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FY2026 NIH awards · Principal investigators

Biochemistry at UT Southwestern Medical Center

Dallas, TX

Funding
$35.7M
$35,742,308
Awards
73
FY2026 NIH awards in Biochemistry
Principal investigators
64
55 lead a grant here, 9 co-investigators
Department rank
#3
of 136 · Ranking
  • NIH names only the principal investigators on an award, so this page lists only them. The department is the award's: it is where ScienceDex counts the award, not a list of the department's members.
  • These are the awards in the Biochemistry row of the UT Southwestern Medical Center page.

Leads a grant in this department

55 contact PIs of these awards, by the funding they lead. Other principal investigators on an award are listed with it and under Co-investigators.

  1. Xiaochen Bai

    Leads 3 awards · $3,793,257

    • 1P01AI186772-01A1Department: NIH department code
      An Integrated Strategy for Targeting the cGAS-STING Pathway

      Principal investigators: Chuo Chen (contact PI), Nan Yan (contact PI), Noelle Sevilir Williams (contact PI), Xiaochen Bai (contact PI), Xuewu Zhang (contact PI), Yonghao Yu (contact PI)

      $2,576,518
      award amount
    • 5R01CA299257-02Department: NIH department code
      Novel endogenous and engineered activators of STING: from mechanisms to cancer therapy

      Principal investigators: Xiaochen Bai (contact PI), Xuewu Zhang, Zhijian J Chen

      $642,739
      award amount
    • 5R35GM156386-02Department: NIH department code
      Understanding general principles in receptor tyrosine kinase signaling through structural and functional studies
      $574,000
      award amount

  2. Chuo Chen

    Leads 2 awards · $3,218,430

    • 1P01AI186772-01A1Department: NIH department code
      An Integrated Strategy for Targeting the cGAS-STING Pathway

      Principal investigators: Chuo Chen (contact PI), Nan Yan (contact PI), Noelle Sevilir Williams (contact PI), Xiaochen Bai (contact PI), Xuewu Zhang (contact PI), Yonghao Yu (contact PI)

      $2,576,518
      award amount
    • 5R01CA269377-04Department: NIH department code
      Therapeutic targeting of Wnt signaling in cancer
      $641,912
      award amount

  3. Nan Yan

    Leads 1 award · $2,576,518

  4. Noelle Sevilir Williams

    Leads 1 award · $2,576,518

  5. Xuewu Zhang

    Leads 1 award · $2,576,518

    Also a principal investigator on 5R01CA299257-02, led by Xiaochen Bai.

  6. Yonghao Yu

    Leads 1 award · $2,576,518

  7. Lu Sun

    Leads 1 award · $2,271,828

    • 1R01EY039360-01Department: NIH department code
      Cellular and Molecular Mechanisms Governing Optic Nerve Myelin Integrity
      $2,271,828
      award amount

  8. Michael Buszczak

    Leads 5 awards · $2,126,195

    • 1R01NS147445-01Department: NIH department code
      A blastocyst complementation approach to study forebrain development, evolution and function

      Principal investigators: Jun Wu (contact PI), Michael Buszczak (contact PI)

      $655,557
      award amount
    • 5R35GM144043-05Department: NIH department code
      Genetic Dissection of Germ Cell Differentiation and Function
      $488,952
      award amount
    • 5R01HD103627-05Department: NIH department code
      Dissect the mechanisms underlying interspecies pluripotent stem cell competition

      Principal investigators: Michael Buszczak (contact PI), Ondine B Cleaver

      $352,600
      award amount
    • 5R01AG079513-05Department: NIH department code
      Characterization of how mRNA translation influences reproductive aging
      $336,200
      award amount
    • 5UG3CA290312-03Department: NIH department code
      Developing ribosome biogenesis inhibitors for the prevention of cancer

      Principal investigators: Michael Buszczak (contact PI), Vincent Scott Tagliabracci

      $292,886
      award amount

  9. Daniel Luke Kober

    Leads 3 awards · $1,431,756

    • 1R01DK148727-01Department: NIH department code
      How intermolecular chaperones enable spatial control of prohormone convertase activity

      Principal investigators: Daniel Luke Kober (contact PI), Iris Lindberg

      $710,470
      award amount
    • 1R01CA310872-01Department: NIH department code
      Developing new inhibitors of site-one protease to prevent and treat cancers
      $376,886
      award amount
    • 5R01GM155152-03Department: NIH department code
      Structural and mechanistic basis for the maturation of site-one protease in the secretory pathway
      $344,400
      award amount

