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opennotspecifiedJul 2014View details →

Fig. 2. MCF-7 in Ethanolic extract of Mimosa caesalpiniifolia leaves: Chemical characterization and cytotoxic effect on human breast cancer MCF-7 cell line

Fig. 2. MCF-7 cell protein content decreasing (%), estimated by the sulforhodamine B assay, after treatment with cyclophosphamide (CP, 550 μg/mL) and different concentrations of the ethanolic extract of Mimosa caesalpiniifolia leaves (EEM 5.0 - 320.0 μg/mL) for 24 and 48 h. The results are expressed as mean ± SEM of three independent experiments. Different letters indicate significant differences (p <0.001) by the Tukey test. Protein content was calculated relative to the negative control and 320.0 μg/mL EEM produced the maximum effect.

opennotspecifiedJul 2014View details →

Fig. 1 in Ethanolic extract of Mimosa caesalpiniifolia leaves: Chemical characterization and cytotoxic effect on human breast cancer MCF-7 cell line

Fig. 1. HPLC-DAD-ESI-MS analysis of the ethanolic extract of Mimosa caesalpiniifolia leaves. (A) UV 360 nm; (B) ESI-MS, base peak chromatogram, negative ion mode, m/z 100–1500. No additional peaks were detected when the UV trace was recorded at wavelengths down to 360 nm. Peaks assigned as m/z: 288.97, 318.00, and 576.77 were identified, respectively, as catechin, 2,3 dihydroquercetagetin, and procyanidin B2 [(epi)catechin–(epi)catechin)] (see structures).

opennotspecifiedJul 2014View details →

Fig. 4. MCF-7 in Ethanolic extract of Mimosa caesalpiniifolia leaves: Chemical characterization and cytotoxic effect on human breast cancer MCF-7 cell line

Fig. 4. MCF-7 cell diameter (μm) after treatment with cyclophosphamide (CP, 550 μg/mL) and different concentrations (5.0–320.0 μg/mL) of the ethanolic extract of Mimosa caesalpiniifolia leaves (EEM) for 24 or 48 h, compared to the negative control cells (NC). Results are expressed as mean ± SEM of three independent experiments. Different letters indicate significant differences (p <0.01) by the Tukey test. Note cell-diameter reduction after treatment, in comparison to the negative control cells, thereby indicating EEM cytotoxicity.

opencc-zeroFeb 2023View details →

Evaluation of SPIRES on Chemical-Disease-Relation extraction task 2023-01

SPIRES CDR evaluation results. See https://github.com/monarch-initiative/ontogpt

opencc-by-4.0May 2023View details →

Automated patent extraction powers generative modeling in focused chemical spaces: Training data and model checkpoints release

Training data and model checkpoints accompanying paper on "Automated patent extraction powers generative modeling in focused chemical spaces". If you use this data, please cite the following manuscript: <pre>@article{subramanian2023automated, title={Automated patent extraction powers generative modeling in focused chemical spaces}, author={Subramanian, Akshay and Greenman, Kevin P and Gervaix, Alexis and Yang, Tzuhsiung and G{\'o}mez-Bombarelli, Rafael}, journal={Digital Discovery}, year={2023}, publisher={Royal Society of Chemistry} }</pre>

opennotspecifiedFeb 2022View details →

Fig. 2. A in Psilostachyins as trypanocidal compounds: Bioguided fractionation of Ambrosia tenuifolia chemically modified extract

Fig. 2. A) Schematic representation of bioguided separation of CH2Cl2-m-CPBA modified extract of Ambrosia tenuifolia to isolate and identify the main SLs responsible for the trypanocidal activity. B) Percentage of parasite inhibition after treatment with the pools (I-VI) and benznidazole at 5 μg/mL. Asterisks indicate significant differences between the indicated groups and the control, benznidazole (****, p <0.001), and ns indicates no significant differences. C) Percentage of parasite inhibition after treatment at different concentrations (1, 5 and 10 μg/mL) with the pure compounds obtained after chemical extract derivatization. At 1 and 5 μg/mL, only the indicated groups did not exhibit significant differences compared to the respective concentration of benznidazole (ns). At 10 μg/mL, the indicated group showed significant differences compared to benznidazole at the same concentration (****, p <0.001). The molar concentrations equivalent to 1 μg/mL of each compound are 3.8 μM (Psi C and benznidazol) and 3.6 μM (Psi A, paulitin, isopaulitin, 2 and 3), for more details see figure S8.

Fig. 4 in An extensive study on the chemical diversity of lipophilic extractives from Eucalyptus globulus wood

Fig. 4. Radial profile of different chemical families (proportion of chemical families) in the lipophilic DCM along the tree height levels (0%, 35% and 60%) in E. globulus mature wood trees.

Fig. 3 in An extensive study on the chemical diversity of lipophilic extractives from Eucalyptus globulus wood

Fig. 3. Proportion of chemical families in the lipophilic DCM extracts of E. globulus mature wood trees. Average of 36 runs (3 trees × 3 height levels x 2 extractions x 2 injections).

