Biochemistry at UT Southwestern Medical Center

Leads a grant in this department

49 contact PIs of these awards, by the funding they lead. Other principal investigators on an award are listed with it and under Co-investigators.

1. Kendra King Frederick

   Leads 3 awards · $3,750,878

   • 1RF1NS143938-01Department: NIH department code

     Spatial organization and conformational ensembles of amyloids inside cells
     $3,178,675

     award amount
   • 5R01NS134921-02Department: NIH department code

     High sensitivity NMR for structure determination of neurodegenerative disease associated protein aggregates in native contexts
     $369,000

     award amount
   • 5R21NS136951-02Department: NIH department code

     Determining the influence of cellular environments on a-synuclein fibril conformations
     $203,203

     award amount

2. Margaret A. Phillips

   Leads 2 awards · $1,466,516

   • 5R01AI103947-13Department: NIH department code

     Lead Optimization of DHODH Inhibitors for Malaria
     $748,960

     award amount
   • 5R01AI155784-05Department: NIH department code

     Optimization of novel phenotypic screening hits for treatment of Malaria

     Principal investigators: Margaret A. Phillips (contact PI), Joseph M Ready

     $717,556

     award amount

3. Joseph M Ready

   Leads 1 award · $1,354,462

   • 5RM1GM142002-05Department: NIH department code

     Chemical, Structural and Cell-Signaling Interrogation of 15-Prostanglandin Dehydrogenase in Tissue Repair and Regeneration

     Principal investigators: Joseph M Ready (contact PI), Andrew A Pieper, Sanford D. Markowitz

     $1,354,462

     award amount

   Also a principal investigator on 5R01AI155784-05, led by Margaret A. Phillips.

4. Joshua T Mendell

   Leads 2 awards · $1,340,177

   • 1U01CA305105-01Department: NIH department code

     Regulation of mitochondrial activity and metastasis by dihydrouridine-modified tRNAs in renal cell carcinoma

     Principal investigators: Joshua T Mendell (contact PI), Jan Peter Erzberger

     $850,611

     award amount
   • 5R01CA282036-03Department: NIH department code

     The role of long noncoding RNA CRNDE in normal physiology and cancer
     $489,566

     award amount

5. Xiaochen Bai

   Leads 2 awards · $1,216,739

   • 1R01CA299257-01Department: NIH department code

     Novel endogenous and engineered activators of STING: from mechanisms to cancer therapy

     Principal investigators: Xiaochen Bai (contact PI), Xuewu Zhang, Zhijian J Chen

     $642,739

     award amount
   • 1R35GM156386-01Department: NIH department code

     Understanding general principles in receptor tyrosine kinase signaling through structural and functional studies
     $574,000

     award amount

6. Michael Buszczak

   Leads 3 awards · $1,166,928

   • 5R35GM144043-04Department: NIH department code

     Genetic Dissection of Germ Cell Differentiation and Function
     $488,952

     award amount
   • 5UG3CA290312-02Department: NIH department code

     Developing ribosome biogenesis inhibitors for the prevention of cancer

     Principal investigators: Michael Buszczak (contact PI), Vincent Scott Tagliabracci

     $348,500

     award amount
   • 5R01AG079513-04Department: NIH department code

     Characterization of how mRNA translation influences reproductive aging
     $329,476

     award amount

7. Eric N Olson

   Leads 2 awards · $987,172

   • 5R01HL157281-04Department: NIH department code

     Transcriptional Control of Neonatal Heart Regeneration

     Principal investigators: Eric N Olson (contact PI), Rhonda Bassel-Duby

     $565,036

     award amount
   • 5R01AR080676-03Department: NIH department code

     The role of nuclear envelope protein NET39 in skeletal muscle function and diseases

