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NIH funding notice PAR-26-121

Maximizing Investigators' Research Award (MIRA) (R35 - Clinical Trial Optional)

Open. Closes May 26, 2028.

Posted
December 11, 2025
Close date
May 26, 2028
Activity codes
R35
Institutes taking part
NIGMS

Read the notice on Grants.gov

The notices it replaced

  1. Reissues: PAR-22-180 Maximizing Investigators' Research Award (R35 - Clinical Trial Optional)
  2. 2 steps back: PAR-19-367 Maximizing Investigators' Research Award (R35 - Clinical Trial Optional)
  3. 3 steps back: PAR-17-094 Maximizing Investigators' Research Award (R35)

Who won it before

2,397 competing awards (new and renewals) from FY2014 to FY2025 under this notice and the notices it replaced: $1,163,211,459 in first-year total cost, median $433,125.

Most frequent study sections

  1. Maximizing Investigators' Research Award C Study Section[MRAC]268
  2. Maximizing Investigators’ Research Award B Study Section[MRAB]200
  3. Special Emphasis Panel[ZRG1 CB-J (55)]200
  4. Maximizing Investigators? Research Award A Study Section[MRAA]186
  5. Maximizing Investigators' Research Award - E Study Section[MRAE]144

Most frequent institutions

  1. UNIVERSITY OF MICHIGAN AT ANN ARBOR74
  2. UNIV OF NORTH CAROLINA CHAPEL HILL63
  3. JOHNS HOPKINS UNIVERSITY59
  4. STANFORD UNIVERSITY56
  5. UNIVERSITY OF PENNSYLVANIA51
Competing awards under PAR-26-121 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
2025Decoding Positional Epigenetic Memory1R35GM158209-01 · under PAR-22-180MAZZONI, ESTEBAN ORLANDONEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$3,125,817MRAA
2025Unveiling Hidden Signatures in Life by Vibrational Photothermal Microscopy2R35GM136223-06 · under PAR-22-180CHENG, JI-XINBOSTON UNIVERSITY (CHARLES RIVER CAMPUS), MA$2,811,668ZRG1
2025The role of the ribosome and translation factors in mediating stress signaling1R35GM158294-01 · under PAR-22-180ZAHER, HANIWASHINGTON UNIVERSITY, MO$2,777,852MRAF
2025tRNA in codon usage2R35GM134931-06 · under PAR-22-180HOU, YA-MINGTHOMAS JEFFERSON UNIVERSITY, PA$2,730,000MRAF
2025Sample Multiplexing as a Key Enabling Technology for Quantitative Proteomics1R35GM158136-01 · under PAR-22-180GYGI, STEVEN PHARVARD MEDICAL SCHOOL, MA$2,527,500ZRG1
2025An integrative structural biology approach to understanding metabolite recognition by cellular receptors2R35GM125034-07 · under PAR-22-180SGOURAKIS, NIKOLAOSCHILDREN'S HOSP OF PHILADELPHIA, PA$2,447,500MRAE
2025Structure and Function of Protein Disorder in Membrane Trafficking and Organization2R35GM136686-06 · under PAR-22-180ELIEZER, DAVIDWEILL MEDICAL COLL OF CORNELL UNIV, NY$2,427,082MRAB
2025Multifunctional morphogens: patterning precision and mesoderm migration2R35GM138346-06 · under PAR-22-180HEEMSKERK, IDSE JOANNESUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$2,271,279ZRG1
2025Next-generation imaging to interrogate biological systems across time and space1R35GM158040-01 · under PAR-22-180LEGANT, WESLEY R.UNIV OF NORTH CAROLINA CHAPEL HILL, NC$2,257,345ZRG1
2025Molecular genetic dissection of tube morphogenesis in the Drosophila tracheal system1R35GM158364-01 · under PAR-22-180GHABRIAL, AMIN SCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$2,250,542MRAC
2025Structural biology of DNA damage response in chromatin2R35GM136262-06 · under PAR-22-180MER, GEORGESMAYO CLINIC ROCHESTER, MN$2,219,250MRAE
2025Molecular Basis of Centromere Specification and Inheritance2R35GM134920-06 · under PAR-22-180LI, FEINEW YORK UNIVERSITY, NY$2,213,750MRAC
2025Defining the Rules for Pioneer Factor Nucleosome Engagement1R35GM158384-01 · under PAR-22-180BUCK, MICHAEL JOSEPHSTATE UNIVERSITY OF NEW YORK AT BUFFALO, NY$2,203,340MRAA
2025Quantifying Physiologic and Pathologic Viscoelastic Phases of Biomolecular Condensates by Correlative Force and Fluorescence Microscopy2R35GM138186-06 · under PAR-22-180BANERJEE, PRIYA R.STATE UNIVERSITY OF NEW YORK AT BUFFALO, NY$2,161,607ZRG1
2025Molecular mechanisms of ribosome-mediated kinase signaling1R35GM156244-01 · under PAR-22-180GREEN, RACHELJOHNS HOPKINS UNIVERSITY, MD$2,136,693MRAF
2025Developmental regulation of oscillatory expression1R35GM158157-01 · under PAR-22-180AMACHER, SHARON LOHIO STATE UNIVERSITY, OH$2,130,924MRAC
2025The genetic basis of complex traits: from yeast to humans1R35GM156526-01 · under PAR-22-180FRASER, HUNTER BSTANFORD UNIVERSITY, CA$2,117,247MRAA