  10. Vincent Scott Tagliabracci

    Leads 3 awards · $1,381,835

    • 1R01HL181065-01A1Department: NIH department code
      Dietary ether lipid salvage by ACAD10

      Principal investigators: Vincent Scott Tagliabracci (contact PI), Judith Anne Simcox

      $662,275
      award amount
    • 5R35GM158265-02Department: NIH department code
      Discovering catalytic activities for pseudoenzymes
      $562,800
      award amount
    • 1R03NS147052-01Department: NIH department code
      Rare Neurological Disease-Associated Pseudokinases
      $156,760
      award amount

    Also a principal investigator on 5UG3CA290312-03, led by Michael Buszczak.

  11. Joshua T Mendell

    Leads 2 awards · $1,357,292

    • 5U01CA305105-02Department: NIH department code
      Regulation of mitochondrial activity and metastasis by dihydrouridine-modified tRNAs in renal cell carcinoma

      Principal investigators: Joshua T Mendell (contact PI), Jan Peter Erzberger

      $867,724
      award amount
    • 5R01CA282036-04Department: NIH department code
      The role of long noncoding RNA CRNDE in normal physiology and cancer
      $489,568
      award amount

  12. Elizabeth H Chen

    Leads 3 awards · $1,346,930

    • 1R01HD122357-01Department: NIH department code
      Molecular Control of ER Remodeling During Spermiogenesis
      $500,118
      award amount
    • 5R35GM136316-07Department: NIH department code
      Decoding the mechanisms of cell-cell fusion - Renewal - 1
      $451,000
      award amount
    • 5R01AR085116-02Department: NIH department code
      Molecular Mechanisms of Myoblast Fusion
      $395,812
      award amount

  13. Jun Wu

    Leads 2 awards · $1,338,405

    • 1R01HD121186-01Department: NIH department code
      Unraveling mitochondrial function in germ cell development through enforced mitophagy
      $682,848
      award amount
    • 1R01NS147445-01Department: NIH department code
      A blastocyst complementation approach to study forebrain development, evolution and function

      Principal investigators: Jun Wu (contact PI), Michael Buszczak (contact PI)

      $655,557
      award amount

  14. Chun-Li Zhang

    Leads 2 awards · $1,123,198

    • 1R01NS142000-01A1Department: NIH department code
      Adult neurogenesis for improving urinary function after contusion spinal cord injury

      Principal investigators: Chun-Li Zhang (contact PI), Bo Chen

      $642,712
      award amount
    • 5R01NS127375-05Department: NIH department code
      PAX6-induced adult neurogenesis
      $480,486
      award amount

  15. Kathryn Ann O'Donnell

    Leads 2 awards · $1,058,570

    • 1R01CA315846-01Department: NIH department code
      Oncogenic activity and therapeutic targeting of PCDH7 in lung cancer
      $582,150
      award amount
    • 5R01CA273585-04Department: NIH department code
      The role of translation initiation factor eIF5B in lung cancer pathogenesis
      $476,420
      award amount

  16. Daniel Rosenbaum

    Leads 2 awards · $1,005,535

    • 1R01NS143214-01A1Department: NIH department code
      Structure-guided discovery of positive allosteric modulators for the D2 dopamine receptor

      Principal investigators: Daniel Rosenbaum (contact PI), Vsevolod Katritch

      $513,535
      award amount
    • 5R35GM136387-07Department: NIH department code
      Structural mechanisms of Scap/SREBP signaling in membrane homeostasis
      $492,000
      award amount

  17. Luke W Rice

    Leads 2 awards · $922,922

    • 5R35GM156385-02Department: NIH department code
      Structural and Biochemical Mechanisms of Microtubule Dynamics and Regulation
      $651,001
      award amount
    • 5T32GM131963-07Department: NIH department code
      Molecular Biophysics Training Program
      $271,921
      award amount

  18. Jin Jiang

    Leads 1 award · $917,070

    • 2R35GM118063-11Department: NIH department code
      Cell signaling in development and regeneration
      $917,070
      award amount

  19. Lukasz A. Joachimiak

    Leads 2 awards · $825,000

    • 4R01AG076459-02Department: NIH department code
      Structural profiling of tauopathy seeds
      $415,000
      award amount
    • 5R01AG078888-03Department: NIH department code
      J-domain protein conformational selectivity for tau in disease
      $410,000
      award amount

  20. Matthew W. Parker

    Leads 2 awards · $787,849

    • 1R21GM163082-01Department: NIH department code
      Resolving multi-site protein phosphorylation by phosphoryl-AMPylation
      $449,900
      award amount
    • 5R01GM155100-03Department: NIH department code
      Defining the modular architecture of protein intrinsically disordered regions for a predictive understanding of biological function
      $337,949
      award amount

  21. Zhijian J Chen

    Leads 1 award · $770,699

    • 3OT2CA278683-01S4Department: NIH department code
      eDyNAmiC-TEXASSW
      $770,699
      award amount

    Also a principal investigator on 5R01CA299257-02, led by Xiaochen Bai.

