
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Data from: Age influences the thermal suitability of Plasmodium falciparum transmission in the Asian malaria vector Anopheles stephensi
<p><span>Models predicting disease transmission are vital tools for long-term planning of malaria reduction efforts, particularly for mitigating impacts of climate change. We compared temperature-dependent malaria transmission models when mosquito life history traits were estimated from a truncated portion of the lifespan (a common practice) to traits measured across the full lifespan. We conducted an experiment on adult female <i>Anopheles stephensi, </i>the Asian urban malaria mosquito, to generate daily per capita values for mortality, egg production, and biting rate at six constant temperatures. Both temperature and age significantly affected trait values. Further, we found quantitative and qualitative differences between temperature-trait relationships estimated from truncated data versus observed lifetime values. Incorporating these temperature-trait relationships into an expression governing the thermal suitability of transmission, relative <i>R<sub>0</sub></i></span><span>(</span><i><span>T</span></i><span>)<i>,</i> resulted in minor differences in the breadth of suitable temperatures for <i>Plasmodium falciparum</i> transmission between the two models constructed from only <i>An. stephensi</i> trait data. However, we found a substantial increase in thermal niche breadth compared to a previously published model consisting of trait data from multiple <i>Anopheles</i> mosquito species. Overall, this work highlights the importance of considering how mosquito trait values vary with mosquito age and mosquito species when generating temperature-based suitability predictions of transmission.</span></p>
Monitoring Plasmodium falciparum and Plasmodium vivax using microsatellite markers indicates limited changes in population structure after substantial transmission decline in Papua New Guinea
Monitoring the genetic structure of pathogen populations may be an economical and sensitive approach to quantify the impact of control on transmission dynamics, highlighting the need for a better understanding of changes in population genetic parameters as transmission declines. Here we describe the first population genetic analysis of the major human malaria parasites, <i>Plasmodium falciparum</i> (Pf) and <i>Plasmodium vivax</i> (Pv) populations following nationwide distribution of long-lasting insecticide treated nets (LLIN) in Papua New Guinea (PNG). Parasite isolates from pre- (2005-6) and post-LLIN (2010-2014) were genotyped using microsatellite markers. Despite parasite prevalence declining substantially (East Sepik: Pf=54.9-8.5%, Pv=35.7-5.6%, Madang: Pf=38.0-9.0%, Pv: 31.8-19.7%), genetically diverse and intermixing parasite populations remained. Pf diversity declined modestly post-LLIN relative to pre-LLIN (East Sepik: Rs = 7.1-6.4, He = 0.77-0.71; Madang: Rs= 8.2-6.1, He = 0.79-0.71). Unexpectedly, population structure present in pre-LLIN populations was lost post-LLIN, suggesting that more frequent human movement between provinces may have contributed to higher gene flow. Pv prevalence initially declined but increased again in one province, yet diversity remained high throughout the study period (East Sepik: Rs=11.4-9.3, He=0.83-0.80; Madang: Rs=12.2-14.5, He=0.85-0.88). Although genetic differentiation values increased between provinces over time, no significant population structure was observed at any time point. For both species, a decline in multiple infections and increasing clonal transmission and significant multilocus linkage disequilibrium (mLD) post-LLIN was a positive indicator of impact on the parasite population using microsatellite markers. These parameters may be useful adjuncts to traditional epidemiological tools in the early stages of transmission reduction.
Data from: K-13 Propeller gene polymorphisms isolated between 2014 and 2017 from Cameroonian Plasmodium falciparum malaria patients
The emergence of artemisinin-resistant parasites since the late 2000s at the border of Cambodia and Thailand poses serious threats to malaria control globally, particularly in Africa which bears the highest malaria transmission burden. This study aimed to obtain reliable data on the current state of the kelch13 molecular marker for artemisinin resistance in Plasmodium falciparum in Cameroon. DNA was extracted from the dried blood spots collected from epidemiologically distinct endemic areas in the Center, Littoral and North regions of Cameroon. Nested PCR products from the Kelch13-propeller gene were sequenced and analyzed on an ABI 3730XL automatic sequencer. Of 219 dried blood spots, 175 were sequenced successfully. We identified six K13 mutations in 2.9% (5/175) of samples, including 2 non-synonymous, the V589I allele had been reported in Africa already and one new allele E612K had not been reported yet. These two non-synonymous mutations were uniquely found in parasites from the Littoral region. One sample showed two synonymous mutations within the kelch13 gene. We also observed two infected samples with mixed K13 mutant and K13 wild-type infection. Taken together, our data suggested the circulation of the non-synonymous K13 mutations in Cameroon. Albeit no mutations known to be associated with parasite clearance delays in the study population, there is need for continuous surveillance for earlier detection of resistance as long as ACTs are used and scaled up in the community.
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Allen Brain Atlas
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OpenNeuro
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