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NIH funding notice RFA-MH-19-136

BRAIN Initiative: Development and Validation of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in the Brain (R01 Clinical Trial Not Allowed)

Closed on September 9, 2020.

Posted
May 3, 2018
Close date
September 9, 2020
Activity codes
R01
Institutes taking part
ORWH, NEI, NIA, NIAAA, NIBIB, NICHD, NIDCD, NIDA, NINDS, NCCIH
Read the notice on Grants.govNIH Guide page

The notices it replaced

4 notices since 2013, oldest first, each with its awards since FY2014.

  1. Posted 2013RFA-MH-14-21610 awards
  2. Posted 2014RFA-MH-15-22515 awards
  3. Posted 2015RFA-MH-16-7759 awards
  4. Posted 2016RFA-MH-17-22017 awards
  5. Posted 2018RFA-MH-19-136This notice, closed · 16 awards

Replaced by RFA-MH-21-175.

Who won it before

Competing awards, new and renewals, since FY2014, under this notice and the notices it replaced.

Past awards
67
67 new
Median first-year cost
$1,146,862
$107,572,549 in all
Institutions
43
59 contact PIs
Patents
34
from 15 funded projects

Awards by fiscal year

Fiscal years 2014 to 2026.

Most frequent institutions

  1. JOHNS HOPKINS UNIVERSITY5
  2. MASSACHUSETTS INSTITUTE OF TECHNOLOGY5
  3. WASHINGTON UNIVERSITY4
  4. COLD SPRING HARBOR LABORATORY3
  5. STANFORD UNIVERSITY3

and 38 other institutions

Most frequent study sections

  1. Special Emphasis Panel (ZMH1 ERB-L (04))19
  2. Special Emphasis Panel (ZMH1 ERB-L (06))15
  3. Special Emphasis Panel (ZMH1 ERB-M (03))11
  4. Special Emphasis Panel (ZMH1 ERB-C (03))6
  5. Special Emphasis Panel (ZMH1 ERB-Q (03))6

