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NIH funding notice PA-19-117

Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Not Allowed)

Closed on May 12, 2020.

Posted
December 20, 2018
Close date
May 12, 2020
Activity codes
K08
Institutes taking part
NCI, NEI, NHLBI, NHGRI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDCD, NIDCR, NIDDK, NIDA, NIEHS, NIGMS, NIMH, NINDS, NCCIH, NIMHD

Read the notice on Grants.gov · NIH Guide page

The notices it replaced

  1. Reissues: PA-18-373 Mentored Clinical Scientist Research Career Development Award (Parent K08 - No Independent Clinical Trials)
  2. 2 steps back: PA-16-191 Mentored Clinical Scientist Research Career Development Award (Parent K08)
  3. 3 steps back: PA-14-046 Mentored Clinical Scientist Research Career Development Award (Parent K08)
  4. 4 steps back: PA-11-193 Mentored Clinical Scientist Research Career Development Award (Parent K08)
  5. 5 steps back: PA-10-059 Mentored Clinical Scientist Research Career Development Award (Parent K08)
  6. 6 steps back: PA-09-042 Mentored Clinical Scientist Research Career Development Award (K08)
  7. 7 steps back: PA-06-512 Mentored Clinical Scientist Research Career Development Award (K08)
  8. 8 steps back: PA-00-003

Replaced by PA-20-203.

Who won it before

1,337 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $230,757,070 in first-year total cost, median $170,747.

Most frequent study sections

  1. Career Development Study Section (J)[NCI-J]199
  2. NST-1 Study Section[NST-1]113
  3. NHLBI Mentored Clinical and Basic Science Study Section[MCBS (MA)]105
  4. Digestive Diseases and Nutrition C Study Section[DDK-C]88
  5. NHLBI Mentored Clinical and Basic Science Study Section[MCBS (OA)]88

Most frequent institutions

  1. UNIVERSITY OF CALIFORNIA, SAN FRANCISCO73
  2. MASSACHUSETTS GENERAL HOSPITAL61
  3. UNIVERSITY OF MICHIGAN AT ANN ARBOR61
  4. STANFORD UNIVERSITY58
  5. UNIVERSITY OF PENNSYLVANIA56
Competing awards under PA-19-117 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2021WT1 as an oncogene and therapeutic target in anaplastic Wilms tumor1K08CA255569-01MURPHY, ANDREW JST. JUDE CHILDREN'S RESEARCH HOSPITAL, TN$265,113NCI
2021Supporting Personalized Decision Making for Breast Cancer Screening among Older Women1K08CA248725-01A1RICHMAN, ILANAYALE UNIVERSITY, CT$257,051NCI
2021Mechanism of intravitreal VEGF-A165a and topical calcitriol for the treatment of retinopathy of prematurity1K08EY032203-01MEZU-NDUBUISI, OLACHI JOYUNIVERSITY OF WISCONSIN-MADISON, WI$244,346ZEY1
2021Elucidating the role and mechanisms by which collagenase producing intestinal bacteria promote colorectal cancer recurrence and metastasis following surgery.1K08CA248957-01A1SHOGAN, BENJAMINUNIVERSITY OF CHICAGO, IL$241,703NCI
2021Advancing WRN as a synthetic lethal target for microsatellite unstable Cancers1K08CA256173-01CHAN, EDMONDDANA-FARBER CANCER INST, MA$237,994NCI
2021Defining the genetic landscape of nanophthalmos and the role of MYRF1K08EY032098-01PRASOV, LEVUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$230,148ZEY1
2021The ontogeny and function of CD8 T cells in lung cancer1K08CA256044-01SCHENKEL, JASON M.BRIGHAM AND WOMEN'S HOSPITAL, MA$217,653NCI
2021Mural stem cells in normal development and germinal matrix hemorrhage in the preterm human brain1K08NS116161-01A1CROUCH, ELIZABETH ERINUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$202,878NST
2021Intrinsic modifiers of beta-lactam resistance in nosocomial Enterobacterales1K08AI155830-01LAZARUS, JACOB ERICMASSACHUSETTS GENERAL HOSPITAL, MA$199,348MID
2021Defining mechanisms of Zika-virus associated microcephaly: cell population dynamics and gene expression in infected human cerebral organoids and neural progenitor cells1K08AI156126-01OCWIEJA, KAREN EMILYBOSTON CHILDREN'S HOSPITAL, MA$194,940MID
2021Elucidating the Spatiotemporal Regulation of a Long Non-Coding RNA Required for Neurodevelopment1K08NS119567-01WONTAKAL, SANDEEP NAGARAJCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$193,536NST
2021Elucidating the role of microglia and neurotrophin receptor p75 on neuronal degeneration in frontotemporal dementia1K08NS116166-01A1HARGUS, GUNNARCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$193,536NST
2021Smad8 is a driver of Duchenne muscular dystrophy pathology via myomiR repression1K08NS120812-01LOPEZ, MICHAEL ALONZOUNIVERSITY OF ALABAMA AT BIRMINGHAM, AL$193,056ZNS1