  22. Margaret A. Phillips

    Leads 1 award · $747,532

    • 5R01AI103947-14Department: NIH department code
      Lead Optimization of DHODH Inhibitors for Malaria
      $747,532
      award amount

  23. Peter Mahan Douglas

    Leads 2 awards · $719,586

    • 5R01GM153859-03Department: NIH department code
      Multimodal regulation of intracellular lipid surveillance
      $376,962
      award amount
    • 5R01AG076529-05Department: NIH department code
      Lipid sensing through G protein geranylgeranylation
      $342,624
      award amount

  24. Jennifer J Kohler

    Leads 2 awards · $691,698

    • 5R35GM145599-05Department: NIH department code
      Function and regulation of epithelial glycosylation
      $525,698
      award amount
    • 1R03TR005985-01A1Department: NIH department code
      Role of B3GNT4 mutations in alpha-dystroglycanopathy
      $166,000
      award amount

  25. Yunsun Nam

    Leads 1 award · $649,193

    • 1R01ES038329-01Department: NIH department code
      Molecular Mechanisms of Epitranscriptomic Dysregulation Induced by Toxic Metals
      $649,193
      award amount

  26. Jan Peter Erzberger

    Leads 1 award · $639,514

    • 1R01CA311928-01Department: NIH department code
      Targeting Ribosome Biogenesis as a Non-Genotoxic Chemotherapy Strategy: Mechanistic Characterization of NVL Inhibition by Benzothiazepinones

      Principal investigators: Jan Peter Erzberger (contact PI), Deepak Nijhawan

      $639,514
      award amount

    Also a principal investigator on 5U01CA305105-02, led by Joshua T Mendell.

  27. Sarah H Shahmoradian

    Leads 1 award · $572,039

    • 5R01NS133517-04Department: NIH department code
      Determine the neurotoxicity of RNA metabolism dysfunction caused by cytoplasmic TDP-43 aggregates
      $572,039
      award amount

  28. Konstantin Doubrovinski

    Leads 2 awards · $554,589

    • 5R01GM134207-08Department: NIH department code
      Physical aspects of Drosophila Gastrulation
      $354,732
      award amount
    • 3R01GM134207-08S1Department: NIH department code
      Physical aspects of Drosophila Gastrulation - Equipment supplement
      $199,857
      award amount

  29. Lorena Saelices Gomez

    Leads 1 award · $553,184

  30. Steven L McKnight

    Leads 1 award · $533,000

    • 5R35GM130358-08Department: NIH department code
      A solid state conceptualization of information transfer from gene to message to protein
      $533,000
      award amount

  31. Jenna L Jewell

    Leads 1 award · $492,000

    • 5R35GM149351-04Department: NIH department code
      mTORC1 Regulation by Upstream Stimuli
      $492,000
      award amount

  32. Chad Brautigam

    Leads 1 award · $471,712

    • 1S10OD040177-01Department: NIH department code
      Biacore 1S+ Surface Plasmon Resonance Instrument
      $471,712
      award amount

  33. Jose Rizorey

    Leads 1 award · $464,188

    • 1R01NS150707-01Department: NIH department code
      Control of neurotransmitter release by Munc13-1
      $464,188
      award amount

  34. Benjamin P Tu

    Leads 1 award · $459,517

    • 5R35GM136370-07Department: NIH department code
      Metabolic signals regulating cell growth versus survival
      $459,517
      award amount

  35. Jinfan Wang

    Leads 1 award · $456,500

    • 1R35GM166152-01Department: NIH department code
      Dynamic mechanisms of human mitochondrial translation
      $456,500
      award amount

  36. Xiaofeng Qi

    Leads 1 award · $456,500

    • 1R35GM162146-01Department: NIH department code
      Structure and Mechanisms of Mitochondrial Pyruvate Carrier (MPC)
      $456,500
      award amount