Fig. 2 in An extensive study on the chemical diversity of lipophilic extractives from Eucalyptus globulus wood

Fig. 2. Example of one GC-MS chromatogram of dichloromethane extracts (as TMS derivatives) of Eucalyptus globulus mature wood trees and range of the principal chemical family distribution. Main peaks: 3 - Decanoic acid (C10:0); 5 - Vanillin; 11 - Dodecanoic acid (C12:0); 12 - 4-hydroxy-3,5- dimethoxybenzaldehyde; 13 - homovanillic alcohol; 14 - Vanillic acid; 25 - Syringic acid; 36 - Propiovanillone; 39 - Hexadecanoic acid (C16:0); 52 - Octadeca-9,12-dienoic acid (C18:2); 55 - Octadecanoic acid (C18:0); 66 - ω-hydroxy fatty acid (C18:2); 67 - Icosanoic acid (C20:0) 74 - 1-palmitoylglycerol (G- C16:0); 79 - 2-hydroxy-decane-1,10-dioic acid (C10:0); 86 - Octacosane (C28); 90 -Tetracosanoic acid; 94 - Hexacosan-1-ol (C26); 102 - a-tocopherol; 109 - campesterol; 115 - tritriacontane (C33); 118 - β-Sitosterol; 123 - 2-tetracosanoylglycerol (G-C24:0); 140 - Betulinic acid isomer; 146 - 1-hexacosanoylglycerol (G-C26:0); 147 - Ursolic acid; 161 - Arjunolic acid; 162 - Asiatic acid; 168 - sitosteryl 3-β-D-glucopyranoside. All the identified peaks are listed in Tables 1–6

Fig. 1 in An extensive study on the chemical diversity of lipophilic extractives from Eucalyptus globulus wood

Fig. 1. Schematic drawing of sapwood heartwood outer and inner in the stems of E. globulus trees harvested for these study. Heartwood area and extractives content (average of three trees ± STDEV) (Adapted from Gominho et al., 2015).

publicNov 2023View details →

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Chemical profiling of milkweed and monarch butterfly wing extracts via mass spectrometry

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Data from: Chemical extraction of phosphorus from dairy manure and utilization of recovered manure solids

This is digital research data corresponding to a published manuscript, Chemical extraction of phosphorus from dairy manure and utilization of recovered manure solids. Agronomy 2020, 10, 1725; doi:10.3390/agronomy10111725 Repeated land application of dairy manure can increase soil phosphorus above crop requirements because of manure's low nitrogen (N) to phosphorus (P) ratio (N:P < 4:1). This soil P build-up can lead to off-site P transport and impairment of surface water quality. We evaluated a treatment process to extract P from manures, called Quick Wash, integrated with a double-stage solids separation system to recover coarse and fine manure solids. The Quick Wash process uses a combination of acid, base, and organic polymers to extract and recover P from manures, improving the N:P ratio of recovered manure solids (RMS).

opencc-zeroFeb 2022View details →

Fig. 2 in Chemical constituents and toxic, repellent, and oviposition-deterrent effects of ethanol-extracted Myristica fragrans (Myristicaceae) oil on Bemisia tabaci (Hemiptera: Aleyrodidae)

Fig. 2. Contact toxicity of nutmeg essential oil to whitefly nymphs in laboratory experiments at concentrations of 10, 5, and 2.5 mg/mL. Values are the means of 8 replications. The mean numbers of nymphs were analyzed by 1-way ANOVA, with a Tukey HSD post-hoc test at a significance level of P <0.05; means topped by the same letter are not significantly different.

Fig. 1 in Chemical constituents and toxic, repellent, and oviposition-deterrent effects of ethanol-extracted Myristica fragrans (Myristicaceae) oil on Bemisia tabaci (Hemiptera: Aleyrodidae)

Fig. 1. Fumigant toxicity of nutmeg essential oil to whitefly adults in laboratory experiments at concentrations of 10, 5, and 2.5 mg/mL. Values are the means of 8 replications. The mean numbers of adults were analyzed by 1-way ANOVA, with a Tukey HSD post-hoc test at a significance level of P <0.05; means topped by the same letter are not significantly different.

Fig. 5 in Chemical constituents and toxic, repellent, and oviposition-deterrent effects of ethanol-extracted Myristica fragrans (Myristicaceae) oil on Bemisia tabaci (Hemiptera: Aleyrodidae)

Fig. 5. Greenhouse experiments with whitefly adults, testing nutmeg essential oil at concentrations of 10, 5, and 2.5 mg/mL. A. Repellency at 24 h, B. repellency at 48 h, C. oviposition at 24 h, D. oviposition at 48 h of exposure. Values are means of 8 replications. The mean numbers of adults and eggs were analyzed by 1-way ANOVA, with a Tukey HSD post-hoc test at a significance level of P <0.05; means topped by the same letter are not significantly different.

Fig. 4 in Chemical constituents and toxic, repellent, and oviposition-deterrent effects of ethanol-extracted Myristica fragrans (Myristicaceae) oil on Bemisia tabaci (Hemiptera: Aleyrodidae)

Fig. 4. Repellency of nutmeg essential oil to whitefly adults in laboratory experiments at A. 24 h, B. 48 h, and C. 72 h of exposure to concentrations of 10, 5, and 2.5 mg/mL. Values are means of 8 replications. The mean numbers of adults were compared by paired t-tests at a significance level of P ≤ 0.05. Asterisk indicates a significant difference between control and treatment.

opennotspecifiedFeb 2022View details →

Fig. 1 in Psilostachyins as trypanocidal compounds: Bioguided fractionation of Ambrosia tenuifolia chemically modified extract

Fig. 1. Natural compounds isolated from Ambrosia tenuifolia.

opennotspecifiedFeb 2022View details →

Fig. 3 in Psilostachyins as trypanocidal compounds: Bioguided fractionation of Ambrosia tenuifolia chemically modified extract

Fig. 3. Proposed oxidative derivatization of Psi B with mCPBA.