2021Reprogramming the chimeric antigen receptor T cell epigenome to augment anti-tumor activity1K08CA255932-01JAN, MAXMASSACHUSETTS GENERAL HOSPITAL, MA$192,138NCI
2021Cannabis Toxicology in Relation to Neurocognitive Outcomes in Adolescents1K08DA050779-01A1WADE, NATASHA EUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$191,358CP
2021Decision-Making Factors for Therapeutic Opioid Use after Emergency Care1K08DA049948-01A1PUNCHES, BRITTANY EUNIVERSITY OF CINCINNATI, OH$191,014HSOD
2021Restriction of psoriatic skin and joint disease by A201K08AR077065-01A1RAZANI, BAHRAMUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$189,000AMS
2021Investigation of the impact of viral factors on the severity of chronic HSV-2 infection1K08AI151092-01A1CASTO, AMANDAUNIVERSITY OF WASHINGTON, WA$187,726MID
2021Amygdala modulation of volitional versus automatic breathing1K08NS112573-01A1DLOUHY, BRIAN JUNIVERSITY OF IOWA, IA$186,127NST
2021Neural Mechanisms Underlying the Auditory Phenotype of Mild Traumatic Brain Injury1K08DC019128-01KOZIN, ELLIOTTMASSACHUSETTS EYE AND EAR INFIRMARY, MA$186,095CDRC
2021Functions for novel IL-15-responsive macrophages in the uterus during pregnancy1K08AI151265-01A1GORDON, SCOTT MICHAELCHILDREN'S HOSP OF PHILADELPHIA, PA$185,328AITC
2021Functional epigenomics of transgenic cellular immunotherapies for cancer1K08CA241088-01A1NOWICKI, THEODORE SCOTTUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$181,886NCI
2021Regulatory control of inflammatory cytokine production by a linear ubiquitin-binding protein1K08AI155818-01GITLIN, ALEXANDERSTANFORD UNIVERSITY, CA$180,769AITC
2021Mechanisms of HIF1 alpha mediated dysregulated skeletal muscle proteostasis in alcoholic liver disease1K08AA028794-01WELCH, NICOLECLEVELAND CLINIC LERNER COM-CWRU, OH$179,129AA
2021Exploring neural crest stem cell-derived enteric neurogenesis in post-embryonic development and regeneration1K08DK123387-01A1EL-NACHEF, WAELUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$175,392DDK
2021Translating Human Height Genetics to Skeletal Biology by Functional Genomics of the Growth Plate1K08AR078370-01RENTHAL, NORA EDWARDSBOSTON CHILDREN'S HOSPITAL, MA$173,340AMS
2021The Role of the Tau in Homeostatic Scaling and Mechanisms of Alzheimer's Disease1K08AG070053-01MORRIS, MEAGHAN O'MALLEYJOHNS HOPKINS UNIVERSITY, MD$171,180NIA
2021Role of Tissue Resident Macrophages in Conventional Outflow Function1K08EY032202-01LIU, KATY CDUKE UNIVERSITY, NC$170,878ZEY1
2021Telemedicine Utilization and Impacts on Access Among Rural Medicare Beneficiaries1K08AG065444-01A1CHAIYACHATI, KRISDA HUNIVERSITY OF PENNSYLVANIA, PA$169,884NIA
2021Solitary Chemosensory Cell Regulation of Airway Inflammation and Repair1K08HL151911-01A1KOHANSKI, MICHAEL AARONUNIVERSITY OF PENNSYLVANIA, PA$169,884MCBS
2021Myeloid TLR4 epigenetic regulation and signaling in accelerating venous thrombus resolution1K08HL155408-01OBI, ANDREA TARAUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$169,472MCBS
2021Discovery and pathogenic characterization of novel monogenic causes of bladder dysfunction.1K08DK127011-01MANN, NINABOSTON CHILDREN'S HOSPITAL, MA$169,440DDK
2021Development of an artificial intelligence-driven, imaging-based platform for pretreatment identification of extranodal extension in head and neck cancer1K08DE030216-01KANN, BENJAMIN HARRISBRIGHAM AND WOMEN'S HOSPITAL, MA$168,240DSR
2021Using Induced Pluripotent Stem Cells to Characterize Cystic Fibrosis1K08HL155892-01WANG, RUOBINGBOSTON CHILDREN'S HOSPITAL, MA$167,940MCBS
2021The effects of Mkrn3 on delayed puberty1K08HD100595-01A1ROBERTS, STEPHANIE ANNEBOSTON CHILDREN'S HOSPITAL, MA$167,940CHHD
2021Improving Surgical Risk Prediction and Decision Making among Patients with Cirrhosis1K08DK124577-01A1MAHMUD, NADIMUNIVERSITY OF PENNSYLVANIA, PA$167,856DDK
2021Role of SCGN in Intestinal Immune Homeostasis1K08DK127197-01SIFUENTES-DOMINGUEZ, LUISUT SOUTHWESTERN MEDICAL CENTER, TX$167,400DDK
2021Muscle ­bone interaction and its role in diabetic bone disease of Type I diabetes1K08DK124566-01A1KALAITZOGLOU, EVANGELIAUNIVERSITY OF KENTUCKY, KY$166,018DDK
2021Interaction of the Microtubule Cytoskeleton and Perilipin-2 Regulates Hepatic Lipid Droplets - a Potential Therapeutic Target for Fatty Liver Disease1K08DK123381-01A1JOPHLIN, LORETTA L.UNIVERSITY OF LOUISVILLE, KY$165,780DDK
2021The Role of Follistatin Like Protein 1 in the cardiac inflammation of Kawasaki Disease1K08HL155033-01GORELIK, MARKCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$165,456MCBS