     Principal investigators: Eric N Olson (contact PI), Ning Liu

     $422,136

     award amount

8. Chun-Li Zhang

   Leads 2 awards · $931,486

   • 5R01NS127375-04Department: NIH department code

     PAX6-induced adult neurogenesis
     $480,486

     award amount
   • 1R21NS136893-01A1Department: NIH department code

     In Vivo Neuronal Reprogramming of Fibroblasts After Spinal Cord Injury
     $451,000

     award amount

9. Elizabeth H Chen

   Leads 2 awards · $890,791

   • 2R35GM136316-06Department: NIH department code

     Decoding the mechanisms of cell-cell fusion - Renewal - 1
     $451,000

     award amount
   • 1R01AR085116-01Department: NIH department code

     Molecular Mechanisms of Myoblast Fusion
     $439,791

     award amount

10. Jin Jiang

    Leads 1 award · $888,257

    • 5R35GM118063-10Department: NIH department code

      Cell signaling in development and regeneration
      $888,257

      award amount

11. Jennifer J Kohler

    Leads 3 awards · $770,553

    • 5R35GM145599-04Department: NIH department code

      Function and regulation of epithelial glycosylation
      $525,698

      award amount
    • 5R21AI183574-02Department: NIH department code

      Discovery of pertussis toxin receptors
      $198,850

      award amount
    • 3R35GM145599-03S1Department: NIH department code

      Function and regulation of epithelial glycosylation
      $46,005

      award amount

12. Yunsun Nam

    Leads 2 awards · $765,314

    • 5R01CA258589-04Department: NIH department code

      Small molecules to target the RNA methyltransferase complex METTL3/METTL14
      $410,564

      award amount
    • 5R01GM122960-09Department: NIH department code

      Mechanisms of Microprocessor Function and Regulation
      $354,750

      award amount

13. Peter Mahan Douglas

    Leads 2 awards · $712,734

    • 5R01GM153859-02Department: NIH department code

      Multimodal regulation of intracellular lipid surveillance
      $376,962

      award amount
    • 5R01AG076529-04Department: NIH department code

      Lipid sensing through G protein geranylgeranylation
      $335,772

      award amount

14. Jun Wu

    Leads 2 awards · $693,168

    • 5R01HD103627-04Department: NIH department code

      Dissect the mechanisms underlying interspecies pluripotent stem cell competition
      $352,600

      award amount
    • 5R01GM138565-05Department: NIH department code

      Dissect formative pluripotency using cultured pluripotent stem cells
      $340,568

      award amount

15. Luke W Rice

    Leads 1 award · $651,001

    • 1R35GM156385-01Department: NIH department code

      Structural and Biochemical Mechanisms of Microtubule Dynamics and Regulation
      $651,001

      award amount

16. Chuo Chen

    Leads 1 award · $648,718

    • 5R01CA269377-03Department: NIH department code

      Therapeutic targeting of Wnt signaling in cancer
      $648,718

      award amount

17. Sarah H Shahmoradian

    Leads 1 award · $625,668

    • 5R01NS133517-03Department: NIH department code

      Determine the neurotoxicity of RNA metabolism dysfunction caused by cytoplasmic TDP-43 aggregates
      $625,668

      award amount

18. Daniel Luke Kober

    Leads 2 awards · $593,400

    • 5R01GM155152-02Department: NIH department code

      Structural and mechanistic basis for the maturation of site-one protease in the secretory pathway
      $344,400

      award amount
    • 5R00GM141261-04Department: NIH department code

      The mechanistic basis for targeted protein degradation in lipid metabolism
      $249,000

      award amount

19. Vincent Scott Tagliabracci

    Leads 1 award · $562,800

    • 1R35GM158265-01Department: NIH department code

      Discovering catalytic activities for pseudoenzymes
      $562,800

      award amount

    Also a principal investigator on 5UG3CA290312-02, led by Michael Buszczak.

20. Jenna L Jewell

    Leads 2 awards · $534,781

    • 5R35GM149351-03Department: NIH department code

      mTORC1 Regulation by Upstream Stimuli
      $492,000

      award amount
    • 3R35GM149351-02S1Department: NIH department code

      mTORC1 Regulation by Upstream Stimuli
      $42,781

      award amount

21. Steven L McKnight

    Leads 1 award · $533,000

    • 5R35GM130358-07Department: NIH department code

      A solid state conceptualization of information transfer from gene to message to protein
      $533,000

      award amount

22. Zhijian J Chen

    Leads 1 award · $515,342

    • 3OT2CA278683-01S3Department: NIH department code

      eDyNAmiC-TEXASSW
      $515,342

      award amount

    Also a principal investigator on 1R01CA299257-01, led by Xiaochen Bai.

