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56 results for “severe malaria”
Inter-Chemical Correlation results for the study: HHEARx2016-1432 (Micronutrient deficiencies, environmental exposures and severe malaria: Risk factors for adverse neurodevelopmental outcomes in Ugandan children)
Title: Micronutrient deficiencies, environmental exposures and severe malaria: Risk factors for adverse neurodevelopmental outcomes in Ugandan children <br>Species: Homo sapiens <br>Number of samples: 1256 <br>Number of named analytes: 51 <br>Datasource url: https://hheardatacenter.mssm.edu/PublicFile/ViewPublicFile?projectid=5 <br>
A dataset of human and Plasmodium falciparum genotypes in severe malaria cases from The Gambia and Kenya
<p>This data release contains human and <em>Plasmodium falciparum</em> malaria genotypes from the article:</p> <p><strong>Malaria protection due to sickle haemoglobin depends on parasite genotype</strong></p> <p>Gavin Band, Ellen M. Leffler, Muminatou Jallow, Fatoumatta Sisay-Joof, Carolyne<br> M. Ndila, Alexander W. Macharia, Christina Hubbart, Anna E. Jeffreys, Kate Rowlands, Thuy<br> Nguyen, Sónia Gonçalves, Cristina V. Ariani, Jim Stalker, Richard D. Pearson, Roberto<br> Amato, Eleanor Drury, Giorgio Sirugo, Umberto d'Alessandro, Kalifa A. Bojang, Kevin<br> Marsh, Norbert Peshu, Joseph W. Saelens, Mahamadou Diakité, Steve M. Taylor10, David J.<br> Conway, Thomas N. Williams, Kirk A. Rockett, Dominic P. Kwiatkowski</p> <p>Nature (2021) doi: <a href="https://doi.org/10.1038/s41586-021-04288-3">10.1038/s41586-021-04288-3</a> <strong>bioRxiv link</strong>: <a href="http://doi.org/10.1101/2021.03.30.437659">doi.org/10.1101/2021.03.30.437659</a>.</p> <p>The release contains genotypes from human and <em>Plasmodium falciparum</em> genetic variants, genotyped using blood samples from 4,171 children ascertained with severe symptoms of malaria at the Royal Victoria Teaching Hospital (now the Edward Francis Small Teaching Hospital), The Gambia, and from the Kilifi District Hospital (now Kilifi County Hospital), Kenya in the period 1995-2009.</p> <p>An accompanying set of association test summary statistics has also been released on Zenodo (doi: <a href="https://doi.org/10.5281/zenodo.5722497">10.5281/zenodo.5722497</a>). Please see <a href="http://www.malariagen.net/resource/32">www.malariagen.net/resource/32</a> for full details of other resources associated with the above manuscript.</p> <p> </p>
Dataset: Health worker compliance with severe malaria treatment guidelines in the context of implementing pre-referral rectal artesunate in the Democratic Republic of the Congo, Nigeria and Uganda: an operational study
<p>Dataset underlying the publication "<strong>Health worker compliance with severe malaria treatment guidelines in the context of implementing pre-referral rectal artesunate in the Democratic Republic of the Congo, Nigeria and Uganda: an operational study</strong>" (Plos Medicine)</p> <p>Data originating from the Community Access to Rectal Artesunate for Malaria (CARAMAL) Project, 2018-2021.</p> <p>Analysis of health workers' compliance with the treatment guidelines for severe malaria in the context of rolling out pre-referral rectal artesunate (RAS) in the Democratic Republic of the Congo, Nigeria and Uganda. Details provided in the publication.</p>
Summary statistics for association tests between human and Plasmodium falciparum genetic variants in 3,346 severe malaria cases from The Gambia and Kenya
<p>This dataset contains summary statistics for association tests between human and<br> <em>Plasmodium falciparum</em> malaria parasite genetic variants, using data from 3,346 severe malaria cases from The Gambia and Kenya. These results underlie the analysis described in our paper:</p> <p><strong>"Malaria protection due to sickle haemoglobin depends on parasite genotype"</strong></p> <p>Gavin Band, Ellen M. Leffler, Muminatou Jallow, Fatoumatta Sisay-Joof, Carolyne M. Ndila, Alexander W. Macharia, Christina Hubbart, Anna E. Jeffreys, Kate Rowlands, Thuy Nguyen, Sónia M. Gonçalves, Cristina V. Ariani, Jim Stalker, Richard D. Pearson, Roberto Amato, Eleanor Drury, Giorgio Sirugo, Umberto d'Alessandro, Kalifa A. Bojang, Kevin Marsh, Norbert Peshu, Joseph W. Saelens, Mahamadou Diakité, Steve M. Taylor, David J. Conway, Thomas N. Williams, Kirk A. Rockett, Dominic P. Kwiatkowski</p> <p>Nature (2021) doi: <a href="https://doi.org/10.1038/s41586-021-04288-3">10.1038/s41586-021-04288-3</a> <strong>bioRxiv link</strong>:: <a href="https://doi.org/10.1101/2021.03.30.437659">doi.org/10.1101/2021.03.30.437659</a><br> <br> The genotype data underlying these summary statistics has also been deposited on Zenodo<br> (<a href="https://zenodo.org/record/4973477">doi:10.5281/zenodo.4973477</a>). The <a href="https://www.well.ox.ac.uk/~gav/hptest)">HPTEST software</a> used to generate these results has also been deposited (<a href="https://doi.org/10.5281/zenodo.5685580">doi:10.5281/zenodo.5685580</a>). Please see the <a href="https://www.malariagen.net/resource/32">MalariaGEN website</a> for a full list of datasets which have been released with this manuscript.</p> <p><strong>Data contents.</strong></p> <p>The dataset consists of a single <a href="http://sqlite.org">sqlite database file</a> containing the results, and an accompanying README file in markdown and html format. Please see the README file for full details of the data contents.</p> <p> </p>
Dataset for Starting at the community: Treatment seeking pathways of children with suspected severe malaria in Uganda