2021Regulators and interactomes of CaV1.2 in health and disease1K08HL151969-01A1KUSHNER, JARED SCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$165,456MCBS
2021Mechanisms and Modulation of Opsin 3 Mediated Airway Smooth Muscle Relaxation1K08HL150314-01A1YIM, PETER DCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$165,376MCBS
2021Macrophage Regulation of Immune Pathogenesis of Biliary Atresia1K08DK121937-01A1TAYLOR, SARAH ANNLURIE CHILDREN'S HOSPITAL OF CHICAGO, IL$164,475DDK
2021TGF-Beta Regulates CFTR-Mediated Airway Smooth Muscle Dysfunction1K08HL151762-01A1KRAMER, ELIZABETH LCINCINNATI CHILDRENS HOSP MED CTR, OH$164,160MCBS
2021Preventing the Calcium Channel Blocker – Lower Extremity Edema – Loop Diuretic Prescribing Cascade in Older Adults1K08AG066854-01A1VOURI, SCOTT MARTINUNIVERSITY OF FLORIDA, FL$163,944NIA
2021Immunization against Pf bacteriophage in Pseudomonas aeruginosa infection1K08AI151089-01A1DE VRIES, CHRISTIAAN ROBERTSTANFORD UNIVERSITY, CA$161,792MID
2021Drug-drug interactions and kidney disease in hospitalized patients1K08DK124658-01A1MIANO, TODD ANTHONYUNIVERSITY OF PENNSYLVANIA, PA$158,896DDK
2021The Retroelement LINE1 and the DNA Sensor IF16 in Sjogren's Syndrome1K08AR077100-01A1ANTIOCHOS, BRENDANJOHNS HOPKINS UNIVERSITY, MD$158,755AMS
2021The Role of the GATA2 Interactome in Erythropoiesis1K08DK127244-01MATSON, DANIEL R.UNIVERSITY OF WISCONSIN-MADISON, WI$158,359DDK
2021Regulation of portal hypertension through neutrophil-platelet interactions in liver sinusoids1K08DK127064-01HILSCHER, MOIRA BMAYO CLINIC ROCHESTER, MN$157,356DDK
2021Biomarking the Sclerostin Antibody Effects on Osseointegration in an Osteogenesis Imperfecta Model1K08DE030116-01SUNG HSIEH, HSIAO HSINUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$150,058DSR
2021Targeting Pannexin 1 as a Novel Mechanism for Arrhythmia and Fibrosis in Duchenne Cardiomyopathy1K08HL155852-01RAUCCI, FRANK JVIRGINIA COMMONWEALTH UNIVERSITY, VA$148,714MCBS
2021Understanding and improving responses to adaptive NK cell therapy for leukemia and multiple myeloma1K08CA255426-01MERINO, AIMEEUNIVERSITY OF MINNESOTA, MN$148,665NCI
2021To define the novel roles of endochondrogenesis in mandible formation and trauma repair1K08DE028593-01A1JING, YANTEXAS A&M UNIVERSITY HEALTH SCIENCE CTR, TX$117,860DSR
2020Triggering Innate Immunity in Tumor Cells to Overcome Resistance to Immunotherapy1K08CA245112-01ISHIZUKA, JEFFREY J.YALE UNIVERSITY, CT$279,077NCI
2020Resistance Mechanisms to Combined Trametinib and 4-aminoquinolones in the Inhibition of Pancreatic Cancer1K08CA230151-01A1KINSEY, CONANUNIVERSITY OF UTAH, UT$272,944NCI
2020Targeting EP300, a selective dependency in neuroblastoma1K08CA245251-01A1DURBIN, ADAM DAVIDST. JUDE CHILDREN'S RESEARCH HOSPITAL, TN$271,074NCI
2020Biomarker Identification to Increase Adjunctive Cryoablation and Checkpoint-Inhibitor Immunotherapy Response1K08CA245257-01A1WEHRENBERG-KLEE, ERICMASSACHUSETTS GENERAL HOSPITAL, MA$269,684NCI
2020Enhancing the therapeutic effect of receptor radionuclide therapy in neuroendocrine tumors by somatostatin receptor upregulation1K08CA249047-01HEIDARI, PEDRAMMASSACHUSETTS GENERAL HOSPITAL, MA$269,667NCI
2020Defining mechanisms of thalidomide analog resistance1K08CA252174-01SPERLING, ADAMDANA-FARBER CANCER INST, MA$266,668NCI
2020Targeting SOCS1 and RASA2 to Engineer More Potent Adoptive T Cell Therapies for Cancer Treatment.1K08CA252605-01CARNEVALE, JULIA CUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$263,267NCI
2020Local blockade of IL10R on innate immune cells to mediate both innate and adaptive anti-tumor immunity1K08CA248964-01KHALIL, DANNYSLOAN-KETTERING INST CAN RESEARCH, NY$263,034NCI
2020Investigating altered T-cell metabolism during chronic antigen encounter1K08CA237731-01A1VARDHANA, SANTOSHASLOAN-KETTERING INST CAN RESEARCH, NY$263,034NCI
2020Multi-antigen-specific CAR T cells to treat acute myeloid leukemia1K08CA252157-01JAMES, SCOTT ESLOAN-KETTERING INST CAN RESEARCH, NY$263,034NCI
2020Investigating a hierarchical model for PI3K activation and inhibition in breast cancer by double PIK3CA mutations in cis1K08CA245192-01A1VASAN, NEILSLOAN-KETTERING INST CAN RESEARCH, NY$263,034NCI
2020Personalized preclinical models in pancreas cancer: a tractable approach to precision medicine1K08CA248710-01BURKHART, RICHARD ANDREWJOHNS HOPKINS UNIVERSITY, MD$262,723NCI
