Biochemistry at UT Southwestern Medical Center

Leads a grant in this department

60 contact PIs of these awards, by the funding they lead. Other principal investigators on an award are listed with it and under Co-investigators.

1. Bassel-Duby, Rhonda

   Leads 3 awards · $2,715,819

   • 5P50HD087351-09Department: NIH department code

     Myoediting of Duchenne Muscular Dystrophy
     $1,605,786

     award amount
   • 5R01HL157281-02Department: NIH department code

     Transcriptional Control of Neonatal Heart Regeneration
     $565,036

     award amount
   • 5R01HL130253-08Department: NIH department code

     Deciphering the role of a novel micropeptide in cardiac function and dysfunction
     $544,997

     award amount

2. Phillips, Margaret A.

   Leads 4 awards · $2,020,142

   • 2R01AI103947-11Department: NIH department code

     Lead Optimization of DHODH Inhibitors for Malaria
     $755,889

     award amount
   • 5R01AI155784-03Department: NIH department code

     Optimization of novel phenotypic screening hits for treatment of Malaria
     $737,236

     award amount
   • 5R01AI034432-28Department: NIH department code

     POLYAMINE AND TRYPANOTHIONE METABOLISM IN TRYPANOSOMA BRUCEI
     $445,837

     award amount
   • 3R01AI155784-03S1Department: NIH department code

     Optimization of novel phenotypic screening hits for treatment of Malaria
     $81,180

     award amount

3. Markowitz, Sanford D.

   Leads 1 award · $1,354,462

   • 5RM1GM142002-03Department: NIH department code

     Chemical, Structural and Cell-Signaling Interrogation of 15-Prostanglandin Dehydrogenase in Tissue Repair and Regeneration
     $1,354,462

     award amount

4. Joachimiak, Lukasz A.

   Leads 1 award · $1,230,000

   • 1RF1AG076459-01A1Department: NIH department code

     Structural profiling of tauopathy seeds
     $1,230,000

     award amount

5. Cleaver, Ondine B

   Leads 3 awards · $1,149,347

   • 5R01DK121408-05Department: NIH department code

     Hippo suppression of NFkB controls pancreas morphogenesis and beta cell fate
     $405,000

     award amount
   • 5R01HL126518-08Department: NIH department code

     Molecular regulation of Rho and Ras family GTPase activity controls vascular lumen formation.
     $391,875

     award amount
   • 5R01DK124393-04Department: NIH department code

     Renal vascular remodeling and arteriogenesis: cues from smooth muscle progenitor cells
     $352,472

     award amount

6. Chen, Elizabeth H

   Leads 4 awards · $1,041,469

   • 5R35GM136316-04Department: NIH department code

     Decoding the mechanisms of cell-cell fusion
     $410,000

     award amount
   • 5R01AR075005-04Department: NIH department code

     Investigating mechanisms of vertebrate myoblast fusion using zebrafish as a model
     $360,800

     award amount
   • 2R56AR053173-17Department: NIH department code

     Molecular Mechanisms of Myoblast Fusion
     $200,000

     award amount
   • 3R35GM136316-04S1Department: NIH department code

     Decoding the mechanisms of cell-cell fusion
     $70,669

     award amount

7. Jiang, Jin

   Leads 2 awards · $1,030,257

   • 5R35GM118063-08Department: NIH department code

     Cell signaling in development and regeneration
     $888,257

     award amount
   • 3R35GM118063-08S1Department: NIH department code

     Cell signaling in development and regeneration
     $142,000

     award amount

8. Chen, Chuo

   Leads 2 awards · $1,028,935

   • 1R01CA269377-01A1Department: NIH department code

     Therapeutic targeting of Wnt signaling in cancer
     $648,718

     award amount
   • 5R01CA226419-05Department: NIH department code

     Explore the therapeutic potential of small-molecule immune modulators
     $380,217

     award amount

9. Rizorey, Jose

   Leads 1 award · $967,526

   • 5R35NS097333-07Department: NIH department code

     Mechanisms of neurotransmitter release and its regulation
     $967,526

     award amount

10. Zhang, Chun-Li

    Leads 2 awards · $903,739

    • 5R01NS127375-02Department: NIH department code

      PAX6-induced adult neurogenesis
      $480,486

      award amount
    • 5R01NS117065-04Department: NIH department code

      In Vivo Reprogramming of NG2 Glia for Neurogenesis
      $423,253

      award amount

11. Shahmoradian, Sarah H

    Leads 2 awards · $863,068

    • 1R01NS133517-01Department: NIH department code

      Determine the neurotoxicity of RNA metabolism dysfunction caused by cytoplasmic TDP-43 aggregates
      $617,068