and 2 other study sections

67 awards under RFA-MH-19-136 and the notices it replaced
FYProjectPIsInstitutionFirst-year costStudy section
FY2021Molecular recording to predict cell fate decisions and animal behavior1RF1MH126723-01Dougherty, Joseph DMitra, Robi DWASHINGTON UNIVERSITY, MOFirst-year cost $3,693,282Study section ZMH1
FY2021AnteroTag, a Novel Method for Trans-Synaptic Delivery of Active Agents to Map and Modify Anterograde Populations1RF1MH126706-01Christie, Jason MHantman, AdamWilliams, Michael RolandMICHIGAN STATE UNIVERSITY, MIFirst-year cost $2,304,752Study section ZMH1
FY2021Intersectional transgenic targeting of discrete neuronal and glial subtypes1RF1MH126731-01Mumm, JeffreyJOHNS HOPKINS UNIVERSITY, MDFirst-year cost $1,921,258Study section ZMH1
FY2021Small molecule regulation of endogenous transcription factors for circuit-specific neuromodulation1RF1MH126720-01Crabtree, Gerald R.STANFORD UNIVERSITY, CAFirst-year cost $1,261,798Study section ZMH1
FY2020Optical control of neuromodulatory GPCRs1RF1MH123246-01Isacoff, EhudTrauner, Dirk HartwigUNIVERSITY OF CALIFORNIA BERKELEY, CAFirst-year cost $3,263,925Study section ZMH1
FY2020Transgenic tools for revealing the contributions of electrical synapses to neural circuits1RF1MH120016-01A1Miller, Adam CO'Brien, JohnPereda, Alberto EALBERT EINSTEIN COLLEGE OF MEDICINE, NYFirst-year cost $3,095,939Study section ZMH1
FY2020Molecular Multi-Species Approach for Trans-Synaptic Labeling of Neural Circuits1RF1MH123213-01Barnea, GiladHalpern, Marnie ELi, Jennifer MengboRobson, DrewDARTMOUTH COLLEGE, NHFirst-year cost $2,731,808Study section ZMH1
FY2020New approaches for chemical-genetic targeting of specific circuits and cell types in the mammalian brain1RF1MH123224-01Maximov, AntonSCRIPPS RESEARCH INSTITUTE, THE, CAFirst-year cost $2,666,892Study section ZMH1
FY2020Developing Molecular and Computational Tools to Enable Visualization of Synaptic Plasticity In Vivo1RF1MH123212-01Huganir, Richard LJOHNS HOPKINS UNIVERSITY, MDFirst-year cost $1,757,079Study section ZMH1
FY2020Generation of viral vectors that use alternative splicing to drive cell type-specific gene expression in the nervous system1RF1MH123237-01Blackshaw, SethJOHNS HOPKINS UNIVERSITY, MDFirst-year cost $1,534,482Study section ZMH1
FY2019Genetically engineered anterograde monosynaptic viral tracers for multi-species neural circuit analysis1RF1MH120020-01Horwitz, Gregory DSandri-Goldin, Rozanne MSemler, Bert LXu, XiangminUNIVERSITY OF CALIFORNIA-IRVINE, CAFirst-year cost $4,332,719Study section ZMH1
FY2019Cell-Specific Visualization of Endogenous Proteins1RF1MH120119-01Mao, TianyiZhong, HainingOREGON HEALTH & SCIENCE UNIVERSITY, ORFirst-year cost $2,769,525Study section ZMH1
FY2019Re-engineering Rabies Virus1RF1MH120017-01Wickersham, Ian RMASSACHUSETTS INSTITUTE OF TECHNOLOGY, MAFirst-year cost $2,634,774Study section ZMH1
FY2019A multimodal platform to bridge the experimental gap between behavioral, neuronal, and molecular studies1RF1MH120005-01Cai, DawenCui, MengUNIVERSITY OF MICHIGAN AT ANN ARBOR, MIFirst-year cost $2,251,144Study section ZMH1
FY2019Developing genetically-encoded detectors for neuropeptide release based on class B G-protein coupled peptide receptors1RF1MH120144-01Pang, Zhiping P.RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL, NJFirst-year cost $2,187,116Study section ZMH1
FY2019A new approach to biological recording of lineage hierarchy in primate brains1RF1MH120026-01Brivanlou, Ali HROCKEFELLER UNIVERSITY, NYFirst-year cost $1,207,688Study section ZMH1
FY2018DART2.0: comprehensive cell type-specific behavioral neuropharmacology1RF1MH117055-01 · under RFA-MH-17-220Tadross, Michael RDUKE UNIVERSITY, NCFirst-year cost $3,838,425Study section ZMH1