2020Dissecting mechanisms of resistance underlying CD47-SIRPα inhibition in T-cell lymphomas1K08CA230498-01A1JAIN, SALVIABETH ISRAEL DEACONESS MEDICAL CENTER, MA$262,116NCI
2020Improved early prognostic algorithm for hepatocellulcar carcinoma1K08CA237624-01A1KIM, AMY KJOHNS HOPKINS UNIVERSITY, MD$261,880NCI
2020Exploring the combinatorial efficacy between chemotherapy and T cell checkpoint inhibition and the role of cellular senescence1K08CA245206-01BOTT, MATTHEW JSLOAN-KETTERING INST CAN RESEARCH, NY$260,099NCI
2020Decoupling Bidirectional EphB/ephrinB2 in Multiple Myeloma1K08CA245483-01SASINE, JOSHUA PUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$257,099NCI
2020CHARACTERIZING AGGRESSIVE GLIOMA COPY NUMBER SUBTYPES1K08CA245037-01A1CIMINO, PATRICK J.UNIVERSITY OF WASHINGTON, WA$256,230NCI
2020Targeting molecular vulnerabilities of ovarian cancer1K08CA241093-01A1HILL, SARAH JAMESDANA-FARBER CANCER INST, MA$253,377NCI
2020Cost Effectiveness of Germline Genetic Testing in Pancreatic Cancer1K08CA248473-01PETERS, MARY LINTON BBETH ISRAEL DEACONESS MEDICAL CENTER, MA$251,129NCI
2020Hepatic metabolic reprogramming drives pancreatic cancer cachexia1K08CA245188-01A1GROSSBERG, AARONOREGON HEALTH & SCIENCE UNIVERSITY, OR$247,925NCI
2020Dissecting and overcoming cross-resistance to DNA damaging agents in SCLC1K08CA237832-01A1DRAPKIN, BENJAMIN JUT SOUTHWESTERN MEDICAL CENTER, TX$246,878NCI
2020Mechanistic Determination of KRAS Lung Cancer Regression upon CRAF Suppression1K08CA249744-01WANG, VICTORIAUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$246,690NCI
2020Dissecting the Roles and Requirements for RBM39 in Acute Myeloid Leukemia and Normal Hematopoiesis1K08CA245242-01LU, SYDNEY XSLOAN-KETTERING INST CAN RESEARCH, NY$241,634NCI
2020Mechanisms of Neuroregulation of Corneal Angiogenesis1K08EY031340-01YIN, JIAMASSACHUSETTS EYE AND EAR INFIRMARY, MA$238,682ZEY1
2020The Fibrosis-Immunity Interface in Corneal Transplantation1K08EY031759-01DOHLMAN, THOMASMASSACHUSETTS EYE AND EAR INFIRMARY, MA$238,682ZEY1
2020Defining clinically relevant transcriptional networks in gastrointestinal stromal tumor1K08CA245235-01A1HEMMING, MATTHEWDANA-FARBER CANCER INST, MA$237,583NCI
2020Epigenetic Regulation of Cutaneous Tumorigenesis1K08CA237727-01A1CHEN, DAVIDWASHINGTON UNIVERSITY, MO$235,763NCI
2020Complement in Paclitaxel-induced peripheral neuropathy1K08CA228039-01A1XU, JIJUNCLEVELAND CLINIC LERNER COM-CWRU, OH$234,943NCI
2020Photoreceptor Regeneration in a Murine Model of Leber Congenital Amaurosis1K08EY031754-01UYHAZI, KATHERINE E.UNIVERSITY OF PENNSYLVANIA, PA$233,075ZEY1
2020Glutamine as an alternative fuel source for photoreceptors1K08EY031757-01WUBBEN, THOMAS JOSEPHUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$232,607ZEY1
2020In vivo Application of Electrical Fields Directs Retinal Ganglion Cell Axon Regeneration1K08EY031797-01GOKOFFSKI, KIMBERLY KUNIVERSITY OF SOUTHERN CALIFORNIA, CA$232,607ZEY1
2020The role of Wnt signaling in aggressive thyroid carcinoma1K08CA240901-01A1WEISS, VIVIAN LEEVANDERBILT UNIVERSITY MEDICAL CENTER, TN$229,545NCI
2020Mechanism of Action of Spautin-1, A Novel Degrader of IKZF11K08CA252611-01KODURI, VIDYASAGARDANA-FARBER CANCER INST, MA$228,182NCI
2020Gamma delta T-cell immunotherapy for T-cell acute lymphoblastic leukemia1K08CA248962-01RAIKAR, SUNIL SUDHIREMORY UNIVERSITY, GA$224,496NCI
2020Role of Macrophage Efferocytosis in Ozone-Induced ARDS1K08ES031678-01RADBEL, JARED M.RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL, NJ$221,942ZES1
2020Development and Maintenance of the Human Photoreceptor-Bipolar Cell Synapse.1K08EY030924-01NAGIEL, AARONCHILDREN'S HOSPITAL OF LOS ANGELES, CA$221,206ZEY1
2020The role of beta2-adrenergic receptor and interleukin-6 signaling in macrophage-driven choroidal neovascularization1K08EY030923-01LAVINE, JEREMY ANORTHWESTERN UNIVERSITY AT CHICAGO, IL$220,045ZEY1
2020Elucidating human leukemia and T cell interactions within the tumor microenvironment1K08CA248458-01BACHIREDDY, PAVANDANA-FARBER CANCER INST, MA$217,528NCI
2020Mechanisms and Fetal Origins Underlying Gonadal Germ Cell Tumor1K08CA248704-01PYLE, LOUISE CLARECHILDREN'S HOSP OF PHILADELPHIA, PA$216,847NCI
2020Psychobiological stress vulnerability, executive control, and emotion regulation in children and adolescents with cancer1K08CA237528-01A1COSGROVE, VICTORIA EILEENSTANFORD UNIVERSITY, CA$216,211NCI
2020CRISPR-Cas9 editing in C9orf72 patient derived iPSC1K08NS112330-01A1CLELLAND, CLAIREUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$213,300NST
