| #1 | Oregon Health & Science University | Portland | School Of Medicine | $257M | 507 | 493 |
| #2 | University of Oregon | Eugene | University | $38.3M | 115 | 101 |
| #3 | Oregon State University | Corvallis | University | $17.4M | 48 | 58 |
| #4 | Portland State University | Portland | University | $4.8M | 16 | 17 |
| #5 | Oregon Research Institute | Springfield | Research Institute | $4.1M | 8 | 10 |
| #6 | Oregon Res Behavioral Intervention Strat | Springfield | Other | $4M | 6 | 10 |
| #7 | Legacy Emanuel Hospital and Health Center | Portland | Hospital | $2.9M | 5 | 9 |
| #8 | Aronora, Inc. | Portland | Other | $2.6M | 3 | 2 |
| #9 | Pdx Pharmaceuticals, Inc. | Portland | Other | $2M | 3 | 2 |
| #10 | Saavsus, Inc. | Eugene | Other | $1.9M | 2 | 2 |
| #11 | Northwest Prevention Science Inc | Eugene | Other | $1.8M | 3 | 4 |
| #12 | Ochin, Inc. | Portland | Other | $1.8M | 3 | 5 |
| #13 | Hemex Health, Inc. | Portland | Other | $1.6M | 3 | 2 |
| #14 | Nemametrix, Inc. | Eugene | Other | $1.6M | 2 | 4 |
| #15 | Madorra, Inc. | Portland | Other | $1.5M | 1 | 1 |
| #16 | Brain Electrophysiology Laboratory Company, LLC | Eugene | Other | $1.5M | 2 | 2 |
| #17 | Ksana Health, Inc. | Eugene | Other | $1.2M | 3 | 1 |
| #18 | Providence Portland Medical Center | Portland | Hospital | $1.1M | 3 | 4 |
| #19 | Northwest Portland Area Indian Hlth Bd | Portland | Other | $1M | 3 | 4 |
| #20 | Najit Technologies, Inc. | Beaverton | Other | $986.1K | 1 | 2 |
| #21 | Collinge and Associates | Eugene | Other | $968.3K | 1 | 2 |
| #22 | Siloam Vision, Inc. | Lake Oswego | Other | $934.7K | 2 | 3 |
| #23 | Penderia Technologies, Inc. | Eugene | Other | $872.8K | 1 | 1 |
| #24 | Trace Biosciences Inc | Beaverton | Other | $810.8K | 1 | 1 |
| #25 | Oregon State Department of Agriculture | Salem | Other | $630K | 1 | 1 |
| #26 | Nzumbe Epigenetics | Portland | Other | $576.7K | 1 | 1 |
| #27 | Pacific University | Forest Grove | University | $535.1K | 2 | 4 |
| #28 | Torralva Medical Therapeutics, LLC | Portland | Other | $522.9K | 1 | 1 |
| #29 | Lewis and Clark College | Portland | University | $414K | 1 | 1 |
| #30 | Multnomah County Health Department | Portland | Other | $410.5K | 1 | 1 |
| #31 | Senaptec Inc. | Beaverton | Other | $407.5K | 1 | 1 |
| #32 | Virogenomics Biodevelopment, Inc. | Tigard | Other | $405.3K | 1 | 3 |
| #33 | Keliomics, Inc. | Portland | Other | $398.9K | 1 | 1 |
| #34 | Oregon Health Authority | Portland | Other | $365K | 2 | 2 |
| #35 | Portland Va Research Foundation, Inc. | Portland | Research Institute | $343.4K | 3 | 2 |
| #36 | Hemingway Designs, LLC | Oregon City | Other | $324.2K | 1 | 1 |
| #37 | Ifocus Imaging LLC | Portland | Other | $306.5K | 1 | 2 |
| #38 | Boulder Care, Inc. | Portland | Other | $297.1K | 1 | 1 |
| #39 | Finnegan the Dragon, Inc | Hillsboro | Other | $294.5K | 1 | 1 |
| #40 | Enterx Biosciences, Inc. | Portland | Other | $294.1K | 1 | 1 |
| #41 | Children's Cancer Therapy Develop/Inst | Beaverton | Other | $288.6K | 1 | 1 |
| #42 | Iris Media, Inc. | Eugene | Other | $283.5K | 1 | 3 |
| #43 | Rewire Neuroscience, LLC | Portland | Other | $275.7K | 1 | 1 |
| #44 | Teo Therapeutics Incorporated | Beaverton | Other | $270.4K | 1 | 1 |
| #45 | Oregon Museum of Sciences and Industry | Portland | Other | $268.9K | 1 | 2 |
| #46 | Double S Instructional Systems | Eugene | Other | $135.2K | 1 | 1 |
| #47 | National University of Natural Medicine | Portland | University | $103.1K | 2 | 3 |
| #48 | Pediatric Dermatology Research Alliance, Inc | Portland | Other | $75K | 1 | 3 |
| #49 | Center Mom, Inc. | Portland | Other | $55K | 1 | 1 |
| #50 | Academic Consortium for Integrative Medicine and Health, Inc. | Lake Oswego | Other | $30K | 1 | 2 |