  37. Eric N Olson

    Leads 1 award · $445,588

    • 5R01AR080676-04Department: NIH department code
      The role of nuclear envelope protein NET39 in skeletal muscle function and diseases

      Principal investigators: Eric N Olson (contact PI), Ning Liu

      $445,588
      award amount

  38. Zbyszek Otwinowski

    Leads 1 award · $435,502

    • 5R35GM145365-05Department: NIH department code
      From complex data to complex structures: new methods for structural biology
      $435,502
      award amount

  39. Uttam Krishan Tambar

    Leads 1 award · $433,780

    • 1R35GM161642-01Department: NIH department code
      Chemical Reactions to Advance Drug Discovery: Stereoselective Synthesis of Heterocycles and Late-Stage Functionalization for Mechanism of Action Studies
      $433,780
      award amount

  40. Glen Liszczak

    Leads 1 award · $410,000

    • 5R35GM147140-05Department: NIH department code
      Regulation and function of site-specific protein poly-ADP-ribosylation
      $410,000
      award amount

  41. Kendra King Frederick

    Leads 1 award · $410,000

    • 5R01NS134921-03Department: NIH department code
      High sensitivity NMR for structure determination of neurodegenerative disease associated protein aggregates in native contexts
      $410,000
      award amount

  42. Weiwei Wang

    Leads 1 award · $410,000

    • 5R35GM146860-05Department: NIH department code
      Understanding higher-order glycine receptor assemblies in neurotransmission
      $410,000
      award amount

  43. Tian Qin

    Leads 1 award · $348,600

    • 2R01GM141088-06Department: NIH department code
      Development of Sulfur-Based Reactions with Translational Applications
      $348,600
      award amount

  44. Richard Dustin Schaeffer

    Leads 1 award · $344,400

    • 5R01GM147367-04Department: NIH department code
      ECOD: Large scale classification of predicted and experimental protein structures
      $344,400
      award amount

  45. Nick V. Grishin

    Leads 1 award · $332,000

    • 1R03DE036205-01Department: NIH department code
      Spatial structure-based annotation of proteins for the NIH Human Virome Program
      $332,000
      award amount

  46. Myles Warwick Smith

    Leads 1 award · $328,000

    • 5R35GM155273-03Department: NIH department code
      Expanding Access to Molecular Complexity through Natural Product Synthesis
      $328,000
      award amount

  47. Elijah L Mena

    Leads 1 award · $249,000

    • 4R00AG081456-03Department: NIH department code
      Characterization of a ubiquitin-independent pathway for proteasomal degradation
      $249,000
      award amount

  48. Hanieh Mazloom Farsibaf

    Leads 1 award · $140,097

    • 5K99CA283246-02Department: NIH department code
      Data-driven mechanistic models of morphology-controlled Ras oncogenic signaling
      $140,097
      award amount

  49. Runwen Yao

    Leads 1 award · $124,956

    • 1K99GM159056-01A1Department: NIH department code
      Nuclear condensate-associated nascent RNA fluxes
      $124,956
      award amount

  50. Stanislaw Marek Deja

    Leads 1 award · $103,385

    • 5K01DK133630-05Department: NIH department code
      Sympathetic Control of Liver Metabolism in Exercise and Obesity
      $103,385
      award amount

  51. Benjamin Jacob Mayro

    Leads 1 award · $101,380

    • 5K00CA264162-06Department: NIH department code
      Understanding the impact that tumor representative oxygen tension has on phosphotyrosine-dependent signaling networks in solid tumors
      $101,380
      award amount

  52. Neha Ahuja

    Leads 1 award · $89,424

    • 5K99DK140516-02Department: NIH department code
      Mechanisms of Cellular Communication: The Role of Merlin in Pancreatic Development
      $89,424
      award amount

  53. Peter Luo

    Leads 1 award · $47,856

    • 5F30DK137405-04Department: NIH department code
      The role and regulation of pericytes in remodeling the periarterial niche during nephrogenesis
      $47,856
      award amount

  54. Jordan McCall Wall

    Leads 1 award · $41,625

    • 5F31GM154433-02Department: NIH department code
      Investigating the role of the RNA helicase F57B9.3 in translational regulation under conditions of lipid depletion
      $41,625
      award amount

  55. Blake Christopher Williams

    Leads 1 award · $41,267

    • 5F31HL176187-02Department: NIH department code
      Structural and biophysical investigation of Scap regulation by cholesterol
      $41,267
      award amount

Co-investigators

Named as principal investigators on these awards, which someone else leads. They may belong to another department or institution: their own, below, comes from the awards they lead.