2020Fc-enhanced CD40 agonist antibodies for immune modulation of the tumor microenvironment1K08CA248966-01KNORR, DAVID A.ROCKEFELLER UNIVERSITY, NY$212,009NCI
2020Functional Consequences of Ubiquitin Depletion During B Lymphocyte Differentiation1K08CA245100-01A1BIANCHI, GIADABRIGHAM AND WOMEN'S HOSPITAL, MA$207,255NCI
2020The Effect of Natural Killer Cell-Based Therapy on the HIV Reservoir1K08AI155232-01KIM, JOCELYN TUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$204,444AIDS
2020A role for glycolipids and unconventional T cell subsets in alpha-gal allergy1K08AI141691-01A1IWEALA, ONYINYE IUNIV OF NORTH CAROLINA CHAPEL HILL, NC$201,471MID
2020Resistin-induced immunosuppression increases susceptibility to infectious lung injury and sepsis during AKI1K08GM138825-01BONAVIA, ANTHONY SPENNSYLVANIA STATE UNIV HERSHEY MED CTR, PA$201,155SAT
2020Characterizing Hepatitis B Transmission in Congolese Children1K08AI148607-01A1THOMPSON, PEYTON JUNIV OF NORTH CAROLINA CHAPEL HILL, NC$200,869MID
2020Developing a zebrafish model of Slc6a1/GAT1 hypofunction and an in vitro assay to identify novel treatments1K08NS118107-01MCGRAW, CHRISTOPHERMASSACHUSETTS GENERAL HOSPITAL, MA$200,763ZNS1
2020Assessment of Tim-4+ Pleural Macrophages as Negative Regulators of Anti-Tumor T Cell Immunity in Lung Cancer1K08CA248723-01CHOW, ANDREWSLOAN-KETTERING INST CAN RESEARCH, NY$200,575NCI
2020Targeting SNO-GAPDH in inflammatory neurodegeneration and mitochondrial injury1K08NS104266-01A1KORNBERG, MICHAEL DJOHNS HOPKINS UNIVERSITY, MD$200,560NST
2020Improving the Precision of Genetic Markers for Psychotic Disorders1K08MH122673-01JONAS, KATHERINE GSTATE UNIVERSITY NEW YORK STONY BROOK, NY$200,535BGES
2020Targeting lipopolysaccharide transport machinery in Pseudomonas aeruginosa1K08AI148581-01ROMANO, KEITH PATRICKBRIGHAM AND WOMEN'S HOSPITAL, MA$199,800MID
2020Mechanisms of disruption of axon transport of autophagic vesicles and lysosomes in C9orf72 ALS1K08NS118123-01BERTH, SARAH HATCHJOHNS HOPKINS UNIVERSITY, MD$199,260NST
2020Modeling genetic risk for epilepsy using IPSC and animal models.1K08NS102526-01A1HABELA, CHRISTAJOHNS HOPKINS UNIVERSITY, MD$199,260NST
2020CRISPR Editing of Primary Human Cells to Model and Correct Primary Immunodeficiency Mutations1K08AI153767-01NGUYEN, DAVID-HUY NHUUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$198,735AITC
2020Role of orexin/hypocretin circuit in anesthesia and analgesia1K08GM138981-01ZHOU, WEIUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$198,047SAT
2020Viral-based Therapeutic Approaches for Reversal of ALS Pathology1K08NS114106-01A1AMADO, DEFNE AUDREYUNIVERSITY OF PENNSYLVANIA, PA$197,964NST
2020Neural pathways of light aversion in a rodent model of migraine1K08NS120595-01KAISER, ERIC ALANUNIVERSITY OF PENNSYLVANIA, PA$197,964ZNS1
2020Defining the disorders of genome organization1K08NS117891-01BOONE, PHILIP MICHAELMASSACHUSETTS GENERAL HOSPITAL, MA$197,518NST
2020Innate Immunity of Zika Virus Infection In Human Neural Progenitors1K08AI150996-01STOKES, CALEBUNIVERSITY OF WASHINGTON, WA$197,100MID
2020Efficient prediction of transmembrane binding sites for anesthetic ligands1K08GM139031-01JOSEPH, THOMAS THENGANPALLILUNIVERSITY OF PENNSYLVANIA, PA$196,884ZRG1
2020Septohippocampal circuit deep brain stimulation for selective RDoC aspects of cognition1K08MH121757-01A1LEE, DARRIN JASONUNIVERSITY OF SOUTHERN CALIFORNIA, CA$196,326NPAS
2020Activity-Dependent Regulation of the Neuronal Epigenome1K08NS112338-01A1KALISH, BRIANHARVARD MEDICAL SCHOOL, MA$196,085NST
2020A longitudinal study of Puerto Rican children and the impact of adverse childhood experiences on the development of cognitive control and risk for substance use disorders1K08DA049913-01A1SUSSMAN, TAMARANEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC, NY$196,020PDRP
2020Early Life Stress Effects on Ventral Hippocampal Microcircuitry during Emotional Behaviors1K08MH122893-01CHANG, WEI-LINEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC, NY$195,479PMDA
2020Mechanisms of non-genetic variation in melanoma1K08CA237856-01A1GARG, SALILMASSACHUSETTS GENERAL HOSPITAL, MA$195,134NCI
2020Determining the role of noradrenergic heterogeneity in innate threat response1K08MH122733-01KAYE, ALFRED PYALE UNIVERSITY, CT$194,940NMB
2020Constitutive Integrin Beta1 Signaling in Lung Cancer1K08CA241351-01A1HAAKE, SCOTTVANDERBILT UNIVERSITY MEDICAL CENTER, TN$194,768NCI