2025The Architectures and Underpinnings of Adaptive Evolution and Reproductive Isolation2R35GM136306-06 · under PAR-22-180POOL, JOHN EUNIVERSITY OF WISCONSIN-MADISON, WI$2,088,435MRAA
2025Small molecule signaling in regulation of gut microbiota structure and colonization resistance1R35GM158026-01 · under PAR-22-180HSIAO, ANSELUNIVERSITY OF CALIFORNIA RIVERSIDE, CA$2,065,745MRAF
2025Mechanisms of Left Right Organizer Development1R35GM158119-01 · under PAR-22-180HEHNLY, HEIDISYRACUSE UNIVERSITY, NY$2,055,625MRAC
2025Multiscale Simulation of Key Biomolecular Processes in the Cell1R35GM158238-01 · under PAR-22-180VOTH, GREGORY A.UNIVERSITY OF CHICAGO, IL$1,970,835MRAB
2025Computational approaches for elucidating proteomes and interactomes1R35GM158278-01 · under PAR-22-180SINGH, MONAPRINCETON UNIVERSITY, NJ$1,968,575MRAA
2025Unlocking Biologically-Relevant Opportunities Through Applications of Excited-State Aromaticity and Antiaromaticity2R35GM133548-06 · under PAR-22-180WU, JUDY I-CHIAUNIVERSITY OF HOUSTON, TX$1,962,500MRAE
2025On differentiating selective and neutral evolutionary processes2R35GM139383-06 · under PAR-22-180JENSEN, JEFFREY DARIZONA STATE UNIVERSITY-TEMPE CAMPUS, AZ$1,768,213MRAA
2025Chromosome organization and function in time and space: meiosis, mitosis and E. coli2R35GM136322-06 · under PAR-22-180KLECKNER, NANCY EHARVARD UNIVERSITY, MA$1,110,887MRAA
2025Mechanisms controlling cellular actin dynamics and cytoskeletal crosstalk2R35GM134895-06 · under PAR-22-180GOODE, BRUCE LBRANDEIS UNIVERSITY, MA$1,076,381MRAD
2025Mechanisms of Cell Regulation and Manipulation by the Ubiquitin System2R35GM136325-06 · under PAR-22-180HOCHSTRASSER, MARK WYALE UNIVERSITY, CT$988,057MRAC
2025Photoredox Catalysis Applications in Organometallics and Chemical Biology2R35GM134897-06 · under PAR-22-180MACMILLAN, DAVID WPRINCETON UNIVERSITY, NJ$984,000MRAB
2025Accurate Molecular Decision Making during Protein Biogenesis2R35GM136321-06 · under PAR-22-180SHAN, SHU-OUCALIFORNIA INSTITUTE OF TECHNOLOGY, CA$972,810MRAB
2025Group II Intron and Related Reverse Transcriptases2R35GM136216-06 · under PAR-22-180LAMBOWITZ, ALAN M.UNIVERSITY OF TEXAS AT AUSTIN, TX$914,003MRAA
2025Regulation of proliferation and differentiation in the male germ line adult stem cell lineage2R35GM136433-06 · under PAR-22-180FULLER, MARGARET TSTANFORD UNIVERSITY, CA$904,601MRAC
2025Dynamics of the Bacterial Ribosome and Proteome2R35GM136412-06 · under PAR-22-180WILLIAMSON, JAMES RSCRIPPS RESEARCH INSTITUTE, THE, CA$895,950MRAE
2025Enantioselective and site-selective C-H activation reactions with Bifunctional ligands1R35GM158311-01 · under PAR-22-180YU, JIN-QUANSCRIPPS RESEARCH INSTITUTE, THE, CA$874,000MRAE
2025Catalytic and Regulatory Mechanisms of Heme-based Dioxygenases1R35GM156326-01 · under PAR-22-180YEH, SYUN-RUALBERT EINSTEIN COLLEGE OF MEDICINE, NY$861,420ZRG1
2025Genetic control of developmental timing2R35GM131741-06 · under PAR-22-180AMBROS, VICTORUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$844,267MRAC
2025Mechanisms of Helicases, Translocases and SSB Proteins involved in Genome Maintenance2R35GM136632-06 · under PAR-22-180LOHMAN, TIMOTHY MWASHINGTON UNIVERSITY, MO$843,965MRAB
2025Dissecting the Mechanisms of Regulation and Quality Control in Ribosome Assembly and the Consequences of their Failure2R35GM136323-08 · under PAR-22-180KARBSTEIN, KATRINVANDERBILT UNIVERSITY, TN$804,521MRAA
2025Mechanisms of Post-transcriptional Gene Regulation by RNA Binding Proteins2R35GM136426-06 · under PAR-22-180BLACK, DOUGLAS LUNIVERSITY OF CALIFORNIA LOS ANGELES, CA$801,043MRAA
2025Functional Characterization of LncRNAs Involved in Pluripotency or Differentiation2R35GM131833-06 · under PAR-22-180SPECTOR, DAVID LCOLD SPRING HARBOR LABORATORY, NY$791,040MRAF
2025Structure and function of phospholipids and inositol phosphates in the nucleus.1R35GM156389-01 · under PAR-22-180BLIND, RAYMOND DANIELVANDERBILT UNIVERSITY MEDICAL CENTER, TN$778,444MRAB
2025The Physiology of Oxidative Stress in Bacteria1R35GM158067-01 · under PAR-22-180IMLAY, JAMES A.UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$761,271MRAF
2025Designer Molecular Probes for Biomedical Applications2R35GM131907-06 · under PAR-22-180DMOCHOWSKI, IVAN JULIANUNIVERSITY OF PENNSYLVANIA, PA$741,257ZRG1
2025Molecular and Cellular Mechanisms of Bacterial Cell Wall Constriction and Chromosome Organization2R35GM136436-06 · under PAR-22-180XIAO, JIEJOHNS HOPKINS UNIVERSITY, MD$740,660MRAF