FY2018PARALLEL ANALYSIS OF TRANSCRIPTION AND PROTEIN-DNA INTERACTIONS IN SINGLE CNS CELLS1RF1MH117070-01 · under RFA-MH-17-220Dougherty, Joseph DMitra, Robi DWASHINGTON UNIVERSITY, MOFirst-year cost $3,148,838Study section ZMH1
FY2018Technology for functional study of cells and circuits in large postmortem brains ex vivo1RF1MH117064-01 · under RFA-MH-17-220Sestan, NenadYALE UNIVERSITY, CTFirst-year cost $2,801,084Study section ZMH1
FY2018Noninvasive Gene Delivery for Monitoring and Perturbing Cell Types and Circuits in Transgenic and Non-Transgenic Animals1RF1MH117069-01 · under RFA-MH-17-220Gradinaru, VivianaCALIFORNIA INSTITUTE OF TECHNOLOGY, CAFirst-year cost $2,301,120Study section ZMH1
FY2018A method for anterograde trans-synaptic tracing1RF1MH116989-01 · under RFA-MH-17-220Arnold, Donald BUNIVERSITY OF SOUTHERN CALIFORNIA, CAFirst-year cost $1,706,735Study section ZMH1
FY2018Brain-wide correlation of single-cell firing properties to patterns of gene expression1RF1MH117042-01 · under RFA-MH-17-220Cohen, Adam EzraHARVARD UNIVERSITY, MAFirst-year cost $1,203,825Study section ZMH1
FY2017Development of tools for cell-type specific labeling of human and mouse neocortical neurons1RF1MH114126-01 · under RFA-MH-17-220Lein, EdLevi, Boaz PirieTing, Jonathan TALLEN INSTITUTE, WAFirst-year cost $4,479,935Study section ZMH1
FY2017Integrative approach to classifying neuronal cell types of the mouse hippocampus1RF1MH114112-01 · under RFA-MH-17-220Dong, Hong-WeiZhang, Li IUNIVERSITY OF SOUTHERN CALIFORNIA, CAFirst-year cost $4,225,053Study section ZMH1
FY2017Revealing circuit control of neuronal excitation with next-generation voltage indicators1RF1MH114105-01 · under RFA-MH-17-220Clandinin, Thomas RobertLin, Michael Z.STANFORD UNIVERSITY, CAFirst-year cost $2,893,914Study section ZMH1
FY2017High throughput mapping of neuronal circuitry using DNA sequencing1RF1MH114132-01 · under RFA-MH-17-220Zador, Anthony MCOLD SPRING HARBOR LABORATORY, NYFirst-year cost $2,723,622Study section ZMH1
FY2017A General Approach for the Development of New Cell-Type-Specific Viral Vectors1RF1MH114081-01 · under RFA-MH-17-220Greenberg, Michael EldonHARVARD MEDICAL SCHOOL, MAFirst-year cost $2,446,424Study section ZMH1
FY2017Split RNA polymerases for sensitive, multidimensional analysis of intercellular PPIs at synapses1RF1MH114102-01 · under RFA-MH-17-220Dickinson, BryanOzkan, EnginUNIVERSITY OF CHICAGO, ILFirst-year cost $2,299,353Study section ZMH1
FY2017High Throughput Approaches for Cell-Specific Synapse Characterization1RF1MH114103-01 · under RFA-MH-17-220Barth, Alison LBruchez, Marcel PCARNEGIE-MELLON UNIVERSITY, PAFirst-year cost $2,194,397Study section ZMH1
FY2017Nano-switches for optogenetic control of neuronal proteins with ultra-specificity1RF1MH114079-01 · under RFA-MH-17-220Wang, LeiUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CAFirst-year cost $1,751,778Study section ZMH1
FY2017Cerebellar network mapping with a high-throughput TEM platform1RF1MH114047-01 · under RFA-MH-17-220Lee, Wei-Chung AllenHARVARD MEDICAL SCHOOL, MAFirst-year cost $1,271,250Study section ZMH1
FY2017Develop and validate novel chemogenetic tools to modulate synaptic transmission1RF1MH114078-01 · under RFA-MH-17-220Tomita, SusumuYALE UNIVERSITY, CTFirst-year cost $1,256,250Study section ZMH1
FY2017Brain circuit mapping using light inducible recombinase systems1RF1MH114106-01 · under RFA-MH-17-220Cetin, Ali HaydarALLEN INSTITUTE, WAFirst-year cost $1,080,298Study section ZMH1
FY2016In situ transcriptional analysis of brain circuits at single cell resolution1R01MH111502-01 · under RFA-MH-16-775Dulac, CatherineRegev, AvivZhuang, XiaoweiHARVARD UNIVERSITY, MAFirst-year cost $1,593,922Study section ZMH1