2020Improving targeted therapy in FLT3-mutated AML1K08CA230190-01A1SUNG, PAMELA JEANNETTEUNIVERSITY OF PENNSYLVANIA, PA$194,670NCI
2020Targeting Unique Myeloid Populations to Overcome Anti-PD-1 Resistance Conferred by Specific Cancer Mutations1K08CA248960-01MILLER, BRIAN CHARVARD MEDICAL SCHOOL, MA$194,590NCI
2020B7-H3 in Medulloblastoma: evaluating its expression and function to harness new therapeutic targets1K08NS116651-01MARTIN, ALLISON M.ALBERT EINSTEIN COLLEGE OF MEDICINE, NY$194,184NST
2020Alcohol's Impact on the Gut-Brain Axis in a Mouse Model of Multiple Sclerosis1K08AA027837-01A1MELAMED, ESTHERUNIVERSITY OF TEXAS AT AUSTIN, TX$194,184AA
2020Origin, mechanism, and behavioral context of persistent firing in cortical parvalbumin-positive interneurons1K08NS118114-01THEYEL, BRIANBROWN UNIVERSITY, RI$193,631NST
2020Elucidating the genotypic determinants and phenotypic effects of polymyxin resistance in Klebsiella pneumoniae utilizing CRISPR-Cas91K08AI146284-01A1MCCONVILLE, THOMAS HOWECOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$192,456MID
2020Neural circuits of frustration1K08MH123791-01ESHEL, NEIRSTANFORD UNIVERSITY, CA$192,306NMB
2020The Role of Complement in Cerebrospinal Fluid Shunt Infections1K08NS110923-01A1SKAR, GWENN LUNIVERSITY OF NEBRASKA MEDICAL CENTER, NE$192,132NST
2020Characterizing and targeting subphenotypes of schizophrenia and bipolar disorder via individually imputed tissue and cell-type specific transcriptomes1K08MH122911-01A1VOLOUDAKIS, GEORGIOSICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NY$191,944PMDA
2020Connectome-based neuromarkers of problem cannabis use1K08DA051667-01LICHENSTEIN, SARAH D.YALE UNIVERSITY, CT$191,700NPAS
2020Blood Brain Barrier Disruption during Chimeric Antigen Receptor (CAR) T cell therapy1K08NS118138-01GUST, JULIANESEATTLE CHILDREN'S HOSPITAL, WA$190,620NST
2020Mechanisms of Conductive Presbycusis in Humans1K08DC018575-01REMENSCHNEIDER, AARON KYLEMASSACHUSETTS EYE AND EAR INFIRMARY, MA$190,080CDRC
2020HSV-2 specificity and phenotyping of tissue-based T cells in genital skin biopsies of HSV-2 reactivation1K08AI148588-01FORD, EMILYFRED HUTCHINSON CANCER RESEARCH CENTER, WA$189,272MID
2020Mental Health Provider Networks in Medicaid and Implications for Care Utilization and Health Outcomes1K08MH123624-01ZHU, JANE MINGJIAOREGON HEALTH & SCIENCE UNIVERSITY, OR$189,000ZMH1
2020Local slow wave sleep in repair and recovery after stroke1K08NS109292-01A1LANDSNESS, ERIC CWASHINGTON UNIVERSITY, MO$188,560NST
2020Transplantation of human stem cell-derived neurons for retinal ganglion cell replacement and optic nerve regeneration.1K08EY031801-01JOHNSON, THOMAS VINCENTJOHNS HOPKINS UNIVERSITY, MD$188,442ZEY1
2020Dynamic Analysis of Tumor and Microenvironment in Patients Undergoing Immunotherapy1K08CA252637-01SHREE, TANAYASTANFORD UNIVERSITY, CA$188,385NCI
2020Analyzing the mechanism of exosome mediated DNA Methyltransferase activity during sepsis1K08GM137078-01WISLER, JON ROHIO STATE UNIVERSITY, OH$188,347SAT
2020Therapeutic strategies to improve function of high risk liver grafts1K08AI150990-01BARBAS, ANDREW SERGHIOSDUKE UNIVERSITY, NC$187,704AITC
2020Study of Neisseria gonorrhoeae adaptability to impact microbial survival and host response inside human neutrophil phagosomes1K08AI143799-01A1CHO, CHRISTINEUNIVERSITY OF IOWA, IA$187,488MID
2020Discovering the Immunologic Mechanism of Ascaris-induced Allergic Airway Disease.1K08AI143968-01A1WEATHERHEAD, JILL ELIZABETHBAYLOR COLLEGE OF MEDICINE, TX$187,477AITC
2020Molecular mechanisms of neuronal hyperactivity in Tuberous Sclerosis Complex1K08NS112598-01A1WINDEN, KELLENBOSTON CHILDREN'S HOSPITAL, MA$187,272NST
2020MR1-dependent presentation of Mycobacterium tuberculosis: a unique role for calcium signaling1K08AI153359-01KARAMOOZ, ELHAMOREGON HEALTH & SCIENCE UNIVERSITY, OR$185,760MID
2020Developing a virtual placenta biobank1K08EB030120-01GOLDSTEIN, JEFFERY ANORTHWESTERN UNIVERSITY AT CHICAGO, IL$185,630ZEB1
2020Reversing inflammatory macrophage activation as treatment for neonatal intraventricular hemorrhage and hydrocephalus1K08NS112580-01A1MILLER, BRANDON AUNIVERSITY OF KENTUCKY, KY$185,437NST
2020Defining the impact of zinc on Streptococcus agalactiae biofilm and colonization1K08AI151100-01DOSTER, RYAN SVANDERBILT UNIVERSITY MEDICAL CENTER, TN$185,436MID
2020Epigenetic regulation of esophageal epithelial barrier function in eosinophilic esophagitis1K08AI148456-01RUFFNER, MELANIE ACHILDREN'S HOSP OF PHILADELPHIA, PA$185,328AITC