      award amount
    • 1R21AG080497-01Department: NIH department code

      Cellular Anatomy of Tau Seeding
      $246,000

      award amount

12. Tu, Benjamin P

    Leads 3 awards · $833,608

    • 5R35GM136370-04Department: NIH department code

      Metabolic signals regulating cell growth versus survival
      $402,168

      award amount
    • 5R01NS115546-05Department: NIH department code

      Redox regulation of protein functions linked to neurodegeneration
      $358,750

      award amount
    • 3R01NS115546-05S1Department: NIH department code

      Redox regulation of protein functions linked to neurodegeneration
      $72,690

      award amount

13. Nam, Yunsun

    Leads 2 awards · $784,978

    • 5R01CA258589-02Department: NIH department code

      Small molecules to target the RNA methyltransferase complex METTL3/METTL14
      $430,228

      award amount
    • 5R01GM122960-07Department: NIH department code

      Mechanisms of Microprocessor Function and Regulation
      $354,750

      award amount

14. Bai, Xiaochen

    Leads 2 awards · $758,919

    • 5R01GM143158-03Department: NIH department code

      Structural insights into the unique activation mechanisms of receptor tyrosine kinases
      $406,319

      award amount
    • 5R01GM136976-04Department: NIH department code

      Structural and Functional Analyses of the Full-length Insulin Receptor (IR) and Type 1 Insulin-like Growth Factor Receptor (IGF1R) in the Liganded Active State
      $352,600

      award amount

15. Buszczak, Michael

    Leads 2 awards · $694,952

    • 5R35GM144043-02Department: NIH department code

      Genetic Dissection of Germ Cell Differentiation and Function
      $358,752

      award amount
    • 5R01AG079513-02Department: NIH department code

      Characterization of how mRNA translation influences reproductive aging
      $336,200

      award amount

16. Wu, Jun

    Leads 2 awards · $693,168

    • 5R01HD103627-02Department: NIH department code

      Dissect the mechanisms underlying interspecies pluripotent stem cell competition
      $352,600

      award amount
    • 5R01GM138565-03Department: NIH department code

      Dissect formative pluripotency using cultured pluripotent stem cells
      $340,568

      award amount

17. Douglas, Peter Mahan

    Leads 2 awards · $674,724

    • 5R01AG076529-02Department: NIH department code

      Lipid sensing through G protein geranylgeranylation
      $342,624

      award amount
    • 5R01AG061338-05Department: NIH department code

      Heat Shock Factor mediates actin phosphorylation in tissue integrity and age
      $332,100

      award amount

18. Jewell, Jenna L

    Leads 2 awards · $664,200

    • 5R01GM130792-02Department: NIH department code

      Deciphering the Molecular Mechanisms by which PKA inhibits mTORC1
      $344,400

      award amount
    • 1R35GM149351-01Department: NIH department code

      mTORC1 Regulation by Upstream Stimuli
      $319,800

      award amount

19. Otwinowski, Zbyszek

    Leads 2 awards · $542,722

    • 5R35GM145365-02Department: NIH department code

      From complex data to complex structures: new methods for structural biology
      $435,502

      award amount
    • 3R35GM145365-02S1Department: NIH department code

      From complex data to complex structures: new methods for structural biology
      $107,220

      award amount

20. Kohler, Jennifer J

    Leads 1 award · $525,698

    • 5R35GM145599-02Department: NIH department code

      Function and regulation of epithelial glycosylation
      $525,698

      award amount

21. Mendell, Joshua T

    Leads 1 award · $489,568

    • 1R01CA282036-01Department: NIH department code

      The role of long noncoding RNA CRNDE in normal physiology and cancer
      $489,568

      award amount

22. McKnight, Steven L

    Leads 1 award · $486,000

    • 5R35GM130358-05Department: NIH department code

      A solid state conceptualization of information transfer from gene to message to protein
      $486,000

      award amount

23. Mu, Ping

    Leads 2 awards · $485,426

    • 5R37CA258730-03Department: NIH department code

      Elucidating the Molecular Role of SYNCRIP in Prostate Cancer and AR Targeted Therapy Resistance
      $400,194