2025Molecular Biophysics of Mitochondrial Membranes2R35GM136415-07 · under PAR-22-180KIRICHOK, YURIYWASHINGTON UNIVERSITY, MO$738,625MRAD
2025Phosphoinositide Signaling in Cytosol and Nucleus2R35GM134955-06 · under PAR-22-180ANDERSON, RICHARD A.UNIVERSITY OF WISCONSIN-MADISON, WI$733,559MRAD
2025Reconstitution and biophysical study of chromosome segregation machinery2R35GM134842-06 · under PAR-22-180ASBURY, CHARLES LUNIVERSITY OF WASHINGTON, WA$727,855MRAC
2025Mechanisms of Human DNA Double-Strand Break Repair via Quantitative Single-Molecule Imaging2R35GM134947-06 · under PAR-22-180ROTHENBERG, ELINEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY$726,555MRAF
2025Role of histone PTMs in epigenetic control of metazoan transcription and RNA processing2R35GM136435-06 · under PAR-22-180MATERA, A. GREGORYUNIV OF NORTH CAROLINA CHAPEL HILL, NC$725,271MRAF
2025Building and shaping the apical extracellular matrix2R35GM136315-06 · under PAR-22-180SUNDARAM, MEERAUNIVERSITY OF PENNSYLVANIA, PA$714,094MRAC
2025Molecular Mechanisms of Cell Cycle Control2R35GM136280-06 · under PAR-22-180BENANTI, JENNIFER AUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$703,540MRAC
2025Defining Genome Stability Mechanisms and their Regulation by SUMO and Ubiquitin2R35GM136273-06 · under PAR-22-180BODDY, MICHAEL NSCRIPPS RESEARCH INSTITUTE, THE, CA$699,200MRAF
2025The Mechanism and Regulation of the Dynein Transport Machinery2R35GM136414-06 · under PAR-22-180YILDIZ, AHMETUNIVERSITY OF CALIFORNIA BERKELEY, CA$698,450MRAB
2025Addressing the complexity and plasticity of heterotrimeric G protein signaling1R35GM156286-01 · under PAR-22-180GARCIA-MARCOS, MIKELBOSTON UNIVERSITY MEDICAL CAMPUS, MA$694,875MRAC
2025Fluorescence tools that illuminate biology and inspire translation2R35GM134963-06 · under PAR-22-180SCHEPARTZ, ALANNAUNIVERSITY OF CALIFORNIA BERKELEY, CA$691,843ZRG1
2025Assembly Mechanisms of RNA-Protein Complexes for Genetic Control2R35GM136351-06 · under PAR-22-180WOODSON, SARAH A.JOHNS HOPKINS UNIVERSITY, MD$684,837ZRG1
2025Structure and Function of Pentameric Ligand-gated Ion Channels2R35GM134896-06 · under PAR-22-180CHAKRAPANI, SUDHACASE WESTERN RESERVE UNIVERSITY, OH$684,250MRAE
2025Regulation and function of multicellular calcium signaling in organ growth and regeneration1R35GM156615-01 · under PAR-22-180ZARTMAN, JEREMIAH JAMESUNIVERSITY OF NOTRE DAME, IN$681,393ZRG1
2025Mechanisms of eukaryotic translation and ribosome-associated mRNA surveillance and protein quality control2R35GM122602-06 · under PAR-22-180PESTOVA, TATYANA VSUNY DOWNSTATE MEDICAL CENTER, NY$681,240MRAF
2025Linking gene and function through comparative genomic and experimental approaches1R35GM156215-01 · under PAR-22-180DE CRECY-LAGARD, VALERIE AUNIVERSITY OF FLORIDA, FL$680,790MRAA
2025Mechanisms of ribosome assembly1R35GM156426-01 · under PAR-22-180KLINGE, SEBASTIANROCKEFELLER UNIVERSITY, NY$678,000ZRG1
2025The effects of synaptically released zinc on neuronal processing and brain function2R35GM138023-06 · under PAR-22-180ANDERSON, CHARLESWEST VIRGINIA UNIVERSITY, WV$675,064ZRG1
2025Structural mechanisms of multimeric ATPases1R35GM156361-01 · under PAR-22-180KELCH, BRIAN ANTHONYUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$669,281MRAB
2025Structural and Functional Studies of Chromatin1R35GM158165-01 · under PAR-22-180HALIC, MARIOST. JUDE CHILDREN'S RESEARCH HOSPITAL, TN$667,480MRAE
2025Emergent mechanics of mammalian chromosome segregation2R35GM136420-06 · under PAR-22-180DUMONT, SOPHIEUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$667,215MRAC
2025Epigenetic regulations of DNA and histone methylation and deMethylation: Structures and Mechanisms2R35GM134744-06 · under PAR-22-180CHENG, XIAODONGUNIVERSITY OF TX MD ANDERSON CAN CTR, TX$660,050MRAF
2025Phages as Lenses to Study Virus Assembly and Virus: Host Interactions1R35GM156358-01 · under PAR-22-180TESCHKE, CAROLYN MUNIVERSITY OF CONNECTICUT STORRS, CT$659,949MRAE
2025Dissection of the TORC1 Signaling Network in Yeast1R35GM158300-01 · under PAR-22-180CAPALDI, ANDREW PAULUNIVERSITY OF ARIZONA, AZ$659,591MRAC
2025Control of actin filament networks by Arp2/3 complex and its regulators2R35GM136319-06 · under PAR-22-180NOLEN, BRADLEY JUNIVERSITY OF OREGON, OR$659,275MRAD