2020Development and clinical validation of multimodal risk algorithms for predicting future internalizing psychopathology1K08MH121654-01A1ALBAUGH, MATTHEW DUNIVERSITY OF VERMONT & ST AGRIC COLLEGE, VT$184,535CPDD
2020O-glycosylation mechanisms of neurological deficits in congenital disorders of glycosylation1K08NS118119-01EDMONDSON, ANDREW CHARLESCHILDREN'S HOSP OF PHILADELPHIA, PA$180,760NST
2020Transmission of drug-resistant tuberculosis in a South African city with a high prevalence of HIV infection1K08AI150352-01A1BERHANU, REBECCA HAFKINBOSTON UNIVERSITY MEDICAL CAMPUS, MA$178,835AIDS
2020Defining the Role of Lipoprotein(a) and its Oxidized Phospholipids in the Development and Progression of Calcific Aortic Valve Disease Using Unique Transgenic Mouse Models1K08HL150271-01YEANG, CALVINUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$177,552MCBS
2020The Implications of Insurance Benefit Design for Health and Disability Among Low Income Adults with Diabetes.1K08AG068372-01NARAIN, KIMBERLY DUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$177,444NIA
2020Rare Genetic Risk and Gene Networks in Tauopathy1K08AG065519-01A1CHANG, TIMOTHY SUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$177,444NIA
2020Pulmonary vascular glutamine metabolism at the intersection of hemodynamic forces and smooth muscle proliferation in congenital heart disease1K08HL148512-01A1BOEHME, JASONUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$174,798MCBS
2020Overcoming Barriers to Implementing Policies to Reduce Sugar Consumption for Dental Caries Prevention1K08DE028947-01A1KEARNS, CRISTIN ELIZABETHUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$174,798DSR
2020The impact of the aging immune system on periodontal disease1K08DE029505-01A1CLARK, DANIEL R.UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$174,798DSR
2020Lysophosphatidic acid (LPA) is a novel FGF23 regulator in acute kidney injury.1K08DK124568-01SIMIC, PETRAMASSACHUSETTS GENERAL HOSPITAL, MA$174,300ZDK1
2020Mechanisms Determining Dysregulation of the NRF2 Oxidative Stress Response in Head and Neck Squamous Cell Carcinoma1K08DE029241-01A1SCHRANK, TRAVIS P.UNIV OF NORTH CAROLINA CHAPEL HILL, NC$173,993DSR
2020The Role of FXR on the Intestinal Barrier in Acute Injury.1K08DK123377-01GAYER, CHRISTOPHERCHILDREN'S HOSPITAL OF LOS ANGELES, CA$172,356DDK
2020Mechanisms of intestinal epithelial injury in intestinal inflammation1K08DK123202-01KATTAH, MICHAEL GEORGEUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$172,098DDK
2020Modeling the Effects of HIV, Chlamydia, and Gonorrhea in Mother-Infant Pairs in Botswana.1K08HD101342-01DUGDALE, CAITLINMASSACHUSETTS GENERAL HOSPITAL, MA$171,887PPAH
2020Evaluation of variability in care and outcomes for patients with gastrointestinal bleeding1K08DK120902-01A1SIDDIQUE, SHAZIA MEHMOODUNIVERSITY OF PENNSYLVANIA, PA$171,384DDK
2020Novel signaling pathways in the ciliary inversin compartment1K08DK123400-01CZARNECKI, PETER GBRIGHAM AND WOMEN'S HOSPITAL, MA$171,060DDK
2020Molecular genetic mechanisms of renal cell regeneration1K08DK125776-01BEAMISH, JEFFREY ALANUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$171,060DDK
2020Perioperative and long-term risks following nephrectomy in older live kidney donors1K08AG065520-01MUZAALE, ABIMEREKI DJOHNS HOPKINS UNIVERSITY, MD$170,920ZAG1
2020Syndecan-1 regulation of lung fibrosis1K08HL141590-01A1PARIMON, TANYALAKCEDARS-SINAI MEDICAL CENTER, CA$170,748MCBS
2020CD4+ Tissue resident memory T-cells in Crohn's Disease1K08DK123403-01A1BISHU, SHRINIVASUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$170,551DDK
2020Role of Kidney-Draining Lymph Node in Crescentic Glomerulonephritis1K08DK124685-01KASINATH, VIVEKBRIGHAM AND WOMEN'S HOSPITAL, MA$169,994DDK
2020Genetic Determinants of Outcomes in Diverticular Disease1K08DK124687-01MAGUIRE, LILLIAS HOLMESUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$169,981DDK
2020Genome-Wide Somatic Mutation in Alzheimer's Disease Pathogenesis Using Single Neuron Analysis1K08AG065502-01MILLER, MICHAEL BBRIGHAM AND WOMEN'S HOSPITAL, MA$169,560NIA
2020Role of SLIT-ROBO and MT1-MMP in MSC-Mediated Neovascularization.1K08HL146351-01A1SI, MING-SINGUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$169,560MCBS
2020The role of COPD genetic risk factor HHIP on lymphocytic inflammation1K08HL146972-01A1YUN, JEONG HBRIGHAM AND WOMEN'S HOSPITAL, MA$169,560MCBS