FY2016Mapping and controlling gene expression in inhibitory interneurons mammals1R01MH111529-01 · under RFA-MH-16-775Fishell, Gordon JNEW YORK UNIVERSITY SCHOOL OF MEDICINE, NYFirst-year cost $1,124,687Study section ZMH1
FY2016Next-gen Opto-GPCRs: spatiotemporal simulation of neuromodulator signaling1R01MH111520-01 · under RFA-MH-16-775Bruchas, Michael R.Sunahara, Roger KWASHINGTON UNIVERSITY, MOFirst-year cost $1,103,836Study section ZMH1
FY2016Developing a noninvasive method to manipulate specific cell types within the mammalian brain1R01MH111534-01 · under RFA-MH-16-775Chalasani, Sreekanth H.SALK INSTITUTE FOR BIOLOGICAL STUDIES, CAFirst-year cost $1,035,349Study section ZMH1
FY2016Realization of Optical Cell-based Reporters for in vivo Detection of Neuropeptides1R01MH111499-01 · under RFA-MH-16-775Kleinfeld, DavidSlesinger, Paul AICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NYFirst-year cost $996,914Study section ZMH1
FY2016A platform for high-throughput production of targeting systems for cell-type-specific transgene expression in wild-type animals1R01MH111503-01 · under RFA-MH-16-775Wickersham, Ian RMASSACHUSETTS INSTITUTE OF TECHNOLOGY, MAFirst-year cost $993,992Study section ZMH1
FY2016Multiparametric Biosensor Imaging in Brain Slices1R01MH111527-01 · under RFA-MH-16-775Blanpied, Thomas AMeredith, Andrea LRizzo, Megan AUNIVERSITY OF MARYLAND BALTIMORE, MDFirst-year cost $635,832Study section ZMH1
FY2016Multiplex in vivo imaging of cell-specific and circuit-specific signaling pathways during synaptic plasticity1R01MH111516-01 · under RFA-MH-16-775Huganir, Richard LZhang, JinJOHNS HOPKINS UNIVERSITY, MDFirst-year cost $619,950Study section ZMH1
FY2016Optogenetic signaling inhibitors for studying brain plasticity1R01MH111486-01 · under RFA-MH-16-775Gan, WenbiaoYasuda, RyoheiMAX PLANCK FLORIDA CORPORATION, FLFirst-year cost $482,250Study section ZMH1
FY2015AN INDUCIBLE MOLECULAR MEMORY SYSTEM TO RECORD TRANSIENT STATES OF CNS CELLS1U01MH109133-01 · under RFA-MH-15-225Mitra, Robi DWASHINGTON UNIVERSITY, MOFirst-year cost $1,146,862Study section ZMH1
FY2015Intrabody-dependent activation of cell-specific gene expression in CNS1U01MH109102-01 · under RFA-MH-15-225Blackshaw, SethJOHNS HOPKINS UNIVERSITY, MDFirst-year cost $1,048,356Study section ZMH1
FY2015SYNPLA: A scaleable method for monitoring circuit-specific learning-induced changes in synaptic strength1U01MH109113-01 · under RFA-MH-15-225Malinow, RobertoZador, Anthony MCOLD SPRING HARBOR LABORATORY, NYFirst-year cost $1,005,931Study section ZMH1
FY2015Tracing Brain Circuits by Transneuronal Control of Transcription1U01MH109147-01 · under RFA-MH-15-225Hong, Elizabeth JenniferLois, CarlosZinn, Kai GCALIFORNIA INSTITUTE OF TECHNOLOGY, CAFirst-year cost $936,185Study section ZMH1
FY2015Anion channelrhodopsin-based viral tools to manipulate brain networks in behaving animals1U01MH109146-01 · under RFA-MH-15-225Dragoi, ValentinJanz, RogerSpudich, John LeeUNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, TXFirst-year cost $931,074Study section ZMH1
FY2015BRAIN Initiative: Integrated Multimodal Analysis of Cell and Circuit-Specific Processes in Hippocampal Function1U01MH109062-01 · under RFA-MH-15-225Sweedler, Jonathan V.UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, ILFirst-year cost $778,402Study section ZMH1
FY2015A new strategy for cell-type specific gene disruption in flies and mice1U01MH109119-01 · under RFA-MH-15-225Clandinin, Thomas RobertShah, Nirao MaheshSTANFORD UNIVERSITY, CAFirst-year cost $750,263Study section ZMH1
FY2015Anterograde monosynaptic tracing1U01MH109129-01 · under RFA-MH-15-225Wickersham, Ian RMASSACHUSETTS INSTITUTE OF TECHNOLOGY, MAFirst-year cost $728,000Study section ZMH1