2025Effects of ions on mRNA elements, ribosomes and antibiotic-RNA interactions1R35GM156585-01 · under PAR-22-180SANBONMATSU, KARISSA YTRIAD NATIONAL SECURITY, LLC, NM$658,165MRAE
2025Characterizing the molecular mechanisms of centriole duplication and elongation2R35GM136265-06 · under PAR-22-180ROGERS, GREGORY CHARLESUNIVERSITY OF ARIZONA, AZ$657,994MRAC
2025The Logic of Aptamer Isolation1R35GM158246-01 · under PAR-22-180STOJANOVIC, MILAN NCOLUMBIA UNIVERSITY HEALTH SCIENCES, NY$654,950MRAB
2025Catalytic Redox Reactions for Pharmaceutical Synthesis2R35GM134929-06 · under PAR-22-180STAHL, SHANNON SUNIVERSITY OF WISCONSIN-MADISON, WI$653,553MRAB
2025Molecular mechanisms that regulate vesicle formation and transport2R35GM134865-06 · under PAR-22-180AUDHYA, ANJONUNIVERSITY OF WISCONSIN-MADISON, WI$651,492MRAD
2025Structural and Biochemical Mechanisms of Microtubule Dynamics and Regulation1R35GM156385-01 · under PAR-22-180RICE, LUKE WUT SOUTHWESTERN MEDICAL CENTER, TX$651,001ZRG1
2025GTPase Regulation of the Golgi Complex2R35GM136258-06 · under PAR-22-180FROMME, J CHRISTOPHERCORNELL UNIVERSITY, NY$649,673MRAB
2025Chemical Approaches to Understanding the Mechanisms of Iron-Sulfur Enzymes1R35GM156872-01 · under PAR-22-180SUESS, DANIEL LEIF MIGDOWMASSACHUSETTS INSTITUTE OF TECHNOLOGY, MA$647,301ZRG1
2025Variation in chemotactic strategies within and across bacterial species1R35GM158058-01 · under PAR-22-180EMONET, THIERRYYALE UNIVERSITY, CT$645,905MRAA
2025Diverse Nucleic Acids Chemistry: FundamentalStudies and Applications.2R35GM131736-06 · under PAR-22-180GREENBERG, MARC MJOHNS HOPKINS UNIVERSITY, MD$645,870MRAB
2025Chemical Strategies to Reveal Cellular Glycation and Ubiquitination1R35GM158376-01 · under PAR-22-180SCHECK, REBECCATUFTS UNIVERSITY MEDFORD, MA$645,712ZRG1
2025PAS proteins: Study and application of signaling mechanisms1R35GM156296-01 · under PAR-22-180GARDNER, KEVIN HADVANCED SCIENCE RESEARCH CENTER, NY$644,900MRAB
2025Mapping transient interactions with and on genomic DNA2R35GM134918-06 · under PAR-22-180SMITH, DUNCAN JNEW YORK UNIVERSITY, NY$642,390MRAF
2025Multiplex Imaging of Signaling Pathways in Cell Motility2R35GM136226-06 · under PAR-22-180HODGSON, LOUISALBERT EINSTEIN COLLEGE OF MEDICINE, NY$640,705MRAC
2025Molecular and Cellular Dynamics in Mammalian Signal Transduction2R35GM136392-06 · under PAR-22-180AHN, NATALIE G.UNIVERSITY OF COLORADO, CO$638,017MRAC
2025Centromere identity, strength, and regulation2R35GM130302-06 · under PAR-22-180BLACK, BEN E.UNIVERSITY OF PENNSYLVANIA, PA$632,821MRAA
2025Mitochondrial respiratory chain disease mechanistic and therapeutic modeling2R35GM134863-06 · under PAR-22-180FALK, MARNI JCHILDREN'S HOSP OF PHILADELPHIA, PA$628,340MRAD
2025Genetic and Molecular Dissection of Wnt Pathway Activation2R35GM136233-06 · under PAR-22-180AHMED, YASMATHDARTMOUTH COLLEGE, NH$627,840MRAC
2025Molecular mechanisms connecting endocytic and junctional complexes with epithelial pathology in C. elegans1R35GM156633-01 · under PAR-22-180HOLLOPETER, GUNTHERCORNELL UNIVERSITY, NY$627,797MRAC
2025Elucidating calcineurin signaling mechanisms at membranes2R35GM136243-06 · under PAR-22-180CYERT, MARTHA S.STANFORD UNIVERSITY, CA$621,686MRAD
2025Structure/Function of Potential Human Cytochrome P450 Drug Targets1R35GM158062-01 · under PAR-22-180SCOTT, EMILY EUNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$620,934MRAE
2025Data Analysis Tools for Emerging High-throughput Technologies2R35GM131802-06 · under PAR-22-180IRIZARRY, RAFAEL ANGELDANA-FARBER CANCER INST, MA$620,001ZRG1
2025Catalytic Radical Processes for Stereoselective Chemical Synthesis1R35GM156311-01 · under PAR-22-180ZHANG, X. PETERBOSTON COLLEGE, MA$620,000ZRG1
2025Uncovering physiological and genomic mechanisms that enable dehydration tolerance in rodents2R35GM128843-06 · under PAR-22-180MACMANES, MATTHEW DAVIDUNIVERSITY OF NEW HAMPSHIRE, NH$619,897ZRG1
2025Mechanisms of Error-Prone DNA Repair1R35GM158214-01 · under PAR-22-180LOPARO, JOSEPH J.HARVARD MEDICAL SCHOOL, MA$617,007MRAB
2025Human evolution and the genetic architecture of complex traits1R35GM158240-01 · under PAR-22-180HERNANDEZ, RYAN D.UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$616,786MRAF
2025Mechanisms of energy storage in lipid droplets1R35GM158244-01 · under PAR-22-180FARESE, ROBERT VSLOAN-KETTERING INST CAN RESEARCH, NY$609,493MRAD
2025New Synthetic Methods Enabled by Excited-State Redox Chemistry2R35GM134893-06 · under PAR-22-180KNOWLES, ROBERT RPRINCETON UNIVERSITY, NJ$606,800ZRG1