2020The Role of Wnt2b in Intestinal Health1K08DK120871-01A1OCONNELL, AMY EBOSTON CHILDREN'S HOSPITAL, MA$169,505DDK
2020Role of Interferon lambda signaling in mucosal homeostasis and infantile-onset inflammatory bowel disease1K08DK122133-01A1OUAHED, JODIEBOSTON CHILDREN'S HOSPITAL, MA$169,505DDK
2020Role of intestinal luminal and epigenetic factors to mediate intestinal metabolic remodeling after gastric bypass surgery1K08DK125878-01STEFATER-RICHARDS, MARGARETBOSTON CHILDREN'S HOSPITAL, MA$169,440DDK
2020Red blood cell modifiers for Plasmodium falciparum growth in sickle cell disease erythrocytes1K08DK123386-01A1ARCHER, NATASHA MARIE BERNADETTEBOSTON CHILDREN'S HOSPITAL, MA$169,440DDK
2020A Systems Biology and Patient Stratification Approach to Improve Outcomes of Patients with Hypoxic Injury in Renal Tubular Cells in Chronic Kidney Diseases1K08DK124449-01SCHAUB, JENNIFER ANNUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$168,955DDK
2020Nuclear lamins and the hepatocyte nuclear envelope in nonalcoholic fatty liver disease1K08DK120948-01A1BRADY, GRAHAM F.UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$168,900DDK
2020Ubiquitination and Endothelial Fibrosis in Early Pulmonary Arterial Hypertension1K08HL151976-01WERTHEIM, BRADLEYBRIGHAM AND WOMEN'S HOSPITAL, MA$168,696MCBS
2020Pathogenic fibroblast differentiation in rheumatoid arthritis1K08AR077037-01WEI, KEVIN SBRIGHAM AND WOMEN'S HOSPITAL, MA$168,669AMS
2020Optical Functional Neuroimaging of Acute and Chronic Hypoxia1K08NS117897-01WHITE, BRIAN RICHARDCHILDREN'S HOSP OF PHILADELPHIA, PA$168,590NST
2020The Utah-Cohort Of Postnatally persistent Antenatal Hydronephrosis (U-COPAH)1K08DK119535-01A1SCHAEFFER, ANTHONY JUNIVERSITY OF UTAH, UT$168,411DDK
2020Regulatory role for an epithelial repair protein, LINGO2, in colitis1K08DK125880-01BELLE, NICOLE MALONEYUNIVERSITY OF PENNSYLVANIA, PA$168,360DDK
2020Determinants of bacterial biofilm formation at the intestinal mucosal interface and their roles in pathogen exclusion1K08DK123316-01A1NI, JOSEPHINEUNIVERSITY OF PENNSYLVANIA, PA$168,360DDK
2020CFTR-Independent Bicarbonate Secretion is a Novel CF Therapeutic Target1K08DK124684-01SELLERS, ZACHARY MICHAELSTANFORD UNIVERSITY, CA$168,036DDK
2020Immune system evasion of stem cell-derived cardiomyocytes1K08HL150335-01A1GARBERN, JESSICABOSTON CHILDREN'S HOSPITAL, MA$168,005MCBS
2020Sepsis phenotypes at risk for infections caused by multidrug resistant Gram-negative bacilli: elucidating the impact of sepsis definition and patient case mix on prediction performance1K08GM140310-01VAZQUEZ GUILLAMET, MARIA CRISTINAWASHINGTON UNIVERSITY, MO$167,942SAT
2020Understanding how alveolar epithelial cell stress drives aberrant repair in interstitial lung disease1K08HL150226-01KATZEN, JEREMY BINDERUNIVERSITY OF PENNSYLVANIA, PA$167,940MCBS
2020Mitochondrial DNA and TLR9 in Pulmonary Fibrosis1K08HL151970-01RYU, CHANGWANYALE UNIVERSITY, CT$167,940MCBS
2020Health Equity and Risk Communication in Pharmacogenomics1K08HG011505-01SAULSBERRY, LORENUNIVERSITY OF CHICAGO, IL$167,251GNOM
2020Role of Autophagy in Regulating Cytokine-Induced Macrophage Cell Death and Systemic Inflammatory Responses1K08AI144033-01A1ORVEDAHL, ANTHONY WWASHINGTON UNIVERSITY, MO$167,181AITC
2020Mapping the unique features of fetal and neonatal hematopoietic stem and progenitor cells conferring susceptibility to inflammation and infection1K08DK124657-01A1COLLINS, AMELIECOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$166,956DDK
2020Epigenetic determinants of competence for germ line specification during human embryonic development1K08HD098556-01A1NEUHAUSSER, WERNERBETH ISRAEL DEACONESS MEDICAL CENTER, MA$166,860CHHD
2020Regulating proliferation and differentiation of erythroid progenitors1K08DK123414-01LI, HOJUNDANA-FARBER CANCER INST, MA$166,740DDK
2020The role of TWIST1 in smooth muscle cells during atherosclerosis1K08HL152308-01WIRKA, ROBERTSTANFORD UNIVERSITY, CA$166,536MCBS
2020Immunosuppressive human invariant natural killer T cells for prevention of graft-versus-host disease1K08HL151809-01MAVERS, MELISSASTANFORD UNIVERSITY, CA$166,536MCBS
2020From Locus to Function: Role of ZEB2 in Human Risk of Coronary Artery Disease1K08HL153798-01CHENG, PAUL PO SHENGSTANFORD UNIVERSITY, CA$166,536MCBS
2020Elucidation of the Development and Function of the Cardiac Conduction System1K08HL153785-01GOODYER, WILLIAM RSTANFORD UNIVERSITY, CA$166,536MCBS

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