FY2015Novel tools for cell-specific imaging of functional connectivity and circuit operations1U01MH109069-01 · under RFA-MH-15-225Isacoff, EhudUNIVERSITY OF CALIFORNIA BERKELEY, CAFirst-year cost $705,670Study section ZMH1
FY2015Generating Multiple Circuit and Neuron Type Specific AAV Vectors With Cross-Species Applicability1U01MH109107-01 · under RFA-MH-15-225He, ZhigangBOSTON CHILDREN'S HOSPITAL, MAFirst-year cost $700,563Study section ZMH1
FY2015Sub-micrometer x-ray tomography for neuroanatomy1U01MH109100-01 · under RFA-MH-15-225Jacobsen, Chris JohnsonKording, Konrad P.NORTHWESTERN UNIVERSITY, ILFirst-year cost $677,177Study section ZMH1
FY2015Sparse, Strong and Large Area Targeting of Genetically Encoded Indicators1U01MH109091-01 · under RFA-MH-15-225Antic, Srdjan DKnopfel, ThomasUNIVERSITY OF CONNECTICUT SCH OF MED/DNT, CTFirst-year cost $549,797Study section ZMH1
FY2015LIPS: A novel technology for spatial and temporal control of protein synthesis in dendritic spines1U01MH109087-01 · under RFA-MH-15-225Gan, WenbiaoJaffrey, Samie RWEILL MEDICAL COLL OF CORNELL UNIV, NYFirst-year cost $525,875Study section ZMH1
FY2015Genetic tools and imaging technology for mapping cholinergic engrams of anxiety1U01MH109104-01 · under RFA-MH-15-225Role, Lorna WSTATE UNIVERSITY NEW YORK STONY BROOK, NYFirst-year cost $479,913Study section ZMH1
FY2015Engineered viral tropism for cell-type specific manipulation of neuronal circuits1U01MH109038-01 · under RFA-MH-15-225Schmidt, DanielThomas, Mark JohnUNIVERSITY OF MINNESOTA, MNFirst-year cost $357,250Study section ZMH1
FY2014DREADD2.0: AN ENHANCED CHEMOGENETIC TOOLKIT1U01MH105892-01 · under RFA-MH-14-216Jin, JianKash, Thomas L.Roth, Bryan L.UNIV OF NORTH CAROLINA CHAPEL HILL, NCFirst-year cost $997,398Study section ZMH1
FY2014Mapping neuronal chloride microdomains1U01MH106013-01 · under RFA-MH-14-216Staley, Kevin J.MASSACHUSETTS GENERAL HOSPITAL, MAFirst-year cost $913,294Study section ZMH1
FY2014Ultra-Multiplexed Nanoscale In Situ Proteomics for Understanding Synapse Types1U01MH106011-01 · under RFA-MH-14-216Bathe, MarkBoyden, Edward S.Yin, PengMASSACHUSETTS INSTITUTE OF TECHNOLOGY, MAFirst-year cost $735,278Study section ZMH1
FY2014Novel technologies for nontoxic transsynaptic tracing1U01MH106018-01 · under RFA-MH-14-216Wickersham, Ian RMASSACHUSETTS INSTITUTE OF TECHNOLOGY, MAFirst-year cost $699,916Study section ZMH1
FY2014Developing drivers for neuron type-specific gene expression1U01MH105924-01 · under RFA-MH-14-216Hobert, OliverCOLUMBIA UNIVERSITY HEALTH SCIENCES, NYFirst-year cost $626,021Study section ZMH1
FY2014Novel Genetic Strategy for Sparse Labeling and Manipulation of Mammalian Neurons1U01MH106008-01 · under RFA-MH-14-216Yang, Xiangdong WilliamUNIVERSITY OF CALIFORNIA LOS ANGELES, CAFirst-year cost $592,089Study section ZMH1
FY2014In-vivo circuit activity measurement at single cell, sub-threshold resolution1U01MH106027-01 · under RFA-MH-14-216Forest, CraigStanley, Garrett B.GEORGIA INSTITUTE OF TECHNOLOGY, GAFirst-year cost $504,959Study section ZMH1
FY2014Identification of enhancers whose activity defines cortical interneuron types1U01MH105948-01 · under RFA-MH-14-216Rubenstein, John L. R.Sohal, Vikaas SinghUNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CAFirst-year cost $487,159Study section ZMH1
FY2014An optogenetic toolkit for the interrogation and control of single cells.1U01MH106035-01 · under RFA-MH-14-216Hannon, Gregory JCOLD SPRING HARBOR LABORATORY, NYFirst-year cost $452,400Study section ZMH1
FY2014Remote regulation of neural activity1U01MH105941-01 · under RFA-MH-14-216Stanley, Sarah AmyROCKEFELLER UNIVERSITY, NYFirst-year cost $419,503Study section ZMH1
Newest fiscal year first, then first-year cost.