23. Daniel Rosenbaum

    Leads 1 award · $492,000

    • 2R35GM136387-06Department: NIH department code

      Structural mechanisms of Scap/SREBP signaling in membrane homeostasis
      $492,000

      award amount

24. Kathryn Ann O'Donnell

    Leads 1 award · $476,420

    • 5R01CA273585-03Department: NIH department code

      The role of translation initiation factor eIF5B in lung cancer pathogenesis
      $476,420

      award amount

25. Zbyszek Otwinowski

    Leads 1 award · $435,502

    • 5R35GM145365-04Department: NIH department code

      From complex data to complex structures: new methods for structural biology
      $435,502

      award amount

26. Aparajita Kamalesh Dasgupta

    Leads 1 award · $426,095

    • 5R35GM119619-10Department: NIH department code

      Mechanisms and Functional Consequences of Signaling Protein Organization at Membranes
      $426,095

      award amount

27. Lorena Saelices Gomez

    Leads 1 award · $416,849

    • 1R01HL177670-01Department: NIH department code

      Screening for Cardiac Amyloidosis with a Blood Biomarker in Minority Populations – SCABB-MP

      Principal investigators: Lorena Saelices Gomez (contact PI), Frederick Lief Ruberg, Mathew S Maurer

      $416,849

      award amount

28. Glen Liszczak

    Leads 1 award · $410,000

    • 5R35GM147140-04Department: NIH department code

      Regulation and function of site-specific protein poly-ADP-ribosylation
      $410,000

      award amount

29. Weiwei Wang

    Leads 1 award · $410,000

    • 5R35GM146860-04Department: NIH department code

      Understanding higher-order glycine receptor assemblies in neurotransmission
      $410,000

      award amount

30. Lukasz A. Joachimiak

    Leads 1 award · $401,800

    • 4R01AG078888-02Department: NIH department code

      J-domain protein conformational selectivity for tau in disease
      $401,800

      award amount

31. Benjamin P Tu

    Leads 1 award · $379,992

    • 2R35GM136370-06Department: NIH department code

      Metabolic signals regulating cell growth versus survival
      $379,992

      award amount

32. Michael K Rosen

    Leads 1 award · $369,000

    • 5R35GM141736-05Department: NIH department code

      Cell Organization Through Phase Separation: Mechanisms, Functions and Disease
      $369,000

      award amount

33. Konstantin Doubrovinski

    Leads 1 award · $354,732

    • 5R01GM134207-07Department: NIH department code

      Physical aspects of Drosophila Gastrulation
      $354,732

      award amount

34. Richard Dustin Schaeffer

    Leads 1 award · $344,400

    • 5R01GM147367-03Department: NIH department code

      ECOD: Large scale classification of predicted and experimental protein structures
      $344,400

      award amount

35. Matthew W. Parker

    Leads 1 award · $337,949

    • 5R01GM155100-02Department: NIH department code

      Defining the modular architecture of protein intrinsically disordered regions for a predictive understanding of biological function
      $337,949

      award amount

36. Myles Warwick Smith

    Leads 1 award · $328,000

    • 5R35GM155273-02Department: NIH department code

      Expanding Access to Molecular Complexity through Natural Product Synthesis
      $328,000

      award amount

37. Tian Qin

    Leads 1 award · $324,060

    • 5R01GM141088-05Department: NIH department code

      Development of Sulfur-Based Reactions with Translational Applications
      $324,060

      award amount

38. Hanieh Mazloom Farsibaf

    Leads 1 award · $140,097

    • 1K99CA283246-01A1Department: NIH department code

      Data-driven mechanistic models of morphology-controlled Ras oncogenic signaling
      $140,097