2025Determining how cell growth triggers cell division2R35GM134858-06 · under PAR-22-180SKOTHEIM, JAN MSTANFORD UNIVERSITY, CA$606,722MRAC
2025Structure and Mechanism of G-proteins and cell adhesion proteins in regulation of cell growth and motility2R35GM134962-06 · under PAR-22-180CAMPBELL, SHARON LUNIV OF NORTH CAROLINA CHAPEL HILL, NC$602,153MRAE
2025The DNA replication-repair interface: mechanisms and regulation2R35GM136401-06 · under PAR-22-180EICHMAN, BRANDT FVANDERBILT UNIVERSITY, TN$600,985MRAE
2025Helicase Mechanism and G-Quadruplex Signaling1R35GM156702-01 · under PAR-22-180RANEY, KEVIN DOUGLASUNIV OF ARKANSAS FOR MED SCIS, AR$598,543MRAE
2025Structural and dynamic studies of protein and protein-nucleic acid assemblies in health and disease1R35GM156238-01 · under PAR-22-180JARONIEC, CHRISTOPHER POHIO STATE UNIVERSITY, OH$597,573MRAB
2025A genetically encoded toolset to decipher the biology of post-translational modifications in the mammalian proteome2R35GM136437-06 · under PAR-22-180CHATTERJEE, ABHISHEKBOSTON COLLEGE, MA$596,750ZRG1
2025From protein structures to effective drugs via machine learning and molecular simulation1R35GM158122-01 · under PAR-22-180DROR, RONSTANFORD UNIVERSITY, CA$590,806MRAB
2025Control of cell growth and size2R35GM131826-06 · under PAR-22-180KELLOGG, DOUGLAS R.UNIVERSITY OF CALIFORNIA SANTA CRUZ, CA$590,254MRAD
2025Chemoenzymatic Strategies for Molecular Discovery and Asymmetric Synthesis1R35GM158365-01 · under PAR-22-180FASAN, RUDIUNIVERSITY OF TEXAS DALLAS, TX$585,000MRAE
2025Spatiotemporal mapping and engineering in the dark proteome1R35GM156806-01 · under PAR-22-180COWBURN, DAVIDALBERT EINSTEIN COLLEGE OF MEDICINE, NY$584,420MRAE
2025Decoding the rules that govern the coordination of the bacterial cell cycle1R35GM158016-01 · under PAR-22-180MERA, PAOLA EUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$583,698MRAA
2025Decoding the role of entropy in protein structural stability, dynamics, and function in health and disease1R35GM158127-01 · under PAR-22-180WAND, A. JOSHUATEXAS A&M AGRILIFE RESEARCH, TX$583,420MRAB
2025Accelerating Discovery by Merging Kinetics with Data Science Methods in Catalytic Organic Reactions1R35GM158320-01 · under PAR-22-180BLACKMOND, DONNA GSCRIPPS RESEARCH INSTITUTE, THE, CA$582,422MRAB
2025ATP-driven detection of foreign proteins triggers diverse mechanisms of cellular defense and phage-mediated counter defense2R35GM134867-06 · under PAR-22-180WIEDENHEFT, BLAKE AMONTANA STATE UNIVERSITY - BOZEMAN, MT$582,105MRAA
2025Signaling and Metabolic Regulation of Nucleotide Metabolism and Cell Growth1R35GM158171-01 · under PAR-22-180BEN-SAHRA, ISSAMNORTHWESTERN UNIVERSITY, IL$577,280MRAC
2025Molecular Basis for Transmembrane Conduction & Signaling1R35GM156263-01 · under PAR-22-180STROUD, ROBERT MUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$576,104ZRG1
2025The functional organization of mammalian membranes2R35GM134949-07 · under PAR-22-180LEVENTAL, ILYAUNIVERSITY OF VIRGINIA, VA$576,030ZRG1
2025Unraveling the molecular interconnections between circadian rhythms and lipid metabolism1R35GM156366-01 · under PAR-22-180WANG, XUEMINUNIVERSITY OF MISSOURI-ST. LOUIS, MO$574,021MRAD
2025Understanding general principles in receptor tyrosine kinase signaling through structural and functional studies1R35GM156386-01 · under PAR-22-180BAI, XIAOCHENUT SOUTHWESTERN MEDICAL CENTER, TX$574,000MRAE
2025In vivo regulation of cell trafficking and the extracellular matrix2R35GM136236-06 · under PAR-22-180FAY, DAVID SUNIVERSITY OF WYOMING, WY$570,775MRAD
2025Variant Chromatin Structures-Targeting and Functions1R35GM156364-01 · under PAR-22-180LUK, EDWARD ESTATE UNIVERSITY NEW YORK STONY BROOK, NY$568,113MRAF
2025Nutritional Control of Nematode Development1R35GM156356-01 · under PAR-22-180BAUGH, LARRY RYANDUKE UNIVERSITY, NC$565,826MRAC
2025Discovering catalytic activities for pseudoenzymes1R35GM158265-01 · under PAR-22-180TAGLIABRACCI, VINCENT SCOTTUT SOUTHWESTERN MEDICAL CENTER, TX$562,800MRAE
2025Auxin Response Factors as a model of transcriptional control2R35GM136338-06 · under PAR-22-180STRADER, LUCIASALK INSTITUTE FOR BIOLOGICAL STUDIES, CA$562,500MRAC
2025The Role of Dynamics in Regulating Multi-Activity Protein Complexes and Chromatin2R35GM133751-06 · under PAR-22-180D'ARCY, SHEENAUNIVERSITY OF TEXAS DALLAS, TX$562,420MRAE