<p>Dataset for the publication <strong>"Starting at the community: Treatment seeking pathways of children with suspected severe malaria in Uganda".</strong></p> <p>Data from the Community Access to Rectal Artesunate for Malaria (CARAMAL) Project, 2018-2021</p> <p>Descriptive analysis of treatment-seeking pathways of and antimalarial treatment provision for children under 5 years with suspected severe malaria in three districts of Northern Uganda. All children first sought treatment from a community health worker before being referred to a higher-level facility.</p>
Dataset for: Effectiveness of rectal artesunate as pre-referral treatment for severe malaria in children under 5 years of age: a multi-country observational study
<p>Dataset underlying the publication "<strong>Effectiveness of rectal artesunate as pre-referral treatment for severe malaria in children under 5 years of age: a multi-country observational study</strong>" (BMC Medicine)</p> <p>Data originating from the Community Access to Rectal Artesunate for Malaria (CARAMAL) Project, 2018-2021.</p> <p>Analysis of the health effect of the roll-out and administration of pre-referral rectal artesunate (RAS) in the Democratic Republic of the Congo, Nigeria and Uganda. Details provided in the publication.</p> <p> </p>
Detection of novel P. falciparum haplotypes under treatment pressure in pediatric severe malaria
<p>The dataset contains Amplicon sequencing data targeting three <em>Plasmodium falciparum</em> polymorphic markers—<em>cpmp</em>, <em>cpp</em>, and <em>ama1</em>. These markers were analyzed to investigate the association between parasite clearance rate and the multiplicity of infection in Beninese children undergoing treatment for severe malaria.</p>
The effect of parasite dose on disease severity in the rodent malaria Plasmodium chabaudi
<p>Experiments were designed to look at the relationship between infective dose and disease severity using two clones of <em>Plasmodium chabaudi</em> that differ in virulence. We asked whether there were dose–severity relationships, whether clone differences in virulence were maintained over a range of doses, and whether disease severity could be accounted for by parasite dynamics. Groups of mice were infected with parasite doses differing by an order of magnitude, ranging from 100 to 1×10<sup><sup>8</sup></sup> parasites. Infective dose affected the probability of death, but only with the more virulent clone. Dose also affected morbidity. For both clones, higher doses induced greater anaemia. Larger doses caused greater weight loss, but only for infections with the more virulent clone. Here, for a given dose, mice lost a fixed amount of weight, irrespective of their initial weight. Larger doses induced earlier mortality and morbidity than did lower dose treatments. Finally, dose affected parasite dynamics, with earlier and higher peak parasite densities in larger dose infections. All these effects were small relative to clone differences in disease severity, which were apparent across the range of doses. Dose effects were manifested through the timing and/or magnitude of peak parasite densities, broadly supporting the idea that dose affects disease severity by altering the time the host has to control parasite densities and ameliorate the effects of parasites. We discuss the possible efficacy of intervention strategies aimed at reducing human disease severity by reducing infective parasite dose.</p>
Superiority of ArTiMist Versus Quinine in Children With Severe Malaria
ClinicalTrials.gov study NCT01258049. IPD Sharing: Not stated. Countries: 3. Publications: 1.
The effect of parasite dose on disease severity in the rodent malaria Plasmodium chabaudi
Open the record for dataset details and reuse information.
Clinical and laboratory variables of severe malaria extracted from included studies
<p>Data extracted from included studies per prognostic indicator needed to construct two-by-two tables made up of outcome (survival/death) and presence/absence of an indicator.</p>
Severe and Cerebral Malaria Investigated Through Host Metabolomics
ClinicalTrials.gov study NCT02451904. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Preventing Mental Health Problems After Childhood Severe Malaria
ClinicalTrials.gov study NCT03432039. IPD Sharing: NO. Countries: 1. Publications: 3.
Delivery of Malaria Chemoprevention in the Post-discharge Management of Children With Severe Anaemia in Malawi
ClinicalTrials.gov study NCT02721420. IPD Sharing: NO. Countries: 1. Publications: 4.
Paracetamol Effect on Oxidative Stress and Renal Function in Severe Malaria
ClinicalTrials.gov study NCT01641289. IPD Sharing: Not stated. Countries: 1. Publications: 1.
PALUREA: Severe Imported Malaria in Adults
ClinicalTrials.gov study NCT00372684. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety and Preliminary Efficacy of L-arginine in Severe Falciparum Malaria
ClinicalTrials.gov study NCT00616304. IPD Sharing: Not stated. Countries: 1. Publications: 2.
The Effect of Paracetamol in the Treatment of Non-severe Malaria in Children in Guinea-Bissau
ClinicalTrials.gov study NCT00137566. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Severe Malaria and Anti-malarial Drug Resistance in Cambodia
ClinicalTrials.gov study NCT00341003. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Evaluation of Volume Status, Haemodynamics and Microcirculatory Flow in Adult Patients With Severe Falciparum Malaria
ClinicalTrials.gov study NCT00692627. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.