      award amount

39. Stanislaw Marek Deja

    Leads 1 award · $103,385

    • 5K01DK133630-04Department: NIH department code

      Sympathetic Control of Liver Metabolism in Exercise and Obesity
      $103,385

      award amount

40. Peiheng Gan

    Leads 1 award · $100,480

    • 5K99HL171888-02Department: NIH department code

      RBPMS, a novel RNA splicing regulator of cardiac function and disease
      $100,480

      award amount

41. Xurde Menendez Caravia

    Leads 1 award · $100,480

    • 5K99HL171887-02Department: NIH department code

      Understanding the roles of nuclear envelope proteins and DNA damage in cardiomyopathy
      $100,480

      award amount

42. Benjamin Jacob Mayro

    Leads 1 award · $96,746

    • 5K00CA264162-05Department: NIH department code

      Understanding the impact that tumor representative oxygen tension has on phosphotyrosine-dependent signaling networks in solid tumors
      $96,746

      award amount

43. Matthieu Dos Santos

    Leads 1 award · $95,080

    • 5K99AR084549-02Department: NIH department code

      Characterization of Maf function in muscle atrophy
      $95,080

      award amount

44. Neha Ahuja

    Leads 1 award · $89,844

    • 1K99DK140516-01A1Department: NIH department code

      Mechanisms of Cellular Communication: The Role of Merlin in Pancreatic Development
      $89,844

      award amount

45. Shayna Thomas-Jardin

    Leads 1 award · $80,224

    • 5F32CA274982-03Department: NIH department code

      Immune Checkpoint Regulation by the Integrated Stress Response Pathway in Lung Ca
      $80,224

      award amount

46. Keril Poukalov

    Leads 1 award · $75,520

    • 1F32AR086604-01Department: NIH department code

      Development of Muscle Optimized Non-viral Gene Editors
      $75,520

      award amount

47. Michael R McConville

    Leads 1 award · $47,403

    • 5F30HL167629-03Department: NIH department code

      Unexpected mechanism underlying mislocalization of thrombocytopenia-associated ETV6 point mutation
      $47,403

      award amount

48. Peter Luo

    Leads 1 award · $47,403

    • 5F30DK137405-03Department: NIH department code

      The role and regulation of pericytes in remodeling the periarterial niche during nephrogenesis
      $47,403

      award amount

49. Jordan McCall Wall

    Leads 1 award · $40,127

    • 1F31GM154433-01A1Department: NIH department code

      Investigating the role of the RNA helicase F57B9.3 in translational regulation under conditions of lipid depletion
      $40,127

      award amount

Co-investigators

Named as principal investigators on these awards, which someone else leads. They may belong to another department or institution: their own, below, comes from the awards they lead.

• Andrew A Pieper

  Co-investigator on 5RM1GM142002-05, led by Joseph M Ready

  Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.

• Sanford D. Markowitz

  Co-investigator on 5RM1GM142002-05, led by Joseph M Ready

  From the FY2025 awards this person leads

  • Case Western Reserve University · Internal Medicine (NIH department code, 2 awards)

• Jan Peter Erzberger

  Co-investigator on 1U01CA305105-01, led by Joshua T Mendell

  From the FY2024 awards this person leads

  • UT Southwestern Medical Center · Biochemistry (NIH department code, 1 award)

• Xuewu Zhang

  Co-investigator on 1R01CA299257-01, led by Xiaochen Bai

  From the FY2025 awards this person leads

  • UT Southwestern Medical Center · Pharmacology (NIH department code, 2 awards)

• Rhonda Bassel-Duby

  Co-investigator on 5R01HL157281-04, led by Eric N Olson

  Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.

• Ning Liu

  Co-investigator on 5R01AR080676-03, led by Eric N Olson

  Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.

• Frederick Lief Ruberg

  Co-investigator on 1R01HL177670-01, led by Lorena Saelices Gomez

  Own institution and department: not known. ScienceDex has no NIH award this person leads as contact PI.

• Mathew S Maurer

  Co-investigator on 1R01HL177670-01, led by Lorena Saelices Gomez

  From the FY2025 awards this person leads

  • Columbia University · Internal Medicine (NIH department code, 1 award)