2025Discovery and Engineering of RiPP Natural Products1R35GM158411-01 · under PAR-22-180MITCHELL, DOUGLAS ALANVANDERBILT UNIVERSITY, TN$558,651MRAE
2025Drivers of adaptation and colonization within individual human microbiomes1R35GM156282-01 · under PAR-22-180LIEBERMAN, TAMI DMASSACHUSETTS INSTITUTE OF TECHNOLOGY, MA$557,900MRAF
2025Understanding how structural mutations and individual RNA isoforms are involved in human health and disease2R35GM138636-07 · under PAR-22-180EBBERT, MARK T WUNIVERSITY OF KENTUCKY, KY$556,531MRAA
2025Molecular Mechanisms and Evolution of the Rhoptry Secretion System1R35GM156396-01 · under PAR-22-180CHANG, YI-WEIUNIVERSITY OF PENNSYLVANIA, PA$556,510MRAE
2025Actin filament mechanics and branched network turnover2R35GM136656-06 · under PAR-22-180DE LA CRUZ, ENRIQUE MYALE UNIVERSITY, CT$555,820MRAB
2025Selective Transformations of Common Feedstocks to Functionalized Amines and Heterocycles1R35GM158111-01 · under PAR-22-180ROVIS, TOMISLAVCOLUMBIA UNIV NEW YORK MORNINGSIDE, NY$552,403MRAB
2025Genetic regulation of inter- and intra-species microbial community formation1R35GM156045-01 · under PAR-22-180NOBILE, CLARISSA JANEUNIVERSITY OF CALIFORNIA, MERCED, CA$550,108ZRG1
2025Structure, Accessibility and Extension of Telomeric Overhangs1R35GM156183-01 · under PAR-22-180BALCI, HAMZAKENT STATE UNIVERSITY, OH$546,146MRAB
2025Mining Cryptic Biosynthetic Gene Clusters for Novel Bioactive Compounds and Biocatalysts2R35GM138002-06 · under PAR-22-180PARKINSON, ELIZABETH IVYPURDUE UNIVERSITY, IN$544,123MRAE
2025Mechanical Information Processing from Sub-cellular to Tissue Scales1R35GM156484-01 · under PAR-22-180GARDEL, MARGARET LISEUNIVERSITY OF CHICAGO, IL$541,967MRAD
2025Probing transcriptional activation at the molecular level2R35GM136356-06 · under PAR-22-180MAPP, ANNA K.UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI$541,353MRAE
2025Characterizing the Effects of Sequence Variability in Molecular Function, Evolution and Design2R35GM133631-06 · under PAR-22-180MORCOS, ALONSO FARUCKUNIVERSITY OF TEXAS DALLAS, TX$541,096ZRG1
2025Macrophage Phenotypes and Tissue Repair2R35GM136228-06 · under PAR-22-180KOH, TIMOTHY JUNIVERSITY OF ILLINOIS AT CHICAGO, IL$540,179MRAD
2025High-throughput discovery and modeling of protein stability and dynamics1R35GM158118-01 · under PAR-22-180ROCKLIN, GABRIEL JACOBNORTHWESTERN UNIVERSITY, IL$540,000MRAE
2025Advanced machine learning models to integrate multi-modal biomedical datasets for gene regulation and precision medicine2R35GM133657-07 · under PAR-22-180BOZDAG, SERDARUNIVERSITY OF NORTH TEXAS, TX$539,986ZRG1
2025Protein-based Self-assembly and Disassembly of Nanostructures2R35GM136395-06 · under PAR-22-180THAYUMANAVAN, SANKARANUNIVERSITY OF MASSACHUSETTS AMHERST, MA$538,897ZRG1
2025Harnessing protein clustering to understand, identify, and manipulate cellular systems2R35GM138211-06 · under PAR-22-180BUGAJ, LUKASZUNIVERSITY OF PENNSYLVANIA, PA$536,106ZRG1
2025Structural regulation of Class-I and Class-II cytochrome P450 enzymes2R35GM133375-06 · under PAR-22-180ESTRADA, DAVID FERNANDOSTATE UNIVERSITY OF NEW YORK AT BUFFALO, NY$535,979MRAE
2025The Biology and Biochemistry of Lipid Transfer Protein-Regulated Phosphoinositide Signaling2R35GM131804-06 · under PAR-22-180BANKAITIS, VYTAS ATEXAS A&M UNIVERSITY HEALTH SCIENCE CTR, TX$535,709MRAE
2025Molecular mechanisms of protein function1R35GM156616-01 · under PAR-22-180HITE, RICHARD KEVINSLOAN-KETTERING INST CAN RESEARCH, NY$534,160MRAE
2025UBIQUITIN-PROTEASOME PATHWAY in HUMAN DISEASE1R35GM156397-01 · under PAR-22-180BEZSONOVA, IRINAUNIVERSITY OF CONNECTICUT SCH OF MED/DNT, CT$528,129MRAE
2025Computational analysis of complex genetic interactions2R35GM133613-06 · under PAR-22-180MCCANDLISH, DAVID MARTINCOLD SPRING HARBOR LABORATORY, NY$528,000MRAF
2025Spatial control of membrane traffic by septin GTPases2R35GM136337-07 · under PAR-22-180SPILIOTIS, ELIAS TUNIVERSITY OF VIRGINIA, VA$527,873MRAD
2025Modeling mechanisms in cytokinesis, cell polarization and motility2R35GM136372-06 · under PAR-22-180VAVYLONIS, DIMITRIOSLEHIGH UNIVERSITY, PA$526,805ZRG1
2025Structure and mechanism of how cells read and repair the genome1R35GM158347-01 · under PAR-22-180HE, YUANJOHNS HOPKINS UNIVERSITY, MD$525,416MRAB
2025Controlled Catalytic Functionalization of Alkenes and Alkynes1R35GM156483-01 · under PAR-22-180ENGLE, KEARY MARKSCRIPPS RESEARCH INSTITUTE, THE, CA$524,400MRAE