Patents from its funded projects

34 patents name 15 of the 67 funded projects. The newest 5, by patent number.

  1. US 12,760,352 (opens the patent at USPTO, a PDF, in a new tab)HIGH-THROUGHPUT AND HIGHLY MULTIPLEXED IMAGING WITH PROGRAMMABLE NUCLEIC ACID PROBESGranted October 13, 2026 to President and Fellows of Harvard CollegeU01MH106011 · MASSACHUSETTS INSTITUTE OF TECHNOLOGY, MA
  2. US 12,747,516 (opens the patent at USPTO, a PDF, in a new tab)PROTEIN LIBRARY DISPLAY SYSTEMS AND METHODS THEREOFGranted September 29, 2026 to DUKE UNIVERSITYRF1MH117055 · DUKE UNIVERSITY, NC
  3. US 12,702,722 (opens the patent at USPTO, a PDF, in a new tab)ARTIFICIAL EXPRESSION CONSTRUCTS FOR SELECTIVELY MODULATING GENE EXPRESSION IN SELECTED NEURONAL CELL POPULATIONSGranted August 11, 2026 to Allen InsituteRF1MH114126 · ALLEN INSTITUTE, WA
  4. US 12,692,515 (opens the patent at USPTO, a PDF, in a new tab)ARTIFICIAL EXPRESSION CONSTRUCTS FOR SELECTIVELY MODULATING GENE EXPRESSION IN INHIBITORY NEOCORTICAL NEURONSGranted July 28, 2026 to Allen InstituteRF1MH114126 · ALLEN INSTITUTE, WA
  5. US 12,685,777 (opens the patent at USPTO, a PDF, in a new tab)Compositions, Systems, and Methods for Modulating a Target GeneGranted July 21, 2026 to The Board of Trustees of the Leland Stanford Junior UniversityRF1MH126720 · STANFORD UNIVERSITY, CA

Each number opens the patent at USPTO, beside the project NIH ties it to and that project's institution. NIH ties a patent to a project, not to a year of its funding, and says its list is incomplete. The grant date and the owners are USPTO's: the organizations the patent names as assignees on the day it was granted. Source: United States Patent and Trademark Office, www.uspto.gov, which does not endorse ScienceDex.

Data: Grants.gov's daily extract and NIH's notice pages, award files and patents file, in ScienceGraph release conductgrants-2026-11-13-0.3.2. An award is listed only where NIH's own record names the notice, and a PI only by NIH's profile ID. Grants.gov and NIH do not endorse ScienceDex.

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RFA-MH-19-136: BRAIN Initiative: Development and Validation of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in the Brain (R01 Clinical Trial Not Allowed) | ScienceDex | ConductScience