      award amount
    • 3R37CA258730-03S1Department: NIH department code

      Elucidating the Molecular Role of SYNCRIP in Prostate Cancer and AR Targeted Therapy Resistance
      $85,232

      award amount

24. O'Donnell, Kathryn Ann

    Leads 1 award · $476,420

    • 1R01CA273585-01A1Department: NIH department code

      The role of translation initiation factor eIF5B in lung cancer pathogenesis
      $476,420

      award amount

25. Liu, Ning

    Leads 1 award · $469,040

    • 1R01AR080676-01A1Department: NIH department code

      The role of nuclear envelope protein NET39 in skeletal muscle function and diseases
      $469,040

      award amount

26. Rice, Luke W

    Leads 2 awards · $466,698

    • 5R01GM098543-13Department: NIH department code

      CONFORMATION & RECOGNITION IN MICROTUBLE DYNAMICS
      $344,999

      award amount
    • 5R01GM135565-04Department: NIH department code

      Single-molecule interrogation of microtubule dynamics mechanisms
      $121,699

      award amount

27. Casey, Amanda Kathleen

    Leads 1 award · $451,000

    • 1R21EY034597-01A1Department: NIH department code

      Regulation of retinal homeostasis and disease by Fic-mediated AMPylation
      $451,000

      award amount

28. Jaqaman, Khuloud

    Leads 1 award · $426,095

    • 5R35GM119619-08Department: NIH department code

      Mechanisms and Functional Consequences of Signaling Protein Organization at Membranes
      $426,095

      award amount

29. Liszczak, Glen

    Leads 1 award · $410,000

    • 5R35GM147140-02Department: NIH department code

      Regulation and function of site-specific protein poly-ADP-ribosylation
      $410,000

      award amount

30. Wang, Weiwei

    Leads 1 award · $410,000

    • 5R35GM146860-02Department: NIH department code

      Understanding higher-order glycine receptor assemblies in neurotransmission
      $410,000

      award amount

31. Rosenbaum, Daniel

    Leads 1 award · $406,794

    • 5R35GM136387-04Department: NIH department code

      Membrane signaling protein modulation by lipids and drugs
      $406,794

      award amount

32. Chen, Zhijian J

    Leads 1 award · $380,633

    • 3OT2CA278683-01S1Department: NIH department code

      eDyNAmiC-TEXASSW
      $380,633

      award amount

33. Kliewer, Steven A.

    Leads 1 award · $369,000

    • 5R01AA028473-04Department: NIH department code

      Coordinate Regulation of an Alcohol Protective Response by the Liver-derived Hormone FGF21
      $369,000

      award amount

34. Orth, Kim

    Leads 1 award · $369,000

    • 5R35GM134945-04Department: NIH department code

      Biochemistry, biology and diversity of Fic domains
      $369,000

      award amount

35. Rosen, Michael K

    Leads 1 award · $369,000

    • 5R35GM141736-03Department: NIH department code

      Cell Organization Through Phase Separation: Mechanisms, Functions and Disease
      $369,000

      award amount

36. Schaeffer, Richard Dustin

    Leads 1 award · $344,400

    • 1R01GM147367-01A1Department: NIH department code

      ECOD: Large scale classification of predicted and experimental protein structures
      $344,400

      award amount

37. Doubrovinski, Konstantin

    Leads 1 award · $340,200

    • 5R01GM134207-05Department: NIH department code

      Physical aspects of Drosophila Gastrulation
      $340,200

      award amount

38. Erzberger, Jan Peter

    Leads 1 award · $340,172

    • 5R01GM135617-04Department: NIH department code

      Integrated studies of DEAD-box ATPase function during large ribosomal subunit maturation
      $340,172

      award amount

39. Tambar, Uttam Krishan

    Leads 1 award · $338,632

    • 5R01GM102604-12Department: NIH department code

      Stereoselective Photochemistry for the Synthesis of Bioactive Molecules
      $338,632

      award amount

40. Tagliabracci, Vincent Scott

    Leads 1 award · $324,518

    • 5R01GM135189-04Department: NIH department code

      Antioxidant signaling by protein AMPylation
      $324,518

      award amount

41. Qin, Tian

    Leads 1 award · $324,060

    • 5R01GM141088-03Department: NIH department code

      Development of Sulfur-Based Reactions with Translational Applications
      $324,060

      award amount

42. Kober, Daniel Luke

    Leads 1 award · $249,000

    • 4R00GM141261-02Department: NIH department code

      The mechanistic basis for targeted protein degradation in lipid metabolism
      $249,000