2025Data Science Guided Organic Reaction Development2R35GM136271-06 · under PAR-22-180SIGMAN, MATTHEW SUTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, UT$523,685MRAE
2025New methods for computational modeling of RNA structures2R35GM134919-06 · under PAR-22-180CHEN, SHI-JIEUNIVERSITY OF MISSOURI-COLUMBIA, MO$520,040MRAE
2025Intracellular Remodeling during Early Development2R35GM131810-06 · under PAR-22-180YANG, JINGUNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL$519,685MRAC
2025Repetitive sequences drive genome variation and plasticity2R35GM133600-06 · under PAR-22-180BECK, CHRISTINE RUNIVERSITY OF CONNECTICUT SCH OF MED/DNT, CT$516,778ZRG1
2025Mechanism and Regulation of DNA Recombination1R35GM158251-01 · under PAR-22-180IRA, GRZEGORZ ABAYLOR COLLEGE OF MEDICINE, TX$516,608MRAF
2025Regulation of cellular plasticity and regeneration in Drosophila spermatogenesis2R35GM136665-06 · under PAR-22-180MATUNIS, ERIKA LJOHNS HOPKINS UNIVERSITY, MD$515,852ZRG1
2025Using naturally evolved phenotypic variation to decipher the positional regulatory code of mammalian skin2R35GM133758-06 · under PAR-22-180MALLARINO, RICARDOPRINCETON UNIVERSITY, NJ$513,550ZRG1
2025Mechanisms of Homeodomain Transcription Factor Specificity1R35GM158075-01 · under PAR-22-180GEBELEIN, BRIANCINCINNATI CHILDRENS HOSP MED CTR, OH$510,390MRAF
2025Mechanisms of Cell Communication in Animal Development1R35GM156377-01 · under PAR-22-180ROY, SOUGATAUNIV OF MARYLAND, COLLEGE PARK, MD$509,982ZRG1
2025A multi-scale systems biology framework for understanding and engineering the human gut microbiome2R35GM124774-06 · under PAR-22-180VENTURELLI, OPHELIADUKE UNIVERSITY, NC$509,125ZRG1
2025Epigenetic gene regulation for stem cell fates1R35GM158393-01 · under PAR-22-180PENG, JAMY C.ST. JUDE CHILDREN'S RESEARCH HOSPITAL, TN$508,750ZRG1
2025Gene regulatory mechanisms driving development during transcriptional silence from oocyte to embryo in mammals1R35GM157073-01 · under PAR-22-180COOK-ANDERSEN, HEIDIUNIVERSITY OF CALIFORNIA, SAN DIEGO, CA$508,315MRAC
2025Evolutionary and functional genomics of genetic novelties and expression adaptation in Drosophila1R35GM156525-01 · under PAR-22-180BEGUN, DAVID JUNIVERSITY OF CALIFORNIA AT DAVIS, CA$507,000MRAA
2025Population genomics in laboratory and outbred mouse populations2R35GM133415-06 · under PAR-22-180DUMONT, BETHANY LJACKSON LABORATORY, ME$506,220ZRG1
2025Cellular Systems Genetic Approaches to Understanding Regulatory Variation2R35GM133724-06 · under PAR-22-180BAKER, CHRISTOPHER LEEJACKSON LABORATORY, ME$506,220MRAA
2025Functional dynamics of essential bacterial proteins and EPR technology development1R35GM158260-01 · under PAR-22-180KLUG, CANDICE SMEDICAL COLLEGE OF WISCONSIN, WI$506,105MRAE
2025Non-coding RNA in stem cell biology1R35GM158281-01 · under PAR-22-180VAN WOLFSWINKEL, JOSEPHINA CYALE UNIVERSITY, CT$504,175ZRG1
2025Dissecting the roles of ubiquitin in translation control2R35GM137954-06 · under PAR-22-180SILVA, GUSTAVO MDUKE UNIVERSITY, NC$502,733MRAC
2025Genomic reprogramming in the early embryo2R35GM136298-06 · under PAR-22-180HARRISON, MELISSAUNIVERSITY OF WISCONSIN-MADISON, WI$502,161MRAF
2025From humans and eukaryotes to viruses and pathogens; how transition metals shape catalysis and allostery1R35GM156452-01 · under PAR-22-180PANDELIA, MARIA-EIRINIBRANDEIS UNIVERSITY, MA$502,043ZRG1
2025Molecular basis for CRISPR-associated transposons and RNA-guided transcriptional regulation1R35GM158248-01 · under PAR-22-180CHANG, LEIFUPURDUE UNIVERSITY, IN$501,917MRAB
2025Precision Pharmacology and Pharmacovigilance: Leveraging AI to address drug safety knowledge gaps2R35GM131905-07 · under PAR-22-180TATONETTI, NICHOLAS PCEDARS-SINAI MEDICAL CENTER, CA$501,000ZRG1
2025Bridging the Gap Between Prediction and Reality in Structural Biology1R35GM158447-01 · under PAR-22-180HOLTON, JAMES MUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$501,000MRAB
2025Dynamic modulation of HCN4 and ASICs2R35GM137912-06 · under PAR-22-180BANKSTON, JOHNUNIVERSITY OF COLORADO DENVER, CO$500,940MRAB
2025Organization of Syncytial Cells1R35GM156800-01 · under PAR-22-180GLADFELTER, AMY SDUKE UNIVERSITY, NC$499,145MRAC
2025Mechanistic studies of ABC importers in pathogenic bacteria1R35GM158705-01 · under PAR-22-180PINKETT, HEATHER WENDYNORTHWESTERN UNIVERSITY, IL$498,778MRAB
2025Accessing the hidden biosynthetic capabilities of fungi1R35GM156119-01 · under PAR-22-180KELLER, NANCY PUNIVERSITY OF WISCONSIN-MADISON, WI$495,117MRAB
2025New Bond Disconnections in the Streamlined Synthesis of Complex Bioactive Molecules1R35GM156482-01 · under PAR-22-180MAIMONE, THOMAS JOHNUNIVERSITY OF CALIFORNIA BERKELEY, CA$493,243MRAE
2025Structural mechanisms of Scap/SREBP signaling in membrane homeostasis2R35GM136387-06 · under PAR-22-180ROSENBAUM, DANIELUT SOUTHWESTERN MEDICAL CENTER, TX$492,000MRAE
2025Molecular Mechanisms Underlying Yeast Transcription Circuit Evolution1R35GM156460-01 · under PAR-22-180JOHNSON, ALEXANDER DUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$491,739MRAA
2025Mechanical coordination and mechano-biochemical feedback in epithelial folding1R35GM156319-01 · under PAR-22-180HE, BINGDARTMOUTH COLLEGE, NH$490,841MRAC
2025Cell Fate Decisions in Epithelial Stem Cell Lineages2R35GM136348-06 · under PAR-22-180NYSTUL, TODDUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA$490,192MRAC
2025Empowering NMR Utilization in Mechanistic Biology: Extending Size Limits and Catalyzing Automation1R35GM158220-01 · under PAR-22-180ARTHANARI, HARIBABUDANA-FARBER CANCER INST, MA$489,500MRAB
2025Decoding cell surface chemistry and function in Staphylococcus aureus1R35GM156332-01 · under PAR-22-180CEGELSKI, LYNETTE SSTANFORD UNIVERSITY, CA$488,783MRAB
2025Design principles and dynamic gene control in embryonic development2R35GM133425-06 · under PAR-22-180LIM, BOMYIUNIVERSITY OF PENNSYLVANIA, PA$486,806ZRG1
2025Defining the genetic architecture of multiple stress response2R35GM133588-06 · under PAR-22-180SUTPHIN, GEORGE LEWISUNIVERSITY OF ARIZONA, AZ$486,436MRAC
2025Dynamics of the cellular interactome2R35GM136255-06 · under PAR-22-180BRUCE, JAMES EDWARDUNIVERSITY OF WASHINGTON, WA$485,375ZRG1
2025Molecular Mechanisms Underlying E-cadherin Mechanotransduction2R35GM136291-06 · under PAR-22-180DEMALI, KRIS AUNIVERSITY OF IOWA, IA$484,990MRAD
2025Spatiotemporal Regulation of Organelle Interactions and Metabolism1R35GM158363-01 · under PAR-22-180KAST, DAVID JWASHINGTON UNIVERSITY, MO$484,625MRAD
2025New Catalytic Methods for the Synthesis of Complex Molecules2R35GM136330-06 · under PAR-22-180NICEWICZ, DAVID AUNIV OF NORTH CAROLINA CHAPEL HILL, NC$484,335MRAE
2025Evolutionary Tradeoffs in Antibiotic Resistance1R35GM156320-01 · under PAR-22-180BAYM, MICHAELHARVARD MEDICAL SCHOOL, MA$483,990MRAF
2025Determining the roles of autophagy in gametogenesis in S. cerevisiae1R35GM156387-01 · under PAR-22-180WANG, FEIUT SOUTHWESTERN MEDICAL CENTER, TX$483,640MRAC
2025Biochemical Mechanisms of Eukaryotic RNA Processing2R35GM136261-06 · under PAR-22-180HOSKINS, AARON ANDREWUNIVERSITY OF WISCONSIN-MADISON, WI$483,497MRAF
2025Circadian regulation of cell outputs2R35GM136363-06 · under PAR-22-180BLAU, JUSTINNEW YORK UNIVERSITY, NY$481,927ZRG1
2025The interplay of extracellular fluid viscosity, stiffness and confinement in regulating cell responses1R35GM156305-01 · under PAR-22-180KONSTANTOPOULOS, KONSTANTINOSJOHNS HOPKINS UNIVERSITY, MD$479,487ZRG1
2025Patterning acentrosomal microtubule arrays2R35GM133573-06 · under PAR-22-180YOGEV, SHAULYALE UNIVERSITY, CT$479,050ZRG1
2025Tracking transcriptome diversity in real-time2R35GM133762-06 · under PAR-22-180PAI, ATHMA AUNIV OF MASSACHUSETTS MED SCH WORCESTER, MA$479,050ZRG1
2025Single Cell Analysis of MAPK Signaling Dynamics in Multicellularity2R35GM133499-06 · under PAR-22-180REGOT, SERGIJOHNS HOPKINS UNIVERSITY, MD$479,038ZRG1
2025Mechanisms of cell-autonomous plasma membrane stabilization and repair in plants1R35GM158354-01 · under PAR-22-180XIAO, SHUNYUANUNIV OF MARYLAND, COLLEGE PARK, MD$478,269ZRG1
2025Uncovering new approaches to manipulate and probe biochemical processes with spatial and temporal precision2R35GM136367-06 · under PAR-22-180TUCKER, CHANDRA LUNIVERSITY OF COLORADO DENVER, CO$478,084ZRG1
2025Understanding the Mechanisms of Respiratory Supercomplexes and mitochondrial Complex I2R35GM137929-06 · under PAR-22-180LETTS, JAMES ANTHONYUNIVERSITY OF CALIFORNIA AT DAVIS, CA$477,345MRAE
2025Coordination of chaperone interactions that dictate protein folding and trafficking2R35GM133552-06 · under PAR-22-180PLATE, LARSVANDERBILT UNIVERSITY, TN$475,254MRAD
2025Mechanisms of Primary Cilium Assembly and Disassembly2R35GM137956-06 · under PAR-22-180BRESLOW, DAVID KINGYALE UNIVERSITY, CT$474,444MRAC

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