      award amount

43. Sun, Lu

    Leads 1 award · $180,201

    • 3DP2MH129988-01S1Department: NIH department code

      Molecular and genetic decoding of neuron-glial interactions
      $180,201

      award amount

44. Kohler, Jennifer J

    Leads 1 award · $154,881

    • 5T32GM127216-05Department: NIH department code

      Chemistry-Biology Interface T32
      $154,881

      award amount

45. Norris, Megan L

    Leads 1 award · $132,390

    • 1K99HD109457-01A1Department: NIH department code

      Regulation and function of subcellular RNA localization in neural crest cells and their derivatives
      $132,390

      award amount

46. Hsieh, Ting-Sung

    Leads 1 award · $125,000

    • 5K99GM147532-02Department: NIH department code

      Phosphatidylinositol 3-Phosphate in the Regulation of Autophagic Membrane Remodeling
      $125,000

      award amount

47. Deja, Stanislaw Marek

    Leads 1 award · $103,385

    • 5K01DK133630-02Department: NIH department code

      Sympathetic Control of Liver Metabolism in Exercise and Obesity
      $103,385

      award amount

48. Mayro, Benjamin Jacob

    Leads 1 award · $89,100

    • 4K00CA264162-03Department: NIH department code

      Understanding the impact that tumor representative oxygen tension has on phosphotyrosine-dependent signaling networks in solid tumors
      $89,100

      award amount

49. Thomas-Jardin, Shayna

    Leads 1 award · $69,500

    • 1F32CA274982-01A1Department: NIH department code

      Immune Checkpoint Regulation by the Integrated Stress Response Pathway in Lung Ca
      $69,500

      award amount

50. Saelices Gomez, Lorena

    Leads 1 award · $67,847

    • 3DP2HL163810-01S1Department: NIH department code

      Closing the gap between structural biology and translational science for amyloid
      $67,847

      award amount

51. Chai, Andreas C

    Leads 1 award · $45,559

    • 5F30HL163915-02Department: NIH department code

      Base Editing Gene Correction of Pathogenic MYH7 Mutations in Models of Hypertrophic Cardiomyopathy
      $45,559

      award amount

52. Bali, Sofia

    Leads 1 award · $38,962

    • 5F31NS127513-02Department: NIH department code

      Inhibiting fibrillation of Tau through changes in local intramolecular interactions
      $38,962

      award amount

53. McConville, Michael R

    Leads 1 award · $38,768

    • 1F30HL167629-01Department: NIH department code

      Unexpected mechanism underlying mislocalization of thrombocytopenia-associated ETV6 point mutation
      $38,768

      award amount

54. Burns, Mary Wilton Newton

    Leads 1 award · $38,616

    • 1F30DK136209-01Department: NIH department code

      The Impact of B3GNT7 on Properties of Intestinal Mucus and the Gut Microbiome
      $38,616

      award amount

55. Luo, Peter

    Leads 1 award · $38,616

    • 1F30DK137405-01Department: NIH department code

      The role and regulation of pericytes in remodeling the periarterial niche during nephrogenesis
      $38,616

      award amount

56. Cano Hernandez, Karla Gabriela

    Leads 1 award · $36,851

    • 5F31CA271675-02Department: NIH department code

      The Molecular function of ecto 5' nucleotidase in fusion-negative rhabdomyosarcoma
      $36,851

      award amount

57. Fang, Yan

    Leads 1 award · $36,705

    • 5F99CA274647-02Department: NIH department code

      Enhancing the antitumor effect of radiation therapy by targeting the cGAS-STING pathway
      $36,705

      award amount

58. Tatge, Lexus Marc

    Leads 1 award · $34,336

    • 5F31GM140620-03Department: NIH department code

      Defining the cytoplasmic sequestration of Caenorhabditis elegans orphan nuclear receptor 49 on trafficking vesicles
      $34,336

      award amount

59. Schmitz, Daniel Andrew

    Leads 1 award · $31,830

    • 5F31NS125906-02Department: NIH department code

      Study of mitochondria-depleted pluripotent stem cells in development and disease
      $31,830

      award amount

60. Rodriguez-Tirado, Carla Sofia

    Leads 1 award · $18,588

    • 5F31CA261019-02Department: NIH department code

      Dissecting the role of UBE2J1 in prostate cancer
      $18,588

      award amount